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The map label for this gene is betA [H]

Identifier: 146338481

GI number: 146338481

Start: 1493759

End: 1495342

Strand: Direct

Name: betA [H]

Synonym: BRADO1398

Alternate gene names: 146338481

Gene position: 1493759-1495342 (Clockwise)

Preceding gene: 146338480

Following gene: 146338483

Centisome position: 20.03

GC content: 67.05

Gene sequence:

>1584_bases
ATGCGACGCGTGCGAGCTGCGGGATTTGAATCGATGTATGATGTCATTGTGGTCGGCGGCGGCTCCGCGGGTGCAGCGGT
GGCGGCGCGCCTGTCTGAAGATCCGCAGCGCCGGGTTCTGCTGCTCGAAGCGGGCGCCGACTGGCGCGCAGCCGACGTGC
CCTGGGAGATCGCGACGCCCAATCCGATCCCGATCATTCATGACCGTGCCTTCCAGGAGAAATGGCAGTGGCCGCAGCTG
ATGTCGCGCCGCGTCGCGGGACAAGAGATGCGTTTCTACTGGCGCGGCAAGGGGCTCGGCGGCAGCTCGATGATGAACGG
CCAGATCGCGATCCGCGGCGTCGCCGATGCGTTCGACGAATGGGCGGCCAATGGCTGTACGGGCTGGTCGGCCGGAGAGG
TCATGCCGCTGTTCTCGTTGATCGAGGATGATCTCGCCTTCGGTGACCGCGAGGGGCACGGACGCGGCGGGCCGCTGCCG
GTGTATCGCGCGCCGCCGGAGCAATGGGGACCGATCGATCGGGCCTTGCGCGACGCGGCGCTTTCGAGCGGCTATCGCTG
GAGCGACGATCTCAACGGTCCTGACGGCGAAGGCGTCGCTTGCTATCCGATCAACAGCCGCAACGGCCGGCGCATCTCGA
CCAATGAGGGCTATCTGGAGCCGGCGCGAGGCCGCGCCAATCTGGAGATCCGTGGCCGCGCGCTGGTCGATCGTCTTCTG
ATCAGCGATTCCAGAGCCACCGGCGTGCGCGTCCATATCGAGGGAGACGACGTCAAGGAGATCGCGGCCCGCGAGATCGT
GCTGTGCGCCGGCGCCATCCACAGTCCGGCGATCCTGCTGCGCTCTGGCATCGGCCCCGCGGCTGATCTTCAGGACATGG
GCATCGCCGTGCTCCGCGATCTGCCTGTGGGACGGCATTTCTTCGACCACCCGCTGTTCCGCACCACCATCCAGTTGCGC
GAGGAGGTGCGTCCGACCGACCGCGACACGCGCCATACCAATTGCTGCGTGACCTACTCGTCGGGCCTGGCCAATGGTGG
CAGGCGCGACATGATCCTGATCGCGTTCAACCATCGCGGCATCGGCATGCCTGGCGCGATCGGAGCGGGTCTGTTCAACG
CCTTCTCGCGCGGCACCTTGAAGCTCGCGTCGACCGATCCGACCGTTGATCCGATCGTGGAGGAGAACATGCTCGCCGAT
CCGCGCGACATCGCACGGATGCGCGATGCGGTGAAGCGGCTGGCAGCGATCACGCTGCAGCCGGCGCTGCAAGAGATCGC
CGACTGGATCCGCCTCGGCGATACGCAATTCACCTTGCCGCAGGCGGCGGCGCTGCCGGATACCGAACTCGACGCGCTGC
TCCGGCAGATCACCGGCGACATCCAGCACGCCGCGGGAAGCTGCCGGATGAGCGGCTTCGATGACGCCGACGGCGTGGTC
AATCCCGACGGCACGGTCAAGGGCATCGCCGGCCTGCGCGTCGCCGACGCCTCGATCATGCCGTCCGACTGCCGCGCCAA
CACGCATTTCACCACGGTCGTGATCGGCGAGGCAATCGCGCGGATGATGCGCAAGGCGGCGTAG

Upstream 100 bases:

>100_bases
GTTCCCGAGGAGGCCGCGAAGCCCTGCGTCGGAATGCTGGTGGCCTGACCAGGACAGGACTTCACGGATCGCCGTCGCTG
GCGCAAGGTGCCCCGCGTGA

Downstream 100 bases:

>100_bases
GAGATCGTAGCCCGGATGAGCGAAGCGACATCCGGGGTCTCCTGTGCAGCTCGTGTGACCCCGGATATCGCTTCGCTCAT
CCGGGCTACGCCGATCAGGC

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MRRVRAAGFESMYDVIVVGGGSAGAAVAARLSEDPQRRVLLLEAGADWRAADVPWEIATPNPIPIIHDRAFQEKWQWPQL
MSRRVAGQEMRFYWRGKGLGGSSMMNGQIAIRGVADAFDEWAANGCTGWSAGEVMPLFSLIEDDLAFGDREGHGRGGPLP
VYRAPPEQWGPIDRALRDAALSSGYRWSDDLNGPDGEGVACYPINSRNGRRISTNEGYLEPARGRANLEIRGRALVDRLL
ISDSRATGVRVHIEGDDVKEIAAREIVLCAGAIHSPAILLRSGIGPAADLQDMGIAVLRDLPVGRHFFDHPLFRTTIQLR
EEVRPTDRDTRHTNCCVTYSSGLANGGRRDMILIAFNHRGIGMPGAIGAGLFNAFSRGTLKLASTDPTVDPIVEENMLAD
PRDIARMRDAVKRLAAITLQPALQEIADWIRLGDTQFTLPQAAALPDTELDALLRQITGDIQHAAGSCRMSGFDDADGVV
NPDGTVKGIAGLRVADASIMPSDCRANTHFTTVVIGEAIARMMRKAA

Sequences:

>Translated_527_residues
MRRVRAAGFESMYDVIVVGGGSAGAAVAARLSEDPQRRVLLLEAGADWRAADVPWEIATPNPIPIIHDRAFQEKWQWPQL
MSRRVAGQEMRFYWRGKGLGGSSMMNGQIAIRGVADAFDEWAANGCTGWSAGEVMPLFSLIEDDLAFGDREGHGRGGPLP
VYRAPPEQWGPIDRALRDAALSSGYRWSDDLNGPDGEGVACYPINSRNGRRISTNEGYLEPARGRANLEIRGRALVDRLL
ISDSRATGVRVHIEGDDVKEIAAREIVLCAGAIHSPAILLRSGIGPAADLQDMGIAVLRDLPVGRHFFDHPLFRTTIQLR
EEVRPTDRDTRHTNCCVTYSSGLANGGRRDMILIAFNHRGIGMPGAIGAGLFNAFSRGTLKLASTDPTVDPIVEENMLAD
PRDIARMRDAVKRLAAITLQPALQEIADWIRLGDTQFTLPQAAALPDTELDALLRQITGDIQHAAGSCRMSGFDDADGVV
NPDGTVKGIAGLRVADASIMPSDCRANTHFTTVVIGEAIARMMRKAA
>Mature_527_residues
MRRVRAAGFESMYDVIVVGGGSAGAAVAARLSEDPQRRVLLLEAGADWRAADVPWEIATPNPIPIIHDRAFQEKWQWPQL
MSRRVAGQEMRFYWRGKGLGGSSMMNGQIAIRGVADAFDEWAANGCTGWSAGEVMPLFSLIEDDLAFGDREGHGRGGPLP
VYRAPPEQWGPIDRALRDAALSSGYRWSDDLNGPDGEGVACYPINSRNGRRISTNEGYLEPARGRANLEIRGRALVDRLL
ISDSRATGVRVHIEGDDVKEIAAREIVLCAGAIHSPAILLRSGIGPAADLQDMGIAVLRDLPVGRHFFDHPLFRTTIQLR
EEVRPTDRDTRHTNCCVTYSSGLANGGRRDMILIAFNHRGIGMPGAIGAGLFNAFSRGTLKLASTDPTVDPIVEENMLAD
PRDIARMRDAVKRLAAITLQPALQEIADWIRLGDTQFTLPQAAALPDTELDALLRQITGDIQHAAGSCRMSGFDDADGVV
NPDGTVKGIAGLRVADASIMPSDCRANTHFTTVVIGEAIARMMRKAA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=563, Percent_Identity=31.4387211367673, Blast_Score=216, Evalue=4e-56,
Organism=Escherichia coli, GI1786503, Length=553, Percent_Identity=33.2730560578662, Blast_Score=230, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17532301, Length=559, Percent_Identity=26.2969588550984, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI17137792, Length=558, Percent_Identity=33.1541218637993, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24642048, Length=580, Percent_Identity=31.3793103448276, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24642039, Length=577, Percent_Identity=31.7157712305026, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24642059, Length=573, Percent_Identity=29.8429319371728, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI18859995, Length=578, Percent_Identity=29.9307958477509, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI18859993, Length=598, Percent_Identity=30.2675585284281, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24642042, Length=577, Percent_Identity=29.9826689774697, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24642055, Length=325, Percent_Identity=36.9230769230769, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24642035, Length=311, Percent_Identity=37.2990353697749, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24642051, Length=315, Percent_Identity=36.8253968253968, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24642037, Length=306, Percent_Identity=37.2549019607843, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI45549471, Length=308, Percent_Identity=35.3896103896104, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI45551458, Length=308, Percent_Identity=35.3896103896104, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24650267, Length=315, Percent_Identity=35.5555555555556, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24645930, Length=588, Percent_Identity=24.8299319727891, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24642057, Length=313, Percent_Identity=31.9488817891374, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 57141; Mature: 57141

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVRAAGFESMYDVIVVGGGSAGAAVAARLSEDPQRRVLLLEAGADWRAADVPWEIATP
CCCCCCCCHHCEEEEEEECCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEECCCC
NPIPIIHDRAFQEKWQWPQLMSRRVAGQEMRFYWRGKGLGGSSMMNGQIAIRGVADAFDE
CCCCEECCHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEEEHHHHHHH
WAANGCTGWSAGEVMPLFSLIEDDLAFGDREGHGRGGPLPVYRAPPEQWGPIDRALRDAA
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHH
LSSGYRWSDDLNGPDGEGVACYPINSRNGRRISTNEGYLEPARGRANLEIRGRALVDRLL
HHCCCCCCCCCCCCCCCCEEEEEECCCCCCEEECCCCCCCCCCCCCCEEECHHHHHHHHH
ISDSRATGVRVHIEGDDVKEIAAREIVLCAGAIHSPAILLRSGIGPAADLQDMGIAVLRD
HCCCCCCEEEEEECCCCHHHHHHHHHEEECCCCCCCHHHHHCCCCCCCCHHHCCHHHHHC
LPVGRHFFDHPLFRTTIQLREEVRPTDRDTRHTNCCVTYSSGLANGGRRDMILIAFNHRG
CCCCCHHHHCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCC
IGMPGAIGAGLFNAFSRGTLKLASTDPTVDPIVEENMLADPRDIARMRDAVKRLAAITLQ
CCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
PALQEIADWIRLGDTQFTLPQAAALPDTELDALLRQITGDIQHAAGSCRMSGFDDADGVV
HHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NPDGTVKGIAGLRVADASIMPSDCRANTHFTTVVIGEAIARMMRKAA
CCCCCEECCCCEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MRRVRAAGFESMYDVIVVGGGSAGAAVAARLSEDPQRRVLLLEAGADWRAADVPWEIATP
CCCCCCCCHHCEEEEEEECCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEECCCC
NPIPIIHDRAFQEKWQWPQLMSRRVAGQEMRFYWRGKGLGGSSMMNGQIAIRGVADAFDE
CCCCEECCHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEEEHHHHHHH
WAANGCTGWSAGEVMPLFSLIEDDLAFGDREGHGRGGPLPVYRAPPEQWGPIDRALRDAA
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHH
LSSGYRWSDDLNGPDGEGVACYPINSRNGRRISTNEGYLEPARGRANLEIRGRALVDRLL
HHCCCCCCCCCCCCCCCCEEEEEECCCCCCEEECCCCCCCCCCCCCCEEECHHHHHHHHH
ISDSRATGVRVHIEGDDVKEIAAREIVLCAGAIHSPAILLRSGIGPAADLQDMGIAVLRD
HCCCCCCEEEEEECCCCHHHHHHHHHEEECCCCCCCHHHHHCCCCCCCCHHHCCHHHHHC
LPVGRHFFDHPLFRTTIQLREEVRPTDRDTRHTNCCVTYSSGLANGGRRDMILIAFNHRG
CCCCCHHHHCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCC
IGMPGAIGAGLFNAFSRGTLKLASTDPTVDPIVEENMLADPRDIARMRDAVKRLAAITLQ
CCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
PALQEIADWIRLGDTQFTLPQAAALPDTELDALLRQITGDIQHAAGSCRMSGFDDADGVV
HHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NPDGTVKGIAGLRVADASIMPSDCRANTHFTTVVIGEAIARMMRKAA
CCCCCEECCCCEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA