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The map label for this gene is acsA [H]

Identifier: 146338424

GI number: 146338424

Start: 1427672

End: 1429279

Strand: Direct

Name: acsA [H]

Synonym: BRADO1339

Alternate gene names: 146338424

Gene position: 1427672-1429279 (Clockwise)

Preceding gene: 146338423

Following gene: 146338425

Centisome position: 19.15

GC content: 65.92

Gene sequence:

>1608_bases
ATGCTTCAGGAAACGTCCGACTACGACCAGCTGTATCGCGACTTCCGCTGGGACATCCCGGCGCAGTTCAACATCGCCGT
CGCTACCTGCGACCGCCACGCCGACGGCACGGGCTGCCTCGCGCTGATCGTCGTCGAGGAGGATGGCGCCGCGCGCCGCG
TGTCGTTCGACGAGTTGCGTGACGCCTCCTGCCGCTTCGCCAATGTGCTGAAGGCCGACGGCCTGGCGCAGGGCGATCGC
GTCGCGGTGTTCCTGTCGCAATCTCTCGAGCTGCCGATCGTCCATCTCGCCGCCTTCCGCGCCGGCCTCGTCTCGGTGCC
GCTGTTCACGCTGTTCGGCGAGGACGCGCTGCAATTCCGCCTGCAGAACTCCGGCGCCAAGGTCGTGGTGACCGACACGA
CGGGCTTCGCCAAGCTCCAGCGCATCCGCGACCGGTTGCCCGAGCTCAAGACGATCTACGTCACCGACGGCGAAGGCAGC
GGCGCCCGGCCGTTCTGGTCGACGCTGGAGCGCGCCTCGGCTCAATTCCCGACCGTCGCGACCTCGAGCAACGATCCCGC
CATCATCATCTACACCTCCGGCACGACAGGAAATCCCAAGGGCGCGCTGCACGCCCATCGCGTGCTGCTCGGCCATCTGC
CGAATGTCGAGATGGTGCACGGCTTCCTGCCGAAGCCCGGCGACGTGATGTGGACGCCGGCGGACTGGGCCTGGATCGGC
GGGCTGTTCGATGCGCTGTTTCCGGCCTGGTATCACGCGGTGCCCGTGGTGGGCTATCGCGCCAGGAAGTTCGTGCCGCA
GGCGGCGATGCAGCTGATGGCGGACTATCAGGTCCGCAACGTATTCCTGCCGCCGACAGCTTTGAAATTGATGCGTCAGG
CCGACGTCAAGCATGATGGCGTCAAGCTGCGCAGCATCCTCACCGGGGGTGAGTCCCTTGGCGCCGAACTGCTCGACTGG
GTGCGCGCGACCTTCGGCATCGACGCGCACGAGATCTATGGGCAGACCGAATGCAACCTCGTCGTCGGCAACAACGCAAA
GCTGTTTCCGATCCGGCCGGGCTCGATGGGCAAGGCCACGCCGGGCTTCGAGGTGCTCATCGTCAACGAGAAGGGCGAGG
AGCTGCCACGCGGCGAGCGCGGCATCATCGGCGTGCGCCAGCCCAATCCCTGCACCATGATCGAATATTGGCGCAATCCC
GAGGCGACGTCGAAGAAGTTCGCGGGCGATGTGCTGCTGACGGGAGATCTCGGCACGCAGGATCAGGACGGCTATTTCTG
GTACGCGAGCCGCGAGGACGACGTCATCACCTCGGCCGGCTACCGCATCGGCCCGGCGGAGATCGAGGACACCCTGCTCA
AGCATCCCGCCGTTGCGCTTGCCGCCGTCGTCGGCATTCCCGATCCCGTACGCACCGAGGCGGTCAAGGCCTGGATCGTG
CTGCGGTCCGGCTTCGTTGCGAATGACACGCTGTCGCGCAAGATCCAGGACTTCGTCAAGGTAAAGCTCGCGGCGCATGA
ATATCCGAGGCATGTCGAATTTACCGACAGCCTGCCGATGACGGCGACCGGCAAGGTGCTGAGGCGCGAGTTGCGCGCGC
GGGGCTAG

Upstream 100 bases:

>100_bases
TTGCATCTTGCGATGCAATCCGACCTCTCCCCGCAAGCGGGGAGAGGTAAGGGCCCGCACCAGCGCTTGAACTAACAACC
GAGAGGGAAACACCTCCGCC

Downstream 100 bases:

>100_bases
GCTGGGGCGCCCGACTGTGAACGCGTAATTCTGGCAAACCTGTCGATTTGTTACTCCGTCATGCCCGGGCTTGACCCGCC
TGCGCGGCCGAAGCCGCGCT

Product: Acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MLQETSDYDQLYRDFRWDIPAQFNIAVATCDRHADGTGCLALIVVEEDGAARRVSFDELRDASCRFANVLKADGLAQGDR
VAVFLSQSLELPIVHLAAFRAGLVSVPLFTLFGEDALQFRLQNSGAKVVVTDTTGFAKLQRIRDRLPELKTIYVTDGEGS
GARPFWSTLERASAQFPTVATSSNDPAIIIYTSGTTGNPKGALHAHRVLLGHLPNVEMVHGFLPKPGDVMWTPADWAWIG
GLFDALFPAWYHAVPVVGYRARKFVPQAAMQLMADYQVRNVFLPPTALKLMRQADVKHDGVKLRSILTGGESLGAELLDW
VRATFGIDAHEIYGQTECNLVVGNNAKLFPIRPGSMGKATPGFEVLIVNEKGEELPRGERGIIGVRQPNPCTMIEYWRNP
EATSKKFAGDVLLTGDLGTQDQDGYFWYASREDDVITSAGYRIGPAEIEDTLLKHPAVALAAVVGIPDPVRTEAVKAWIV
LRSGFVANDTLSRKIQDFVKVKLAAHEYPRHVEFTDSLPMTATGKVLRRELRARG

Sequences:

>Translated_535_residues
MLQETSDYDQLYRDFRWDIPAQFNIAVATCDRHADGTGCLALIVVEEDGAARRVSFDELRDASCRFANVLKADGLAQGDR
VAVFLSQSLELPIVHLAAFRAGLVSVPLFTLFGEDALQFRLQNSGAKVVVTDTTGFAKLQRIRDRLPELKTIYVTDGEGS
GARPFWSTLERASAQFPTVATSSNDPAIIIYTSGTTGNPKGALHAHRVLLGHLPNVEMVHGFLPKPGDVMWTPADWAWIG
GLFDALFPAWYHAVPVVGYRARKFVPQAAMQLMADYQVRNVFLPPTALKLMRQADVKHDGVKLRSILTGGESLGAELLDW
VRATFGIDAHEIYGQTECNLVVGNNAKLFPIRPGSMGKATPGFEVLIVNEKGEELPRGERGIIGVRQPNPCTMIEYWRNP
EATSKKFAGDVLLTGDLGTQDQDGYFWYASREDDVITSAGYRIGPAEIEDTLLKHPAVALAAVVGIPDPVRTEAVKAWIV
LRSGFVANDTLSRKIQDFVKVKLAAHEYPRHVEFTDSLPMTATGKVLRRELRARG
>Mature_535_residues
MLQETSDYDQLYRDFRWDIPAQFNIAVATCDRHADGTGCLALIVVEEDGAARRVSFDELRDASCRFANVLKADGLAQGDR
VAVFLSQSLELPIVHLAAFRAGLVSVPLFTLFGEDALQFRLQNSGAKVVVTDTTGFAKLQRIRDRLPELKTIYVTDGEGS
GARPFWSTLERASAQFPTVATSSNDPAIIIYTSGTTGNPKGALHAHRVLLGHLPNVEMVHGFLPKPGDVMWTPADWAWIG
GLFDALFPAWYHAVPVVGYRARKFVPQAAMQLMADYQVRNVFLPPTALKLMRQADVKHDGVKLRSILTGGESLGAELLDW
VRATFGIDAHEIYGQTECNLVVGNNAKLFPIRPGSMGKATPGFEVLIVNEKGEELPRGERGIIGVRQPNPCTMIEYWRNP
EATSKKFAGDVLLTGDLGTQDQDGYFWYASREDDVITSAGYRIGPAEIEDTLLKHPAVALAAVVGIPDPVRTEAVKAWIV
LRSGFVANDTLSRKIQDFVKVKLAAHEYPRHVEFTDSLPMTATGKVLRRELRARG

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=547, Percent_Identity=34.9177330895795, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI157311624, Length=532, Percent_Identity=35.9022556390977, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI157311622, Length=532, Percent_Identity=35.9022556390977, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI122937307, Length=541, Percent_Identity=36.4140480591497, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI58082049, Length=532, Percent_Identity=36.0902255639098, Blast_Score=292, Evalue=6e-79,
Organism=Homo sapiens, GI38505220, Length=503, Percent_Identity=36.3817097415507, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI115511026, Length=538, Percent_Identity=35.5018587360595, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI28416953, Length=560, Percent_Identity=27.5, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI13375727, Length=564, Percent_Identity=28.5460992907801, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI8923896, Length=580, Percent_Identity=27.4137931034483, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI253970489, Length=593, Percent_Identity=26.8128161888702, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI42544134, Length=383, Percent_Identity=28.7206266318538, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI195947378, Length=415, Percent_Identity=27.9518072289157, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI156151445, Length=548, Percent_Identity=25.5474452554745, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI187761345, Length=529, Percent_Identity=26.2759924385633, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI187761343, Length=529, Percent_Identity=26.2759924385633, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI31982927, Length=534, Percent_Identity=23.4082397003745, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI38524616, Length=519, Percent_Identity=23.6994219653179, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1790505, Length=551, Percent_Identity=28.1306715063521, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786529, Length=563, Percent_Identity=28.0639431616341, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI221142682, Length=533, Percent_Identity=27.3921200750469, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788107, Length=218, Percent_Identity=35.7798165137615, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI145693145, Length=512, Percent_Identity=25.9765625, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786810, Length=518, Percent_Identity=26.0617760617761, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1786801, Length=429, Percent_Identity=24.2424242424242, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1789201, Length=412, Percent_Identity=23.3009708737864, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17559526, Length=531, Percent_Identity=29.1902071563089, Blast_Score=149, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17557194, Length=529, Percent_Identity=25.5198487712665, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982997, Length=527, Percent_Identity=26.3757115749526, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71983001, Length=527, Percent_Identity=26.3757115749526, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17538037, Length=538, Percent_Identity=25.092936802974, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71994690, Length=500, Percent_Identity=26.8, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71994694, Length=500, Percent_Identity=26.8, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71994703, Length=500, Percent_Identity=26.8, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17560140, Length=430, Percent_Identity=27.6744186046512, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=489, Percent_Identity=23.5173824130879, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17558820, Length=512, Percent_Identity=24.0234375, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71996755, Length=522, Percent_Identity=24.5210727969349, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17560308, Length=520, Percent_Identity=26.7307692307692, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71985884, Length=377, Percent_Identity=27.5862068965517, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17531443, Length=458, Percent_Identity=24.235807860262, Blast_Score=103, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319264, Length=565, Percent_Identity=27.6106194690265, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323182, Length=567, Percent_Identity=28.042328042328, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6319699, Length=547, Percent_Identity=24.6800731261426, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI62472339, Length=532, Percent_Identity=28.3834586466165, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24667955, Length=532, Percent_Identity=28.3834586466165, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21355225, Length=565, Percent_Identity=27.6106194690265, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24667959, Length=491, Percent_Identity=27.4949083503055, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI19922652, Length=498, Percent_Identity=25.9036144578313, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI18859661, Length=512, Percent_Identity=28.3203125, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24581924, Length=522, Percent_Identity=26.2452107279693, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI21355181, Length=499, Percent_Identity=25.250501002004, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24648260, Length=481, Percent_Identity=26.1954261954262, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24656500, Length=504, Percent_Identity=25.5952380952381, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356947, Length=498, Percent_Identity=24.4979919678715, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI21356441, Length=456, Percent_Identity=23.9035087719298, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24648253, Length=493, Percent_Identity=22.5152129817444, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281365686, Length=455, Percent_Identity=23.5164835164835, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24653035, Length=501, Percent_Identity=23.9520958083832, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358303, Length=441, Percent_Identity=23.1292517006803, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI161076582, Length=508, Percent_Identity=24.2125984251968, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648255, Length=494, Percent_Identity=22.2672064777328, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20130357, Length=513, Percent_Identity=24.3664717348928, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24648257, Length=353, Percent_Identity=25.7790368271955, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 58885; Mature: 58885

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00455 AMP_BINDING ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQETSDYDQLYRDFRWDIPAQFNIAVATCDRHADGTGCLALIVVEEDGAARRVSFDELR
CCCCCCCHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCHHHHH
DASCRFANVLKADGLAQGDRVAVFLSQSLELPIVHLAAFRAGLVSVPLFTLFGEDALQFR
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEE
LQNSGAKVVVTDTTGFAKLQRIRDRLPELKTIYVTDGEGSGARPFWSTLERASAQFPTVA
EECCCCEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEE
TSSNDPAIIIYTSGTTGNPKGALHAHRVLLGHLPNVEMVHGFLPKPGDVMWTPADWAWIG
ECCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCEEECCCCHHHHH
GLFDALFPAWYHAVPVVGYRARKFVPQAAMQLMADYQVRNVFLPPTALKLMRQADVKHDG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCCCC
VKLRSILTGGESLGAELLDWVRATFGIDAHEIYGQTECNLVVGNNAKLFPIRPGSMGKAT
EEEEHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEECCCEEEEEECCCCCCCCC
PGFEVLIVNEKGEELPRGERGIIGVRQPNPCTMIEYWRNPEATSKKFAGDVLLTGDLGTQ
CCEEEEEECCCCCCCCCCCCCEEEECCCCCCEEEEECCCCCCCCHHCCCCEEEECCCCCC
DQDGYFWYASREDDVITSAGYRIGPAEIEDTLLKHPAVALAAVVGIPDPVRTEAVKAWIV
CCCCEEEEECCCCCEEECCCCEECHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHEEEE
LRSGFVANDTLSRKIQDFVKVKLAAHEYPRHVEFTDSLPMTATGKVLRRELRARG
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLQETSDYDQLYRDFRWDIPAQFNIAVATCDRHADGTGCLALIVVEEDGAARRVSFDELR
CCCCCCCHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCHHHHH
DASCRFANVLKADGLAQGDRVAVFLSQSLELPIVHLAAFRAGLVSVPLFTLFGEDALQFR
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEE
LQNSGAKVVVTDTTGFAKLQRIRDRLPELKTIYVTDGEGSGARPFWSTLERASAQFPTVA
EECCCCEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEE
TSSNDPAIIIYTSGTTGNPKGALHAHRVLLGHLPNVEMVHGFLPKPGDVMWTPADWAWIG
ECCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCEEECCCCHHHHH
GLFDALFPAWYHAVPVVGYRARKFVPQAAMQLMADYQVRNVFLPPTALKLMRQADVKHDG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCCCC
VKLRSILTGGESLGAELLDWVRATFGIDAHEIYGQTECNLVVGNNAKLFPIRPGSMGKAT
EEEEHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEECCCEEEEEECCCCCCCCC
PGFEVLIVNEKGEELPRGERGIIGVRQPNPCTMIEYWRNPEATSKKFAGDVLLTGDLGTQ
CCEEEEEECCCCCCCCCCCCCEEEECCCCCCEEEEECCCCCCCCHHCCCCEEEECCCCCC
DQDGYFWYASREDDVITSAGYRIGPAEIEDTLLKHPAVALAAVVGIPDPVRTEAVKAWIV
CCCCEEEEECCCCCEEECCCCEECHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHEEEE
LRSGFVANDTLSRKIQDFVKVKLAAHEYPRHVEFTDSLPMTATGKVLRRELRARG
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]