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The map label for this gene is trxA [H]

Identifier: 146337258

GI number: 146337258

Start: 101929

End: 102252

Strand: Direct

Name: trxA [H]

Synonym: BRADO0085

Alternate gene names: 146337258

Gene position: 101929-102252 (Clockwise)

Preceding gene: 146337257

Following gene: 146337259

Centisome position: 1.37

GC content: 65.43

Gene sequence:

>324_bases
ATGGCCGCCGTAGCCAAGGTTTCCGACGCCGATTTCGAAAGCGAAGTGCTCAAGGCCGACGGTCCGGTCGTGGTCGACTT
CTGGGCCGAGTGGTGCGGCCCCTGCCGCATGATCGCGCCGGCGCTCGACGAGATCGCCAGCGCGATGGGCGACAAGGTCA
AGATCGTGAAGCTCAACGTCGACGAGAGCCCGAAGACGGCCTCGAAGTATGGCGTGATGTCGATCCCCACCCTGATGGTG
TTCAAGGGAGGCGAACTGGCCTCCCGCCAGGTCGGCGCCGCGCCCAAGGCGAAGCTGCAGCAGTGGATCTCGTCGGCGGT
GTGA

Upstream 100 bases:

>100_bases
AGTGAGCATGCTTGACCCGGCCACGGGCCATTCATACTTTGACACCCACGCTGAGGCGGCCATTCCGGTGCCGCTCCCTC
CAACCCAACGAGGTAATTCC

Downstream 100 bases:

>100_bases
TTTTGTAGGGTGGGCAAAGCAGCCGCCGTCAGGCGGCAGCGTGCCCACCATCTCTCCGCGAGCCTGCAGCAAGACGGTGG
GCACGGCGCCGCAGCCATCT

Product: thioredoxin 1, redox factor

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MAAVAKVSDADFESEVLKADGPVVVDFWAEWCGPCRMIAPALDEIASAMGDKVKIVKLNVDESPKTASKYGVMSIPTLMV
FKGGELASRQVGAAPKAKLQQWISSAV

Sequences:

>Translated_107_residues
MAAVAKVSDADFESEVLKADGPVVVDFWAEWCGPCRMIAPALDEIASAMGDKVKIVKLNVDESPKTASKYGVMSIPTLMV
FKGGELASRQVGAAPKAKLQQWISSAV
>Mature_106_residues
AAVAKVSDADFESEVLKADGPVVVDFWAEWCGPCRMIAPALDEIASAMGDKVKIVKLNVDESPKTASKYGVMSIPTLMVF
KGGELASRQVGAAPKAKLQQWISSAV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=31.9587628865979, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI21361657, Length=86, Percent_Identity=34.8837209302326, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=50.9615384615385, Blast_Score=127, Evalue=1e-31,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=43.010752688172, Blast_Score=99, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=38.7096774193548, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=90, Percent_Identity=41.1111111111111, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=38.3720930232558, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=94, Percent_Identity=35.1063829787234, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=80, Percent_Identity=37.5, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=94, Percent_Identity=35.1063829787234, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=100, Percent_Identity=31, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=100, Percent_Identity=45, Blast_Score=84, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319925, Length=96, Percent_Identity=36.4583333333333, Blast_Score=77, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=88, Percent_Identity=43.1818181818182, Blast_Score=73, Evalue=8e-15,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=39.1752577319588, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=46.7532467532467, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17648013, Length=106, Percent_Identity=38.6792452830189, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583090, Length=106, Percent_Identity=38.6792452830189, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358065, Length=100, Percent_Identity=34, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=42.6229508196721, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921434, Length=79, Percent_Identity=34.1772151898734, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11355; Mature: 11224

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVAKVSDADFESEVLKADGPVVVDFWAEWCGPCRMIAPALDEIASAMGDKVKIVKLNV
CCCCCCCCCCCCHHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEEC
DESPKTASKYGVMSIPTLMVFKGGELASRQVGAAPKAKLQQWISSAV
CCCCCCHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AAVAKVSDADFESEVLKADGPVVVDFWAEWCGPCRMIAPALDEIASAMGDKVKIVKLNV
CCCCCCCCCCCHHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEEC
DESPKTASKYGVMSIPTLMVFKGGELASRQVGAAPKAKLQQWISSAV
CCCCCCHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3129411 [H]