Click here to switch to the map view.

The map label for this gene is pepA [H]

Identifier: 146338115

GI number: 146338115

Start: 1080802

End: 1082130

Strand: Reverse

Name: pepA [H]

Synonym: BRADO1011

Alternate gene names: 146338115

Gene position: 1082130-1080802 (Counterclockwise)

Preceding gene: 146338117

Following gene: 146338114

Centisome position: 14.51

GC content: 69.38

Gene sequence:

>1329_bases
GTGACGAAGGCGAGCTGGCCTGGGATCAAGGACGGCCTGTCGACGGAAGCGCGCAACTTCGCCGAGGCGAATGGCTATGC
CGCCAAGCCCGGCAGCTGCCTGATCCTGCCCGGCGCCGATGGCCGCATCGCGCAGGTGCTGTTCGGCATCGAGGATCCCG
AGGCCAGGCACCGCGACCTGTTCCGGCCCGGCACCTTGCCCGGCCTGCTGCCCGCCGGCACCTACCGCTTCGCCAGCGCG
CCGCATGATGCCAGGCTTGCGGCGCTCGCCTTCGCGCTCGGCAGCTACCGCTTCGGCCGCTACCGCAAGGCCGAGACGCC
GGACGTCCGCCTCGTGCCGCCCGAGGGCGTCGACGCCGCGGAGCTCGATCGGCTGGCCGAGGCGGCGACTTTGGCGCGCG
ATCTCGTCAACACGCCGTCCAACGACATGGGCCCGGAGGAGCTCGAGGCGGCTGCGAAGCAGGTCGCCGACCGCTTCGGC
GCCCGCTTCACCAGCATCGTCGGCGACGATCTGCTGACGCAGAACTTTCCTTTGATCCACGTCGTTGGCCGCGCCTCGAC
GCGCGCGCCGCGGCTGATCGAGCTCACATGGGGCAGCGCTGATCATCCCAAGGTGACGCTGGTCGGCAAGGGCGTGTGCT
TCGACACCGGCGGGCTCGATCTCAAGCCGTCCAGCAGCATGCTCTTGATGAAAAAGGACATGGGCGGCGCCGCCAACGTG
CTGGCGCTGGCCCAGATGGTGATGGACGCGAAGCTGAAGCTACAGCTGCGCGTGCTGATCCCGGCCGTCGAGAATTCAGT
GGCCGGCAACGCCTTCCGCCCGATGGACGTGTTTCCCTCGCGCAAGGGCCCCACGGTCGAGATCGGCAACACCGATGCCG
AGGGCCGGCTGATCCTCGCCGATGCGCTGGCGCTGGCCGACGAGGACAAGCCGGATCTCCTGATCGACATGGGCACGCTC
ACCGGCGCTGCGCGCGTCGCGCTCGGTCCCGAGCTGCCGCCGTTCTACACCAACGACGAGACGCTCGCCGCCGATGTCGC
GCGTTGCGCGGCATCCGAGAACGACCCGCTGTGGCGGATGCCGTTATGGGCGCCGTATGACAGCTGGCTCGACTCGAAGG
TCGCCACGATCAACAACGCGCCGTCGGGCGGCTTCGCCGGCTCGATCACCTGCGCGCTGTTCCTGCAGCGCTTCGTCGAG
CCGACGACGCGCTGGCTGCATCTCGACATCTTCGCCTGGACGCCGTCGGCGAAACCCGGCCGCCCCGAAGGCGGCGAGTG
CCAGGCGGCACGCGCGCTCTACAAGCTCCTGAGCGAGCGCTATGGCTGA

Upstream 100 bases:

>100_bases
CTCTGCGAAGTCTGGCTCTCGCGCGCGACTTGAGGAACCATCAGGCATGCCGTCGATTTTTGAGACGTCCCCCGCATCGT
CAGCCATTCCGATTGCCTTC

Downstream 100 bases:

>100_bases
TCCACGCCTCACGCCGGCGCGCGGCGACATCGCGGCGAGGTATCTCGAAGGTCAGGTCACCGCCGATCGCTTCGTCGACG
GCGAGACGCTGGTCGTGATC

Product: leucine aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTKASWPGIKDGLSTEARNFAEANGYAAKPGSCLILPGADGRIAQVLFGIEDPEARHRDLFRPGTLPGLLPAGTYRFASA
PHDARLAALAFALGSYRFGRYRKAETPDVRLVPPEGVDAAELDRLAEAATLARDLVNTPSNDMGPEELEAAAKQVADRFG
ARFTSIVGDDLLTQNFPLIHVVGRASTRAPRLIELTWGSADHPKVTLVGKGVCFDTGGLDLKPSSSMLLMKKDMGGAANV
LALAQMVMDAKLKLQLRVLIPAVENSVAGNAFRPMDVFPSRKGPTVEIGNTDAEGRLILADALALADEDKPDLLIDMGTL
TGAARVALGPELPPFYTNDETLAADVARCAASENDPLWRMPLWAPYDSWLDSKVATINNAPSGGFAGSITCALFLQRFVE
PTTRWLHLDIFAWTPSAKPGRPEGGECQAARALYKLLSERYG

Sequences:

>Translated_442_residues
MTKASWPGIKDGLSTEARNFAEANGYAAKPGSCLILPGADGRIAQVLFGIEDPEARHRDLFRPGTLPGLLPAGTYRFASA
PHDARLAALAFALGSYRFGRYRKAETPDVRLVPPEGVDAAELDRLAEAATLARDLVNTPSNDMGPEELEAAAKQVADRFG
ARFTSIVGDDLLTQNFPLIHVVGRASTRAPRLIELTWGSADHPKVTLVGKGVCFDTGGLDLKPSSSMLLMKKDMGGAANV
LALAQMVMDAKLKLQLRVLIPAVENSVAGNAFRPMDVFPSRKGPTVEIGNTDAEGRLILADALALADEDKPDLLIDMGTL
TGAARVALGPELPPFYTNDETLAADVARCAASENDPLWRMPLWAPYDSWLDSKVATINNAPSGGFAGSITCALFLQRFVE
PTTRWLHLDIFAWTPSAKPGRPEGGECQAARALYKLLSERYG
>Mature_441_residues
TKASWPGIKDGLSTEARNFAEANGYAAKPGSCLILPGADGRIAQVLFGIEDPEARHRDLFRPGTLPGLLPAGTYRFASAP
HDARLAALAFALGSYRFGRYRKAETPDVRLVPPEGVDAAELDRLAEAATLARDLVNTPSNDMGPEELEAAAKQVADRFGA
RFTSIVGDDLLTQNFPLIHVVGRASTRAPRLIELTWGSADHPKVTLVGKGVCFDTGGLDLKPSSSMLLMKKDMGGAANVL
ALAQMVMDAKLKLQLRVLIPAVENSVAGNAFRPMDVFPSRKGPTVEIGNTDAEGRLILADALALADEDKPDLLIDMGTLT
GAARVALGPELPPFYTNDETLAADVARCAASENDPLWRMPLWAPYDSWLDSKVATINNAPSGGFAGSITCALFLQRFVEP
TTRWLHLDIFAWTPSAKPGRPEGGECQAARALYKLLSERYG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=354, Percent_Identity=33.6158192090396, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI47155554, Length=372, Percent_Identity=34.6774193548387, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI87082123, Length=328, Percent_Identity=38.4146341463415, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1790710, Length=316, Percent_Identity=34.4936708860759, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17556903, Length=305, Percent_Identity=37.0491803278689, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=233, Percent_Identity=33.0472103004292, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24661038, Length=287, Percent_Identity=33.7979094076655, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI21355725, Length=287, Percent_Identity=33.7979094076655, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI221379063, Length=297, Percent_Identity=33.6700336700337, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI221379062, Length=297, Percent_Identity=33.6700336700337, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21357381, Length=297, Percent_Identity=33.6700336700337, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI19922386, Length=300, Percent_Identity=29.3333333333333, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI20129969, Length=287, Percent_Identity=28.5714285714286, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355645, Length=290, Percent_Identity=26.8965517241379, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24662223, Length=290, Percent_Identity=26.8965517241379, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24662227, Length=288, Percent_Identity=26.7361111111111, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI161077148, Length=289, Percent_Identity=29.0657439446367, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20130057, Length=289, Percent_Identity=29.0657439446367, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20129963, Length=350, Percent_Identity=26.5714285714286, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646701, Length=214, Percent_Identity=33.1775700934579, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646703, Length=214, Percent_Identity=33.1775700934579, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358201, Length=214, Percent_Identity=33.1775700934579, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 47393; Mature: 47261

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKASWPGIKDGLSTEARNFAEANGYAAKPGSCLILPGADGRIAQVLFGIEDPEARHRDL
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHEECCCCCCHHHHHC
FRPGTLPGLLPAGTYRFASAPHDARLAALAFALGSYRFGRYRKAETPDVRLVPPEGVDAA
CCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHH
ELDRLAEAATLARDLVNTPSNDMGPEELEAAAKQVADRFGARFTSIVGDDLLTQNFPLIH
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VVGRASTRAPRLIELTWGSADHPKVTLVGKGVCFDTGGLDLKPSSSMLLMKKDMGGAANV
EECCCCCCCCEEEEEECCCCCCCEEEEEECCEEEECCCCCCCCCCCEEEEECCCCCHHHH
LALAQMVMDAKLKLQLRVLIPAVENSVAGNAFRPMDVFPSRKGPTVEIGNTDAEGRLILA
HHHHHHHHCCCEEEEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEE
DALALADEDKPDLLIDMGTLTGAARVALGPELPPFYTNDETLAADVARCAASENDPLWRM
EHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEC
PLWAPYDSWLDSKVATINNAPSGGFAGSITCALFLQRFVEPTTRWLHLDIFAWTPSAKPG
CCCCCCHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCC
RPEGGECQAARALYKLLSERYG
CCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKASWPGIKDGLSTEARNFAEANGYAAKPGSCLILPGADGRIAQVLFGIEDPEARHRDL
CCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHEECCCCCCHHHHHC
FRPGTLPGLLPAGTYRFASAPHDARLAALAFALGSYRFGRYRKAETPDVRLVPPEGVDAA
CCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHH
ELDRLAEAATLARDLVNTPSNDMGPEELEAAAKQVADRFGARFTSIVGDDLLTQNFPLIH
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VVGRASTRAPRLIELTWGSADHPKVTLVGKGVCFDTGGLDLKPSSSMLLMKKDMGGAANV
EECCCCCCCCEEEEEECCCCCCCEEEEEECCEEEECCCCCCCCCCCEEEEECCCCCHHHH
LALAQMVMDAKLKLQLRVLIPAVENSVAGNAFRPMDVFPSRKGPTVEIGNTDAEGRLILA
HHHHHHHHCCCEEEEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEE
DALALADEDKPDLLIDMGTLTGAARVALGPELPPFYTNDETLAADVARCAASENDPLWRM
EHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEC
PLWAPYDSWLDSKVATINNAPSGGFAGSITCALFLQRFVEPTTRWLHLDIFAWTPSAKPG
CCCCCCHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCC
RPEGGECQAARALYKLLSERYG
CCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA