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The map label for this gene is fadD [C]

Identifier: 146302455

GI number: 146302455

Start: 5713413

End: 5715191

Strand: Direct

Name: fadD [C]

Synonym: Fjoh_4728

Alternate gene names: 146302455

Gene position: 5713413-5715191 (Clockwise)

Preceding gene: 146302454

Following gene: 146302462

Centisome position: 93.71

GC content: 35.81

Gene sequence:

>1779_bases
ATGGTTTCAATCACACGCCTTTTTGATTTTCCCTATTATCAACAAGAAACTTACAACCTCCCAGTTGCTCTGGCAAACAA
AAAAAACGGAGTCTGGGAAAAAACATCCACCGAGGAATATATTGCAAAAGCTAATGCCGTTTCGAGAGCATTATTGCGCA
TGGGCGTTCAAAAAGATGATAAAATTGCTTTAATAAGTTCTAATAACCGTACCGAATGGAATATAATGGATATTGGTATT
TTGCAGACTGGTGCGCAAAATGTTCCAATTTATCCAACAATTGCAGAGGAAGATTACGAATATATTTTAAATCACAGCGG
CAGTATTTATTGCTTTGTTTCTGATGACGAAGTTTTACAAAAAGTAAATGCAATTAAAGCCAATGTGCCTACTTTGAAAG
AAGTTTATTCTTTTAATGAAATTCCTGGATGCAAACACTGGTCAGATCTTCTTTTGGCCGGCGAAGACGAAAGCAATCAA
AGCGAAGTTGAGGCCAGAAAAGACAGCATCCACACAGATGATTTAGCTACAATTATTTATACTTCCGGAACTACAGGAAG
ACCTAAGGGCGTTATGCTTTCTCATAAAAATATCGTTTCAAATGTTCTGGACAGTGCTCCAAGAATTCCATTTGATCCGG
GAAAAAGCACTGCTTTGAGCTTTCTGCCAATCTGCCATATTTTTGAAAGAATGATTTTATACATTTATCAATATTATGGA
GTTTCGGTTTATTTTGGAGAATCTATTGATAAAATCAGCGATAACTTAAAAGAAGTTCGTCCAACTGTAATTACAGCTGT
ACCACGACTTTTAGAAAAAGTTTACGATAAAATTTACGCAAAAGGGACTGAATTAACAGGTATCAAGAAAAAACTTTTTT
TCTGGGCTATTGATTTAGGCTTAAAATATGAACCATACGGAGCAAATGGCTTTTGGTATGAATTTCAATTGAAAATCGCC
CGCAAACTTATTTTCAGTAAATGGAAAGAAGGTTTAGGAGGAAAATTAGACTTGATGGTTTCCGGAAGTGCCGCTTTACA
GCCGCGCTTATCAAGAGTTTTTGCTGCTGCAGAAATCCCGGTTATGGAAGGATATGGTTTAACAGAAACTTCTCCCGTAA
TTGCCGTTAACGATCAAAGAAACAGAGGATTTAAAATTGGAACCGTTGGAAAACCAATCCGCAATGTTGAAGTTAAAATT
GCCGAAGACGGAGAAATTTTATTAAAAGGTCCAAACGTAATGCTGGGTTATTATAAAGATCCTGAAAAAACTGCAGAAGC
TGTTATTGACGGGTATTTCCATACAGGCGATATTGGAGAAATTGACAGTGAAGGTTTCTTAAAAATTACCGACCGTAAAA
AAGAAATGTTTAAAACTTCAGGAGGTAAATATATTGCGCCGCAGATGATCGAAAATGCCATGAAACAATCTCGTTTTATT
GAGCAGATTATGGTTATTGGCGAAGGTGAAAAAATGCCTGGAGCTTTTATTCAGCCAAACTTTGAATTTGTAAAAGAATG
GGCAAAAATCCATAAAATTACTTTGGGAAGTTCTGATGCCGAAATTAGTTCAAATCCAGATGTTATTAAACGTATCGATG
AAGAAGTAGAAAGCATCAACAAAAAATTCGGACACTGGGAACAAGTAAAACGCTTTGAATTAACACCAGATGTATGGTCT
ATCGATGGCGGACAGCTTACTCCTACTCTAAAATTGAAACGTAAAATCATTAAAGAAATCTACAAAGATCTTTACGCTAA
AATCTATGATCATAATTAA

Upstream 100 bases:

>100_bases
GATTTTTAATAGTCTCTATAAATTTTCCCATAAAATTCCATAAAATAAAAAATCATACCTAAATTTTATTTAATTTGCAG
TAAAATTCAATATATTAAAC

Downstream 100 bases:

>100_bases
ATCAAAATAATATAACCAAACGAAAAAGGCTGTTCAATTGAACAGCCTTTTTTAATACAGGTAATATGGATACTAAAAAC
ATCTTTTGATTAAAAATTAC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MVSITRLFDFPYYQQETYNLPVALANKKNGVWEKTSTEEYIAKANAVSRALLRMGVQKDDKIALISSNNRTEWNIMDIGI
LQTGAQNVPIYPTIAEEDYEYILNHSGSIYCFVSDDEVLQKVNAIKANVPTLKEVYSFNEIPGCKHWSDLLLAGEDESNQ
SEVEARKDSIHTDDLATIIYTSGTTGRPKGVMLSHKNIVSNVLDSAPRIPFDPGKSTALSFLPICHIFERMILYIYQYYG
VSVYFGESIDKISDNLKEVRPTVITAVPRLLEKVYDKIYAKGTELTGIKKKLFFWAIDLGLKYEPYGANGFWYEFQLKIA
RKLIFSKWKEGLGGKLDLMVSGSAALQPRLSRVFAAAEIPVMEGYGLTETSPVIAVNDQRNRGFKIGTVGKPIRNVEVKI
AEDGEILLKGPNVMLGYYKDPEKTAEAVIDGYFHTGDIGEIDSEGFLKITDRKKEMFKTSGGKYIAPQMIENAMKQSRFI
EQIMVIGEGEKMPGAFIQPNFEFVKEWAKIHKITLGSSDAEISSNPDVIKRIDEEVESINKKFGHWEQVKRFELTPDVWS
IDGGQLTPTLKLKRKIIKEIYKDLYAKIYDHN

Sequences:

>Translated_592_residues
MVSITRLFDFPYYQQETYNLPVALANKKNGVWEKTSTEEYIAKANAVSRALLRMGVQKDDKIALISSNNRTEWNIMDIGI
LQTGAQNVPIYPTIAEEDYEYILNHSGSIYCFVSDDEVLQKVNAIKANVPTLKEVYSFNEIPGCKHWSDLLLAGEDESNQ
SEVEARKDSIHTDDLATIIYTSGTTGRPKGVMLSHKNIVSNVLDSAPRIPFDPGKSTALSFLPICHIFERMILYIYQYYG
VSVYFGESIDKISDNLKEVRPTVITAVPRLLEKVYDKIYAKGTELTGIKKKLFFWAIDLGLKYEPYGANGFWYEFQLKIA
RKLIFSKWKEGLGGKLDLMVSGSAALQPRLSRVFAAAEIPVMEGYGLTETSPVIAVNDQRNRGFKIGTVGKPIRNVEVKI
AEDGEILLKGPNVMLGYYKDPEKTAEAVIDGYFHTGDIGEIDSEGFLKITDRKKEMFKTSGGKYIAPQMIENAMKQSRFI
EQIMVIGEGEKMPGAFIQPNFEFVKEWAKIHKITLGSSDAEISSNPDVIKRIDEEVESINKKFGHWEQVKRFELTPDVWS
IDGGQLTPTLKLKRKIIKEIYKDLYAKIYDHN
>Mature_592_residues
MVSITRLFDFPYYQQETYNLPVALANKKNGVWEKTSTEEYIAKANAVSRALLRMGVQKDDKIALISSNNRTEWNIMDIGI
LQTGAQNVPIYPTIAEEDYEYILNHSGSIYCFVSDDEVLQKVNAIKANVPTLKEVYSFNEIPGCKHWSDLLLAGEDESNQ
SEVEARKDSIHTDDLATIIYTSGTTGRPKGVMLSHKNIVSNVLDSAPRIPFDPGKSTALSFLPICHIFERMILYIYQYYG
VSVYFGESIDKISDNLKEVRPTVITAVPRLLEKVYDKIYAKGTELTGIKKKLFFWAIDLGLKYEPYGANGFWYEFQLKIA
RKLIFSKWKEGLGGKLDLMVSGSAALQPRLSRVFAAAEIPVMEGYGLTETSPVIAVNDQRNRGFKIGTVGKPIRNVEVKI
AEDGEILLKGPNVMLGYYKDPEKTAEAVIDGYFHTGDIGEIDSEGFLKITDRKKEMFKTSGGKYIAPQMIENAMKQSRFI
EQIMVIGEGEKMPGAFIQPNFEFVKEWAKIHKITLGSSDAEISSNPDVIKRIDEEVESINKKFGHWEQVKRFELTPDVWS
IDGGQLTPTLKLKRKIIKEIYKDLYAKIYDHN

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=630, Percent_Identity=32.5396825396825, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI42794756, Length=611, Percent_Identity=32.2422258592471, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI42794760, Length=611, Percent_Identity=32.2422258592471, Blast_Score=249, Evalue=6e-66,
Organism=Homo sapiens, GI42794758, Length=611, Percent_Identity=32.2422258592471, Blast_Score=249, Evalue=6e-66,
Organism=Homo sapiens, GI57165412, Length=615, Percent_Identity=31.3821138211382, Blast_Score=245, Evalue=8e-65,
Organism=Homo sapiens, GI57165410, Length=620, Percent_Identity=31.1290322580645, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI83745141, Length=600, Percent_Identity=28.3333333333333, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI27477105, Length=625, Percent_Identity=27.36, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI12669909, Length=590, Percent_Identity=26.7796610169492, Blast_Score=205, Evalue=9e-53,
Organism=Homo sapiens, GI4758332, Length=590, Percent_Identity=26.7796610169492, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI42794754, Length=605, Percent_Identity=26.2809917355372, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI42794752, Length=605, Percent_Identity=26.2809917355372, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI156151445, Length=137, Percent_Identity=32.8467153284672, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788107, Length=466, Percent_Identity=28.755364806867, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1789201, Length=315, Percent_Identity=28.8888888888889, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693145, Length=170, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17556552, Length=561, Percent_Identity=32.620320855615, Blast_Score=241, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI17541856, Length=603, Percent_Identity=31.3432835820896, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17510401, Length=589, Percent_Identity=32.76740237691, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17553312, Length=607, Percent_Identity=28.171334431631, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI25147511, Length=594, Percent_Identity=27.1043771043771, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI193204819, Length=630, Percent_Identity=28.0952380952381, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17564090, Length=439, Percent_Identity=31.6628701594533, Blast_Score=176, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17558820, Length=457, Percent_Identity=27.7899343544858, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=458, Percent_Identity=26.4192139737991, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17559526, Length=370, Percent_Identity=30.2702702702703, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71994703, Length=539, Percent_Identity=22.6345083487941, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71994690, Length=539, Percent_Identity=22.6345083487941, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71994694, Length=539, Percent_Identity=22.6345083487941, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI133901848, Length=218, Percent_Identity=28.8990825688073, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17531443, Length=434, Percent_Identity=23.0414746543779, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324893, Length=610, Percent_Identity=27.2131147540984, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6323903, Length=625, Percent_Identity=26.72, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6322182, Length=618, Percent_Identity=25.8899676375405, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320852, Length=627, Percent_Identity=25.0398724082935, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319699, Length=426, Percent_Identity=27.2300469483568, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI281366413, Length=600, Percent_Identity=33, Blast_Score=255, Evalue=7e-68,
Organism=Drosophila melanogaster, GI24666501, Length=600, Percent_Identity=33, Blast_Score=254, Evalue=9e-68,
Organism=Drosophila melanogaster, GI24666497, Length=600, Percent_Identity=33, Blast_Score=254, Evalue=9e-68,
Organism=Drosophila melanogaster, GI17933690, Length=612, Percent_Identity=27.7777777777778, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI62471689, Length=594, Percent_Identity=28.956228956229, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI62471679, Length=594, Percent_Identity=28.7878787878788, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI62471683, Length=594, Percent_Identity=28.7878787878788, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI62471685, Length=594, Percent_Identity=28.7878787878788, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24586636, Length=594, Percent_Identity=28.7878787878788, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI62471681, Length=594, Percent_Identity=28.7878787878788, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI62471687, Length=594, Percent_Identity=28.7878787878788, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24586634, Length=594, Percent_Identity=28.7878787878788, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI22026970, Length=594, Percent_Identity=28.7878787878788, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI19921316, Length=630, Percent_Identity=26.6666666666667, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI21355181, Length=522, Percent_Identity=24.904214559387, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21356947, Length=187, Percent_Identity=32.0855614973262, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21358303, Length=334, Percent_Identity=25.4491017964072, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24653035, Length=137, Percent_Identity=30.6569343065693, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24648260, Length=136, Percent_Identity=34.5588235294118, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 66959; Mature: 66959

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSITRLFDFPYYQQETYNLPVALANKKNGVWEKTSTEEYIAKANAVSRALLRMGVQKDD
CCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
KIALISSNNRTEWNIMDIGILQTGAQNVPIYPTIAEEDYEYILNHSGSIYCFVSDDEVLQ
CEEEEECCCCCEEEEEEEEEEECCCCCCCEEEEECCCCHHHHHCCCCEEEEEECCHHHHH
KVNAIKANVPTLKEVYSFNEIPGCKHWSDLLLAGEDESNQSEVEARKDSIHTDDLATIIY
HHHHHHCCCCHHHHHHCCCCCCCCCCHHHCEEECCCCCCHHHHHHHHHCCCCCCEEEEEE
TSGTTGRPKGVMLSHKNIVSNVLDSAPRIPFDPGKSTALSFLPICHIFERMILYIYQYYG
ECCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
VSVYFGESIDKISDNLKEVRPTVITAVPRLLEKVYDKIYAKGTELTGIKKKLFFWAIDLG
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEEEEECC
LKYEPYGANGFWYEFQLKIARKLIFSKWKEGLGGKLDLMVSGSAALQPRLSRVFAAAEIP
CEECCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCC
VMEGYGLTETSPVIAVNDQRNRGFKIGTVGKPIRNVEVKIAEDGEILLKGPNVMLGYYKD
EECCCCCCCCCCEEEECCCCCCCEEEECCCCCCCCEEEEEECCCEEEEECCCEEEEEECC
PEKTAEAVIDGYFHTGDIGEIDSEGFLKITDRKKEMFKTSGGKYIAPQMIENAMKQSRFI
HHHHHHHHHHCCEECCCCCCCCCCCCEEEECHHHHHHHCCCCCEECHHHHHHHHHHHHHH
EQIMVIGEGEKMPGAFIQPNFEFVKEWAKIHKITLGSSDAEISSNPDVIKRIDEEVESIN
HHHHHEECCCCCCCCEECCCHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHH
KKFGHWEQVKRFELTPDVWSIDGGQLTPTLKLKRKIIKEIYKDLYAKIYDHN
HHCCCHHHHHHEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVSITRLFDFPYYQQETYNLPVALANKKNGVWEKTSTEEYIAKANAVSRALLRMGVQKDD
CCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
KIALISSNNRTEWNIMDIGILQTGAQNVPIYPTIAEEDYEYILNHSGSIYCFVSDDEVLQ
CEEEEECCCCCEEEEEEEEEEECCCCCCCEEEEECCCCHHHHHCCCCEEEEEECCHHHHH
KVNAIKANVPTLKEVYSFNEIPGCKHWSDLLLAGEDESNQSEVEARKDSIHTDDLATIIY
HHHHHHCCCCHHHHHHCCCCCCCCCCHHHCEEECCCCCCHHHHHHHHHCCCCCCEEEEEE
TSGTTGRPKGVMLSHKNIVSNVLDSAPRIPFDPGKSTALSFLPICHIFERMILYIYQYYG
ECCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
VSVYFGESIDKISDNLKEVRPTVITAVPRLLEKVYDKIYAKGTELTGIKKKLFFWAIDLG
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEEEEECC
LKYEPYGANGFWYEFQLKIARKLIFSKWKEGLGGKLDLMVSGSAALQPRLSRVFAAAEIP
CEECCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCC
VMEGYGLTETSPVIAVNDQRNRGFKIGTVGKPIRNVEVKIAEDGEILLKGPNVMLGYYKD
EECCCCCCCCCCEEEECCCCCCCEEEECCCCCCCCEEEEEECCCEEEEECCCEEEEEECC
PEKTAEAVIDGYFHTGDIGEIDSEGFLKITDRKKEMFKTSGGKYIAPQMIENAMKQSRFI
HHHHHHHHHHCCEECCCCCCCCCCCCEEEECHHHHHHHCCCCCEECHHHHHHHHHHHHHH
EQIMVIGEGEKMPGAFIQPNFEFVKEWAKIHKITLGSSDAEISSNPDVIKRIDEEVESIN
HHHHHEECCCCCCCCEECCCHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHH
KKFGHWEQVKRFELTPDVWSIDGGQLTPTLKLKRKIIKEIYKDLYAKIYDHN
HHCCCHHHHHHEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]