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The map label for this gene is ilvD [H]

Identifier: 146339754

GI number: 146339754

Start: 2960158

End: 2961996

Strand: Reverse

Name: ilvD [H]

Synonym: BRADO2754

Alternate gene names: 146339754

Gene position: 2961996-2960158 (Counterclockwise)

Preceding gene: 146339757

Following gene: 146339753

Centisome position: 39.72

GC content: 66.67

Gene sequence:

>1839_bases
ATGCCCGCCTATCGCTCCCGCACCTCCACCCATGGCCGCAACATGGCCGGCGCCCGCGGCCTGTGGCGCGCCACCGGCAT
GACCAACGAGGATTTCGGCAAGCCGATCATCGCCGTCGTCAACTCCTTCACCCAGTTCGTCCCCGGCCATGTCCATCTCA
AGGATCTCGGCCAGCTGGTCGCGCGCGAGATCGAGAAGGCCGGCGGCGTCGCGAAGGAGTTCAACACCATCGCGGTCGAC
GACGGCATCGCGATGGGCCATGACGGCATGCTCTACAGCCTGCCGTCGCGCGAGCTGATCGCCGACAGCACGGAATACAT
GGTCAACGCGCATTGCGCCGACGCCATGGTCTGCATCTCCAACTGCGACAAGATCACCCCGGGCATGCTGATGGCCGCGA
TGCGGCTGAATATTCCCGCGGTGTTCGTCTCGGGCGGCCCGATGGAGGCCGGCAAGGTCAACATCGAGGGCAAGCTGCGC
AAGGTCGACCTGATCGACGCGATGATCGTGGCCGCCGACGACAAGGTGTCGGATGCCGACGTCGAGGTGATGGAGCGCTC
GGCCTGCCCGACCTGCGGCTCCTGCTCCGGCATGTTCACCGCCAACTCGATGAACTGCCTGACCGAGGCACTCGGCCTGT
CGCTGCCCGGCAATGGCTCGGTGCTGGCGACGCATGCCGACCGCAAGGGCCTGTTCGTCGAGGCCGGTCACCTGATCGTC
GATCTCGCCCGCCGCTACTACGAGCAGGACGATGCGAGCGTGCTGCCGCGTTCGATCGCCAACTTCAAGGCGTTCGAGAA
CGCGATGAGCATGGACATCGCGATGGGCGGCTCGACCAACACCGTGCTGCATCTGCTCGCCGCCGCGCATGAGGGCGAGA
TCCCGTTCACGATGACCGATATTGACCGGCTGTCGCGCAAGGTGCCCTGCCTGTGCAAGGTCGCGCCCGCGGTAGCCGAC
GTGCACATGGAGGACGTGCATCGCGCCGGCGGCGTGATGGGCATCCTCGGCGAGCTCGCCCGCGCCGGCCTGCTGCACAC
GGAGTTGCCGAGCGTGCATTCGGCCTCGCTCGCGGCAGCGCTGGAGCGCTGGGACATCCGCCAGACCTCCAGCGAGAGCG
TGAAGAACTTCTACATGGCCGCCCCCGGCGGCGTGCCGACCCAGGTCGCCTTCAGCCAGGACCGCCGCTACCAGGAGCTC
GATCTCGACCGGCAGACAGGCTGCATCCGCGACCTCGACCACGCCTATTCCAAGGATGGCGGCTTGGCCGTGCTGACCGG
CAACATCGCGCTCGACGGCTGCATCGTGAAGACCGCCGGCGTTGATGCCTCGATCCTGAAATTCGCAGGCCCCGCGCGGG
TGATGGAGAGCCAGGACGCGGCGGTCGAAGCGATCCTCACCAACAAGATCAAGGCCGGCGACATCGTCGTCATCATCTAT
GAAGGCCCGCGCGGCGGCCCAGGCATGCAGGAGATGCTGTATCCGACCAGCTATCTGAAGTCGAAGGGCCTCGGCAAGGC
CTGCGCGCTGATCACCGACGGCCGCTTCTCCGGCGGCACCTCGGGCCTGTCGATCGGCCACGTCTCGCCAGAAGCCGCCG
AAGGCGGTCTCATCGGCCTGGTGCAGGACGGCGATCGTATCGAGATCGACATCCCCAACCGCACCATCCATCTCGCCGTG
TCAGACGAGGAACTCGCCAAGCGCCGCGCCGCGATGGAGGCGAAGGGCGATCAGGCCTGGAAGCCGAAGACCCGCGCCCG
CAAGGTCTCGACCGCGCTCAAGGCCTATGCTGCATTTGCGTCAAGTGCCGCCAAGGGCGCGGTGCGGGTGGTGAAGTAG

