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The map label for this gene is dltE [H]

Identifier: 146337996

GI number: 146337996

Start: 939907

End: 940623

Strand: Reverse

Name: dltE [H]

Synonym: BRADO0889

Alternate gene names: 146337996

Gene position: 940623-939907 (Counterclockwise)

Preceding gene: 146337997

Following gene: 146337995

Centisome position: 12.61

GC content: 69.46

Gene sequence:

>717_bases
ATGAGTACCTCGATCAAGGACTCCGTCGTCGTCATCACCGGCGCCACCGGTGCCATCGCCTCCGCCCTCGTCGCCGAGCT
GCTCGCGCGCGGCGCCGCCAAGATCTACGCCGCTGCGCGCGATGTCTCGGGCCTCGCGCGCACCGACAAGATCGTGCCGC
TGAAGCTCGACGTCACCAGCGACGCGGACGCGGCGGCCGCCGCGGCGCAGGCGTCCGACGCGACGCTGCTGATCAACAAT
GCCGGCGTCAACCACAACACCGCCTTCCTGCTGGCACCCGATCTCGCCATCGCCACCGAGGAGATCGCGATCAACTATCT
CGCGCCGCTGCGGCTGACCCGCGCCTTCGCGCCAGTGCTGATCAAGAACCACGGCGCGGTGCTCAACATTCTCACCATCC
TGGCGCGCGTGAACCTGCCGCTGATGGGCTCCTACTGCGCCTCCAAGGCCGCCGCGCTGAGCCTGACGCAAGGCCTCCGC
GGCGAGCTGACGCCGAAGGGCGTGCGCGTCGCCGGCGCGCTGCCCGGCGCCGTCGATACCCGGATGACGGCCGGACTTCC
CATCCCGAAGATGACTCCGGCCGACGCCGCCAAGGAGATCCTCGACGGCTACGAGGCGGGCGAGGAGGACATCTATGTCG
GCGACATGGCCAAGGGCCTCGCCGCGGGCCTGGCGCAGGATCACAAGGCGGTGGAGAAACAATTGGCGTCGGGGTGA

Upstream 100 bases:

>100_bases
CGCGCCAGCTTCTCGCCGCCATTCCGCTTCCCGATGTCGAGCCGGGCTGGCTCGACGACACCCCGTCCCGTCAGCAACCT
CAGCAGCAGGGATCAGCCGC

Downstream 100 bases:

>100_bases
CGCGCGAGAATAGTAGCACGATGGCAGCGCAAGCGCGTGCTCCGTCCTTCGAAAGGCTGGCTGCTGGGTTCGATCTCACC
TCTCATGGTGAGGAGGTGCA

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSTSIKDSVVVITGATGAIASALVAELLARGAAKIYAAARDVSGLARTDKIVPLKLDVTSDADAAAAAAQASDATLLINN
AGVNHNTAFLLAPDLAIATEEIAINYLAPLRLTRAFAPVLIKNHGAVLNILTILARVNLPLMGSYCASKAAALSLTQGLR
GELTPKGVRVAGALPGAVDTRMTAGLPIPKMTPADAAKEILDGYEAGEEDIYVGDMAKGLAAGLAQDHKAVEKQLASG

Sequences:

>Translated_238_residues
MSTSIKDSVVVITGATGAIASALVAELLARGAAKIYAAARDVSGLARTDKIVPLKLDVTSDADAAAAAAQASDATLLINN
AGVNHNTAFLLAPDLAIATEEIAINYLAPLRLTRAFAPVLIKNHGAVLNILTILARVNLPLMGSYCASKAAALSLTQGLR
GELTPKGVRVAGALPGAVDTRMTAGLPIPKMTPADAAKEILDGYEAGEEDIYVGDMAKGLAAGLAQDHKAVEKQLASG
>Mature_237_residues
STSIKDSVVVITGATGAIASALVAELLARGAAKIYAAARDVSGLARTDKIVPLKLDVTSDADAAAAAAQASDATLLINNA
GVNHNTAFLLAPDLAIATEEIAINYLAPLRLTRAFAPVLIKNHGAVLNILTILARVNLPLMGSYCASKAAALSLTQGLRG
ELTPKGVRVAGALPGAVDTRMTAGLPIPKMTPADAAKEILDGYEAGEEDIYVGDMAKGLAAGLAQDHKAVEKQLASG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7706318, Length=196, Percent_Identity=29.0816326530612, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI150247226, Length=197, Percent_Identity=28.9340101522843, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI142976729, Length=229, Percent_Identity=25.764192139738, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI19743808, Length=233, Percent_Identity=26.1802575107296, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI20149619, Length=253, Percent_Identity=24.5059288537549, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=196, Percent_Identity=30.6122448979592, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24639444, Length=193, Percent_Identity=28.4974093264249, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=195, Percent_Identity=32.8205128205128, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24203; Mature: 24072

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSIKDSVVVITGATGAIASALVAELLARGAAKIYAAARDVSGLARTDKIVPLKLDVTS
CCCCCCCCEEEEECCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEEEECCC
DADAAAAAAQASDATLLINNAGVNHNTAFLLAPDLAIATEEIAINYLAPLRLTRAFAPVL
CCCHHHHHHCCCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
IKNHGAVLNILTILARVNLPLMGSYCASKAAALSLTQGLRGELTPKGVRVAGALPGAVDT
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHH
RMTAGLPIPKMTPADAAKEILDGYEAGEEDIYVGDMAKGLAAGLAQDHKAVEKQLASG
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STSIKDSVVVITGATGAIASALVAELLARGAAKIYAAARDVSGLARTDKIVPLKLDVTS
CCCCCCCEEEEECCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEEEECCC
DADAAAAAAQASDATLLINNAGVNHNTAFLLAPDLAIATEEIAINYLAPLRLTRAFAPVL
CCCHHHHHHCCCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
IKNHGAVLNILTILARVNLPLMGSYCASKAAALSLTQGLRGELTPKGVRVAGALPGAVDT
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHH
RMTAGLPIPKMTPADAAKEILDGYEAGEEDIYVGDMAKGLAAGLAQDHKAVEKQLASG
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377; 7797557 [H]