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The map label for this gene is hisC [H]

Identifier: 146337928

GI number: 146337928

Start: 868768

End: 869841

Strand: Direct

Name: hisC [H]

Synonym: BRADO0818

Alternate gene names: 146337928

Gene position: 868768-869841 (Clockwise)

Preceding gene: 146337925

Following gene: 146337952

Centisome position: 11.65

GC content: 67.13

Gene sequence:

>1074_bases
TTGAGCCGTTTCTGGTCAGAGCTCGCGCACGGGCTGTCGCCTTATGTGCCGGGTGAGCAGCCGCAGATCCAAGGTCTCGT
CAAGCTCAACACCAATGAGAGCCCGTTCGGGCCTTCGCCCCGGGCGATCGCGGCCATCCAGGCCACGGCGGCCGAGACGC
TGCGCCTCTATCCCGATCCGCAGGCGACGCGCCTGCGCGAGGCGCTGGCCGCCTATCACAAGGTCGCACCCGAGCAGGTG
TTCGTCGGCAACGGCTCCGACGAAGTGCTCGCGCATACCTTCGCCGCACTCTTGAAGCAGCGCGCGCCGCTGCTGTTTCC
CGACGTGACCTACAGCTTCTATCCAGTCTATTGCCGCCTGCTGGGGATCGACTACGCTACCGTTCCGCTCGATGCGTCGA
TGCGCGTGCGCATCGATGATTATCTCGGCGGCAGCGGCCCGGTCATCGTGGCCAATCCGAACGCACCGACCGGCATTGCG
CTGTCGCGGGCAGAGATTGCGCGACTGGTGGCCTCGCGCAGCGACGCCGCCGTCGTGATCGACGAGGCCTATGTCGACTT
CGGCGCCGAGACGGCGATCCCGCTGATCCGCGACTATCCAAATCTGCTGGTGGTACAAACCATGTCGAAGTCGCGTGCGC
TCGCCGGGCTGCGCGTCGGCTATGCGATCGGCGACGCCGGACTGATCGAGGGGCTGGCGCGGGTCAAGGACAGCTTCAAC
TCCTATCCGCTGGGACGGCCGGCCCAGGCCGGCGCCATCGCCTCGCTCGAGGACGAGCCGCACTTTCAGCACGTGCGCAC
GGAGATCATGCAGAATCGCGCCGACCTCACGGCGGCGCTGGTCTGCCTAGGCTTCGATGTTCTGCCCTCCAGCGCCAATT
TCTTATTCGCTCGGCATCCGGAGCACTCGGGCCAGTCGCTGGCTTCGGCGTTGCGCGAGCGCGCGGTGATCGTCCGCCAC
TTCACGGCGCCGCGTATCGCCGACTATCTCCGGATCACCATCGGCTCGACGGCGGAGCTGGCGCGGCTGACCGAGGCGTT
GCGCGCGATCCTGGCGAGCCCTCGGGCGGCCTGA

Upstream 100 bases:

>100_bases
AATCGTTCCGGGCGCGCCATTTGCTGATGATCCGTCTCCGATCCCATCGTCTCCGATCGATGCGCCGCCGGGTCCGGGTC
GGCGCCGCAGGAGGTTCGTC

Downstream 100 bases:

>100_bases
TCGGCTTTCCGCTCAGCTGCTGCCGAGCAGGGTGCAATGGTCCCTGGAATCGTTGGCGGACTCGCAAGCGTCTCCCTGAT
CCGCGCGTGCAAAGCCGGTC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSRFWSELAHGLSPYVPGEQPQIQGLVKLNTNESPFGPSPRAIAAIQATAAETLRLYPDPQATRLREALAAYHKVAPEQV
FVGNGSDEVLAHTFAALLKQRAPLLFPDVTYSFYPVYCRLLGIDYATVPLDASMRVRIDDYLGGSGPVIVANPNAPTGIA
LSRAEIARLVASRSDAAVVIDEAYVDFGAETAIPLIRDYPNLLVVQTMSKSRALAGLRVGYAIGDAGLIEGLARVKDSFN
SYPLGRPAQAGAIASLEDEPHFQHVRTEIMQNRADLTAALVCLGFDVLPSSANFLFARHPEHSGQSLASALRERAVIVRH
FTAPRIADYLRITIGSTAELARLTEALRAILASPRAA

