Click here to switch to the map view.

The map label for this gene is yusP [H]

Identifier: 146339722

GI number: 146339722

Start: 2918269

End: 2919852

Strand: Direct

Name: yusP [H]

Synonym: BRADO2720

Alternate gene names: 146339722

Gene position: 2918269-2919852 (Clockwise)

Preceding gene: 146339721

Following gene: 146339727

Centisome position: 39.14

GC content: 67.61

Gene sequence:

>1584_bases
ATGAACAAGTTTGATCGGCAGAGCCATTACCCTGCCGCGTCCCCATCCTTGCCCGAGGAACTGGCCGCTGAGCTGCCGGC
GATACCGCCGCAGGTTCAGGCGATCGAGGATGGGCCGTCCCTCGCGCCTCCGGTGCCGCTGACTCCGGCCGAGGTGCGCA
CCATCCTGATGAGCCTGTTGCTGACGATGTTCCTGGCCGCGCTCGACCAGACCATCGTCGCCACCGCGCTGCCGACCATC
GGCCGCGAGTTCCAGGACGTGACCAATCTCTCCTGGGTCATCACCGCCTATCTGCTGGCCTCGACTGCGGTGGCGCCGGT
GTTCGGCACGCTGTGCGACATCTATGGCCGGCGCTCGATGATCATCACCGCGCTCAGCCTGTTCGTCGTCGGCTCCGTGG
TCTGCGCGTTGGCGCCGAACATGCCGGTTTTGATCCTCGCCCGTGGCCTGCAGGGGCTCGGCGGTGGCGGCATCATGCCG
GTGGTTCAGACCGTGATCTCCGACGTCGTCAGCCCGCGCGAGCGCGGCCAGTACCAGGCCTGGTTCAGCGGCGTCTGGCT
GCTGGCCGGCCTGCTCGGTCCGGTCATCGGCGGCTTCTTCGCCGACCATCTGCACTGGTCGATGATCTTCTGGATCAACA
TCCCGCTCGCGGTCGCGGCGCTGGCGCTGCTGCTGCCGAAGATGGGCCGGCTGCCGGTCTATCACCGCTTGCGCAAGGTC
GACTGGGCCGGCGGCCTGCTGCTGATGGCCTCGGCCGTCGTGTTCATGCTGGTACTGACCTGGGGCGGCCACAAGCTGGC
CTGGCTGTCGCCGACCATCCTGGCGATGATCGGCAGCGCCGTGGCGCTGGGTCTGGCTTTTGTCTGGCACGCCCGGCGCG
CCGACGAGCCGTTCCTGCCGCTGTCACTGATGGGCGGCACGGTGGTGCCCTATGGCATGCTGGCGAGCGGCTGCGCGCTC
GGCGCCCTGATCGGGCTGACCGTCCATCTGCCGCTGTACTACGAGCTGGTCTATCATCTGACGCCGAGCGAGGCCGGCCT
CGGCCTGATTCCGATCGCGGCGATTTCCACCTTCGGCGCCGGGATCGCCGGTCGCACCATGGCTCGCGTCAAGCACTACA
AGCGCGTCGCGATCATCGGCACGCTGATCGGCACGATCGCCGCCGCGGTCATGACAGTGACGACGCCGTCGCTCTGGGTG
CTGATGGCGCTGCTCTCGGTGTTCGGCATCGGGCTCGGCACCGCGTTCCCGATTTCGGTGGTGTCGCTGCAGAACGCGGT
CGACCGCTCGCAGATCGGCACCATCACCGGCGCGATGAACTTCTTCCGCTCGATGATGTCCTCGTTCACCGTCGCAGCCT
TCAGTGCCATCCTCCTGATGGCGCTCGGCGCCGACATCTCGCTGGCCGAGGGCGCCCATGGTGCCGTCAGCGGCATCGCG
GAAGCCGACATGATCCACGCCTTCCGCTTCGTCTATGCCGCCGCGACCGCGATGCTCGCCTGCGCCTCCGTCTGCATGAT
CCTGATGGAGGAACGCCCGCTGGCCGGCCCATCGCGGAACGAGACAGTGGAGCTCGCGGAGTAG

Upstream 100 bases:

>100_bases
CGAATGCCCCGCTGCCGCAAGGGAAAATTATCCCTTAAGTAGTTCGGTATCTGGCGAATCTGCGCGGCGCTCGCCGCGCG
CGGCATAGCAATTTATCCCC

Downstream 100 bases:

>100_bases
CAAAGTCGGGTGGGCAGAGGCGCGAGGCAGGACCGTCGTTCGAGGCAAACTGTCACGCGCCGTGCCCACCGGCTTCCGGC
ACGTTCCGCGGCAAGATGGT

Product: major facilitator superfamily permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MNKFDRQSHYPAASPSLPEELAAELPAIPPQVQAIEDGPSLAPPVPLTPAEVRTILMSLLLTMFLAALDQTIVATALPTI
GREFQDVTNLSWVITAYLLASTAVAPVFGTLCDIYGRRSMIITALSLFVVGSVVCALAPNMPVLILARGLQGLGGGGIMP
VVQTVISDVVSPRERGQYQAWFSGVWLLAGLLGPVIGGFFADHLHWSMIFWINIPLAVAALALLLPKMGRLPVYHRLRKV
DWAGGLLLMASAVVFMLVLTWGGHKLAWLSPTILAMIGSAVALGLAFVWHARRADEPFLPLSLMGGTVVPYGMLASGCAL
GALIGLTVHLPLYYELVYHLTPSEAGLGLIPIAAISTFGAGIAGRTMARVKHYKRVAIIGTLIGTIAAAVMTVTTPSLWV
LMALLSVFGIGLGTAFPISVVSLQNAVDRSQIGTITGAMNFFRSMMSSFTVAAFSAILLMALGADISLAEGAHGAVSGIA
EADMIHAFRFVYAAATAMLACASVCMILMEERPLAGPSRNETVELAE

Sequences:

>Translated_527_residues
MNKFDRQSHYPAASPSLPEELAAELPAIPPQVQAIEDGPSLAPPVPLTPAEVRTILMSLLLTMFLAALDQTIVATALPTI
GREFQDVTNLSWVITAYLLASTAVAPVFGTLCDIYGRRSMIITALSLFVVGSVVCALAPNMPVLILARGLQGLGGGGIMP
VVQTVISDVVSPRERGQYQAWFSGVWLLAGLLGPVIGGFFADHLHWSMIFWINIPLAVAALALLLPKMGRLPVYHRLRKV
DWAGGLLLMASAVVFMLVLTWGGHKLAWLSPTILAMIGSAVALGLAFVWHARRADEPFLPLSLMGGTVVPYGMLASGCAL
GALIGLTVHLPLYYELVYHLTPSEAGLGLIPIAAISTFGAGIAGRTMARVKHYKRVAIIGTLIGTIAAAVMTVTTPSLWV
LMALLSVFGIGLGTAFPISVVSLQNAVDRSQIGTITGAMNFFRSMMSSFTVAAFSAILLMALGADISLAEGAHGAVSGIA
EADMIHAFRFVYAAATAMLACASVCMILMEERPLAGPSRNETVELAE
>Mature_527_residues
MNKFDRQSHYPAASPSLPEELAAELPAIPPQVQAIEDGPSLAPPVPLTPAEVRTILMSLLLTMFLAALDQTIVATALPTI
GREFQDVTNLSWVITAYLLASTAVAPVFGTLCDIYGRRSMIITALSLFVVGSVVCALAPNMPVLILARGLQGLGGGGIMP
VVQTVISDVVSPRERGQYQAWFSGVWLLAGLLGPVIGGFFADHLHWSMIFWINIPLAVAALALLLPKMGRLPVYHRLRKV
DWAGGLLLMASAVVFMLVLTWGGHKLAWLSPTILAMIGSAVALGLAFVWHARRADEPFLPLSLMGGTVVPYGMLASGCAL
GALIGLTVHLPLYYELVYHLTPSEAGLGLIPIAAISTFGAGIAGRTMARVKHYKRVAIIGTLIGTIAAAVMTVTTPSLWV
LMALLSVFGIGLGTAFPISVVSLQNAVDRSQIGTITGAMNFFRSMMSSFTVAAFSAILLMALGADISLAEGAHGAVSGIA
EADMIHAFRFVYAAATAMLACASVCMILMEERPLAGPSRNETVELAE

