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The map label for this gene is pkn1 [H]

Identifier: 146338376

GI number: 146338376

Start: 1372878

End: 1374527

Strand: Reverse

Name: pkn1 [H]

Synonym: BRADO1286

Alternate gene names: 146338376

Gene position: 1374527-1372878 (Counterclockwise)

Preceding gene: 146338377

Following gene: 146338375

Centisome position: 18.43

GC content: 66.36

Gene sequence:

>1650_bases
GTGAGCGCGCATTCGCGGATGCGTTCACCGCCTGGGGACAATGAAGCAACGGCGAGGCCGATCCACAATGGCTCGCGCGC
AATGACAAGCCTCGACGTCCTCAAGCCGCCGCACACCGGAGTGTCCGAGGCCGGCGAGACAGCGCTGGGCACGGTCACCT
ATCCGGTGCCTTGCGAGCGGTGCGGCCGCGTCGTACGCGTCGCGCTGAACGCGTTGCGCGGCCCGAGCTTCCATCATCTC
GCCGAGCAGGCGTCGTGTCCGGAGATCCAGCAGCGACGAAGCAATGGCGACGGCGGCCTGCTGCTGATGATGTGCGGCCC
GTTGAAGCAATCGCTTGCAAACCTTTGCGAGGCCGCGGACGTCGAGGCCACCATTCCAGGCGCCGGAGGGTCGCCCCGGG
TCGTCTGCAGCATTCCCGGCGTGTCGATCGCTCAATACGAACCGGATGAGGCGCGGCGACGCGCCGAGATCTGGCAGGCC
CACGGGCTCGACAAGCTGGCCGGCCGGCTCCGCAAGGCTGCTGCTACCGCGGAGCGCGGTCCGCGGCTCTGGACCCGCGT
CGCCGCAGGTCTCGGTGCATCGCTGCTCGCGGCCGCCGGTCTGTGGTTCGTCCTCGCGCGAGAGCCCGCTTCGGCGCCAT
CGTCACAGCCGAAAACGGCCGAACTGTCCGAACCACTGCCAGATCGCGCGAAGATCGAACCTCCGCCCTCGCCCGTCGCC
GGCCTCCAGCCCGTAGCGACCGCGACGGCCCCCGATCCGCGCCCGTCAGCAGACGCGTCCGCGGACGCCGTGACCAGCGA
GACGCCGCCGACTCAAGTCCAAACCCAAGTCCAAGCTCAAGTCCAAGCTCAGGTCCAACCTCAAGTCGAACCTCAAGTGC
AAGCTCGAGCCGAAGCCCAAGTCCAAAGCGATACGCGCGTCGCGGACGCGACACCTGCCGTCGCACCGCCAGCTCCAAGT
GCTGAAGCGGCCAACATTCGCTTGCCTGACGTCGTCATGATCCCGGGCGGCACGTTCACCATGGGCGGTTCGGAAACGTC
CGAGCTGCCGGCTCACCGCGTCGCGATCAAGCCGTTCGCGCTCGGCAAATACCCGGTCACGCTTGGCGAATGGAAGGAAT
GCGTCGCCGACAAGGCGTGCACTGACGTCACGAGTGGTCCGGATGACAATCCGGTCACCAATGTCAGCTACGACGATGCC
AGGGACTATCTCGGTTGGCTCTCGCGGAAAATCGGAAAGCCGTTCCGGCTTCCCACCGAGGCCGAATGGGAATATGCCGC
GCGCGGCGGGGCGGCCACGAAATTCTGGTGGGGTGATCAGATGCGCCCCGGCATGGCCAACTGCAACCGCTGCAACGAGG
CCGATGCGCCGCCGCAGTTGATGAAGGTCGGAAGCTTTCCAGCCAATCCGTTCGGCCTGTACGACATGGGCGGCGGCGTC
GACCAATGGGTTGCCGACAGCTGGCACAAATCCTATCAGGGCGCGCCGTCCGATGGCTCGGCCTGGATAGACGAGCAGAG
CTTCCTCCATGTCATCCGCTCGGGCTCGTGGAAGAACGATGCGAGCTATGCCCGCAGCGGCAGCCGCGATCGCTATGATG
GGCGGGTGAGATATCCGACGCACGGCTTCCGCGTCGCTCTGTCGCTATGA

Upstream 100 bases:

>100_bases
CGCAATGTCCTGCTGCTGAAAGGCAAGGAGTGGATCGATATCCCGATCGTGTACAACGGCGGCAGCCGCGCCGTGCTGGC
GATCGAGAAGGGAGCGGACG

Downstream 100 bases:

>100_bases
CCGCGGATCGCCCGCGACCACCGGCGCCCGCCGCATCAGTTTAGTTCGATTCTGATCGGCAAGCGCGTCGCGCGGCCTGC
CGGAACCTCAATTTTGCCTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MSAHSRMRSPPGDNEATARPIHNGSRAMTSLDVLKPPHTGVSEAGETALGTVTYPVPCERCGRVVRVALNALRGPSFHHL
AEQASCPEIQQRRSNGDGGLLLMMCGPLKQSLANLCEAADVEATIPGAGGSPRVVCSIPGVSIAQYEPDEARRRAEIWQA
HGLDKLAGRLRKAAATAERGPRLWTRVAAGLGASLLAAAGLWFVLAREPASAPSSQPKTAELSEPLPDRAKIEPPPSPVA
GLQPVATATAPDPRPSADASADAVTSETPPTQVQTQVQAQVQAQVQPQVEPQVQARAEAQVQSDTRVADATPAVAPPAPS
AEAANIRLPDVVMIPGGTFTMGGSETSELPAHRVAIKPFALGKYPVTLGEWKECVADKACTDVTSGPDDNPVTNVSYDDA
RDYLGWLSRKIGKPFRLPTEAEWEYAARGGAATKFWWGDQMRPGMANCNRCNEADAPPQLMKVGSFPANPFGLYDMGGGV
DQWVADSWHKSYQGAPSDGSAWIDEQSFLHVIRSGSWKNDASYARSGSRDRYDGRVRYPTHGFRVALSL

Sequences:

>Translated_549_residues
MSAHSRMRSPPGDNEATARPIHNGSRAMTSLDVLKPPHTGVSEAGETALGTVTYPVPCERCGRVVRVALNALRGPSFHHL
AEQASCPEIQQRRSNGDGGLLLMMCGPLKQSLANLCEAADVEATIPGAGGSPRVVCSIPGVSIAQYEPDEARRRAEIWQA
HGLDKLAGRLRKAAATAERGPRLWTRVAAGLGASLLAAAGLWFVLAREPASAPSSQPKTAELSEPLPDRAKIEPPPSPVA
GLQPVATATAPDPRPSADASADAVTSETPPTQVQTQVQAQVQAQVQPQVEPQVQARAEAQVQSDTRVADATPAVAPPAPS
AEAANIRLPDVVMIPGGTFTMGGSETSELPAHRVAIKPFALGKYPVTLGEWKECVADKACTDVTSGPDDNPVTNVSYDDA
RDYLGWLSRKIGKPFRLPTEAEWEYAARGGAATKFWWGDQMRPGMANCNRCNEADAPPQLMKVGSFPANPFGLYDMGGGV
DQWVADSWHKSYQGAPSDGSAWIDEQSFLHVIRSGSWKNDASYARSGSRDRYDGRVRYPTHGFRVALSL
>Mature_548_residues
SAHSRMRSPPGDNEATARPIHNGSRAMTSLDVLKPPHTGVSEAGETALGTVTYPVPCERCGRVVRVALNALRGPSFHHLA
EQASCPEIQQRRSNGDGGLLLMMCGPLKQSLANLCEAADVEATIPGAGGSPRVVCSIPGVSIAQYEPDEARRRAEIWQAH
GLDKLAGRLRKAAATAERGPRLWTRVAAGLGASLLAAAGLWFVLAREPASAPSSQPKTAELSEPLPDRAKIEPPPSPVAG
LQPVATATAPDPRPSADASADAVTSETPPTQVQTQVQAQVQAQVQPQVEPQVQARAEAQVQSDTRVADATPAVAPPAPSA
EAANIRLPDVVMIPGGTFTMGGSETSELPAHRVAIKPFALGKYPVTLGEWKECVADKACTDVTSGPDDNPVTNVSYDDAR
DYLGWLSRKIGKPFRLPTEAEWEYAARGGAATKFWWGDQMRPGMANCNRCNEADAPPQLMKVGSFPANPFGLYDMGGGVD
QWVADSWHKSYQGAPSDGSAWIDEQSFLHVIRSGSWKNDASYARSGSRDRYDGRVRYPTHGFRVALSL

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI194248087, Length=232, Percent_Identity=30.6034482758621, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI257470975, Length=211, Percent_Identity=29.8578199052133, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI194248088, Length=240, Percent_Identity=29.1666666666667, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI38202250, Length=236, Percent_Identity=26.271186440678, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI257470977, Length=236, Percent_Identity=26.271186440678, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI226437577, Length=129, Percent_Identity=37.2093023255814, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 58479; Mature: 58348

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAHSRMRSPPGDNEATARPIHNGSRAMTSLDVLKPPHTGVSEAGETALGTVTYPVPCER
CCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHCCCCEECEEECCCCHHH
CGRVVRVALNALRGPSFHHLAEQASCPEIQQRRSNGDGGLLLMMCGPLKQSLANLCEAAD
HHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCC
VEATIPGAGGSPRVVCSIPGVSIAQYEPDEARRRAEIWQAHGLDKLAGRLRKAAATAERG
CCEECCCCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
PRLWTRVAAGLGASLLAAAGLWFVLAREPASAPSSQPKTAELSEPLPDRAKIEPPPSPVA
HHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GLQPVATATAPDPRPSADASADAVTSETPPTQVQTQVQAQVQAQVQPQVEPQVQARAEAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VQSDTRVADATPAVAPPAPSAEAANIRLPDVVMIPGGTFTMGGSETSELPAHRVAIKPFA
HHCCCEECCCCCCCCCCCCCCCCCCEECCEEEEECCCEEEECCCCCCCCCCHHEEECEEE
LGKYPVTLGEWKECVADKACTDVTSGPDDNPVTNVSYDDARDYLGWLSRKIGKPFRLPTE
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
AEWEYAARGGAATKFWWGDQMRPGMANCNRCNEADAPPQLMKVGSFPANPFGLYDMGGGV
CCCHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCH
DQWVADSWHKSYQGAPSDGSAWIDEQSFLHVIRSGSWKNDASYARSGSRDRYDGRVRYPT
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEECCC
HGFRVALSL
CCEEEEEEC
>Mature Secondary Structure 
SAHSRMRSPPGDNEATARPIHNGSRAMTSLDVLKPPHTGVSEAGETALGTVTYPVPCER
CCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHCCCCEECEEECCCCHHH
CGRVVRVALNALRGPSFHHLAEQASCPEIQQRRSNGDGGLLLMMCGPLKQSLANLCEAAD
HHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCC
VEATIPGAGGSPRVVCSIPGVSIAQYEPDEARRRAEIWQAHGLDKLAGRLRKAAATAERG
CCEECCCCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
PRLWTRVAAGLGASLLAAAGLWFVLAREPASAPSSQPKTAELSEPLPDRAKIEPPPSPVA
HHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GLQPVATATAPDPRPSADASADAVTSETPPTQVQTQVQAQVQAQVQPQVEPQVQARAEAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VQSDTRVADATPAVAPPAPSAEAANIRLPDVVMIPGGTFTMGGSETSELPAHRVAIKPFA
HHCCCEECCCCCCCCCCCCCCCCCCEECCEEEEECCCEEEECCCCCCCCCCHHEEECEEE
LGKYPVTLGEWKECVADKACTDVTSGPDDNPVTNVSYDDARDYLGWLSRKIGKPFRLPTE
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
AEWEYAARGGAATKFWWGDQMRPGMANCNRCNEADAPPQLMKVGSFPANPFGLYDMGGGV
CCCHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCH
DQWVADSWHKSYQGAPSDGSAWIDEQSFLHVIRSGSWKNDASYARSGSRDRYDGRVRYPT
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEECCC
HGFRVALSL
CCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]