Click here to switch to the map view.

The map label for this gene is mro [H]

Identifier: 146338876

GI number: 146338876

Start: 1940511

End: 1941590

Strand: Direct

Name: mro [H]

Synonym: BRADO1815

Alternate gene names: 146338876

Gene position: 1940511-1941590 (Clockwise)

Preceding gene: 146338875

Following gene: 146338877

Centisome position: 26.02

GC content: 67.13

Gene sequence:

>1080_bases
ATGGCGGAGGCAGATATCTCCAGGGATGTGTTTGGCAGCCTGCCCGACGGCCGAGAGGTCGAGCGCGTCACCTTGCGGGG
CGCCGGCGGCTTCGAGGCGCGGATCATCACGTTCGGTGCGGCGCTGCAGACCCTCCTGGTGCCGGACGCGCAAGGTACCG
TCGACGACGTCGTGCTCGGCCACGACGATCTGCTGAGCTACGTCAAGCTGCGGAAGTTCTTCGGCGCGACGGTCGGACGC
TACGCCAACCGGATCGCCAAGGCGCGCTTTATGCTCGACGGCGAGGAGATCCGCCTCGACGCCAACAATGGTCCCCACGC
CTTGCATGGCGGCCCCGATGGCTTCGACCGCAAGCTCTGGCAGATCGTCGCCATCGACGACGGTCCACAGCCCTCCGTCA
CGATGCTTTACGTCAGCGCCGACGGCGAGGCCAACTATCCCGGGCGGCTCGACGTCCGCGTCACCTATCGGCTGACCGGT
CCGACCGAACTGGCCATCAGCTTCAGCGCCCGGACGACCCGCACGACGGTCGTCAACCTGACCAATCACAGCTTCTTCAA
TCTCGACGGCCTGGCCGCGGGCACCGACATTCTCGACCATCGTCTGACGCTCGCGGCCGACCACTATCTCGCGATCGACG
AGACCGCGATCCCGCTGGAGGGACCACCGCAATCCGTGATCGGCACGCCGTTCGACTTTCGCGAGGCCCATCCGGTCGGC
GCGCGAATCCGTGCCGATGACGCGCAGATCAAGTGCGGCCGCGGCTACGACCACAATTTCTGTCTGCGAGCCGGCGAGGG
CGTCCGCCTGGCGGCGCGGGTGGAGTCGCCACGCTCTGGACGGGTCATGGAGCTGCTCACGGATCAGCCCGGCCTGCAGA
TCTATTCCGGCAACTACATCGACGCGACCGTCAGCGGCAAGGGACGCGTCTATCGCCAGTCCGACGCGATCTGTCTGGAG
CCGCAGGTGTGGCCGGACAGCCCGAACCGGCCGGACTTCCCGAGCGCGCGGCTTTCGCCGGAGGACGTCTATCGGCACGA
GACGGTCTATCGCTTCTCGACCGCGGGAGCGGCCGCATGA

Upstream 100 bases:

>100_bases
GAGCGGGACAAGCGACGTGGATCTCGCGCCGCTGCGGCTCGTGGCCGACGCCTTCCTGCTCGGCCGCCGCGCGGTCGTCG
AGCCGTTCGAGGACTGAATC

Downstream 100 bases:

>100_bases
TGGAGCAGGTGCCAACCACCGTGCTCTGCGCCGAGCATTGCCATCTCGGTGAGGGGCCGACCTATGATCCGGCCTCGGAC
ACGGCGTGGTGGTTCGACAT

Product: galactose mutarotase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MAEADISRDVFGSLPDGREVERVTLRGAGGFEARIITFGAALQTLLVPDAQGTVDDVVLGHDDLLSYVKLRKFFGATVGR
YANRIAKARFMLDGEEIRLDANNGPHALHGGPDGFDRKLWQIVAIDDGPQPSVTMLYVSADGEANYPGRLDVRVTYRLTG
PTELAISFSARTTRTTVVNLTNHSFFNLDGLAAGTDILDHRLTLAADHYLAIDETAIPLEGPPQSVIGTPFDFREAHPVG
ARIRADDAQIKCGRGYDHNFCLRAGEGVRLAARVESPRSGRVMELLTDQPGLQIYSGNYIDATVSGKGRVYRQSDAICLE
PQVWPDSPNRPDFPSARLSPEDVYRHETVYRFSTAGAAA

Sequences:

>Translated_359_residues
MAEADISRDVFGSLPDGREVERVTLRGAGGFEARIITFGAALQTLLVPDAQGTVDDVVLGHDDLLSYVKLRKFFGATVGR
YANRIAKARFMLDGEEIRLDANNGPHALHGGPDGFDRKLWQIVAIDDGPQPSVTMLYVSADGEANYPGRLDVRVTYRLTG
PTELAISFSARTTRTTVVNLTNHSFFNLDGLAAGTDILDHRLTLAADHYLAIDETAIPLEGPPQSVIGTPFDFREAHPVG
ARIRADDAQIKCGRGYDHNFCLRAGEGVRLAARVESPRSGRVMELLTDQPGLQIYSGNYIDATVSGKGRVYRQSDAICLE
PQVWPDSPNRPDFPSARLSPEDVYRHETVYRFSTAGAAA
>Mature_358_residues
AEADISRDVFGSLPDGREVERVTLRGAGGFEARIITFGAALQTLLVPDAQGTVDDVVLGHDDLLSYVKLRKFFGATVGRY
ANRIAKARFMLDGEEIRLDANNGPHALHGGPDGFDRKLWQIVAIDDGPQPSVTMLYVSADGEANYPGRLDVRVTYRLTGP
TELAISFSARTTRTTVVNLTNHSFFNLDGLAAGTDILDHRLTLAADHYLAIDETAIPLEGPPQSVIGTPFDFREAHPVGA
RIRADDAQIKCGRGYDHNFCLRAGEGVRLAARVESPRSGRVMELLTDQPGLQIYSGNYIDATVSGKGRVYRQSDAICLEP
QVWPDSPNRPDFPSARLSPEDVYRHETVYRFSTAGAAA

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=354, Percent_Identity=44.3502824858757, Blast_Score=276, Evalue=2e-74,
Organism=Escherichia coli, GI1786971, Length=341, Percent_Identity=39.5894428152493, Blast_Score=238, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17557428, Length=334, Percent_Identity=31.1377245508982, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI115533334, Length=334, Percent_Identity=31.1377245508982, Blast_Score=163, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319493, Length=353, Percent_Identity=28.8951841359773, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324399, Length=345, Percent_Identity=25.7971014492754, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322004, Length=358, Percent_Identity=26.536312849162, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24659048, Length=349, Percent_Identity=38.10888252149, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI24668282, Length=347, Percent_Identity=38.9048991354467, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24668278, Length=340, Percent_Identity=35.5882352941176, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24583720, Length=348, Percent_Identity=36.4942528735632, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24641876, Length=366, Percent_Identity=31.1475409836066, Blast_Score=167, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39171; Mature: 39040

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEADISRDVFGSLPDGREVERVTLRGAGGFEARIITFGAALQTLLVPDAQGTVDDVVLG
CCCCCCCHHHHCCCCCCCCEEEEEEECCCCCEEEEEEECHHHHHHCCCCCCCCHHHEEEC
HDDLLSYVKLRKFFGATVGRYANRIAKARFMLDGEEIRLDANNGPHALHGGPDGFDRKLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCCCCCCCCCCCCEEE
QIVAIDDGPQPSVTMLYVSADGEANYPGRLDVRVTYRLTGPTELAISFSARTTRTTVVNL
EEEEECCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEECCCCEEEEEEECCCEEEEEEEE
TNHSFFNLDGLAAGTDILDHRLTLAADHYLAIDETAIPLEGPPQSVIGTPFDFREAHPVG
CCCCEECCCCCCCCCHHHHCEEEEEECCEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCC
ARIRADDAQIKCGRGYDHNFCLRAGEGVRLAARVESPRSGRVMELLTDQPGLQIYSGNYI
CEEECCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCEEEEECCCCCCEEEECCEE
DATVSGKGRVYRQSDAICLEPQVWPDSPNRPDFPSARLSPEDVYRHETVYRFSTAGAAA
EEEECCCCEEEECCCCEEECCEECCCCCCCCCCCCCCCCHHHHHHCCEEEEEECCCCCC
>Mature Secondary Structure 
AEADISRDVFGSLPDGREVERVTLRGAGGFEARIITFGAALQTLLVPDAQGTVDDVVLG
CCCCCCHHHHCCCCCCCCEEEEEEECCCCCEEEEEEECHHHHHHCCCCCCCCHHHEEEC
HDDLLSYVKLRKFFGATVGRYANRIAKARFMLDGEEIRLDANNGPHALHGGPDGFDRKLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCCCCCCCCCCCCEEE
QIVAIDDGPQPSVTMLYVSADGEANYPGRLDVRVTYRLTGPTELAISFSARTTRTTVVNL
EEEEECCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEECCCCEEEEEEECCCEEEEEEEE
TNHSFFNLDGLAAGTDILDHRLTLAADHYLAIDETAIPLEGPPQSVIGTPFDFREAHPVG
CCCCEECCCCCCCCCHHHHCEEEEEECCEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCC
ARIRADDAQIKCGRGYDHNFCLRAGEGVRLAARVESPRSGRVMELLTDQPGLQIYSGNYI
CEEECCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCEEEEECCCCCCEEEECCEE
DATVSGKGRVYRQSDAICLEPQVWPDSPNRPDFPSARLSPEDVYRHETVYRFSTAGAAA
EEEECCCCEEEECCCCEEECCEECCCCCCCCCCCCCCCCHHHHHHCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]