Upstream 100 bases:

>100_bases
GCCTCCGAAATCTTTGCCGCCGGTCCGGCCGGCGCGGCCCGCCGCCCCGTCCGCCGGACCCAACATTGCCGCTCCCGAGG
AACGTCTCAAGGAACCCGTC

Downstream 100 bases:

>100_bases
GTAACCAACCAACCCTCTTAATGGTTCATAGACCCGGCCGCCAACGGCCGGGTCTCACCTCAGCGAAGTCTTAGATCCTG
ATCTATGGCGGAGCCCGTCA

Product: dihydroxyacid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MPAYRSRTSTHGRNMAGARGLWRATGMTNEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSTEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVNIEGKLR
KVDLIDAMIVAADDKVSDADVEVMERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSVLATHADRKGLFVEAGHLIV
DLARRYYEQDDASVLPRSIANFKAFENAMSMDIAMGGSTNTVLHLLAAAHEGEIPFTMTDIDRLSRKVPCLCKVAPAVAD
VHMEDVHRAGGVMGILGELARAGLLHTELPSVHSASLAAALERWDIRQTSSESVKNFYMAAPGGVPTQVAFSQDRRYQEL
DLDRQTGCIRDLDHAYSKDGGLAVLTGNIALDGCIVKTAGVDASILKFAGPARVMESQDAAVEAILTNKIKAGDIVVIIY
EGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAAEGGLIGLVQDGDRIEIDIPNRTIHLAV
SDEELAKRRAAMEAKGDQAWKPKTRARKVSTALKAYAAFASSAAKGAVRVVK

Sequences:

>Translated_612_residues
MPAYRSRTSTHGRNMAGARGLWRATGMTNEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSTEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVNIEGKLR
KVDLIDAMIVAADDKVSDADVEVMERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSVLATHADRKGLFVEAGHLIV
DLARRYYEQDDASVLPRSIANFKAFENAMSMDIAMGGSTNTVLHLLAAAHEGEIPFTMTDIDRLSRKVPCLCKVAPAVAD
VHMEDVHRAGGVMGILGELARAGLLHTELPSVHSASLAAALERWDIRQTSSESVKNFYMAAPGGVPTQVAFSQDRRYQEL
DLDRQTGCIRDLDHAYSKDGGLAVLTGNIALDGCIVKTAGVDASILKFAGPARVMESQDAAVEAILTNKIKAGDIVVIIY
EGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAAEGGLIGLVQDGDRIEIDIPNRTIHLAV
SDEELAKRRAAMEAKGDQAWKPKTRARKVSTALKAYAAFASSAAKGAVRVVK
>Mature_611_residues
PAYRSRTSTHGRNMAGARGLWRATGMTNEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRELIADSTEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVNIEGKLRK
VDLIDAMIVAADDKVSDADVEVMERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSVLATHADRKGLFVEAGHLIVD
LARRYYEQDDASVLPRSIANFKAFENAMSMDIAMGGSTNTVLHLLAAAHEGEIPFTMTDIDRLSRKVPCLCKVAPAVADV
HMEDVHRAGGVMGILGELARAGLLHTELPSVHSASLAAALERWDIRQTSSESVKNFYMAAPGGVPTQVAFSQDRRYQELD
LDRQTGCIRDLDHAYSKDGGLAVLTGNIALDGCIVKTAGVDASILKFAGPARVMESQDAAVEAILTNKIKAGDIVVIIYE
GPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAAEGGLIGLVQDGDRIEIDIPNRTIHLAVS
DEELAKRRAAMEAKGDQAWKPKTRARKVSTALKAYAAFASSAAKGAVRVVK

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=609, Percent_Identity=75.0410509031199, Blast_Score=946, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=566, Percent_Identity=32.1554770318021, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1788157, Length=588, Percent_Identity=28.7414965986395, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1786464, Length=546, Percent_Identity=32.2344322344322, Blast_Score=182, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=607, Percent_Identity=36.9028006589786, Blast_Score=341, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 64948; Mature: 64817

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYRSRTSTHGRNMAGARGLWRATGMTNEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCHHEECCCCCCHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSTEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCCHHHCCCHHHEEECCHHHHHHHHH
NCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVNIEGKLRKVDLIDAMIVAADDKVSDAD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCEEEEEEEEEEEEECCCCCCCCH
VEVMERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSVLATHADRKGLFVEAGHLIV
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEECCHHHH
DLARRYYEQDDASVLPRSIANFKAFENAMSMDIAMGGSTNTVLHLLAAAHEGEIPFTMTD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHCCCCCCEEEHH
IDRLSRKVPCLCKVAPAVADVHMEDVHRAGGVMGILGELARAGLLHTELPSVHSASLAAA
HHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHCCCCCCHHHHHHHH
LERWDIRQTSSESVKNFYMAAPGGVPTQVAFSQDRRYQELDLDRQTGCIRDLDHAYSKDG
HHHHCCCCCCHHHHHHEEEECCCCCCCEEEEHHCCCHHHCCCCCCCCHHHHHHHHHCCCC
GLAVLTGNIALDGCIVKTAGVDASILKFAGPARVMESQDAAVEAILTNKIKAGDIVVIIY
CEEEEECCEEECCEEEEECCCCHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAAEGGLIGL
ECCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VQDGDRIEIDIPNRTIHLAVSDEELAKRRAAMEAKGDQAWKPKTRARKVSTALKAYAAFA
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
SSAAKGAVRVVK
HHHCCCCEEECC
>Mature Secondary Structure 
PAYRSRTSTHGRNMAGARGLWRATGMTNEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCHHEECCCCCCHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSTEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCCHHHCCCHHHEEECCHHHHHHHHH
NCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVNIEGKLRKVDLIDAMIVAADDKVSDAD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCEEEEEEEEEEEEECCCCCCCCH
VEVMERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSVLATHADRKGLFVEAGHLIV
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEECCHHHH
DLARRYYEQDDASVLPRSIANFKAFENAMSMDIAMGGSTNTVLHLLAAAHEGEIPFTMTD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHCCCCCCEEEHH
IDRLSRKVPCLCKVAPAVADVHMEDVHRAGGVMGILGELARAGLLHTELPSVHSASLAAA
HHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHCCCCCCHHHHHHHH
LERWDIRQTSSESVKNFYMAAPGGVPTQVAFSQDRRYQELDLDRQTGCIRDLDHAYSKDG
HHHHCCCCCCHHHHHHEEEECCCCCCCEEEEHHCCCHHHCCCCCCCCHHHHHHHHHCCCC
GLAVLTGNIALDGCIVKTAGVDASILKFAGPARVMESQDAAVEAILTNKIKAGDIVVIIY
CEEEEECCEEECCEEEEECCCCHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAAEGGLIGL
ECCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VQDGDRIEIDIPNRTIHLAVSDEELAKRRAAMEAKGDQAWKPKTRARKVSTALKAYAAFA
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
SSAAKGAVRVVK
HHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA