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The map label for this gene is dxs [H]

Identifier: 146339201

GI number: 146339201

Start: 2296076

End: 2298001

Strand: Reverse

Name: dxs [H]

Synonym: BRADO2161

Alternate gene names: 146339201

Gene position: 2298001-2296076 (Counterclockwise)

Preceding gene: 146339202

Following gene: 146339200

Centisome position: 30.82

GC content: 66.46

Gene sequence:

>1926_bases
GTGACCACATTTAGTAAGACGCCGCTTCTCGACACCATCAAGACTCCGGAAGATCTGCGCCGGCTGAAGGTCGAGCAGGT
CCGGCAGGTCGCTGACGAATTGCGCCAGGAGACGATCGACGCGGTTTCGGTGACCGGCGGTCATTTCGGTGCAGGGCTCG
GCGTCGTCGAGCTCACCACGGCCATCCACTATGTGTTCGACACGCCGCGCGACCGTCTGATCTGGGACGTCGGCCATCAG
GCCTACCCGCACAAGATCCTGACCGGGCGCCGCGACCGCATCCGCACGCTGCGCACCGGCGGCGGCCTCTCCGGTTTCAC
CAAGCGCGCCGAGAGCGATTACGATCCGTTCGGCGCCGCGCACTCCTCGACCTCGATCTCCGCCGGCCTGGGCATGGCGG
TGGCCCGCGATCTCTCGGGCGGCAAGAACAACGTGATCGCCGTGATCGGCGACGGCGCGATGTCCGCCGGCATGGCCTAT
GAGGCCATGAACAACGCCGGCGCGATGAACTCCCGCCTGATCGTGATCCTCAACGACAACGACATGTCGATCGCCCCGCC
GGTCGGCGCGATGTCGGCCTATCTGTCGCGGCTCTACTCGGGCAAGACCTACCGCACCCTGCGCGATGCGGCGAAGCAGC
TCGGCCAGCATCTGCCGAAGGTGATCGCCAACCGCGCCAGCCGCGTCGAGGAATATTCCCGCGGCTTCATGATGGACGGC
GGCACGCTGTTCGAGGAGCTCGGCTTCTATTATGTCGGCCCGATCGACGGCCACAACCTCGATCACCTGCTGCCCGTGCT
GAAGAACGTCCGCGACATGGAGACCGGCCCGATCCTGGTCCACGTCGTGACCCAGAAGGGCAAGGGCTATTCGCCGGCGG
AAGCCGCGGCCGACAAATATCACGCGGTCGCCAAGTTCGACATCGCCACCGGCACCCAGGCCAAGGCCAAGCCGAACGCG
CCGGCCTATCAGAACGTGTTCGGACAGAGCCTGGTCAAGGAAGCCGAGAAGGACGAGAAGATCGTCGGCATCACCGCCGC
GATGCCCTCGGGCACCGGCATCGACATCTTCGCCAAGGCCTTCCCGAAGCGCACCTTTGACGTCGGCATCGCCGAGCAGC
ACGCGGTGACCTTCGCCGCCGGTCTCGCCGCCGAGGGCTACAAGCCGTTCTGCGCGATCTACTCGACCTTCCTGCAGCGC
GGCTACGACCAGATCGTCCACGACGTCTGCATCCAGTCGCTGCCGGTCCGCTTCGCGATCGACCGCGCCGGCCTGGTCGG
CGCCGACGGCGCCACCCATGCCGGTTCGTTCGACAACGCCTATCTCGGCTGCCTGCCGAACATGGTGATCATGGCGGCCT
CCGATGAGGCCGAGCTGGTGCACATGGTGGCGACGCAGGTCGCGATCGACGATCGTCCGAGTTCGGTGCGCTATCCCCGC
GGCGAAGGCCGCGGCGTCGAGATGCCGGAAGTCGGTGTGGCCCTTCCGATCGGCAAGGGCCGCATGATCCGCCAGGGTAA
GCAGGTCGCGCTGCTCTCCTTCGGCACCCGCCTCGCCGAGTGCGAGAAGGCGGCCGACGAACTCGCCGCTCATGGTCTCT
CCGCTTCGATCGCCGATGCGCGCTTCATGAAGCCGCTCGACGAGGAGCTGGTGCTGAAGCTGGCACGCGACCACGAGATC
CTGATCACCATCGAGGAAGGCTCGATCGGCGGCTTCGGCTCGCATGTGATGCAGTACCTGGCCGACCAGGGCATGCTCGA
CGGCGGCCTGAAGATGCGCTCGATGGTACTGCCCGACGAGTTCCAGGACCACGACACGCCGGCGGCGATGTACGCCCGCG
CCGGCCTCGACGCCAAGGGCATCGTCCGCAAGGTGTTCGAGGTGCTCGGCAAGGACTACGCCGCAGAGGCCGTCAAGCTC
GCCTGA

Upstream 100 bases:

>100_bases
GCGCGGATGTGACCTTCGAAATACCCGGTTTCGCCGCCCGTTACGATGAACCTCTCAGACGTCGGCCCTTGAACCCGACC
TGCAAAATTGGAATGTCACC

Downstream 100 bases:

>100_bases
GGCGGGGCTTGGTAGCCGACGCTGGTGACTCATGAAGATCTATCTGGCAGGTCCCGACGTGTTCCTGCCGGACGCCGTTG
AGATCGGCCGGCGGAAGGCC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MTTFSKTPLLDTIKTPEDLRRLKVEQVRQVADELRQETIDAVSVTGGHFGAGLGVVELTTAIHYVFDTPRDRLIWDVGHQ
AYPHKILTGRRDRIRTLRTGGGLSGFTKRAESDYDPFGAAHSSTSISAGLGMAVARDLSGGKNNVIAVIGDGAMSAGMAY
EAMNNAGAMNSRLIVILNDNDMSIAPPVGAMSAYLSRLYSGKTYRTLRDAAKQLGQHLPKVIANRASRVEEYSRGFMMDG
GTLFEELGFYYVGPIDGHNLDHLLPVLKNVRDMETGPILVHVVTQKGKGYSPAEAAADKYHAVAKFDIATGTQAKAKPNA
PAYQNVFGQSLVKEAEKDEKIVGITAAMPSGTGIDIFAKAFPKRTFDVGIAEQHAVTFAAGLAAEGYKPFCAIYSTFLQR
GYDQIVHDVCIQSLPVRFAIDRAGLVGADGATHAGSFDNAYLGCLPNMVIMAASDEAELVHMVATQVAIDDRPSSVRYPR
GEGRGVEMPEVGVALPIGKGRMIRQGKQVALLSFGTRLAECEKAADELAAHGLSASIADARFMKPLDEELVLKLARDHEI
LITIEEGSIGGFGSHVMQYLADQGMLDGGLKMRSMVLPDEFQDHDTPAAMYARAGLDAKGIVRKVFEVLGKDYAAEAVKL
A

Sequences:

>Translated_641_residues
MTTFSKTPLLDTIKTPEDLRRLKVEQVRQVADELRQETIDAVSVTGGHFGAGLGVVELTTAIHYVFDTPRDRLIWDVGHQ
AYPHKILTGRRDRIRTLRTGGGLSGFTKRAESDYDPFGAAHSSTSISAGLGMAVARDLSGGKNNVIAVIGDGAMSAGMAY
EAMNNAGAMNSRLIVILNDNDMSIAPPVGAMSAYLSRLYSGKTYRTLRDAAKQLGQHLPKVIANRASRVEEYSRGFMMDG
GTLFEELGFYYVGPIDGHNLDHLLPVLKNVRDMETGPILVHVVTQKGKGYSPAEAAADKYHAVAKFDIATGTQAKAKPNA
PAYQNVFGQSLVKEAEKDEKIVGITAAMPSGTGIDIFAKAFPKRTFDVGIAEQHAVTFAAGLAAEGYKPFCAIYSTFLQR
GYDQIVHDVCIQSLPVRFAIDRAGLVGADGATHAGSFDNAYLGCLPNMVIMAASDEAELVHMVATQVAIDDRPSSVRYPR
GEGRGVEMPEVGVALPIGKGRMIRQGKQVALLSFGTRLAECEKAADELAAHGLSASIADARFMKPLDEELVLKLARDHEI
LITIEEGSIGGFGSHVMQYLADQGMLDGGLKMRSMVLPDEFQDHDTPAAMYARAGLDAKGIVRKVFEVLGKDYAAEAVKL
A
>Mature_640_residues
TTFSKTPLLDTIKTPEDLRRLKVEQVRQVADELRQETIDAVSVTGGHFGAGLGVVELTTAIHYVFDTPRDRLIWDVGHQA
YPHKILTGRRDRIRTLRTGGGLSGFTKRAESDYDPFGAAHSSTSISAGLGMAVARDLSGGKNNVIAVIGDGAMSAGMAYE
AMNNAGAMNSRLIVILNDNDMSIAPPVGAMSAYLSRLYSGKTYRTLRDAAKQLGQHLPKVIANRASRVEEYSRGFMMDGG
TLFEELGFYYVGPIDGHNLDHLLPVLKNVRDMETGPILVHVVTQKGKGYSPAEAAADKYHAVAKFDIATGTQAKAKPNAP
AYQNVFGQSLVKEAEKDEKIVGITAAMPSGTGIDIFAKAFPKRTFDVGIAEQHAVTFAAGLAAEGYKPFCAIYSTFLQRG
YDQIVHDVCIQSLPVRFAIDRAGLVGADGATHAGSFDNAYLGCLPNMVIMAASDEAELVHMVATQVAIDDRPSSVRYPRG
EGRGVEMPEVGVALPIGKGRMIRQGKQVALLSFGTRLAECEKAADELAAHGLSASIADARFMKPLDEELVLKLARDHEIL
ITIEEGSIGGFGSHVMQYLADQGMLDGGLKMRSMVLPDEFQDHDTPAAMYARAGLDAKGIVRKVFEVLGKDYAAEAVKLA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=605, Percent_Identity=23.3057851239669, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI4507521, Length=605, Percent_Identity=23.3057851239669, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI225637459, Length=365, Percent_Identity=23.8356164383562, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI225637461, Length=365, Percent_Identity=23.8356164383562, Blast_Score=70, Evalue=9e-12,
Organism=Homo sapiens, GI225637463, Length=365, Percent_Identity=23.8356164383562, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI133778974, Length=614, Percent_Identity=21.8241042345277, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786622, Length=623, Percent_Identity=51.2038523274478, Blast_Score=614, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17539652, Length=429, Percent_Identity=24.009324009324, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45551847, Length=651, Percent_Identity=21.9662058371736, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550715, Length=651, Percent_Identity=21.9662058371736, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24645119, Length=532, Percent_Identity=22.3684210526316, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666278, Length=607, Percent_Identity=23.8879736408567, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68953; Mature: 68821

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFSKTPLLDTIKTPEDLRRLKVEQVRQVADELRQETIDAVSVTGGHFGAGLGVVELTT
CCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHH
AIHYVFDTPRDRLIWDVGHQAYPHKILTGRRDRIRTLRTGGGLSGFTKRAESDYDPFGAA
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHCCCCCCHHHHHCCCCCCCCCCC
HSSTSISAGLGMAVARDLSGGKNNVIAVIGDGAMSAGMAYEAMNNAGAMNSRLIVILNDN
CCCCCHHHCHHHHHHHHCCCCCCCEEEEEECCCHHCCHHHHHHHCCCCCCCEEEEEECCC
DMSIAPPVGAMSAYLSRLYSGKTYRTLRDAAKQLGQHLPKVIANRASRVEEYSRGFMMDG
CCEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
GTLFEELGFYYVGPIDGHNLDHLLPVLKNVRDMETGPILVHVVTQKGKGYSPAEAAADKY
HHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHH
HAVAKFDIATGTQAKAKPNAPAYQNVFGQSLVKEAEKDEKIVGITAAMPSGTGIDIFAKA
HHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHH
FPKRTFDVGIAEQHAVTFAAGLAAEGYKPFCAIYSTFLQRGYDQIVHDVCIQSLPVRFAI
CCCCCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
DRAGLVGADGATHAGSFDNAYLGCLPNMVIMAASDEAELVHMVATQVAIDDRPSSVRYPR
CCCCEECCCCCCCCCCCCCCHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCC
GEGRGVEMPEVGVALPIGKGRMIRQGKQVALLSFGTRLAECEKAADELAAHGLSASIADA
CCCCCCCCCCCCEEEECCCCHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RFMKPLDEELVLKLARDHEILITIEEGSIGGFGSHVMQYLADQGMLDGGLKMRSMVLPDE
HHHCCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
FQDHDTPAAMYARAGLDAKGIVRKVFEVLGKDYAAEAVKLA
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
TTFSKTPLLDTIKTPEDLRRLKVEQVRQVADELRQETIDAVSVTGGHFGAGLGVVELTT
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHH
AIHYVFDTPRDRLIWDVGHQAYPHKILTGRRDRIRTLRTGGGLSGFTKRAESDYDPFGAA
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHCCCCCCHHHHHCCCCCCCCCCC
HSSTSISAGLGMAVARDLSGGKNNVIAVIGDGAMSAGMAYEAMNNAGAMNSRLIVILNDN
CCCCCHHHCHHHHHHHHCCCCCCCEEEEEECCCHHCCHHHHHHHCCCCCCCEEEEEECCC
DMSIAPPVGAMSAYLSRLYSGKTYRTLRDAAKQLGQHLPKVIANRASRVEEYSRGFMMDG
CCEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
GTLFEELGFYYVGPIDGHNLDHLLPVLKNVRDMETGPILVHVVTQKGKGYSPAEAAADKY
HHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHH
HAVAKFDIATGTQAKAKPNAPAYQNVFGQSLVKEAEKDEKIVGITAAMPSGTGIDIFAKA
HHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHH
FPKRTFDVGIAEQHAVTFAAGLAAEGYKPFCAIYSTFLQRGYDQIVHDVCIQSLPVRFAI
CCCCCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
DRAGLVGADGATHAGSFDNAYLGCLPNMVIMAASDEAELVHMVATQVAIDDRPSSVRYPR
CCCCEECCCCCCCCCCCCCCHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCC
GEGRGVEMPEVGVALPIGKGRMIRQGKQVALLSFGTRLAECEKAADELAAHGLSASIADA
CCCCCCCCCCCCEEEECCCCHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RFMKPLDEELVLKLARDHEILITIEEGSIGGFGSHVMQYLADQGMLDGGLKMRSMVLPDE
HHHCCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
FQDHDTPAAMYARAGLDAKGIVRKVFEVLGKDYAAEAVKLA
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]