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The map label for this gene is fadH [H]

Identifier: 146339586

GI number: 146339586

Start: 2759155

End: 2760030

Strand: Reverse

Name: fadH [H]

Synonym: BRADO2577

Alternate gene names: 146339586

Gene position: 2760030-2759155 (Counterclockwise)

Preceding gene: 146339590

Following gene: 146339585

Centisome position: 37.01

GC content: 64.95

Gene sequence:

>876_bases
ATGTTCAAGGACAATCTCCTCGAGGGTCGACGCATTTTGGTGACCGGCGGCGGCACCGGCCTCGGCAAGGCGATGGCCGC
CCGCTTCCTGCAGCTCGGCGCCGAAGTGCATATTTGCGGACGGCGGAAAATCGTCTGCGACGAGACCGCCACCGAGCTGA
TGGATCTCTATGGCGGGCGCGTCACCAGCCATGGGGTCGACATCCGCAACGCGATGGCGGTGGAGGAGATGATCGAGGCG
ATCTTCCAGGAGGGCGGTCTGACCGATCTCATCAACAACGCCGCCGGCAATTTCATTTCCCGCACCGAGGAATTGAGCCC
GCGCGGCTTCGATGCGGTCGCCAACATCGTGATGCACGGCACGTTCTACGTGACGCATGCCGTTGGCAAGCGCTGGATCG
CGGCGAAGCAACCGGGCAACGTCGTCTCGATCACGGTGACCTGGGTGCGCAACGGCTCGCCCTATGTGGTGCCGTCGGCG
ATGAGCAAGTCGGCGATCCACGCCATGACGATGTCGCTGGCCACCGAATGGGGCCGCTACGGCATCCGCCTCAACACCAT
CGCGCCCGGCGAGATCCCGACCGAGGGCATGAGCAAGCGCATCAAGCCCGGCGACGAGGCCGGCGCGCGCACCAAGGCGA
TGAACCCCATGGGCCGCGTCGGCACCATGGAGGAGTTGCAGAACCTCGCCGTCTTCCTGATCTCCGGCGGCTGCAACTGG
ATCAACGGCGAGACCATCGCGATGGACGGCGCGCAGGCGCTGGCGATGGGCGGCAATTTCTATCAGCTGCGCGACTGGAG
CGACGACGACTGGACCAAGGCCAAGGAGTCGATCAAGGCGCAGAACGAGAAGGACCGCGCGACACGGACGAGCTGA

Upstream 100 bases:

>100_bases
GGCGGTCTCCTCACGATTGTCTTTGTGACTTTACATGGGGCTGTCGGAGCGATTTAGTCAATCGACCAATTAACTCACAA
CATGTCAGGCGGAAACTTCC

Downstream 100 bases:

>100_bases
TGCGGTGTTGATCGGCGACGCACGCTCGGTAGACTGATCGAATGATGCTCGCTCCGGCACGATCCGGGGCGAGAAAAAAA
TAAGACTAAGAACACGTCAC

Product: putative oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MFKDNLLEGRRILVTGGGTGLGKAMAARFLQLGAEVHICGRRKIVCDETATELMDLYGGRVTSHGVDIRNAMAVEEMIEA
IFQEGGLTDLINNAAGNFISRTEELSPRGFDAVANIVMHGTFYVTHAVGKRWIAAKQPGNVVSITVTWVRNGSPYVVPSA
MSKSAIHAMTMSLATEWGRYGIRLNTIAPGEIPTEGMSKRIKPGDEAGARTKAMNPMGRVGTMEELQNLAVFLISGGCNW
INGETIAMDGAQALAMGGNFYQLRDWSDDDWTKAKESIKAQNEKDRATRTS

Sequences:

>Translated_291_residues
MFKDNLLEGRRILVTGGGTGLGKAMAARFLQLGAEVHICGRRKIVCDETATELMDLYGGRVTSHGVDIRNAMAVEEMIEA
IFQEGGLTDLINNAAGNFISRTEELSPRGFDAVANIVMHGTFYVTHAVGKRWIAAKQPGNVVSITVTWVRNGSPYVVPSA
MSKSAIHAMTMSLATEWGRYGIRLNTIAPGEIPTEGMSKRIKPGDEAGARTKAMNPMGRVGTMEELQNLAVFLISGGCNW
INGETIAMDGAQALAMGGNFYQLRDWSDDDWTKAKESIKAQNEKDRATRTS
>Mature_291_residues
MFKDNLLEGRRILVTGGGTGLGKAMAARFLQLGAEVHICGRRKIVCDETATELMDLYGGRVTSHGVDIRNAMAVEEMIEA
IFQEGGLTDLINNAAGNFISRTEELSPRGFDAVANIVMHGTFYVTHAVGKRWIAAKQPGNVVSITVTWVRNGSPYVVPSA
MSKSAIHAMTMSLATEWGRYGIRLNTIAPGEIPTEGMSKRIKPGDEAGARTKAMNPMGRVGTMEELQNLAVFLISGGCNW
INGETIAMDGAQALAMGGNFYQLRDWSDDDWTKAKESIKAQNEKDRATRTS

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503301, Length=280, Percent_Identity=39.6428571428571, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI19923817, Length=276, Percent_Identity=32.2463768115942, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI10190704, Length=270, Percent_Identity=31.8518518518519, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=27.0992366412214, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=28.1746031746032, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI59889578, Length=231, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI7705925, Length=250, Percent_Identity=25.6, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1789208, Length=246, Percent_Identity=31.3008130081301, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082160, Length=247, Percent_Identity=28.3400809716599, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=27.734375, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=31.0077519379845, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=31.7073170731707, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787905, Length=253, Percent_Identity=26.4822134387352, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788459, Length=251, Percent_Identity=25.4980079681275, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=26.6129032258064, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786812, Length=262, Percent_Identity=25.9541984732824, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17536025, Length=292, Percent_Identity=40.4109589041096, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17536651, Length=293, Percent_Identity=38.9078498293515, Blast_Score=207, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17561272, Length=273, Percent_Identity=39.9267399267399, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17562908, Length=287, Percent_Identity=28.2229965156794, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=280, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=277, Percent_Identity=28.158844765343, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=276, Percent_Identity=26.0869565217391, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=26.2948207171315, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=25.2788104089219, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=25.9541984732824, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=276, Percent_Identity=25.3623188405797, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=268, Percent_Identity=25.7462686567164, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=26.4227642276423, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=272, Percent_Identity=25.7352941176471, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=26.2745098039216, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=26.1904761904762, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=228, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=288, Percent_Identity=24.6527777777778, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=24.7148288973384, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=270, Percent_Identity=26.2962962962963, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=28.0632411067194, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=253, Percent_Identity=28.8537549407115, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=29.3172690763052, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=29.0196078431373, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=26.7716535433071, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=26.9076305220884, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=27.3809523809524, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=29.4573643410853, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 31574; Mature: 31574

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKDNLLEGRRILVTGGGTGLGKAMAARFLQLGAEVHICGRRKIVCDETATELMDLYGGR
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEECCCEEEECHHHHHHHHHHCCE
VTSHGVDIRNAMAVEEMIEAIFQEGGLTDLINNAAGNFISRTEELSPRGFDAVANIVMHG
EECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHH
TFYVTHAVGKRWIAAKQPGNVVSITVTWVRNGSPYVVPSAMSKSAIHAMTMSLATEWGRY
HHEEEEHHCCCEEEECCCCCEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHC
GIRLNTIAPGEIPTEGMSKRIKPGDEAGARTKAMNPMGRVGTMEELQNLAVFLISGGCNW
CEEEEEECCCCCCCHHHHCCCCCCCCCCCHHHCCCCCCCCCCHHHHHCEEEEEEECCCCE
INGETIAMDGAQALAMGGNFYQLRDWSDDDWTKAKESIKAQNEKDRATRTS
ECCCEEEECCCHHEEECCCEEEECCCCCCHHHHHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure
MFKDNLLEGRRILVTGGGTGLGKAMAARFLQLGAEVHICGRRKIVCDETATELMDLYGGR
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEECCCEEEECHHHHHHHHHHCCE
VTSHGVDIRNAMAVEEMIEAIFQEGGLTDLINNAAGNFISRTEELSPRGFDAVANIVMHG
EECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHH
TFYVTHAVGKRWIAAKQPGNVVSITVTWVRNGSPYVVPSAMSKSAIHAMTMSLATEWGRY
HHEEEEHHCCCEEEECCCCCEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHC
GIRLNTIAPGEIPTEGMSKRIKPGDEAGARTKAMNPMGRVGTMEELQNLAVFLISGGCNW
CEEEEEECCCCCCCHHHHCCCCCCCCCCCHHHCCCCCCCCCCHHHHHCEEEEEEECCCCE
INGETIAMDGAQALAMGGNFYQLRDWSDDDWTKAKESIKAQNEKDRATRTS
ECCCEEEECCCHHEEECCCEEEECCCCCCHHHHHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]