Sequences:

>Translated_357_residues
MSRFWSELAHGLSPYVPGEQPQIQGLVKLNTNESPFGPSPRAIAAIQATAAETLRLYPDPQATRLREALAAYHKVAPEQV
FVGNGSDEVLAHTFAALLKQRAPLLFPDVTYSFYPVYCRLLGIDYATVPLDASMRVRIDDYLGGSGPVIVANPNAPTGIA
LSRAEIARLVASRSDAAVVIDEAYVDFGAETAIPLIRDYPNLLVVQTMSKSRALAGLRVGYAIGDAGLIEGLARVKDSFN
SYPLGRPAQAGAIASLEDEPHFQHVRTEIMQNRADLTAALVCLGFDVLPSSANFLFARHPEHSGQSLASALRERAVIVRH
FTAPRIADYLRITIGSTAELARLTEALRAILASPRAA
>Mature_356_residues
SRFWSELAHGLSPYVPGEQPQIQGLVKLNTNESPFGPSPRAIAAIQATAAETLRLYPDPQATRLREALAAYHKVAPEQVF
VGNGSDEVLAHTFAALLKQRAPLLFPDVTYSFYPVYCRLLGIDYATVPLDASMRVRIDDYLGGSGPVIVANPNAPTGIAL
SRAEIARLVASRSDAAVVIDEAYVDFGAETAIPLIRDYPNLLVVQTMSKSRALAGLRVGYAIGDAGLIEGLARVKDSFNS
YPLGRPAQAGAIASLEDEPHFQHVRTEIMQNRADLTAALVCLGFDVLPSSANFLFARHPEHSGQSLASALRERAVIVRHF
TAPRIADYLRITIGSTAELARLTEALRAILASPRAA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=355, Percent_Identity=31.2676056338028, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788722, Length=260, Percent_Identity=29.2307692307692, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322075, Length=378, Percent_Identity=27.5132275132275, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38494; Mature: 38363

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFWSELAHGLSPYVPGEQPQIQGLVKLNTNESPFGPSPRAIAAIQATAAETLRLYPDP
CCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHEEECCCC
QATRLREALAAYHKVAPEQVFVGNGSDEVLAHTFAALLKQRAPLLFPDVTYSFYPVYCRL
HHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHH
LGIDYATVPLDASMRVRIDDYLGGSGPVIVANPNAPTGIALSRAEIARLVASRSDAAVVI
HCCCEEEECCCCCEEEEEHHCCCCCCCEEEECCCCCCCEEEHHHHHHHHHHCCCCCEEEE
DEAYVDFGAETAIPLIRDYPNLLVVQTMSKSRALAGLRVGYAIGDAGLIEGLARVKDSFN
EHHHHHCCCCCCCHHHHCCCCEEEEEEHHHHHHHHHEEEHHEECCHHHHHHHHHHHHHHC
SYPLGRPAQAGAIASLEDEPHFQHVRTEIMQNRADLTAALVCLGFDVLPSSANFLFARHP
CCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
EHSGQSLASALRERAVIVRHFTAPRIADYLRITIGSTAELARLTEALRAILASPRAA
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEECCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SRFWSELAHGLSPYVPGEQPQIQGLVKLNTNESPFGPSPRAIAAIQATAAETLRLYPDP
CHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHEEECCCC
QATRLREALAAYHKVAPEQVFVGNGSDEVLAHTFAALLKQRAPLLFPDVTYSFYPVYCRL
HHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHH
LGIDYATVPLDASMRVRIDDYLGGSGPVIVANPNAPTGIALSRAEIARLVASRSDAAVVI
HCCCEEEECCCCCEEEEEHHCCCCCCCEEEECCCCCCCEEEHHHHHHHHHHCCCCCEEEE
DEAYVDFGAETAIPLIRDYPNLLVVQTMSKSRALAGLRVGYAIGDAGLIEGLARVKDSFN
EHHHHHCCCCCCCHHHHCCCCEEEEEEHHHHHHHHHEEEHHEECCHHHHHHHHHHHHHHC
SYPLGRPAQAGAIASLEDEPHFQHVRTEIMQNRADLTAALVCLGFDVLPSSANFLFARHP
CCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
EHSGQSLASALRERAVIVRHFTAPRIADYLRITIGSTAELARLTEALRAILASPRAA
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEECCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]