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The map label for this gene is 146339273

Identifier: 146339273

GI number: 146339273

Start: 2397054

End: 2398055

Strand: Direct

Name: 146339273

Synonym: BRADO2248

Alternate gene names: NA

Gene position: 2397054-2398055 (Clockwise)

Preceding gene: 146339272

Following gene: 146339274

Centisome position: 32.15

GC content: 62.48

Gene sequence:

>1002_bases
GTGATGATGAGAAAGATCAAAATGCCGATGCGGCTTCCCGCAACGCTGATGTCAACGCTCCTGCTGGCGCTCGCGTGGCC
GGTCGAGGCTCAGGTGCTGCCGCCGAACGTGCCATCCAAGGAGCAGCTCGCGAACGACAATCATTTGTTCCTTTCGCTGG
CCAGGAAGATCTTCAAGTGGGAGGAGCCCGCCGAGCCGGTGCGGATCGTAGGACCGATCTATTTCGTGGGGACCAGAGGC
CTCGGCGCATTCCTCATCGTGACGTCGGAGGGACACATCCTGATGAACACGGGGATGCCGTCGTCCGGACCGATGATCGT
GGAGTCGATTCGCAAGCTTGGCTTCAAGCCGGATGACGTCAAGTTGATGATCAACGGCCACGCGCATATCGATCATGCGG
GTGCGTTCGCCTTCATGAAAAGGCTGACGGGGGCGCAGCTGGCCATCATGAAGGACGATGTCGCGGCGATCGAGAGCGGC
GACAGGGGCGATTTCAAGTATGCGGACGACCTGGCCTATGAAGGCGTGACGGTCGACCGGGTGCTGCGCGACGGCGACCA
GATCAGGATGGGTGATGTCCTGCTCACCGCCTACCACACGCCGGGCCACACGCGGGGAGCGACCACATGGATCGCCAACC
TCGTCGTGGATGGCAAGGCCTATCTGGTGGCATTCCCGGACGGCGCCGGCGTCAACCCCGGCTACCGCCTGGCGAAGGAC
CCGTCGTATCCCGGCATCGAGGGCGACTACCGCAAGACCCACCACGCTCTCGAGATGATCAAGCCGGACATCTGGCTGGC
GCAGCACAACGAATACTACGATTTCGAAGGTAAGCGGAAGCGTGCGGAGACGCAGGGCGTCAGCGCCTGGATCGATCCGG
AAGGCTATCGCCGCTTCATTGCCGGCAAGAAGCGCGCGTTCGAGGACGAGGTCGACGAGGAGCTTGGGGCTCCCAAAGCC
GCCGCGACATCGTCGGCCGACGCGCCTAGCAACAACAGATAG

Upstream 100 bases:

>100_bases
TGAATCCTTCGTGTTCCTGCTCGAAGAGCTGAGCCGTCCGCAAGACGCCAATCGAGCAAGTTAGCGGCGACAAGACCTGC
CGGTTTAAGGGTGATTTTCT

Downstream 100 bases:

>100_bases
CGCGTGGTCGGACAAAGGTCGCCGCGAATGCGGAGGTGGACTCATTGAACGGTCGCATCGGCGCGAGAACGGCTCATCCC
GAGCAATTTCGTTCAACGCG

Product: putative beta-lactamase

Products: NA

Alternate protein names: Beta-lactamase type II; Penicillinase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MMMRKIKMPMRLPATLMSTLLLALAWPVEAQVLPPNVPSKEQLANDNHLFLSLARKIFKWEEPAEPVRIVGPIYFVGTRG
LGAFLIVTSEGHILMNTGMPSSGPMIVESIRKLGFKPDDVKLMINGHAHIDHAGAFAFMKRLTGAQLAIMKDDVAAIESG
DRGDFKYADDLAYEGVTVDRVLRDGDQIRMGDVLLTAYHTPGHTRGATTWIANLVVDGKAYLVAFPDGAGVNPGYRLAKD
PSYPGIEGDYRKTHHALEMIKPDIWLAQHNEYYDFEGKRKRAETQGVSAWIDPEGYRRFIAGKKRAFEDEVDEELGAPKA
AATSSADAPSNNR

Sequences:

>Translated_333_residues
MMMRKIKMPMRLPATLMSTLLLALAWPVEAQVLPPNVPSKEQLANDNHLFLSLARKIFKWEEPAEPVRIVGPIYFVGTRG
LGAFLIVTSEGHILMNTGMPSSGPMIVESIRKLGFKPDDVKLMINGHAHIDHAGAFAFMKRLTGAQLAIMKDDVAAIESG
DRGDFKYADDLAYEGVTVDRVLRDGDQIRMGDVLLTAYHTPGHTRGATTWIANLVVDGKAYLVAFPDGAGVNPGYRLAKD
PSYPGIEGDYRKTHHALEMIKPDIWLAQHNEYYDFEGKRKRAETQGVSAWIDPEGYRRFIAGKKRAFEDEVDEELGAPKA
AATSSADAPSNNR
>Mature_333_residues
MMMRKIKMPMRLPATLMSTLLLALAWPVEAQVLPPNVPSKEQLANDNHLFLSLARKIFKWEEPAEPVRIVGPIYFVGTRG
LGAFLIVTSEGHILMNTGMPSSGPMIVESIRKLGFKPDDVKLMINGHAHIDHAGAFAFMKRLTGAQLAIMKDDVAAIESG
DRGDFKYADDLAYEGVTVDRVLRDGDQIRMGDVLLTAYHTPGHTRGATTWIANLVVDGKAYLVAFPDGAGVNPGYRLAKD
PSYPGIEGDYRKTHHALEMIKPDIWLAQHNEYYDFEGKRKRAETQGVSAWIDPEGYRRFIAGKKRAFEDEVDEELGAPKA
AATSSADAPSNNR

Specific function: Has a high activity against imipenem [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 36805; Mature: 36805

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMRKIKMPMRLPATLMSTLLLALAWPVEAQVLPPNVPSKEQLANDNHLFLSLARKIFKW
CCCHHCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHCCCCHHHHHHHHHHHCC
EEPAEPVRIVGPIYFVGTRGLGAFLIVTSEGHILMNTGMPSSGPMIVESIRKLGFKPDDV
CCCCCCEEEEEEEEEEECCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHCCCCCCCE
KLMINGHAHIDHAGAFAFMKRLTGAQLAIMKDDVAAIESGDRGDFKYADDLAYEGVTVDR
EEEECCCCEECHHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCCCCHHHHHCCCCCHHH
VLRDGDQIRMGDVLLTAYHTPGHTRGATTWIANLVVDGKAYLVAFPDGAGVNPGYRLAKD
HHCCCCCEEECEEEEEEEECCCCCCCHHHHEEHEEECCCEEEEECCCCCCCCCCCEECCC
PSYPGIEGDYRKTHHALEMIKPDIWLAQHNEYYDFEGKRKRAETQGVSAWIDPEGYRRFI
CCCCCCCCCHHHHHHHHHHHCCCEEEEECCCEECCCCCHHHHHHCCCEEEECCHHHHHHH
AGKKRAFEDEVDEELGAPKAAATSSADAPSNNR
HCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMMRKIKMPMRLPATLMSTLLLALAWPVEAQVLPPNVPSKEQLANDNHLFLSLARKIFKW
CCCHHCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHCCCCHHHHHHHHHHHCC
EEPAEPVRIVGPIYFVGTRGLGAFLIVTSEGHILMNTGMPSSGPMIVESIRKLGFKPDDV
CCCCCCEEEEEEEEEEECCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHCCCCCCCE
KLMINGHAHIDHAGAFAFMKRLTGAQLAIMKDDVAAIESGDRGDFKYADDLAYEGVTVDR
EEEECCCCEECHHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCCCCHHHHHCCCCCHHH
VLRDGDQIRMGDVLLTAYHTPGHTRGATTWIANLVVDGKAYLVAFPDGAGVNPGYRLAKD
HHCCCCCEEECEEEEEEEECCCCCCCHHHHEEHEEECCCEEEEECCCCCCCCCCCEECCC
PSYPGIEGDYRKTHHALEMIKPDIWLAQHNEYYDFEGKRKRAETQGVSAWIDPEGYRRFI
CCCCCCCCCHHHHHHHHHHHCCCEEEEECCCEECCCCCHHHHHHCCCEEEECCHHHHHHH
AGKKRAFEDEVDEELGAPKAAATSSADAPSNNR
HCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8018721; 3931629; 9811546 [H]