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=334, Percent_Identity=28.1437125748503, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790195, Length=383, Percent_Identity=27.154046997389, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1788710, Length=414, Percent_Identity=25.8454106280193, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1788392, Length=326, Percent_Identity=33.1288343558282, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081983, Length=351, Percent_Identity=28.2051282051282, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790146, Length=167, Percent_Identity=28.1437125748503, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87081723, Length=134, Percent_Identity=32.089552238806, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323735, Length=434, Percent_Identity=28.110599078341, Blast_Score=136, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6322958, Length=445, Percent_Identity=26.0674157303371, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319770, Length=385, Percent_Identity=26.4935064935065, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6325455, Length=403, Percent_Identity=25.0620347394541, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321663, Length=474, Percent_Identity=21.7299578059072, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324264, Length=159, Percent_Identity=30.188679245283, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322070, Length=232, Percent_Identity=24.5689655172414, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55639; Mature: 55639

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKFDRQSHYPAASPSLPEELAAELPAIPPQVQAIEDGPSLAPPVPLTPAEVRTILMSLL
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHH
LTMFLAALDQTIVATALPTIGREFQDVTNLSWVITAYLLASTAVAPVFGTLCDIYGRRSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IITALSLFVVGSVVCALAPNMPVLILARGLQGLGGGGIMPVVQTVISDVVSPRERGQYQA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHCCCHHH
WFSGVWLLAGLLGPVIGGFFADHLHWSMIFWINIPLAVAALALLLPKMGRLPVYHRLRKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
DWAGGLLLMASAVVFMLVLTWGGHKLAWLSPTILAMIGSAVALGLAFVWHARRADEPFLP
CCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LSLMGGTVVPYGMLASGCALGALIGLTVHLPLYYELVYHLTPSEAGLGLIPIAAISTFGA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
GIAGRTMARVKHYKRVAIIGTLIGTIAAAVMTVTTPSLWVLMALLSVFGIGLGTAFPISV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
VSLQNAVDRSQIGTITGAMNFFRSMMSSFTVAAFSAILLMALGADISLAEGAHGAVSGIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHH
EADMIHAFRFVYAAATAMLACASVCMILMEERPLAGPSRNETVELAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCC
>Mature Secondary Structure
MNKFDRQSHYPAASPSLPEELAAELPAIPPQVQAIEDGPSLAPPVPLTPAEVRTILMSLL
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHH
LTMFLAALDQTIVATALPTIGREFQDVTNLSWVITAYLLASTAVAPVFGTLCDIYGRRSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IITALSLFVVGSVVCALAPNMPVLILARGLQGLGGGGIMPVVQTVISDVVSPRERGQYQA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHCCCHHH
WFSGVWLLAGLLGPVIGGFFADHLHWSMIFWINIPLAVAALALLLPKMGRLPVYHRLRKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
DWAGGLLLMASAVVFMLVLTWGGHKLAWLSPTILAMIGSAVALGLAFVWHARRADEPFLP
CCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LSLMGGTVVPYGMLASGCALGALIGLTVHLPLYYELVYHLTPSEAGLGLIPIAAISTFGA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
GIAGRTMARVKHYKRVAIIGTLIGTIAAAVMTVTTPSLWVLMALLSVFGIGLGTAFPISV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
VSLQNAVDRSQIGTITGAMNFFRSMMSSFTVAAFSAILLMALGADISLAEGAHGAVSGIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHH
EADMIHAFRFVYAAATAMLACASVCMILMEERPLAGPSRNETVELAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]