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The map label for this gene is purL [H]

Identifier: 146339784

GI number: 146339784

Start: 2991992

End: 2994202

Strand: Direct

Name: purL [H]

Synonym: BRADO2785

Alternate gene names: 146339784

Gene position: 2991992-2994202 (Clockwise)

Preceding gene: 146339782

Following gene: 146339786

Centisome position: 40.13

GC content: 67.57

Gene sequence:

>2211_bases
ATGCGCAATGAACCGCAGATCACCCCCGAGCTCGTCGCCGCCCACGGCCTGAAGCCCGACGAATATGAGCGCATCCTGAA
GCTGATCGGGCGGGAGCCGACTTTCACCGAGCTCGGCATCTTCTCGGCGATGTGGAACGAGCATTGCTCGTACAAGTCGT
CGCGCATCCATCTCAAGGGCCTGCCGACCAAGGCGCCCTGGGTGATCCAGGGGCCGGGCGAGAATGCCGGCGTGATCGAT
ATCGGCGACGGCCAGGCCGTCGTGTTCAAGATGGAGAGCCATAACCATCCGAGCTACATCGAGCCTTACCAGGGTGCCAC
TACGGGCGTCGGTGGCATCCTGCGCGACGTCTTCACGATGGGCGCGCGCCCGATCGCCTGCCTGAACGCGCTGTCGTTCG
GCGCCCCGGAGCACCCCAAGACCAGGCACCTCGTATCCGGCGTCGTCGCCGGCATCGGCGGCTATGGCAACTCCTTCGGC
GTGCCCACCGTGGGCGGCCAGACCCGCTTCCACACCCGCTATGACGGCAACATCCTGGTCAACGCCATGGCCGTCGGCCT
TGCCGACGCCGACAAGATTTTCTATGCGGCCGCTTCCGGCGTGAACATGCCGATCGTCTATCTCGGCTCCAAGACCGGCC
GCGACGGCATCCACGGCGCCTCGATGGCCTCGGCCGAGTTCGACGATTCCTCCGAGGAGAAGCGCCCGACGGTGCAGGTT
GGCGACCCCTTCGCCGAGAAGCTGTTGCTCGAGGCGTGCCTGGAGATCATGGCCGCCGATTGCGTGATCGCGATCCAGGA
CATGGGCGCGGCCGGCCTGACCTGCTCGGCGGTCGAGATGGGCGCCAAGGGTGACCTCGGCGTCGACCTCGATCTGGACT
CCGTGCCGACCCGCGAGACCGGCATGAGCGCCTATGAGATGATGCTCTCCGAGAGCCAGGAACGCATGCTCATGGTGCTG
AAGCCGGAGAAGGAGAAGGAGGCCGAAGCGATCTTCCGCAAATGGGGGCTCGATTTCGCCGTGGTCGGCTACACCACGCC
GAGCAAGCGCTTCGTCGTGAAGCATGGCGGTGACGTCATGGCCGACCTGCCGATCAAGGAGCTCGGCGACGAGGCGCCGC
TCTACGATCGTCCGCATGTGGCGTCGCCCGCGCTGCCGGTGATCCATGCCCGCGAGGTCAAGGCGCCGATGGCCATCATC
CCGGCGCTGGAGAAGCTGATCGCGACGCCGGACCTGTGCTCCAAGCGCTGGATCTGGGAGCAGTACGACCACGTCATTCT
CGGCAACACCGTACAGCGCCCCGGCGGCGATGCCGCGGTCGTGCGCGTGCAGGATGGCCCGAAGGGGCTGGCGCTCACCG
TCGATGTCACGCCGCGCTATTGCGAAGCCGACCCGTTCGAGGGCGGCAAGCAGGCGGTGGCGGAAGCCTGGCGCAACATC
ACCGCGGTCGGCGGCCGGCCGCTCGCCATCACCGACAATCTCAATTTCGGCAATCCGGAGCGGCCCGAGATCATGGGCCA
GTTCGTCGGCTGCCTGAAGGGCATCTCGGAGGCCTGCCGGGCGCTCGACTTCCCGGTCGTGTCCGGCAACGTCTCGCTCT
ACAACGAGACCAATGGGCGGGCGATCCTGCCGACGCCCTCGATCGGCGGCGTCGGCTTGCTTGACGACTTTACCAAGTCC
GCCAGCATCGCCTTCAAGACTGAGGGCGAGGCGATCCTGCTGATCGGCGAGACCCACGGCTGGCTCGGCCAGTCGGTCTA
TCTGCGCGACGTCTGCGGCCGCGAGGAGGGGGCTCCGCCGCCGGTCGATCTCGCCGCCGAGAAGCGCATCGGCGATGTCG
TCCGCGGCATGATCCACGCGGGAACGGCGACTGCCGCGCATGATCTATCCGATGGCGGCCTGCTGGTCGCGCTCGCCGAG
ATGGCCATGGCTTCCGGCATCGGCGCGCGCCTCTTGGCCGCGCCTGCCTCGATCGTTCCGCATGCCTATTGGTTCGGCGA
GGACCAGGCGCGCTATCTGGTGACGGTGCCGGAGACCGAGGCGGGCCGCGTCCTCGCCAAGATGCGCGGCGCCAACGTGC
CGTGCACGCGCATCGGCACCACGGGCGGCACGGCCCTGGCGATCGCTGGCGAGGCCTCGGTCGAGGTCGCGACGCTCAGG
ACCCGGTTCGAGAGCTGGTTGCCGGGATACATGGGCGGCGCCGCCGCTTAA

Upstream 100 bases:

>100_bases
GGGCGGATGAGGGCCGTAAAAGGCCTTTTCGCATCAGGCCCGGCTTTCTATGAAGCAGGGTTTAAGGGACCAGCGGCCCT
CGGGGCAAAGGCATTTCTCC

Downstream 100 bases:

>100_bases
ACCTCCACTGTCGTCCCGGACAAGCCACGACGGCGCACCGCGCCGACGTGGCGCCGGGGACCCATACACCGCAGCCGCTA
GTCTATGGTCGCGCACGCTG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 736; Mature: 736

Protein sequence:

>736_residues
MRNEPQITPELVAAHGLKPDEYERILKLIGREPTFTELGIFSAMWNEHCSYKSSRIHLKGLPTKAPWVIQGPGENAGVID
IGDGQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFTMGARPIACLNALSFGAPEHPKTRHLVSGVVAGIGGYGNSFG
VPTVGGQTRFHTRYDGNILVNAMAVGLADADKIFYAAASGVNMPIVYLGSKTGRDGIHGASMASAEFDDSSEEKRPTVQV
GDPFAEKLLLEACLEIMAADCVIAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDSVPTRETGMSAYEMMLSESQERMLMVL
KPEKEKEAEAIFRKWGLDFAVVGYTTPSKRFVVKHGGDVMADLPIKELGDEAPLYDRPHVASPALPVIHAREVKAPMAII
PALEKLIATPDLCSKRWIWEQYDHVILGNTVQRPGGDAAVVRVQDGPKGLALTVDVTPRYCEADPFEGGKQAVAEAWRNI
TAVGGRPLAITDNLNFGNPERPEIMGQFVGCLKGISEACRALDFPVVSGNVSLYNETNGRAILPTPSIGGVGLLDDFTKS
ASIAFKTEGEAILLIGETHGWLGQSVYLRDVCGREEGAPPPVDLAAEKRIGDVVRGMIHAGTATAAHDLSDGGLLVALAE
MAMASGIGARLLAAPASIVPHAYWFGEDQARYLVTVPETEAGRVLAKMRGANVPCTRIGTTGGTALAIAGEASVEVATLR
TRFESWLPGYMGGAAA

Sequences:

>Translated_736_residues
MRNEPQITPELVAAHGLKPDEYERILKLIGREPTFTELGIFSAMWNEHCSYKSSRIHLKGLPTKAPWVIQGPGENAGVID
IGDGQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFTMGARPIACLNALSFGAPEHPKTRHLVSGVVAGIGGYGNSFG
VPTVGGQTRFHTRYDGNILVNAMAVGLADADKIFYAAASGVNMPIVYLGSKTGRDGIHGASMASAEFDDSSEEKRPTVQV
GDPFAEKLLLEACLEIMAADCVIAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDSVPTRETGMSAYEMMLSESQERMLMVL
KPEKEKEAEAIFRKWGLDFAVVGYTTPSKRFVVKHGGDVMADLPIKELGDEAPLYDRPHVASPALPVIHAREVKAPMAII
PALEKLIATPDLCSKRWIWEQYDHVILGNTVQRPGGDAAVVRVQDGPKGLALTVDVTPRYCEADPFEGGKQAVAEAWRNI
TAVGGRPLAITDNLNFGNPERPEIMGQFVGCLKGISEACRALDFPVVSGNVSLYNETNGRAILPTPSIGGVGLLDDFTKS
ASIAFKTEGEAILLIGETHGWLGQSVYLRDVCGREEGAPPPVDLAAEKRIGDVVRGMIHAGTATAAHDLSDGGLLVALAE
MAMASGIGARLLAAPASIVPHAYWFGEDQARYLVTVPETEAGRVLAKMRGANVPCTRIGTTGGTALAIAGEASVEVATLR
TRFESWLPGYMGGAAA
>Mature_736_residues
MRNEPQITPELVAAHGLKPDEYERILKLIGREPTFTELGIFSAMWNEHCSYKSSRIHLKGLPTKAPWVIQGPGENAGVID
IGDGQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFTMGARPIACLNALSFGAPEHPKTRHLVSGVVAGIGGYGNSFG
VPTVGGQTRFHTRYDGNILVNAMAVGLADADKIFYAAASGVNMPIVYLGSKTGRDGIHGASMASAEFDDSSEEKRPTVQV
GDPFAEKLLLEACLEIMAADCVIAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDSVPTRETGMSAYEMMLSESQERMLMVL
KPEKEKEAEAIFRKWGLDFAVVGYTTPSKRFVVKHGGDVMADLPIKELGDEAPLYDRPHVASPALPVIHAREVKAPMAII
PALEKLIATPDLCSKRWIWEQYDHVILGNTVQRPGGDAAVVRVQDGPKGLALTVDVTPRYCEADPFEGGKQAVAEAWRNI
TAVGGRPLAITDNLNFGNPERPEIMGQFVGCLKGISEACRALDFPVVSGNVSLYNETNGRAILPTPSIGGVGLLDDFTKS
ASIAFKTEGEAILLIGETHGWLGQSVYLRDVCGREEGAPPPVDLAAEKRIGDVVRGMIHAGTATAAHDLSDGGLLVALAE
MAMASGIGARLLAAPASIVPHAYWFGEDQARYLVTVPETEAGRVLAKMRGANVPCTRIGTTGGTALAIAGEASVEVATLR
TRFESWLPGYMGGAAA

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=701, Percent_Identity=23.9657631954351, Blast_Score=101, Evalue=3e-21,
Organism=Escherichia coli, GI48994899, Length=727, Percent_Identity=24.6217331499312, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17553022, Length=437, Percent_Identity=23.7986270022883, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321498, Length=737, Percent_Identity=23.7449118046133, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 78208; Mature: 78208

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNEPQITPELVAAHGLKPDEYERILKLIGREPTFTELGIFSAMWNEHCSYKSSRIHLKG
CCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
LPTKAPWVIQGPGENAGVIDIGDGQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFTM
CCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
GARPIACLNALSFGAPEHPKTRHLVSGVVAGIGGYGNSFGVPTVGGQTRFHTRYDGNILV
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEE
NAMAVGLADADKIFYAAASGVNMPIVYLGSKTGRDGIHGASMASAEFDDSSEEKRPTVQV
EEEEECCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
GDPFAEKLLLEACLEIMAADCVIAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDSVPTRET
CCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEHHEECCCCCCCCEEECCCCCCCCHH
GMSAYEMMLSESQERMLMVLKPEKEKEAEAIFRKWGLDFAVVGYTTPSKRFVVKHGGDVM
CHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCEE
ADLPIKELGDEAPLYDRPHVASPALPVIHAREVKAPMAIIPALEKLIATPDLCSKRWIWE
ECCCHHHCCCCCCCCCCCCCCCCCCCEEEHHHHCCCHHHHHHHHHHHCCCCHHHCCCCHH
QYDHVILGNTVQRPGGDAAVVRVQDGPKGLALTVDVTPRYCEADPFEGGKQAVAEAWRNI
HCCCEEECCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCE
TAVGGRPLAITDNLNFGNPERPEIMGQFVGCLKGISEACRALDFPVVSGNVSLYNETNGR
EECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCCCC
AILPTPSIGGVGLLDDFTKSASIAFKTEGEAILLIGETHGWLGQSVYLRDVCGREEGAPP
EEECCCCCCCCCHHHHHCCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHCCCCCCCC
PVDLAAEKRIGDVVRGMIHAGTATAAHDLSDGGLLVALAEMAMASGIGARLLAAPASIVP
CCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHCCHHHCC
HAYWFGEDQARYLVTVPETEAGRVLAKMRGANVPCTRIGTTGGTALAIAGEASVEVATLR
CEEEECCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCEEHHHHH
TRFESWLPGYMGGAAA
HHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRNEPQITPELVAAHGLKPDEYERILKLIGREPTFTELGIFSAMWNEHCSYKSSRIHLKG
CCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
LPTKAPWVIQGPGENAGVIDIGDGQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFTM
CCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
GARPIACLNALSFGAPEHPKTRHLVSGVVAGIGGYGNSFGVPTVGGQTRFHTRYDGNILV
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEE
NAMAVGLADADKIFYAAASGVNMPIVYLGSKTGRDGIHGASMASAEFDDSSEEKRPTVQV
EEEEECCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
GDPFAEKLLLEACLEIMAADCVIAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDSVPTRET
CCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEHHEECCCCCCCCEEECCCCCCCCHH
GMSAYEMMLSESQERMLMVLKPEKEKEAEAIFRKWGLDFAVVGYTTPSKRFVVKHGGDVM
CHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCEE
ADLPIKELGDEAPLYDRPHVASPALPVIHAREVKAPMAIIPALEKLIATPDLCSKRWIWE
ECCCHHHCCCCCCCCCCCCCCCCCCCEEEHHHHCCCHHHHHHHHHHHCCCCHHHCCCCHH
QYDHVILGNTVQRPGGDAAVVRVQDGPKGLALTVDVTPRYCEADPFEGGKQAVAEAWRNI
HCCCEEECCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCE
TAVGGRPLAITDNLNFGNPERPEIMGQFVGCLKGISEACRALDFPVVSGNVSLYNETNGR
EECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCCCC
AILPTPSIGGVGLLDDFTKSASIAFKTEGEAILLIGETHGWLGQSVYLRDVCGREEGAPP
EEECCCCCCCCCHHHHHCCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHCCCCCCCC
PVDLAAEKRIGDVVRGMIHAGTATAAHDLSDGGLLVALAEMAMASGIGARLLAAPASIVP
CCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHCCHHHCC
HAYWFGEDQARYLVTVPETEAGRVLAKMRGANVPCTRIGTTGGTALAIAGEASVEVATLR
CEEEECCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCEEHHHHH
TRFESWLPGYMGGAAA
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]