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The map label for this gene is sdaA [H]

Identifier: 146302436

GI number: 146302436

Start: 5684380

End: 5685807

Strand: Direct

Name: sdaA [H]

Synonym: Fjoh_4709

Alternate gene names: 146302436

Gene position: 5684380-5685807 (Clockwise)

Preceding gene: 146302432

Following gene: 146302437

Centisome position: 93.23

GC content: 38.31

Gene sequence:

>1428_bases
ATGGAAGAATGTATCTCTGTTTTTGATATGCTTAAAATTGGCGTTGGCCCTTCAAGCTCACATACTTTGGGTCCGTGGAG
AGCTGCCGAACGCTTTCTCGAAGAGTTAAAAAGCGAGTCGATTTTAGACCAGATTAAACGAGTAAAAGTCGATTTATACG
GATCACTTTCCTTAACCGGAAAAGGTCATGCTACAGATTTATCGGTTATGCTTGGTTTAAGTGGTCAGGATCCTGAATAT
ATTCCGGTTGAGAATATTGCCGGAATTATCAAAACAATCGAAGACACAAACGAAATAAATCTTGCAAATGAATTTAAAAT
TCCGTTTTATTTTCTGCAGGATATTGTTTTCAATAAAGATTTTCTTCCTTTCCATGCTAACGGATTAAAATTTACGGCTT
ATAAAAATGATGATTCAGAATACGAATCTACATTTTATTCCATAGGCGGTGGTTTTGTTGTGAAAGAAGAACGCGAAAAT
GCCAAGATAAAAGAAGTTATAAAATGTGCATTTCCGTTTCCTATTCAAAATGCGGTTGAACTTTTAAATTATACAATTTC
TGAAAACAAATCGATTTCTGAAATTGTGTATGAAAACGAAAAATCAATGCGTTCTGAAGAAGAAATCCATTCAGAATTAA
TGCGTATCTGGAATACGATGCTTGAATGTATGTATATTGGCTGTCATACCGGAGGAATTCTTCCGGGCGGCTTACACGTT
CGCAGACGAGCTTTTGATATGCACCAAAATTTAATTGGTTTATCAAATTACAACGATCCCCAATCGTGGCTGGAAGAAAT
TAGAAAAACCGAGGTTAAATTCCGTCAGATTTTAAAATGGGTAAGCTGTTTTGCTCTTGCCGTAAATGAAGTAAATGCTT
CTTTAGGACGAGTTGTAACGGCGCCGACTAACGGAAGCGCAGGCGTTATTCCGGCCGTTTTAATGTATTATATGGTAATT
GAAAACCATGATGCCGGAGAAAAAGAAATCAAACAATTTTTAATGGTTGCCGGGGAAATTGGCAGCATCTTTAAAAAAGG
ATCAACAATTTCTGCTGCAATGGGCGGTTGTCAGGCCGAAATTGGTGTTTCGTCGTCTATGGCTGCGGCGGCACTCTGCG
AATTAATGGGCGGTACTCCTGCTCAGGTTTTAATGGCTGCCGAAATTGCAATGGAGCATCATTTAGGTTTAACCTGTGAT
CCTATTGGCGGTTTAGTTCAAATTCCGTGTATTGAAAGAAATACTATGGGTGCCATAAAAGCTATTAATGCAGCTGAACT
GGCGCTTGAAACTGATTCTAAAAACGCAAAAGTGCCTTTAGACAAAGTTATCAATACAATGTGGGAAACCGCAAAAGATA
TGAATTCTAAATACAAAGAAACTTCTGAAGGAGGTCTTGCCGTGGCAGTAAACATGGCAGATTGCTAA

Upstream 100 bases:

>100_bases
TAAAATTTAATATTTTTTTTAACAAATATGCAAGATTAACAATCAAAACTAAACCATCATTGCATTATTCAATTATCTTT
GTCTTAACAAAAATTGAACA

Downstream 100 bases:

>100_bases
GAATAAAGCTGCCACGAATTTCACTAATTTACACTAATTTATCTCCTGTTTCGTAAAAAACAATTTGTGTAAATTCGTGA
AATTCGCGGCAAAAAAACAA

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH 1; L-serine deaminase 1; L-SD1 [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MEECISVFDMLKIGVGPSSSHTLGPWRAAERFLEELKSESILDQIKRVKVDLYGSLSLTGKGHATDLSVMLGLSGQDPEY
IPVENIAGIIKTIEDTNEINLANEFKIPFYFLQDIVFNKDFLPFHANGLKFTAYKNDDSEYESTFYSIGGGFVVKEEREN
AKIKEVIKCAFPFPIQNAVELLNYTISENKSISEIVYENEKSMRSEEEIHSELMRIWNTMLECMYIGCHTGGILPGGLHV
RRRAFDMHQNLIGLSNYNDPQSWLEEIRKTEVKFRQILKWVSCFALAVNEVNASLGRVVTAPTNGSAGVIPAVLMYYMVI
ENHDAGEKEIKQFLMVAGEIGSIFKKGSTISAAMGGCQAEIGVSSSMAAAALCELMGGTPAQVLMAAEIAMEHHLGLTCD
PIGGLVQIPCIERNTMGAIKAINAAELALETDSKNAKVPLDKVINTMWETAKDMNSKYKETSEGGLAVAVNMADC

Sequences:

>Translated_475_residues
MEECISVFDMLKIGVGPSSSHTLGPWRAAERFLEELKSESILDQIKRVKVDLYGSLSLTGKGHATDLSVMLGLSGQDPEY
IPVENIAGIIKTIEDTNEINLANEFKIPFYFLQDIVFNKDFLPFHANGLKFTAYKNDDSEYESTFYSIGGGFVVKEEREN
AKIKEVIKCAFPFPIQNAVELLNYTISENKSISEIVYENEKSMRSEEEIHSELMRIWNTMLECMYIGCHTGGILPGGLHV
RRRAFDMHQNLIGLSNYNDPQSWLEEIRKTEVKFRQILKWVSCFALAVNEVNASLGRVVTAPTNGSAGVIPAVLMYYMVI
ENHDAGEKEIKQFLMVAGEIGSIFKKGSTISAAMGGCQAEIGVSSSMAAAALCELMGGTPAQVLMAAEIAMEHHLGLTCD
PIGGLVQIPCIERNTMGAIKAINAAELALETDSKNAKVPLDKVINTMWETAKDMNSKYKETSEGGLAVAVNMADC
>Mature_475_residues
MEECISVFDMLKIGVGPSSSHTLGPWRAAERFLEELKSESILDQIKRVKVDLYGSLSLTGKGHATDLSVMLGLSGQDPEY
IPVENIAGIIKTIEDTNEINLANEFKIPFYFLQDIVFNKDFLPFHANGLKFTAYKNDDSEYESTFYSIGGGFVVKEEREN
AKIKEVIKCAFPFPIQNAVELLNYTISENKSISEIVYENEKSMRSEEEIHSELMRIWNTMLECMYIGCHTGGILPGGLHV
RRRAFDMHQNLIGLSNYNDPQSWLEEIRKTEVKFRQILKWVSCFALAVNEVNASLGRVVTAPTNGSAGVIPAVLMYYMVI
ENHDAGEKEIKQFLMVAGEIGSIFKKGSTISAAMGGCQAEIGVSSSMAAAALCELMGGTPAQVLMAAEIAMEHHLGLTCD
PIGGLVQIPCIERNTMGAIKAINAAELALETDSKNAKVPLDKVINTMWETAKDMNSKYKETSEGGLAVAVNMADC

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=469, Percent_Identity=46.2686567164179, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI48994925, Length=468, Percent_Identity=45.9401709401709, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI1789161, Length=472, Percent_Identity=45.3389830508475, Blast_Score=411, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 52299; Mature: 52299

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEECISVFDMLKIGVGPSSSHTLGPWRAAERFLEELKSESILDQIKRVKVDLYGSLSLTG
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECC
KGHATDLSVMLGLSGQDPEYIPVENIAGIIKTIEDTNEINLANEFKIPFYFLQDIVFNKD
CCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCC
FLPFHANGLKFTAYKNDDSEYESTFYSIGGGFVVKEERENAKIKEVIKCAFPFPIQNAVE
CCCEECCCEEEEEECCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHH
LLNYTISENKSISEIVYENEKSMRSEEEIHSELMRIWNTMLECMYIGCHTGGILPGGLHV
HHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
RRRAFDMHQNLIGLSNYNDPQSWLEEIRKTEVKFRQILKWVSCFALAVNEVNASLGRVVT
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
APTNGSAGVIPAVLMYYMVIENHDAGEKEIKQFLMVAGEIGSIFKKGSTISAAMGGCQAE
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEE
IGVSSSMAAAALCELMGGTPAQVLMAAEIAMEHHLGLTCDPIGGLVQIPCIERNTMGAIK
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCCEEEECEECCCCCHHHH
AINAAELALETDSKNAKVPLDKVINTMWETAKDMNSKYKETSEGGLAVAVNMADC
HCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCC
>Mature Secondary Structure
MEECISVFDMLKIGVGPSSSHTLGPWRAAERFLEELKSESILDQIKRVKVDLYGSLSLTG
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECC
KGHATDLSVMLGLSGQDPEYIPVENIAGIIKTIEDTNEINLANEFKIPFYFLQDIVFNKD
CCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCC
FLPFHANGLKFTAYKNDDSEYESTFYSIGGGFVVKEERENAKIKEVIKCAFPFPIQNAVE
CCCEECCCEEEEEECCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHH
LLNYTISENKSISEIVYENEKSMRSEEEIHSELMRIWNTMLECMYIGCHTGGILPGGLHV
HHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
RRRAFDMHQNLIGLSNYNDPQSWLEEIRKTEVKFRQILKWVSCFALAVNEVNASLGRVVT
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
APTNGSAGVIPAVLMYYMVIENHDAGEKEIKQFLMVAGEIGSIFKKGSTISAAMGGCQAE
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEE
IGVSSSMAAAALCELMGGTPAQVLMAAEIAMEHHLGLTCDPIGGLVQIPCIERNTMGAIK
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCCEEEECEECCCCCHHHH
AINAAELALETDSKNAKVPLDKVINTMWETAKDMNSKYKETSEGGLAVAVNMADC
HCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2504697; 8436113; 9097040; 9278503 [H]