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The map label for this gene is ghrA [H]

Identifier: 146338249

GI number: 146338249

Start: 1227907

End: 1228950

Strand: Reverse

Name: ghrA [H]

Synonym: BRADO1153

Alternate gene names: 146338249

Gene position: 1228950-1227907 (Counterclockwise)

Preceding gene: 146338255

Following gene: 146338247

Centisome position: 16.48

GC content: 68.49

Gene sequence:

>1044_bases
GTGGTGATGGCCGGAGATTGGCCCATCCGCGCGATCTGGTATGTGGAACAGATCACGCAAGCTCAAGAGGACCCTGCAAT
GACCAAAGGCGCGCTGGCGCTCCTGATCCATGGCGGCACCGATAATTGGTCGCCGCAGCGCTGGAAGGCGCGCTTCAACG
ACGTCTGCGCCGACCGCCCGGTGGTGCTGCTGCCGGATGCGAACCTCGACCCGGCCGACGTCCACTACGCGGCCGTGTGG
AAGCCGGTGCCCGGCGAGCTCGCCGGCTTTCCGAACCTGCGCGTGATCTTCAACCTCGGCGCCGGCGTCGACGCGCTGAT
GGCCGACAAGACCCTGCCGGGCGTACCGCTGGTGCGCGTGGCCGTCGACGACCTGACGCAGCGGATGACCGAATGGGTCG
TGCTGCACGTGCTGATGCACCATCGCCAGGAGCTGTACCTGCGCGAGTCGCAGCGGGTGAAGCGCTGGGCGCCGAAGTAC
CAGTGGCCTGCCGCTGCCATCAACGTCGGCATCCTGGGGCTCGGCACGCTGGGGCTCGATGCCGCCGAGGTGCTCAAGCG
TATCGGCTTCCAGGTCGCGGGCTGGAGCCGCAGCGAAAAGCAAATCGACGGCATCGAGACCTTCCACGGCGCAGCGCAGC
TCGACGCCTTCCTGGCGCGGACCGACATCCTGGTATCGCTGCTGCCGCTGACTCCGGACACGCGCGGCATTCTCGACCGC
AAGATGTTCACGGGGCTGCGGCGCTCGTCGCCGCTCGGCGCGCCCATCATGATCAATGCCGGCCGCGGCGGCCTGCAGGA
CGAGGCGGATATCCTCGCCTGCCTCGATGACGGCACGCTCGGCGCGGTGTCGCTCGACGTGTTCGGCCAGGAGCCGCTGC
CGGCCGACAGCCCGTTCTGGACCCATCCGAAGGTCGTGCTGACGCCGCACAACGCCGCCGACACCGACGCCGACGCGATC
TCGCGCTACGTCGCCGAGCAGATCGCGACCTTCGAGGCCGGCGGCACGCTGCGCAACACGGTCGATCGCACGAGAGGATA
CTGA

Upstream 100 bases:

>100_bases
CCGACAGGATCGAGCCGACGTCGATGGTCTGGGCCTGCGCCGAGGCGGAGGCGATGACGAGGGCGGCGGCGAGCAGAATT
TTGCGCATGACGATGTCTCC

Downstream 100 bases:

>100_bases
GACGTCACCTGCCGCCCAGCATCACATCGATCGCGCCGGCGACGATCGCCTCCAGCGCCTTGCGCGGCACCCGCGCGCGG
GCGCGCACCGCGATCGAGTG

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MVMAGDWPIRAIWYVEQITQAQEDPAMTKGALALLIHGGTDNWSPQRWKARFNDVCADRPVVLLPDANLDPADVHYAAVW
KPVPGELAGFPNLRVIFNLGAGVDALMADKTLPGVPLVRVAVDDLTQRMTEWVVLHVLMHHRQELYLRESQRVKRWAPKY
QWPAAAINVGILGLGTLGLDAAEVLKRIGFQVAGWSRSEKQIDGIETFHGAAQLDAFLARTDILVSLLPLTPDTRGILDR
KMFTGLRRSSPLGAPIMINAGRGGLQDEADILACLDDGTLGAVSLDVFGQEPLPADSPFWTHPKVVLTPHNAADTDADAI
SRYVAEQIATFEAGGTLRNTVDRTRGY

Sequences:

