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The map label for this gene is purC

Identifier: 146339776

GI number: 146339776

Start: 2985969

End: 2986736

Strand: Direct

Name: purC

Synonym: BRADO2776

Alternate gene names: 146339776

Gene position: 2985969-2986736 (Clockwise)

Preceding gene: 146339774

Following gene: 146339777

Centisome position: 40.04

GC content: 62.11

Gene sequence:

>768_bases
ATGAGCCGTCGGCGTCGCATTTATGAAGGCAAGGCCAAGGTCCTGTACGAAGGTCCCGAGCCGGGCACCCTGATCCAGCA
CTTCAAGGACGACGCCACCGCCTTCAATGCCAAGAAGCACCAGGTGATCGAAGGCAAGGGCGTCCTCAACAACCGCATCT
CGGAGTACCTGTTTCAGCACCTCAACGACATCGGGGTGCCGACCCACTTCATCCGCCGCCTCAACATGCGCGAGCAGCTG
ATTCGCGAGGTCGAGATCGTCCCGCTCGAGGTCGTGGTGCGCAACGTTGCGGCGGGTTCGCTGTCGCAGCGCCTGGGCAT
CGAGGAGGGCACCCAGCTGCCGCGTTCGATCATCGAATTCTATTACAAGAACGACCAGCTCAACGACCCCATGGTGTCGG
AGGAGCACATCACCGCGTTCGGCTGGGCCACGCCCCAGGAGATCGACGACATCATGGCGCTCGCCATTCGCGTCAACGAC
TTCCTGACCGGGCTCTTCCTCGGCATCGGCATCCGCCTGGTCGACTTCAAGATGGAATGCGGCCGGCTGTTCGAGAACGA
GATGATGCGGATCATCGTCGCCGACGAGATTTCCCCCGATTCGTGCCGGCTGTGGGACATCAAGTCGAACGAGAAGCTCG
ACAAGGACCGCTTCCGTCGTGATCTTGGCGGCCTCCTGGAGGCCTATACCGAGGTCGCCAAGCGGCTCGGCATCCTGATG
GAGAACGAGCGTCCGGCGGGCTCCGGCCCGGTCCTGGTCAAGAGCTAA

Upstream 100 bases:

>100_bases
CGTCACGATCCGGGCCCTCGCGGCAGCTCCGTCGTGGTCCTGTCCAAAGTCATCCGGAGCCCACCATTTCATGGATTTCA
ACAAAACACGGTACATCCCA

Downstream 100 bases:

>100_bases
AGGGAATCAAGACGTGAAAGCGCGTGTCACGGTGACACTGAAAACCGGCATCCTCGATCCCCAGGGCAAGGCGATCGAGG
GCGCCCTCAAATCGCTCGGC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase A

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHQVIEGKGVLNNRISEYLFQHLNDIGVPTHFIRRLNMREQL
IREVEIVPLEVVVRNVAAGSLSQRLGIEEGTQLPRSIIEFYYKNDQLNDPMVSEEHITAFGWATPQEIDDIMALAIRVND
FLTGLFLGIGIRLVDFKMECGRLFENEMMRIIVADEISPDSCRLWDIKSNEKLDKDRFRRDLGGLLEAYTEVAKRLGILM
ENERPAGSGPVLVKS

Sequences:

>Translated_255_residues
MSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHQVIEGKGVLNNRISEYLFQHLNDIGVPTHFIRRLNMREQL
IREVEIVPLEVVVRNVAAGSLSQRLGIEEGTQLPRSIIEFYYKNDQLNDPMVSEEHITAFGWATPQEIDDIMALAIRVND
FLTGLFLGIGIRLVDFKMECGRLFENEMMRIIVADEISPDSCRLWDIKSNEKLDKDRFRRDLGGLLEAYTEVAKRLGILM
ENERPAGSGPVLVKS
>Mature_254_residues
SRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHQVIEGKGVLNNRISEYLFQHLNDIGVPTHFIRRLNMREQLI
REVEIVPLEVVVRNVAAGSLSQRLGIEEGTQLPRSIIEFYYKNDQLNDPMVSEEHITAFGWATPQEIDDIMALAIRVNDF
LTGLFLGIGIRLVDFKMECGRLFENEMMRIIVADEISPDSCRLWDIKSNEKLDKDRFRRDLGGLLEAYTEVAKRLGILME
NERPAGSGPVLVKS

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=256, Percent_Identity=32.421875, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI5453539, Length=256, Percent_Identity=32.421875, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI119220559, Length=263, Percent_Identity=31.1787072243346, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1788820, Length=241, Percent_Identity=41.49377593361, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17531275, Length=243, Percent_Identity=30.4526748971193, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI18860083, Length=237, Percent_Identity=29.1139240506329, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24583917, Length=207, Percent_Identity=26.5700483091787, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR71_BRAJA (Q89IB0)

Other databases:

- EMBL:   BA000040
- RefSeq:   NP_772369.1
- ProteinModelPortal:   Q89IB0
- SMR:   Q89IB0
- GeneID:   1048812
- GenomeReviews:   BA000040_GR
- KEGG:   bja:bll5729
- NMPDR:   fig|224911.1.peg.5729
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- PhylomeDB:   Q89IB0
- ProtClustDB:   PRK09362
- BioCyc:   BJAP224911:BLL5729-MONOMER
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 29186; Mature: 29055

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHQVIEGKGVLNNRISEYLFQH
CCCCCCHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHH
LNDIGVPTHFIRRLNMREQLIREVEIVPLEVVVRNVAAGSLSQRLGIEEGTQLPRSIIEF
HHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
YYKNDQLNDPMVSEEHITAFGWATPQEIDDIMALAIRVNDFLTGLFLGIGIRLVDFKMEC
HHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEHHHHH
GRLFENEMMRIIVADEISPDSCRLWDIKSNEKLDKDRFRRDLGGLLEAYTEVAKRLGILM
HHHHHHHHEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEE
ENERPAGSGPVLVKS
CCCCCCCCCCEEECC
>Mature Secondary Structure 
SRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHQVIEGKGVLNNRISEYLFQH
CCCCCHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHH
LNDIGVPTHFIRRLNMREQLIREVEIVPLEVVVRNVAAGSLSQRLGIEEGTQLPRSIIEF
HHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
YYKNDQLNDPMVSEEHITAFGWATPQEIDDIMALAIRVNDFLTGLFLGIGIRLVDFKMEC
HHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEHHHHH
GRLFENEMMRIIVADEISPDSCRLWDIKSNEKLDKDRFRRDLGGLLEAYTEVAKRLGILM
HHHHHHHHEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEE
ENERPAGSGPVLVKS
CCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275