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The map label for this gene is lrp [H]

Identifier: 146338407

GI number: 146338407

Start: 1411207

End: 1411686

Strand: Direct

Name: lrp [H]

Synonym: BRADO1322

Alternate gene names: 146338407

Gene position: 1411207-1411686 (Clockwise)

Preceding gene: 146338402

Following gene: 146338412

Centisome position: 18.93

GC content: 63.33

Gene sequence:

>480_bases
GTGACCAAGAATCTTGACGAGATCGATCTCAAAATCCTGAGCGAAATTCAGGCCGATGGCAGGATCACCAACGTGGAACT
GGCCAAGCGGGTCGGCATCTCGCCGCCGCCGTGCCTGCGGCGCGTCAGGACGCTGGAGGAGGAGGGCTATATTACCGGCT
ATCGCGGCCTGCTCGACCCTCGCAAGCTCGGCTTCGACGTCACCGTGTTCGCGTCGGTCCACCTGTCGAGCCAGGCCGAC
GCCGATCTGAAGGCGTTCGAGGAGTTCGTGCGCGCGGAGCCGCTGGTGCGCGAATGCTGGATGCTGTCGGGTGAGGTCGA
CTTCATTCTGAAATGCGTGGCGCCTGACATGGCGACGTTCCAGGAGTTCGTCACGCACCTCACTGCGGCGCCGCATGTGC
GCAATGTCCGGACTTCGCTGGTGCTGCACAGCTCGAAATACGAGGCGGCAGTGCCGCTCGAGGTCAAGGGACGCGGCTAG

Upstream 100 bases:

>100_bases
GAGTAATAAAATTGCGCGAATTGAGCCGGTTGCGCTAAGAGAGTTGCCGTTCACTCCGGGAGCCCGTCTCCCGCCTGTTC
CCGCCAGCCCCCCAATCCCC

Downstream 100 bases:

>100_bases
CGATCGGCGTCATCCGGGCCAGCCCCGAACGAGGCTGGACCCGGGCTATCGAGATCGTCGTCTCAACCCTGGATTCCGGG
TTCGATGCTCGCGCATCGCT

Product: AsnC/Lrp family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MTKNLDEIDLKILSEIQADGRITNVELAKRVGISPPPCLRRVRTLEEEGYITGYRGLLDPRKLGFDVTVFASVHLSSQAD
ADLKAFEEFVRAEPLVRECWMLSGEVDFILKCVAPDMATFQEFVTHLTAAPHVRNVRTSLVLHSSKYEAAVPLEVKGRG

Sequences:

>Translated_159_residues
MTKNLDEIDLKILSEIQADGRITNVELAKRVGISPPPCLRRVRTLEEEGYITGYRGLLDPRKLGFDVTVFASVHLSSQAD
ADLKAFEEFVRAEPLVRECWMLSGEVDFILKCVAPDMATFQEFVTHLTAAPHVRNVRTSLVLHSSKYEAAVPLEVKGRG
>Mature_158_residues
TKNLDEIDLKILSEIQADGRITNVELAKRVGISPPPCLRRVRTLEEEGYITGYRGLLDPRKLGFDVTVFASVHLSSQADA
DLKAFEEFVRAEPLVRECWMLSGEVDFILKCVAPDMATFQEFVTHLTAAPHVRNVRTSLVLHSSKYEAAVPLEVKGRG

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=145, Percent_Identity=42.7586206896552, Blast_Score=123, Evalue=5e-30,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=30.4635761589404, Blast_Score=90, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17769; Mature: 17637

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNLDEIDLKILSEIQADGRITNVELAKRVGISPPPCLRRVRTLEEEGYITGYRGLLDP
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCEECCCCCCCH
RKLGFDVTVFASVHLSSQADADLKAFEEFVRAEPLVRECWMLSGEVDFILKCVAPDMATF
HHCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHCCCHHHH
QEFVTHLTAAPHVRNVRTSLVLHSSKYEAAVPLEVKGRG
HHHHHHHHCCCCHHHHHHHHEEECCCCCEECCEEECCCC
>Mature Secondary Structure 
TKNLDEIDLKILSEIQADGRITNVELAKRVGISPPPCLRRVRTLEEEGYITGYRGLLDP
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCEECCCCCCCH
RKLGFDVTVFASVHLSSQADADLKAFEEFVRAEPLVRECWMLSGEVDFILKCVAPDMATF
HHCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHCCCHHHH
QEFVTHLTAAPHVRNVRTSLVLHSSKYEAAVPLEVKGRG
HHHHHHHHCCCCHHHHHHHHEEECCCCCEECCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]