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The map label for this gene is ivd2 [H]

Identifier: 146338528

GI number: 146338528

Start: 1551824

End: 1552996

Strand: Direct

Name: ivd2 [H]

Synonym: BRADO1447

Alternate gene names: 146338528

Gene position: 1551824-1552996 (Clockwise)

Preceding gene: 146338518

Following gene: 146338529

Centisome position: 20.81

GC content: 65.56

Gene sequence:

>1173_bases
ATGATCGCCAACGCGCAGCGCATGTTCAATTTCGATCTCGGCGAGACCGCCGATGCGATCCGCGAAACGGTGGCCAGCTT
TGCACAGGAGCAGATCGCGCCGCGCGCCGCCGACATCGACCGCTCCAACCAGTTCCCGCGCGACCTCTGGCCGAAGCTCG
GCGAGCTCGGCCTGCACGGCATCACCGTGGAGGAGGAGCATGGCGGCGCCGGCCTCGGCTATCTCGAGCACTGCATCGCG
ATGGAGGAGATCTCGCGCGCCTCGGCCTCGGTCGGCCTGTCCTACGGCGCCCACTCCAATCTCTGCGTCAATCAGATCCG
CCGCAACGGCAGCGAGGCGCAGAAGCGCAAATACCTCCCCAAGCTGATCTCGGGCGAGCATGTCGGTTCGCTGGCGATGT
CCGAGCCGCAGGCGGGCTCCGATGTCGTCTCGATGAAGACGCGCGCCGACAGACGCGGCGATCGGTTCGTCCTCAACGGC
AACAAGATGTGGATCACCAACGGGCCGGTCGCCGAGACCCTCGTGGTGTATGCCAAGACCGATCCGCAGGGTGGTCCGCG
CGGTATCACCGCCTTCATCATCGAGAAGGGCATGAAGGGCTTCTCGACGGCGCAGAAGCTCGACAAGCTCGGCATGCGCG
GCTCCGACACCTGTGAGCTGGTGTTCGAGGATTGCGAGGTGCCGGAGGAGAACGTGCTCGGGCAGGTCGGCCGCGGCGTG
AACGTGCTGATGAGCGGTCTCGACTACGAGCGCGCCGTGCTCGCGGCCGGTCCGCTCGGCATCATGCAGGCCTGCATGGA
CGTCGTGCTTCCTTACGTGCACGAGCGCAAGCAGTTCGGCCAGCCGATCGGCACCTTCCAGCTGGTCCAGGGCAAGGTCG
CCGACATGTACACGACGATGAATGCCGCGCGGGCCTATGTCTACGCGGTGGCCAAGGCGTGCGACCGCGGCGAGACGACG
CGCGAGGATGCGGCCGGCGCTATTCTATTTGCAGCAGAGAAAGCGACGCAGTGCGCGCTGGACGCGATTCAGCTGCTCGG
CGGCAACGGCTACATCAACGATTATGCGACCGGGCGGCTGCTGCGCGATGCCAAGCTTTATGAGATCGGCGCCGGCACGA
GCGAGATCCGGCGCATGCTGATCGGGCGGGAATTGTTCGACAAGACCTCCTGA

Upstream 100 bases:

>100_bases
GCTGCCGTTTGGCCGGATGTTGGGCGTGACAAGCGCCACGTCACGGAATAAGGCTTTGGGCAATTGTTGCAAAGCAGAAG
AATAGCAGGAGGCCGCCGCC

Downstream 100 bases:

>100_bases
GGCGCCGAAACGCGAGGTTCGGGCGCGGAAGCCGCGTTCGCCAACCGGCCAACAGCAGATATTTTGATCATCGTCGTCCA
GGCCGGTGTTTTTTTCCGGC

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MIANAQRMFNFDLGETADAIRETVASFAQEQIAPRAADIDRSNQFPRDLWPKLGELGLHGITVEEEHGGAGLGYLEHCIA
MEEISRASASVGLSYGAHSNLCVNQIRRNGSEAQKRKYLPKLISGEHVGSLAMSEPQAGSDVVSMKTRADRRGDRFVLNG
NKMWITNGPVAETLVVYAKTDPQGGPRGITAFIIEKGMKGFSTAQKLDKLGMRGSDTCELVFEDCEVPEENVLGQVGRGV
NVLMSGLDYERAVLAAGPLGIMQACMDVVLPYVHERKQFGQPIGTFQLVQGKVADMYTTMNAARAYVYAVAKACDRGETT
REDAAGAILFAAEKATQCALDAIQLLGGNGYINDYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFDKTS

Sequences:

>Translated_390_residues
MIANAQRMFNFDLGETADAIRETVASFAQEQIAPRAADIDRSNQFPRDLWPKLGELGLHGITVEEEHGGAGLGYLEHCIA
MEEISRASASVGLSYGAHSNLCVNQIRRNGSEAQKRKYLPKLISGEHVGSLAMSEPQAGSDVVSMKTRADRRGDRFVLNG
NKMWITNGPVAETLVVYAKTDPQGGPRGITAFIIEKGMKGFSTAQKLDKLGMRGSDTCELVFEDCEVPEENVLGQVGRGV
NVLMSGLDYERAVLAAGPLGIMQACMDVVLPYVHERKQFGQPIGTFQLVQGKVADMYTTMNAARAYVYAVAKACDRGETT
REDAAGAILFAAEKATQCALDAIQLLGGNGYINDYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFDKTS
>Mature_390_residues
MIANAQRMFNFDLGETADAIRETVASFAQEQIAPRAADIDRSNQFPRDLWPKLGELGLHGITVEEEHGGAGLGYLEHCIA
MEEISRASASVGLSYGAHSNLCVNQIRRNGSEAQKRKYLPKLISGEHVGSLAMSEPQAGSDVVSMKTRADRRGDRFVLNG
NKMWITNGPVAETLVVYAKTDPQGGPRGITAFIIEKGMKGFSTAQKLDKLGMRGSDTCELVFEDCEVPEENVLGQVGRGV
NVLMSGLDYERAVLAAGPLGIMQACMDVVLPYVHERKQFGQPIGTFQLVQGKVADMYTTMNAARAYVYAVAKACDRGETT
REDAAGAILFAAEKATQCALDAIQLLGGNGYINDYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFDKTS

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=66.4, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=68.141592920354, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=40.3183023872679, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI4501859, Length=366, Percent_Identity=39.0710382513661, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI4557231, Length=393, Percent_Identity=37.1501272264631, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI187960098, Length=393, Percent_Identity=37.1501272264631, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI21361497, Length=367, Percent_Identity=37.6021798365123, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=34.2175066312997, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI7656849, Length=380, Percent_Identity=33.1578947368421, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI76496475, Length=368, Percent_Identity=35.5978260869565, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI4557235, Length=368, Percent_Identity=35.5978260869565, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI4503943, Length=371, Percent_Identity=32.8840970350404, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI7669494, Length=367, Percent_Identity=33.5149863760218, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI211971008, Length=284, Percent_Identity=26.056338028169, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI48976061, Length=284, Percent_Identity=26.056338028169, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI218563752, Length=228, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI38505218, Length=278, Percent_Identity=22.3021582733813, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786223, Length=364, Percent_Identity=30.7692307692308, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=30.2083333333333, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI87082384, Length=258, Percent_Identity=27.5193798449612, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081702, Length=338, Percent_Identity=24.5562130177515, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=63.1299734748011, Blast_Score=510, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17569725, Length=389, Percent_Identity=37.7892030848329, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17534899, Length=390, Percent_Identity=36.4102564102564, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17506239, Length=362, Percent_Identity=36.1878453038674, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=35.0404312668464, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17570075, Length=384, Percent_Identity=33.3333333333333, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71990804, Length=296, Percent_Identity=41.2162162162162, Blast_Score=227, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17533517, Length=371, Percent_Identity=34.2318059299191, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=33.1428571428571, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17534353, Length=375, Percent_Identity=30.6666666666667, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17551932, Length=368, Percent_Identity=31.7934782608696, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=39.5652173913043, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=34.3065693430657, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=31.7204301075269, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71985192, Length=297, Percent_Identity=32.996632996633, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=29.7071129707113, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI86563381, Length=281, Percent_Identity=25.9786476868327, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=281, Percent_Identity=25.9786476868327, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=64.3799472295514, Blast_Score=497, Evalue=1e-141,
Organism=Drosophila melanogaster, GI21356377, Length=379, Percent_Identity=42.7440633245383, Blast_Score=308, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=39.572192513369, Blast_Score=271, Evalue=5e-73,
Organism=Drosophila melanogaster, GI24666513, Length=364, Percent_Identity=37.0879120879121, Blast_Score=258, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=38.0577427821522, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI281363737, Length=354, Percent_Identity=34.180790960452, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI19920834, Length=388, Percent_Identity=29.639175257732, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42311; Mature: 42311

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIANAQRMFNFDLGETADAIRETVASFAQEQIAPRAADIDRSNQFPRDLWPKLGELGLHG
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHCCCCC
ITVEEEHGGAGLGYLEHCIAMEEISRASASVGLSYGAHSNLCVNQIRRNGSEAQKRKYLP
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
KLISGEHVGSLAMSEPQAGSDVVSMKTRADRRGDRFVLNGNKMWITNGPVAETLVVYAKT
HHHCCCCCCCHHCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEEECCCCCEEEEEEEEC
DPQGGPRGITAFIIEKGMKGFSTAQKLDKLGMRGSDTCELVFEDCEVPEENVLGQVGRGV
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHCCCH
NVLMSGLDYERAVLAAGPLGIMQACMDVVLPYVHERKQFGQPIGTFQLVQGKVADMYTTM
HHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
NAARAYVYAVAKACDRGETTREDAAGAILFAAEKATQCALDAIQLLGGNGYINDYATGRL
HHHHHHHHHHHHHHCCCCCCHHHHCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHCHH
LRDAKLYEIGAGTSEIRRMLIGRELFDKTS
HHCCCEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIANAQRMFNFDLGETADAIRETVASFAQEQIAPRAADIDRSNQFPRDLWPKLGELGLHG
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHCCCCC
ITVEEEHGGAGLGYLEHCIAMEEISRASASVGLSYGAHSNLCVNQIRRNGSEAQKRKYLP
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
KLISGEHVGSLAMSEPQAGSDVVSMKTRADRRGDRFVLNGNKMWITNGPVAETLVVYAKT
HHHCCCCCCCHHCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEEECCCCCEEEEEEEEC
DPQGGPRGITAFIIEKGMKGFSTAQKLDKLGMRGSDTCELVFEDCEVPEENVLGQVGRGV
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHCCCH
NVLMSGLDYERAVLAAGPLGIMQACMDVVLPYVHERKQFGQPIGTFQLVQGKVADMYTTM
HHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
NAARAYVYAVAKACDRGETTREDAAGAILFAAEKATQCALDAIQLLGGNGYINDYATGRL
HHHHHHHHHHHHHHCCCCCCHHHHCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHCHH
LRDAKLYEIGAGTSEIRRMLIGRELFDKTS
HHCCCEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]