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The map label for this gene is serA [H]

Identifier: 146338824

GI number: 146338824

Start: 1885096

End: 1886343

Strand: Direct

Name: serA [H]

Synonym: BRADO1760

Alternate gene names: 146338824

Gene position: 1885096-1886343 (Clockwise)

Preceding gene: 146338822

Following gene: 146338825

Centisome position: 25.28

GC content: 67.15

Gene sequence:

>1248_bases
ATGCCGCTCTCGCTGCCCAAGCAAAAGATTCGCGTTCTGCTCCTCGAGGGCGTGAACGACTCGGCCGTCCGCATGTTCGA
GGCCAGCGGCTATACCGAGGTCGAACGGCTGCCCAAGGCGCTCGGCTCGGCGGAATTGAAGCGGATGCTGTCCGGCGTTC
ACATGCTCGGCATCCGCTCGCGGACGAATCTGACCGCCGACGTGCTGCAGGCGGCCGACCGGCTGATGGCCGTGGGCTGC
TTCTCGGTCGGCACCAACCAGGTCGATCTCGATGCGGCGCGGCGGCTCGGCATCCCCGTCTTCAACGCGCCCTATTCGAA
CACCCGCAGCGTCGCCGAGCTGACCATCGCCGAGGTCGTGATGCTGATGCGGCGGATCTTCCCGCGCTCGGTGTCGGCGC
ATGCCGGCGGCTGGGACAAGTCGGCCAATGGCAGCCGCGAGGTGCGCGGCAAGACGCTCGGCATCATCGGCTACGGCAAT
ATCGGCTCGCAGCTGTCGAACCTCGCCGAAGCCATGGGCATGCGGGTGATCTTCTTCGACCTCACCGACAAGCTCCGCCA
CGGCAACACCGAGCCGGTCGAAAGCCTCGACGAACTGCTGGCTAATAGCGACGTCGTGTCGCTGCACGTGCCGGAGACGC
CGGCGACCGCCAACATGATCGGCGAGCGCCAGATCCGGCACATGAAGGACGGCGCCTACCTCATCAACAATTCGCGCGGC
ACGGTGGTCGACATCGACGCGCTGGCGAGCGCGCTGCGCGAGGGCAAGCTGTCGGGCGCCGCCGTCGACGTGTTTCCGGT
CGAACCGGCCTCGAACGCCGATCCGTTCGTGTCGCCGCTGCAGGGCCTGCCCAACGTGATCCTGACCCCGCATGTCGGCG
GCTCCACCGAGGAGGCGCAGGATCGCATCGGCGGCGAGGTCGCGCGCAAGCTGATCGATTACTCCGACGTCGGCTCGACT
TTCGGCGCGGTCAACTTCCCGCAGGTGCAGCTGCCGGCGCGCCCGACCGGCACGCGCTTCATCCACGTCCACCGCAACGT
GCCGGGCGTGCTGCGCCAGGTCAACGAGGCGGTGTCACGGCACAACATCAACATCCTCGCGCAATATCTGCAGACCGATC
CGGAAGTCGGCTACGTCGTGCTGGAAACCGACGTGGTTGGCGGCGAAGGTGAGGAGCTGCTGTCGGAGCTGCGCGCGGTG
GACGGCACGATCCGCGTGCGCGTGCTGTACGATCACGACAGGCCGTGA

Upstream 100 bases:

>100_bases
AGAAAGCGCTCCTGCCGCGGCGCATTCACCAAGTTTCAACGCATCGCGACTGTAACACCTGCAACACGACGCCACACCCA
CGATCAACCAGGCCAGGCCC

Downstream 100 bases:

>100_bases
ATGGGAAAGGCTGACGTCGATGAGCGCACAGTCCCCGTCCTCGTCAGCCTCCTCCATCGTGCTCAGCACGACCGTCCCGG
CACGGGTGCTGCGGCATGAT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MPLSLPKQKIRVLLLEGVNDSAVRMFEASGYTEVERLPKALGSAELKRMLSGVHMLGIRSRTNLTADVLQAADRLMAVGC
FSVGTNQVDLDAARRLGIPVFNAPYSNTRSVAELTIAEVVMLMRRIFPRSVSAHAGGWDKSANGSREVRGKTLGIIGYGN
IGSQLSNLAEAMGMRVIFFDLTDKLRHGNTEPVESLDELLANSDVVSLHVPETPATANMIGERQIRHMKDGAYLINNSRG
TVVDIDALASALREGKLSGAAVDVFPVEPASNADPFVSPLQGLPNVILTPHVGGSTEEAQDRIGGEVARKLIDYSDVGST
FGAVNFPQVQLPARPTGTRFIHVHRNVPGVLRQVNEAVSRHNINILAQYLQTDPEVGYVVLETDVVGGEGEELLSELRAV
DGTIRVRVLYDHDRP

Sequences:

>Translated_415_residues
MPLSLPKQKIRVLLLEGVNDSAVRMFEASGYTEVERLPKALGSAELKRMLSGVHMLGIRSRTNLTADVLQAADRLMAVGC
FSVGTNQVDLDAARRLGIPVFNAPYSNTRSVAELTIAEVVMLMRRIFPRSVSAHAGGWDKSANGSREVRGKTLGIIGYGN
IGSQLSNLAEAMGMRVIFFDLTDKLRHGNTEPVESLDELLANSDVVSLHVPETPATANMIGERQIRHMKDGAYLINNSRG
TVVDIDALASALREGKLSGAAVDVFPVEPASNADPFVSPLQGLPNVILTPHVGGSTEEAQDRIGGEVARKLIDYSDVGST
FGAVNFPQVQLPARPTGTRFIHVHRNVPGVLRQVNEAVSRHNINILAQYLQTDPEVGYVVLETDVVGGEGEELLSELRAV
DGTIRVRVLYDHDRP
>Mature_414_residues
PLSLPKQKIRVLLLEGVNDSAVRMFEASGYTEVERLPKALGSAELKRMLSGVHMLGIRSRTNLTADVLQAADRLMAVGCF
SVGTNQVDLDAARRLGIPVFNAPYSNTRSVAELTIAEVVMLMRRIFPRSVSAHAGGWDKSANGSREVRGKTLGIIGYGNI
GSQLSNLAEAMGMRVIFFDLTDKLRHGNTEPVESLDELLANSDVVSLHVPETPATANMIGERQIRHMKDGAYLINNSRGT
VVDIDALASALREGKLSGAAVDVFPVEPASNADPFVSPLQGLPNVILTPHVGGSTEEAQDRIGGEVARKLIDYSDVGSTF
GAVNFPQVQLPARPTGTRFIHVHRNVPGVLRQVNEAVSRHNINILAQYLQTDPEVGYVVLETDVVGGEGEELLSELRAVD
GTIRVRVLYDHDRP

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=35.0157728706625, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI145580578, Length=246, Percent_Identity=36.9918699186992, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4557499, Length=246, Percent_Identity=36.9918699186992, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI61743967, Length=238, Percent_Identity=35.2941176470588, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4557497, Length=238, Percent_Identity=35.2941176470588, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI145580575, Length=247, Percent_Identity=36.8421052631579, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI6912396, Length=277, Percent_Identity=29.2418772563177, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1789279, Length=408, Percent_Identity=55.3921568627451, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI87082289, Length=263, Percent_Identity=33.4600760456274, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=31.7460317460317, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87081824, Length=193, Percent_Identity=31.0880829015544, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788660, Length=312, Percent_Identity=28.8461538461538, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=275, Percent_Identity=35.6363636363636, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=225, Percent_Identity=34.6666666666667, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=48.0676328502416, Blast_Score=388, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=47.3429951690821, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=30.078125, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=238, Percent_Identity=28.9915966386555, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324980, Length=187, Percent_Identity=28.3422459893048, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=152, Percent_Identity=29.6052631578947, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=157, Percent_Identity=28.6624203821656, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921140, Length=315, Percent_Identity=33.6507936507937, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24646446, Length=263, Percent_Identity=33.4600760456274, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646448, Length=263, Percent_Identity=33.4600760456274, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646452, Length=263, Percent_Identity=33.4600760456274, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646450, Length=263, Percent_Identity=33.4600760456274, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI62472511, Length=263, Percent_Identity=33.4600760456274, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28571528, Length=344, Percent_Identity=27.906976744186, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28574286, Length=267, Percent_Identity=29.9625468164794, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585514, Length=282, Percent_Identity=25.531914893617, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574282, Length=282, Percent_Identity=25.531914893617, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45552429, Length=282, Percent_Identity=25.531914893617, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574284, Length=282, Percent_Identity=25.531914893617, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45551003, Length=282, Percent_Identity=25.531914893617, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585516, Length=275, Percent_Identity=25.8181818181818, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44910; Mature: 44779

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSLPKQKIRVLLLEGVNDSAVRMFEASGYTEVERLPKALGSAELKRMLSGVHMLGIRS
CCCCCCHHHEEEEEEECCCHHHEEEEECCCCHHHHHHHHHHCHHHHHHHHCCHHHEEECC
RTNLTADVLQAADRLMAVGCFSVGTNQVDLDAARRLGIPVFNAPYSNTRSVAELTIAEVV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEECCCCCCCHHHHHHHHHHHH
MLMRRIFPRSVSAHAGGWDKSANGSREVRGKTLGIIGYGNIGSQLSNLAEAMGMRVIFFD
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEEE
LTDKLRHGNTEPVESLDELLANSDVVSLHVPETPATANMIGERQIRHMKDGAYLINNSRG
CHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCC
TVVDIDALASALREGKLSGAAVDVFPVEPASNADPFVSPLQGLPNVILTPHVGGSTEEAQ
CEEEHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEECCCCCCCHHHH
DRIGGEVARKLIDYSDVGSTFGAVNFPQVQLPARPTGTRFIHVHRNVPGVLRQVNEAVSR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCEEEEEECCCCHHHHHHHHHHHH
HNINILAQYLQTDPEVGYVVLETDVVGGEGEELLSELRAVDGTIRVRVLYDHDRP
CCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEEECCCCC
>Mature Secondary Structure 
PLSLPKQKIRVLLLEGVNDSAVRMFEASGYTEVERLPKALGSAELKRMLSGVHMLGIRS
CCCCCHHHEEEEEEECCCHHHEEEEECCCCHHHHHHHHHHCHHHHHHHHCCHHHEEECC
RTNLTADVLQAADRLMAVGCFSVGTNQVDLDAARRLGIPVFNAPYSNTRSVAELTIAEVV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEECCCCCCCHHHHHHHHHHHH
MLMRRIFPRSVSAHAGGWDKSANGSREVRGKTLGIIGYGNIGSQLSNLAEAMGMRVIFFD
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEEE
LTDKLRHGNTEPVESLDELLANSDVVSLHVPETPATANMIGERQIRHMKDGAYLINNSRG
CHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCC
TVVDIDALASALREGKLSGAAVDVFPVEPASNADPFVSPLQGLPNVILTPHVGGSTEEAQ
CEEEHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEECCCCCCCHHHH
DRIGGEVARKLIDYSDVGSTFGAVNFPQVQLPARPTGTRFIHVHRNVPGVLRQVNEAVSR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCEEEEEECCCCHHHHHHHHHHHH
HNINILAQYLQTDPEVGYVVLETDVVGGEGEELLSELRAVDGTIRVRVLYDHDRP
CCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]