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The map label for this gene is icd [H]

Identifier: 146339759

GI number: 146339759

Start: 2965851

End: 2967065

Strand: Reverse

Name: icd [H]

Synonym: BRADO2759

Alternate gene names: 146339759

Gene position: 2967065-2965851 (Counterclockwise)

Preceding gene: 146339761

Following gene: 146339758

Centisome position: 39.79

GC content: 62.14

Gene sequence:

>1215_bases
ATGGCAAAAATCAAGGTGACCAATCCGGTCGTCGAGCTCGACGGCGACGAGATGACCCGGATCATCTGGCAGTACATCAA
GGACAAGCTGATCAACCCGTTCCTTGAGATCGATCTGCAGTATTACGACCTGGGGATGGAGAGCCGCGACAAGACCAACG
ACCAAATCACGATCGATGCCGCCAACGCGATCAAGAAGGTCGGCGTCGGCGTGAAGTGCGCCACCATCACCCCCGACGAA
GCCCGCGTGAAGGAGTTCGGCCTCAAGGAGATGTGGAAGTCGCCGAATGGCACCATCCGCAACATCCTTGGCGGCGTCGT
GTTCCGCGAGCCGATCATCTGCAAGAACGTGCCGCGCCTCGTCCCCGGCTGGACCAAGCCGATCATCATCGGCCGCCACG
CCTATGGCGACCAGTACCGCGCCACCGACTTCAAATTCCCCGGCAAGGGCACCCTGTCGATGAAGTTCGTCGGCGAGGAC
GGCACCGTGATCGAGCGCGAGGTATTCAAGGCGCCGGGTCCGGGCATCGCGATGGAGATGTACAATCTCGATGACTCGAT
CGTCGATTTCGCCCGCGCCTCGTTCAACATGGGCCTGGCCAAGAACTACTCGGTGTACCTGTCGACCAAGAACACCATCC
TCAAGGTGTATGACGGCCGCTTCAAGGACCTGTTCCAGGAGGTCTACGACAAGGAGTTCAAGGACAAGTTCGAGGCCAAG
AAGATCACCTATGAGCACCGCCTGATCGACGACATGGTCGCCGCGGCGCTGAAGTGGTCGGGCGGCTATGTCTGGGCCTG
TAAGAACTATGACGGCGACGTGCAGTCCGACACGGTGGCGCAGGGCTACGGCTCGCTCGGCTTGATGACCTCGGTGCTGC
TGACCCCGGACGGCAACACGGTGGAGGCCGAGGCCGCCCACGGCACGGTGACCCGCCACTTCCGCGAGCACCAGAAGGGC
AAGGAGACCTCGACCAACTCGATCGCCTCGATCTTCGCCTGGACCCGCGGCCTGTCGCACCGCGCCAAGCTCGACAACAA
TGCCGAGCTCGCCAAGTTCGCCTCCACCCTGGAGAAGGTCTGCGTCGACACCGTCGAGGCCGGCTACATGACCAAGGACC
TCGCGCTCCTGGTCGGCGCTGACCAGCGCTGGCTGTCGACCACCGGCTTCCTCGACAAGATCGCCGAGAACCTCACCAAG
GCGATGGCGGCGTAA

Upstream 100 bases:

>100_bases
GGGTGCGCTTCCGCCCGCGGTGCAGCAGTGCTATGACGCGCTTGATTTCACAAGCGCTTTCCATTCCTGGCGCGCTGTTC
CCAAGAAGGCCCCATCGATC

Downstream 100 bases:

>100_bases
GCCTCCCCACTTTCGCCTTCTGGTTTTGCCAATTTACTACGGGCTGCGCCACAAGCGCGGCCCGTTTTCGTTTTCTGCTG
TCATTTGAGGAATTGAACAT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAKIKVTNPVVELDGDEMTRIIWQYIKDKLINPFLEIDLQYYDLGMESRDKTNDQITIDAANAIKKVGVGVKCATITPDE
ARVKEFGLKEMWKSPNGTIRNILGGVVFREPIICKNVPRLVPGWTKPIIIGRHAYGDQYRATDFKFPGKGTLSMKFVGED
GTVIEREVFKAPGPGIAMEMYNLDDSIVDFARASFNMGLAKNYSVYLSTKNTILKVYDGRFKDLFQEVYDKEFKDKFEAK
KITYEHRLIDDMVAAALKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLLTPDGNTVEAEAAHGTVTRHFREHQKG
KETSTNSIASIFAWTRGLSHRAKLDNNAELAKFASTLEKVCVDTVEAGYMTKDLALLVGADQRWLSTTGFLDKIAENLTK
AMAA

Sequences:

>Translated_404_residues
MAKIKVTNPVVELDGDEMTRIIWQYIKDKLINPFLEIDLQYYDLGMESRDKTNDQITIDAANAIKKVGVGVKCATITPDE
ARVKEFGLKEMWKSPNGTIRNILGGVVFREPIICKNVPRLVPGWTKPIIIGRHAYGDQYRATDFKFPGKGTLSMKFVGED
GTVIEREVFKAPGPGIAMEMYNLDDSIVDFARASFNMGLAKNYSVYLSTKNTILKVYDGRFKDLFQEVYDKEFKDKFEAK
KITYEHRLIDDMVAAALKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLLTPDGNTVEAEAAHGTVTRHFREHQKG
KETSTNSIASIFAWTRGLSHRAKLDNNAELAKFASTLEKVCVDTVEAGYMTKDLALLVGADQRWLSTTGFLDKIAENLTK
AMAA
>Mature_403_residues
AKIKVTNPVVELDGDEMTRIIWQYIKDKLINPFLEIDLQYYDLGMESRDKTNDQITIDAANAIKKVGVGVKCATITPDEA
RVKEFGLKEMWKSPNGTIRNILGGVVFREPIICKNVPRLVPGWTKPIIIGRHAYGDQYRATDFKFPGKGTLSMKFVGEDG
TVIEREVFKAPGPGIAMEMYNLDDSIVDFARASFNMGLAKNYSVYLSTKNTILKVYDGRFKDLFQEVYDKEFKDKFEAKK
ITYEHRLIDDMVAAALKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLLTPDGNTVEAEAAHGTVTRHFREHQKGK
ETSTNSIASIFAWTRGLSHRAKLDNNAELAKFASTLEKVCVDTVEAGYMTKDLALLVGADQRWLSTTGFLDKIAENLTKA
MAA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=67.8048780487805, Blast_Score=570, Evalue=1e-163,
Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=66.421568627451, Blast_Score=570, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=66.6666666666667, Blast_Score=558, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17550822, Length=408, Percent_Identity=64.4607843137255, Blast_Score=547, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6320137, Length=410, Percent_Identity=63.1707317073171, Blast_Score=534, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6324319, Length=409, Percent_Identity=62.1026894865526, Blast_Score=534, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6323203, Length=409, Percent_Identity=62.3471882640587, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI21356561, Length=409, Percent_Identity=66.0146699266504, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI221330987, Length=409, Percent_Identity=66.0146699266504, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI221330985, Length=409, Percent_Identity=66.0146699266504, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI28574947, Length=409, Percent_Identity=66.0146699266504, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660849, Length=409, Percent_Identity=66.0146699266504, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660856, Length=409, Percent_Identity=66.0146699266504, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI221330983, Length=409, Percent_Identity=66.0146699266504, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=66.0146699266504, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=66.0146699266504, Blast_Score=561, Evalue=1e-160,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45098; Mature: 44967

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVTNPVVELDGDEMTRIIWQYIKDKLINPFLEIDLQYYDLGMESRDKTNDQITIDA
CCEEEECCCEEEECCHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCCCCCEEEEEH
ANAIKKVGVGVKCATITPDEARVKEFGLKEMWKSPNGTIRNILGGVVFREPIICKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHCHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTKPIIIGRHAYGDQYRATDFKFPGKGTLSMKFVGEDGTVIEREVFKAPGPGIAMEM
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHCCCCCCEEEEE
YNLDDSIVDFARASFNMGLAKNYSVYLSTKNTILKVYDGRFKDLFQEVYDKEFKDKFEAK
ECCCHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
KITYEHRLIDDMVAAALKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLLTPDGNT
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCCCHHHHEEEEECCCCCE
VEAEAAHGTVTRHFREHQKGKETSTNSIASIFAWTRGLSHRAKLDNNAELAKFASTLEKV
EEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHH
CVDTVEAGYMTKDLALLVGADQRWLSTTGFLDKIAENLTKAMAA
HHHHHHCCCHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVTNPVVELDGDEMTRIIWQYIKDKLINPFLEIDLQYYDLGMESRDKTNDQITIDA
CEEEECCCEEEECCHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCCCCCEEEEEH
ANAIKKVGVGVKCATITPDEARVKEFGLKEMWKSPNGTIRNILGGVVFREPIICKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHCHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTKPIIIGRHAYGDQYRATDFKFPGKGTLSMKFVGEDGTVIEREVFKAPGPGIAMEM
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHCCCCCCEEEEE
YNLDDSIVDFARASFNMGLAKNYSVYLSTKNTILKVYDGRFKDLFQEVYDKEFKDKFEAK
ECCCHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
KITYEHRLIDDMVAAALKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLLTPDGNT
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCCCHHHHEEEEECCCCCE
VEAEAAHGTVTRHFREHQKGKETSTNSIASIFAWTRGLSHRAKLDNNAELAKFASTLEKV
EEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHH
CVDTVEAGYMTKDLALLVGADQRWLSTTGFLDKIAENLTKAMAA
HHHHHHCCCHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]