>Translated_347_residues
MVMAGDWPIRAIWYVEQITQAQEDPAMTKGALALLIHGGTDNWSPQRWKARFNDVCADRPVVLLPDANLDPADVHYAAVW
KPVPGELAGFPNLRVIFNLGAGVDALMADKTLPGVPLVRVAVDDLTQRMTEWVVLHVLMHHRQELYLRESQRVKRWAPKY
QWPAAAINVGILGLGTLGLDAAEVLKRIGFQVAGWSRSEKQIDGIETFHGAAQLDAFLARTDILVSLLPLTPDTRGILDR
KMFTGLRRSSPLGAPIMINAGRGGLQDEADILACLDDGTLGAVSLDVFGQEPLPADSPFWTHPKVVLTPHNAADTDADAI
SRYVAEQIATFEAGGTLRNTVDRTRGY
>Mature_347_residues
MVMAGDWPIRAIWYVEQITQAQEDPAMTKGALALLIHGGTDNWSPQRWKARFNDVCADRPVVLLPDANLDPADVHYAAVW
KPVPGELAGFPNLRVIFNLGAGVDALMADKTLPGVPLVRVAVDDLTQRMTEWVVLHVLMHHRQELYLRESQRVKRWAPKY
QWPAAAINVGILGLGTLGLDAAEVLKRIGFQVAGWSRSEKQIDGIETFHGAAQLDAFLARTDILVSLLPLTPDTRGILDR
KMFTGLRRSSPLGAPIMINAGRGGLQDEADILACLDDGTLGAVSLDVFGQEPLPADSPFWTHPKVVLTPHNAADTDADAI
SRYVAEQIATFEAGGTLRNTVDRTRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=233, Percent_Identity=27.8969957081545, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI23308577, Length=262, Percent_Identity=26.3358778625954, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081824, Length=284, Percent_Identity=38.0281690140845, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI87082289, Length=269, Percent_Identity=29.368029739777, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=175, Percent_Identity=26.8571428571429, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24585516, Length=173, Percent_Identity=31.7919075144509, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571528, Length=194, Percent_Identity=28.3505154639175, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574286, Length=144, Percent_Identity=28.4722222222222, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921140, Length=254, Percent_Identity=25.5905511811024, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 37991; Mature: 37991

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMAGDWPIRAIWYVEQITQAQEDPAMTKGALALLIHGGTDNWSPQRWKARFNDVCADRP
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCC
VVLLPDANLDPADVHYAAVWKPVPGELAGFPNLRVIFNLGAGVDALMADKTLPGVPLVRV
EEEECCCCCCCCCEEEEEEECCCCHHHCCCCCEEEEEECCCCCHHHHHCCCCCCCCCHHH
AVDDLTQRMTEWVVLHVLMHHRQELYLRESQRVKRWAPKYQWPAAAINVGILGLGTLGLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEEECCCCCC
AAEVLKRIGFQVAGWSRSEKQIDGIETFHGAAQLDAFLARTDILVSLLPLTPDTRGILDR
HHHHHHHCCCEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KMFTGLRRSSPLGAPIMINAGRGGLQDEADILACLDDGTLGAVSLDVFGQEPLPADSPFW
HHHHHHHCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCC
THPKVVLTPHNAADTDADAISRYVAEQIATFEAGGTLRNTVDRTRGY
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MVMAGDWPIRAIWYVEQITQAQEDPAMTKGALALLIHGGTDNWSPQRWKARFNDVCADRP
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCC
VVLLPDANLDPADVHYAAVWKPVPGELAGFPNLRVIFNLGAGVDALMADKTLPGVPLVRV
EEEECCCCCCCCCEEEEEEECCCCHHHCCCCCEEEEEECCCCCHHHHHCCCCCCCCCHHH
AVDDLTQRMTEWVVLHVLMHHRQELYLRESQRVKRWAPKYQWPAAAINVGILGLGTLGLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEEECCCCCC
AAEVLKRIGFQVAGWSRSEKQIDGIETFHGAAQLDAFLARTDILVSLLPLTPDTRGILDR
HHHHHHHCCCEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KMFTGLRRSSPLGAPIMINAGRGGLQDEADILACLDDGTLGAVSLDVFGQEPLPADSPFW
HHHHHHHCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCC
THPKVVLTPHNAADTDADAISRYVAEQIATFEAGGTLRNTVDRTRGY
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA