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The map label for this gene is dctA [H]

Identifier: 146339405

GI number: 146339405

Start: 2545991

End: 2547313

Strand: Reverse

Name: dctA [H]

Synonym: BRADO2390

Alternate gene names: 146339405

Gene position: 2547313-2545991 (Counterclockwise)

Preceding gene: 146339406

Following gene: 146339404

Centisome position: 34.16

GC content: 65.31

Gene sequence:

>1323_bases
ATGACTGCCACGACCCTCACTGCCGACAGCAAAGCCGGCGCCCGTCGCGCCTGGTGGAAGGAGCTGTGGGTCCAGGTCAT
GATCGCGATGGCCGCCGGCATCCTGCTCGGCGCTGTCAAGCCGGATCTCGGCGCCCAGATGCAGCCGCTGGGCGACGCCT
TCATCAAGGCGATCCGCATGCTGATCGCGCCGATCATCTTCTGCACCGTGGTCAACGGCATCGCCCATATGGCCGACATG
GCCAAGGTCGGGCGGGTCGCGATCAAGGCGCTGATCTATTTCGAGGTGATCACGACGTTGGCGCTGATCATCGGGCTTGC
GGCGGTGAACCTGTTCCAGCCCGGAGCCGGCATGAATGTCGACCCGGCGACGATCAACTCCGCGACCATCGAGCCCTATG
TCAAGCAGACCGCGGCGGTCGGCTTCGTGCCCTTCCTGCTCAATATCATTCCGCAGACCTTCGTCGGCGCCTTCGCCGAA
GGCAACATTCTCCAGGTGCTGTTCATCTCGGTGATGTGCGGCTTCTCGCTGATCTGGCTCGGCGACCGCGCCAAGCCCGT
GACCGACGTGATCGAAATCGCCGGCCAGATGATCTTCGGCGTCGTCAAGATCGTGATGTGGGCCGCGCCGCTCGGCGCCT
TTGGCGCGATCGCGTTCACGGTCGGCAAGTTCGGCATCGCCTCGCTGGTCAAGCTCGGCCTGCTGCTCGGCAGCTTCTAT
CTGACCTGCGTGATCTTCATCGCCGTGGTGCTCGGCCCCATCGCCGCCTACACCGGCTTCAGCCTCTGGAAGCTGATCCG
CTACATCCGCGACGAGGTGCTGGTCTGCATCGCGACCACGTCGTCGGAGACGGTGCTGCCGCGCATGCTGGTCAAGCTCG
AGGCTGCCGGCTGCGAGCGCAGCGTCGTCGGGCTGGTGATACCGACCGGCTACTCGTTCAATCTCGACGGCACCTGCCTC
TATCTCGCCACCGCGGCGGTGTTCCTCGCGCAGGCAACGAACACCCCGCTCGACATCGGCCACCAAATCGGGCTGCTGCT
GATCCTGCTGGTGACATCGAAAGGAGCCGCCGGCATCGCCGGCGCGGCCTTTGTCGTGCTCGCCGCGACGCTTGCCGCCA
CCGGGACCATCCCGGTCGCCAGCGTCGCGCTGGTGCTCGGCATTCATCGGCTGATGTCGCAAGGGCTGACCCCGACCAAC
CTGATCGGCAACGCGGTGGCGACGATCGTGATCGCGAAGTGGGAAAACGCGCTGGACCAGTCGCGTCTCACGCAGGTGCT
CGACGGCGGCGCCGACGCAAGCTCACTCCGGATAAAGCGTTGA

Upstream 100 bases:

>100_bases
ACTCCTTGTCAGCAACCCCGAACGGCTGTTCAAGTTCGAGCCCAAGAGCTGACGCGGGCCGAACGCGCCGGGCGATTCGA
ACGTAACGACAGGACAGATC

Downstream 100 bases:

>100_bases
CCGAAGGGGAGATCGGCATGCGGCGCATCAATTCCGTGCTTGGACAAGCCCTGGCTGTCGCCCTGCTCGCCTGCGCGATC
GTGCGGCCCGATCCGGGCCT

Product: C4-dicarboxylate transport protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MTATTLTADSKAGARRAWWKELWVQVMIAMAAGILLGAVKPDLGAQMQPLGDAFIKAIRMLIAPIIFCTVVNGIAHMADM
AKVGRVAIKALIYFEVITTLALIIGLAAVNLFQPGAGMNVDPATINSATIEPYVKQTAAVGFVPFLLNIIPQTFVGAFAE
GNILQVLFISVMCGFSLIWLGDRAKPVTDVIEIAGQMIFGVVKIVMWAAPLGAFGAIAFTVGKFGIASLVKLGLLLGSFY
LTCVIFIAVVLGPIAAYTGFSLWKLIRYIRDEVLVCIATTSSETVLPRMLVKLEAAGCERSVVGLVIPTGYSFNLDGTCL
YLATAAVFLAQATNTPLDIGHQIGLLLILLVTSKGAAGIAGAAFVVLAATLAATGTIPVASVALVLGIHRLMSQGLTPTN
LIGNAVATIVIAKWENALDQSRLTQVLDGGADASSLRIKR

Sequences:

>Translated_440_residues
MTATTLTADSKAGARRAWWKELWVQVMIAMAAGILLGAVKPDLGAQMQPLGDAFIKAIRMLIAPIIFCTVVNGIAHMADM
AKVGRVAIKALIYFEVITTLALIIGLAAVNLFQPGAGMNVDPATINSATIEPYVKQTAAVGFVPFLLNIIPQTFVGAFAE
GNILQVLFISVMCGFSLIWLGDRAKPVTDVIEIAGQMIFGVVKIVMWAAPLGAFGAIAFTVGKFGIASLVKLGLLLGSFY
LTCVIFIAVVLGPIAAYTGFSLWKLIRYIRDEVLVCIATTSSETVLPRMLVKLEAAGCERSVVGLVIPTGYSFNLDGTCL
YLATAAVFLAQATNTPLDIGHQIGLLLILLVTSKGAAGIAGAAFVVLAATLAATGTIPVASVALVLGIHRLMSQGLTPTN
LIGNAVATIVIAKWENALDQSRLTQVLDGGADASSLRIKR
>Mature_439_residues
TATTLTADSKAGARRAWWKELWVQVMIAMAAGILLGAVKPDLGAQMQPLGDAFIKAIRMLIAPIIFCTVVNGIAHMADMA
KVGRVAIKALIYFEVITTLALIIGLAAVNLFQPGAGMNVDPATINSATIEPYVKQTAAVGFVPFLLNIIPQTFVGAFAEG
NILQVLFISVMCGFSLIWLGDRAKPVTDVIEIAGQMIFGVVKIVMWAAPLGAFGAIAFTVGKFGIASLVKLGLLLGSFYL
TCVIFIAVVLGPIAAYTGFSLWKLIRYIRDEVLVCIATTSSETVLPRMLVKLEAAGCERSVVGLVIPTGYSFNLDGTCLY
LATAAVFLAQATNTPLDIGHQIGLLLILLVTSKGAAGIAGAAFVVLAATLAATGTIPVASVALVLGIHRLMSQGLTPTNL
IGNAVATIVIAKWENALDQSRLTQVLDGGADASSLRIKR

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI194239697, Length=468, Percent_Identity=24.7863247863248, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI40254478, Length=517, Percent_Identity=22.4371373307544, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI169790839, Length=417, Percent_Identity=24.7002398081535, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI4827012, Length=441, Percent_Identity=25.6235827664399, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI21314632, Length=401, Percent_Identity=24.6882793017456, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI5032093, Length=401, Percent_Identity=26.9326683291771, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI66773030, Length=409, Percent_Identity=23.2273838630807, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI262359914, Length=376, Percent_Identity=24.468085106383, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI223468566, Length=283, Percent_Identity=28.2685512367491, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI223468564, Length=273, Percent_Identity=27.1062271062271, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1789947, Length=417, Percent_Identity=56.3549160671463, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1790514, Length=412, Percent_Identity=41.0194174757282, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1788024, Length=407, Percent_Identity=22.8501228501229, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17537407, Length=446, Percent_Identity=24.6636771300448, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71983099, Length=414, Percent_Identity=24.6376811594203, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71983106, Length=414, Percent_Identity=24.6376811594203, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI193206505, Length=444, Percent_Identity=25, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193206654, Length=473, Percent_Identity=22.8329809725159, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71996953, Length=438, Percent_Identity=24.6575342465753, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17541374, Length=405, Percent_Identity=23.4567901234568, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583025, Length=432, Percent_Identity=25, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17137668, Length=432, Percent_Identity=25, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24583023, Length=432, Percent_Identity=25, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281360481, Length=481, Percent_Identity=24.1164241164241, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281360483, Length=481, Percent_Identity=24.1164241164241, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137666, Length=481, Percent_Identity=24.1164241164241, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46172; Mature: 46041

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATTLTADSKAGARRAWWKELWVQVMIAMAAGILLGAVKPDLGAQMQPLGDAFIKAIRM
CCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LIAPIIFCTVVNGIAHMADMAKVGRVAIKALIYFEVITTLALIIGLAAVNLFQPGAGMNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DPATINSATIEPYVKQTAAVGFVPFLLNIIPQTFVGAFAEGNILQVLFISVMCGFSLIWL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEE
GDRAKPVTDVIEIAGQMIFGVVKIVMWAAPLGAFGAIAFTVGKFGIASLVKLGLLLGSFY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTCVIFIAVVLGPIAAYTGFSLWKLIRYIRDEVLVCIATTSSETVLPRMLVKLEAAGCER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHCCCCC
SVVGLVIPTGYSFNLDGTCLYLATAAVFLAQATNTPLDIGHQIGLLLILLVTSKGAAGIA
CEEEEEEECCEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHH
GAAFVVLAATLAATGTIPVASVALVLGIHRLMSQGLTPTNLIGNAVATIVIAKWENALDQ
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
SRLTQVLDGGADASSLRIKR
HHHHHHHCCCCCCCCCEECC
>Mature Secondary Structure 
TATTLTADSKAGARRAWWKELWVQVMIAMAAGILLGAVKPDLGAQMQPLGDAFIKAIRM
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LIAPIIFCTVVNGIAHMADMAKVGRVAIKALIYFEVITTLALIIGLAAVNLFQPGAGMNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DPATINSATIEPYVKQTAAVGFVPFLLNIIPQTFVGAFAEGNILQVLFISVMCGFSLIWL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEE
GDRAKPVTDVIEIAGQMIFGVVKIVMWAAPLGAFGAIAFTVGKFGIASLVKLGLLLGSFY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTCVIFIAVVLGPIAAYTGFSLWKLIRYIRDEVLVCIATTSSETVLPRMLVKLEAAGCER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHCCCCC
SVVGLVIPTGYSFNLDGTCLYLATAAVFLAQATNTPLDIGHQIGLLLILLVTSKGAAGIA
CEEEEEEECCEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHH
GAAFVVLAATLAATGTIPVASVALVLGIHRLMSQGLTPTNLIGNAVATIVIAKWENALDQ
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
SRLTQVLDGGADASSLRIKR
HHHHHHHCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA