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The map label for this gene is hemA [H]

Identifier: 146338718

GI number: 146338718

Start: 1767763

End: 1768974

Strand: Direct

Name: hemA [H]

Synonym: BRADO1651

Alternate gene names: 146338718

Gene position: 1767763-1768974 (Clockwise)

Preceding gene: 146338717

Following gene: 146338719

Centisome position: 23.71

GC content: 67.0

Gene sequence:

>1212_bases
ATGAACTACGAAGACTATTTCCGCCGCCAGCTCGACGGCCTCCGGCGCGAGGGACGCTACCGCGTCTTCGCCGACCTCGA
GCGCAAGGCCGGCGCCTTCCCGCGCGCGACCTACCGCGGTCCGCATGGCGAGCGCGAGGTCTCGGTGTGGTGCTCCAACG
ATTATCTCGGCATGGGCCAGCATCCGAAGGTGCTGGAGGTGATGCACGAGGCGCTCGACCGCTGCGGCGCCGGCGCCGGC
GGCACCCGCAACATCAGCGGTACCAACCACTATCATATTCTGCTGGAAGAAGAGCTCGCCGACCTCCACGGCAAGCAGGC
CGCGCTCTTGTTCAACTCCGGCTACGTCTCGAACTGGACCTCGCTGTCGACGCTCGCGGGGCGCATGCCCGGCTGCGTCA
TCCTCTCCGACGAGCTCAACCACGCCTCGATGATCGAGGGCATCCGCCACAGCCGCTGCGAGACCCGGATCTGGCGCCAC
AACGACGTCGCCGATCTCCGTGACAAGCTGTCGGATCTCGACCCCAAGGTGCCGAAGCTGATCGCCTTCGAGAGCGTCTA
TTCAATGGATGGCGACATCTCGCCGATCTCCGACATCTGCGACGTCGCCGACGAATACAACGCGATGACCTATCTCGATG
AGGTCCATGCCGTCGGCCTGTACGGCCCGCGCGGCGGCGGCATCTCCGAGCGCGACGGCGTCGCCGACCGGCTGACCGTC
ATCGAGGGCACGCTCGCCAAGGCGTTCGGCGTGATCGGCGGCTACATCACGGCGTCCAACACGGTCTGCGACTTCGTCCG
CAGCTTCGCCTCCGGCTTCATCTTCTCGAGCTCGCTGCCGCCGGCCGTGGCCGCCGGCGCGCTGACCAGCATCCGCCACC
TCAAGGCCAGCAATCATGAGCGCGCCCGGCATCAGGATCGCGTCGCGCGGCTGCGGCGCCGGCTCGACGAGGCGGGCGTC
AGCCATCTCGACAATCCCAGCCACATCGTGCCGGTGATGGTGCGCGACCCTGTGCTGTGCAAGCGGATCAGCGACATCCT
GCTCGACCGCTACGGCGTCTATGTGCAGCCGATCAACTATCCGACGGTGCCGCGTGGCACCGAGCGGCTGCGCATCACCC
CGTCGCCCTATCACTCCGACGAGGACATCGAGCATCTGGTCTCGGCGCTGTCCGAGATCTGGGCGGAGATGGGCTTGGCG
CAGGCGGCCTGA

Upstream 100 bases:

>100_bases
AGGCCCGCGCTGATGCGCAGGCGCAAACCATCACCGGACTGGCCGCGGTGTCGGTCACGCCGCCGGTCGATCCGAACACG
ACAGCACAGGGGGGAGTACC

Downstream 100 bases:

>100_bases
TTCAGCGCGATCCGCGCGGCGTTTGCGCCAGATCAATTTGTCAATCCAGCTTGACGTTAGGATGTCAGGACAAATTGATA
ACCGGGGGAGAACGCCGTGC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MNYEDYFRRQLDGLRREGRYRVFADLERKAGAFPRATYRGPHGEREVSVWCSNDYLGMGQHPKVLEVMHEALDRCGAGAG
GTRNISGTNHYHILLEEELADLHGKQAALLFNSGYVSNWTSLSTLAGRMPGCVILSDELNHASMIEGIRHSRCETRIWRH
NDVADLRDKLSDLDPKVPKLIAFESVYSMDGDISPISDICDVADEYNAMTYLDEVHAVGLYGPRGGGISERDGVADRLTV
IEGTLAKAFGVIGGYITASNTVCDFVRSFASGFIFSSSLPPAVAAGALTSIRHLKASNHERARHQDRVARLRRRLDEAGV
SHLDNPSHIVPVMVRDPVLCKRISDILLDRYGVYVQPINYPTVPRGTERLRITPSPYHSDEDIEHLVSALSEIWAEMGLA
QAA

Sequences:

>Translated_403_residues
MNYEDYFRRQLDGLRREGRYRVFADLERKAGAFPRATYRGPHGEREVSVWCSNDYLGMGQHPKVLEVMHEALDRCGAGAG
GTRNISGTNHYHILLEEELADLHGKQAALLFNSGYVSNWTSLSTLAGRMPGCVILSDELNHASMIEGIRHSRCETRIWRH
NDVADLRDKLSDLDPKVPKLIAFESVYSMDGDISPISDICDVADEYNAMTYLDEVHAVGLYGPRGGGISERDGVADRLTV
IEGTLAKAFGVIGGYITASNTVCDFVRSFASGFIFSSSLPPAVAAGALTSIRHLKASNHERARHQDRVARLRRRLDEAGV
SHLDNPSHIVPVMVRDPVLCKRISDILLDRYGVYVQPINYPTVPRGTERLRITPSPYHSDEDIEHLVSALSEIWAEMGLA
QAA
>Mature_403_residues
MNYEDYFRRQLDGLRREGRYRVFADLERKAGAFPRATYRGPHGEREVSVWCSNDYLGMGQHPKVLEVMHEALDRCGAGAG
GTRNISGTNHYHILLEEELADLHGKQAALLFNSGYVSNWTSLSTLAGRMPGCVILSDELNHASMIEGIRHSRCETRIWRH
NDVADLRDKLSDLDPKVPKLIAFESVYSMDGDISPISDICDVADEYNAMTYLDEVHAVGLYGPRGGGISERDGVADRLTV
IEGTLAKAFGVIGGYITASNTVCDFVRSFASGFIFSSSLPPAVAAGALTSIRHLKASNHERARHQDRVARLRRRLDEAGV
SHLDNPSHIVPVMVRDPVLCKRISDILLDRYGVYVQPINYPTVPRGTERLRITPSPYHSDEDIEHLVSALSEIWAEMGLA
QAA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=403, Percent_Identity=49.8759305210918, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI83977440, Length=403, Percent_Identity=49.8759305210918, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI83977444, Length=403, Percent_Identity=49.8759305210918, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=51.1166253101737, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=51.1166253101737, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI7657118, Length=386, Percent_Identity=37.3056994818653, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI284448556, Length=346, Percent_Identity=39.3063583815029, Blast_Score=245, Evalue=6e-65,
Organism=Homo sapiens, GI4758668, Length=360, Percent_Identity=30.2777777777778, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=29.3478260869565, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI5454084, Length=248, Percent_Identity=27.4193548387097, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1790046, Length=353, Percent_Identity=33.7110481586402, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=32.6647564469914, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=400, Percent_Identity=32.25, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI32566772, Length=373, Percent_Identity=29.2225201072386, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17560914, Length=373, Percent_Identity=28.4182305630027, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17560912, Length=373, Percent_Identity=28.4182305630027, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71982617, Length=260, Percent_Identity=25.7692307692308, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71982625, Length=260, Percent_Identity=25.7692307692308, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=424, Percent_Identity=46.2264150943396, Blast_Score=386, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=28.5326086956522, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6323954, Length=271, Percent_Identity=25.830258302583, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17137420, Length=402, Percent_Identity=48.0099502487562, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24662918, Length=385, Percent_Identity=34.025974025974, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI17136286, Length=338, Percent_Identity=29.585798816568, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24653280, Length=294, Percent_Identity=27.2108843537415, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653276, Length=294, Percent_Identity=27.2108843537415, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653278, Length=294, Percent_Identity=27.2108843537415, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44730; Mature: 44730

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYEDYFRRQLDGLRREGRYRVFADLERKAGAFPRATYRGPHGEREVSVWCSNDYLGMGQ
CCHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
HPKVLEVMHEALDRCGAGAGGTRNISGTNHYHILLEEELADLHGKQAALLFNSGYVSNWT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHCCCCCEEEEEECCCCCCCH
SLSTLAGRMPGCVILSDELNHASMIEGIRHSRCETRIWRHNDVADLRDKLSDLDPKVPKL
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHH
IAFESVYSMDGDISPISDICDVADEYNAMTYLDEVHAVGLYGPRGGGISERDGVADRLTV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHH
IEGTLAKAFGVIGGYITASNTVCDFVRSFASGFIFSSSLPPAVAAGALTSIRHLKASNHE
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCHH
RARHQDRVARLRRRLDEAGVSHLDNPSHIVPVMVRDPVLCKRISDILLDRYGVYVQPINY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCC
PTVPRGTERLRITPSPYHSDEDIEHLVSALSEIWAEMGLAQAA
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNYEDYFRRQLDGLRREGRYRVFADLERKAGAFPRATYRGPHGEREVSVWCSNDYLGMGQ
CCHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
HPKVLEVMHEALDRCGAGAGGTRNISGTNHYHILLEEELADLHGKQAALLFNSGYVSNWT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHCCCCCEEEEEECCCCCCCH
SLSTLAGRMPGCVILSDELNHASMIEGIRHSRCETRIWRHNDVADLRDKLSDLDPKVPKL
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHH
IAFESVYSMDGDISPISDICDVADEYNAMTYLDEVHAVGLYGPRGGGISERDGVADRLTV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHH
IEGTLAKAFGVIGGYITASNTVCDFVRSFASGFIFSSSLPPAVAAGALTSIRHLKASNHE
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCHH
RARHQDRVARLRRRLDEAGVSHLDNPSHIVPVMVRDPVLCKRISDILLDRYGVYVQPINY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCC
PTVPRGTERLRITPSPYHSDEDIEHLVSALSEIWAEMGLAQAA
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]