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The map label for this gene is iorA [H]

Identifier: 146338777

GI number: 146338777

Start: 1825209

End: 1825640

Strand: Direct

Name: iorA [H]

Synonym: BRADO1711

Alternate gene names: 146338777

Gene position: 1825209-1825640 (Clockwise)

Preceding gene: 146338776

Following gene: 146338778

Centisome position: 24.48

GC content: 63.19

Gene sequence:

>432_bases
TTGTGGGTCATCCGCGAGGACTTGCAGATGACCGGCACCAAGTTCGGCTGCGGTGCCGGACTGTGCGGCGCCTGCACTGT
TCACGTCGAGGGCGAAGCGGTGCGGTCGTGCCAGACCATGCTCGGCGACGTCACGAACAAGAAGATCACCACCATCGAGG
GCCTTTCGGACAAGGGCGATCATCCCTTGCAGAAGGCGTGGATCGCCGAGCAGGTGCCGCAATGCGGCTACTGCCAATCG
GGACAGATCATGCAGGCGGCCTCGCTGCTCGCCAAGACGACGAGCCCGAGCAAGGAGGAGATCACAGCGCATATGGACGG
CAATCTCTGCCGCTGCATGACCTATTCGCGGATCCAGAAGGCCATTTCGCGCGCGGCGGCAGAAATGCGCACCGCGTCCA
ACACCACCTCGAACGAGCGGAGCCCCACATGA

Upstream 100 bases:

>100_bases
TGCAGAGCAAATCCGTCCCGTAAGGAGGTTCTTGGCAATGGCGAAACTCAGTATCAACGGCAGAGATGTCTCTGTCGACG
CGGCGAACGACACGCCGCTG

Downstream 100 bases:

>100_bases
ATACACATGTGAAGAACGCCGCGGGCGAGCGCATCGCCAGCCACAGCCCTGATCTCAGCCGCCGCTCCTTCCTGGTCGGC
ACCGCCGCCACCGGCCTCGT

Product: putative isoquinoline 1-oxidoreductase subunit alpha, iorA-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MWVIREDLQMTGTKFGCGAGLCGACTVHVEGEAVRSCQTMLGDVTNKKITTIEGLSDKGDHPLQKAWIAEQVPQCGYCQS
GQIMQAASLLAKTTSPSKEEITAHMDGNLCRCMTYSRIQKAISRAAAEMRTASNTTSNERSPT

Sequences:

>Translated_143_residues
MWVIREDLQMTGTKFGCGAGLCGACTVHVEGEAVRSCQTMLGDVTNKKITTIEGLSDKGDHPLQKAWIAEQVPQCGYCQS
GQIMQAASLLAKTTSPSKEEITAHMDGNLCRCMTYSRIQKAISRAAAEMRTASNTTSNERSPT
>Mature_143_residues
MWVIREDLQMTGTKFGCGAGLCGACTVHVEGEAVRSCQTMLGDVTNKKITTIEGLSDKGDHPLQKAWIAEQVPQCGYCQS
GQIMQAASLLAKTTSPSKEEITAHMDGNLCRCMTYSRIQKAISRAAAEMRTASNTTSNERSPT

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786480, Length=147, Percent_Identity=38.7755102040816, Blast_Score=99, Evalue=8e-23,
Organism=Escherichia coli, GI1789232, Length=123, Percent_Identity=36.5853658536585, Blast_Score=70, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17540638, Length=147, Percent_Identity=35.3741496598639, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17539860, Length=133, Percent_Identity=35.3383458646617, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32566215, Length=139, Percent_Identity=33.0935251798561, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24647197, Length=138, Percent_Identity=34.7826086956522, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24647195, Length=138, Percent_Identity=34.7826086956522, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17737937, Length=130, Percent_Identity=34.6153846153846, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24647193, Length=139, Percent_Identity=38.1294964028777, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24647199, Length=137, Percent_Identity=35.7664233576642, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24647201, Length=133, Percent_Identity=36.0902255639098, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 15433; Mature: 15433

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
10.5 %Cys+Met (Translated Protein)
5.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
10.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWVIREDLQMTGTKFGCGAGLCGACTVHVEGEAVRSCQTMLGDVTNKKITTIEGLSDKGD
CCEECCCHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCC
HPLQKAWIAEQVPQCGYCQSGQIMQAASLLAKTTSPSKEEITAHMDGNLCRCMTYSRIQK
CHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEEECCCCCCHHHHHHHHHHH
AISRAAAEMRTASNTTSNERSPT
HHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MWVIREDLQMTGTKFGCGAGLCGACTVHVEGEAVRSCQTMLGDVTNKKITTIEGLSDKGD
CCEECCCHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCC
HPLQKAWIAEQVPQCGYCQSGQIMQAASLLAKTTSPSKEEITAHMDGNLCRCMTYSRIQK
CHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEEECCCCCCHHHHHHHHHHH
AISRAAAEMRTASNTTSNERSPT
HHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]