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The map label for this gene is idhA [H]

Identifier: 146339270

GI number: 146339270

Start: 2391869

End: 2392870

Strand: Direct

Name: idhA [H]

Synonym: BRADO2244

Alternate gene names: 146339270

Gene position: 2391869-2392870 (Clockwise)

Preceding gene: 146339262

Following gene: 146339272

Centisome position: 32.08

GC content: 67.17

Gene sequence:

>1002_bases
ATGATGATTATGCGGTTTGGACTTCTCGGCGCCGGCAGGATCGGGCGAATTCATGGTCTCAATGTCTCGTCGCGCGGCGA
TGCACGGCTCGTCGCGGTGGCCGACGCCTCGAACGAAGCCGCGCTTTCGCTCGCACAGGCGACCGGCGCCGAGGTGGCCG
ATGCGGATGCGATCATCGCCGATGCCAAGATCGACGCGATCCTGATCTGCACGCCGACCGATACGCATGCCGATCTGATC
GAAGCCGCGGTGTCGGCCGGCAAGGCGGTGTTCTGCGAGAAGCCGGTCGACCTCGATTCGGACCGCATTTGCCGCTGCCT
CGCCACAGTGGAAAAAGCCGGCAAGCCGCTGATGATCGGCTTTAACCGCCGCTTCGATCCGAACTTCGCGGCGCTGGAGA
AGCGGCTGCGCAACGGCGAGGCCGGCGAGATCGAGATCGTCAGCATCATCTCGCGTGATCCGGCACCGCCGCCGGTGGAC
TATGTGAAGCGCTCGGGCGGTCTCTTTCGCGACATGATGATCCATGATTTCGACATGGCGCGCTTCCTGCTCGCGGAGGA
GCCGGTCGAGGTGTTCGCGCTCGGCTCAGCGTTGGTCGATAAGGCGATCGGCGAGGCCGGCGACGTCGACACCGCCGCGG
TGCTGATGAAGACGGCGAGCGGGCGCATCGCGCAGATCTCGAACTCGCGCCGCGCCAGCTACGGCTACGACCAGCGCGTC
GAGGTGCATGGCGCAAAGGGCATGCTGCGTGCCGGCAACGTGCACGAGACCACCGTCGAGATCGCGACCGGCCAGGGTTT
TCGCGCCGACCCGGTGCAGAACTTCTTCCTCGAACGCTACAGCGCCGCCTATCGCGCCGAGCTCTCCGCCTTCATCGATG
TCTGCGCCGGCAAGGCGGCGCCGTCGCCGAGCGGCCGCGATGGGCTGCGCGCCCAGATGCTCGCCGACGCCGCGACCTTG
TCGGCGCGCGGCGGGCGGCCCGTCGCCGTCAAGGCCAGCTGA

Upstream 100 bases:

>100_bases
ATGTGATGCTGCGATGCGGCGGATGACATTGAGAACAGCGGCTCCGTCCTTGACTGGACGGCGCAGAGAATGAAATGCTT
CTTCGAAGAGTCAAGCAACG

Downstream 100 bases:

>100_bases
CGATGACGGAGACCGAGCTGCTGCTGCGCTGCTACGCAGTCCAGGGCCTTGTCGCCGAGGCCGGGCGCATCGCGCTCGAT
TATTTCAGCCGCAAGGACAG

Product: inositol 2-dehydrogenase

Products: NA

Alternate protein names: Myo-inositol 2-dehydrogenase; MI-dehydrogenase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MMIMRFGLLGAGRIGRIHGLNVSSRGDARLVAVADASNEAALSLAQATGAEVADADAIIADAKIDAILICTPTDTHADLI
EAAVSAGKAVFCEKPVDLDSDRICRCLATVEKAGKPLMIGFNRRFDPNFAALEKRLRNGEAGEIEIVSIISRDPAPPPVD
YVKRSGGLFRDMMIHDFDMARFLLAEEPVEVFALGSALVDKAIGEAGDVDTAAVLMKTASGRIAQISNSRRASYGYDQRV
EVHGAKGMLRAGNVHETTVEIATGQGFRADPVQNFFLERYSAAYRAELSAFIDVCAGKAAPSPSGRDGLRAQMLADAATL
SARGGRPVAVKAS

Sequences:

>Translated_333_residues
MMIMRFGLLGAGRIGRIHGLNVSSRGDARLVAVADASNEAALSLAQATGAEVADADAIIADAKIDAILICTPTDTHADLI
EAAVSAGKAVFCEKPVDLDSDRICRCLATVEKAGKPLMIGFNRRFDPNFAALEKRLRNGEAGEIEIVSIISRDPAPPPVD
YVKRSGGLFRDMMIHDFDMARFLLAEEPVEVFALGSALVDKAIGEAGDVDTAAVLMKTASGRIAQISNSRRASYGYDQRV
EVHGAKGMLRAGNVHETTVEIATGQGFRADPVQNFFLERYSAAYRAELSAFIDVCAGKAAPSPSGRDGLRAQMLADAATL
SARGGRPVAVKAS
>Mature_333_residues
MMIMRFGLLGAGRIGRIHGLNVSSRGDARLVAVADASNEAALSLAQATGAEVADADAIIADAKIDAILICTPTDTHADLI
EAAVSAGKAVFCEKPVDLDSDRICRCLATVEKAGKPLMIGFNRRFDPNFAALEKRLRNGEAGEIEIVSIISRDPAPPPVD
YVKRSGGLFRDMMIHDFDMARFLLAEEPVEVFALGSALVDKAIGEAGDVDTAAVLMKTASGRIAQISNSRRASYGYDQRV
EVHGAKGMLRAGNVHETTVEIATGQGFRADPVQNFFLERYSAAYRAELSAFIDVCAGKAAPSPSGRDGLRAQMLADAATL
SARGGRPVAVKAS

Specific function: Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI1787574, Length=221, Percent_Identity=28.9592760180996, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87082405, Length=375, Percent_Identity=22.9333333333333, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081947, Length=181, Percent_Identity=28.1767955801105, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581117, Length=254, Percent_Identity=21.6535433070866, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: =1.1.1.18 [H]

Molecular weight: Translated: 35235; Mature: 35235

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIMRFGLLGAGRIGRIHGLNVSSRGDARLVAVADASNEAALSLAQATGAEVADADAIIA
CEEEEECCCCCCCCCEEEECCCCCCCCEEEEEEECCCCHHHEEHHHHCCCCCCCCCEEEE
DAKIDAILICTPTDTHADLIEAAVSAGKAVFCEKPVDLDSDRICRCLATVEKAGKPLMIG
ECCCCEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEE
FNRRFDPNFAALEKRLRNGEAGEIEIVSIISRDPAPPPVDYVKRSGGLFRDMMIHDFDMA
CCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHH
RFLLAEEPVEVFALGSALVDKAIGEAGDVDTAAVLMKTASGRIAQISNSRRASYGYDQRV
HHHHHCCCHHEEEHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCEE
EVHGAKGMLRAGNVHETTVEIATGQGFRADPVQNFFLERYSAAYRAELSAFIDVCAGKAA
EEECCCCEEECCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PSPSGRDGLRAQMLADAATLSARGGRPVAVKAS
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MMIMRFGLLGAGRIGRIHGLNVSSRGDARLVAVADASNEAALSLAQATGAEVADADAIIA
CEEEEECCCCCCCCCEEEECCCCCCCCEEEEEEECCCCHHHEEHHHHCCCCCCCCCEEEE
DAKIDAILICTPTDTHADLIEAAVSAGKAVFCEKPVDLDSDRICRCLATVEKAGKPLMIG
ECCCCEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEE
FNRRFDPNFAALEKRLRNGEAGEIEIVSIISRDPAPPPVDYVKRSGGLFRDMMIHDFDMA
CCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHH
RFLLAEEPVEVFALGSALVDKAIGEAGDVDTAAVLMKTASGRIAQISNSRRASYGYDQRV
HHHHHCCCHHEEEHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCEE
EVHGAKGMLRAGNVHETTVEIATGQGFRADPVQNFFLERYSAAYRAELSAFIDVCAGKAA
EEECCCCEEECCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PSPSGRDGLRAQMLADAATLSARGGRPVAVKAS
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9802033; 11481431 [H]