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The map label for this gene is dctA [H]

Identifier: 146302302

GI number: 146302302

Start: 5534227

End: 5535507

Strand: Reverse

Name: dctA [H]

Synonym: Fjoh_4575

Alternate gene names: 146302302

Gene position: 5535507-5534227 (Counterclockwise)

Preceding gene: 146302303

Following gene: 146302301

Centisome position: 90.79

GC content: 35.44

Gene sequence:

>1281_bases
ATGCAAGTAACAGAAACTAAGAAAAAATCATTTTTAACAGGACTTACAGGGCAGATTTTAATTGCAATGGTTCTTGGCGC
AACGCTGGGAATTATTCTGCATAACTCAATTTCACCTGAAGCAGCGCAGTCATTCAGCACAAAAATTAAAATGCTTGCGA
CTATTTTTATCCGTTTGGTGCAAATGATTATTTCTCCTTTGGTTTTTACCACTTTAATTGTGGGAATTGCAAAACTGGGA
GATATAAAAACAGTAGGAAGAATTGGAGGAAAAGCGCTTGGATGGTTTTTTACAGCTTCTTTTATCTCATTGTTAATTGG
GTTATTTTATGTAAATATTTTAGAGCCTGGAGTAGGTTTAAAATTAAGCCATGTAGATATGGCTTCGGCATCTGAAGTAA
CCGCTAAAACTCAAAACTTATCATTTGAAAACTTCGTTGAGCATATTGTTCCAAAAAGTATTATTGAAGCAATGGCAACC
AACGAAATTCTACAAATTGTAATATTTTCTATTTTCTTCGGATTAGCGGCTGCGTCTTTAGGTAACACTGTAAAACCGGT
AATTGGAGCTTTAGATAAAATCTCGCATATCGTTCTTAAAATGGTAAATTATGTAATGAACTTCGCTCCAATTGGAGTTT
TTGGAGCCATTGCAGCGGTTTTTGCCATTCGTGATGCCGAAGAATTATTAATTACGTATTTCAAGTTTTTCGGATCATTT
TTATTAGGAATTGGAACTTTATGGGTTGTGTTAATTGCAGTAGGTTTTATTTTCTTAGGAAGAAGAATGGTTGAGCTTTT
AAGACGAATCATTGGACCTTTGGCAATTGCTTTTGGTACAACAAGTTCAGAAGCTGTTTTTCCTAAATTAACAGAAGAAT
TAGAAAGTTTTGGTGTAAAAGACAGAATCGTTTCTTTTATGCTGCCGCTTGGCTATTCTTTCAATTTGGACGGCAGTATG
ATGTACATGACTTTTGCGAGTATTTTTATTGCACAGTTTTATAATGTACATTTAGATTTAGGAACTCAAATGGCAATGCT
GTTGGTTTTAATGCTTACGAGTAAAGGAATTGCGGGAGTGCCAAGAGCAAGTTTAGTTGTTGTTGCTGCTACCTGTGGTA
TGTTTGATATTCCGGTTGAAGGTATTGCTTTAATTTTACCAATTGACCATTTCTGCGATATGTTTAGAAGCGCAACCAAT
GTTTTAGGAAATGCTTTGGCAACTTCGGTTGTAGGGCAGTGGGAAGGCAATGATACTGCCGAAAATGTAATAGAAAACTA
A

Upstream 100 bases:

>100_bases
GGCTGCGATTGTTTTGGCAGATTTTTATTTAATCAACAAAACATATTAATAAAAGTAAGGCAGTGAGGGTCTTATATTTT
AATAATTAAAAAACAAATTA

Downstream 100 bases:

>100_bases
TTGTTTTTTTTAGAGAAAACAATACAAGATAACCGAAAAGAAAAGCTGTATTTTTATAGGAAATACGGCTTTTTTTTATT
TTTAAGTGTATATTTGATAA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MQVTETKKKSFLTGLTGQILIAMVLGATLGIILHNSISPEAAQSFSTKIKMLATIFIRLVQMIISPLVFTTLIVGIAKLG
DIKTVGRIGGKALGWFFTASFISLLIGLFYVNILEPGVGLKLSHVDMASASEVTAKTQNLSFENFVEHIVPKSIIEAMAT
NEILQIVIFSIFFGLAAASLGNTVKPVIGALDKISHIVLKMVNYVMNFAPIGVFGAIAAVFAIRDAEELLITYFKFFGSF
LLGIGTLWVVLIAVGFIFLGRRMVELLRRIIGPLAIAFGTTSSEAVFPKLTEELESFGVKDRIVSFMLPLGYSFNLDGSM
MYMTFASIFIAQFYNVHLDLGTQMAMLLVLMLTSKGIAGVPRASLVVVAATCGMFDIPVEGIALILPIDHFCDMFRSATN
VLGNALATSVVGQWEGNDTAENVIEN

Sequences:

>Translated_426_residues
MQVTETKKKSFLTGLTGQILIAMVLGATLGIILHNSISPEAAQSFSTKIKMLATIFIRLVQMIISPLVFTTLIVGIAKLG
DIKTVGRIGGKALGWFFTASFISLLIGLFYVNILEPGVGLKLSHVDMASASEVTAKTQNLSFENFVEHIVPKSIIEAMAT
NEILQIVIFSIFFGLAAASLGNTVKPVIGALDKISHIVLKMVNYVMNFAPIGVFGAIAAVFAIRDAEELLITYFKFFGSF
LLGIGTLWVVLIAVGFIFLGRRMVELLRRIIGPLAIAFGTTSSEAVFPKLTEELESFGVKDRIVSFMLPLGYSFNLDGSM
MYMTFASIFIAQFYNVHLDLGTQMAMLLVLMLTSKGIAGVPRASLVVVAATCGMFDIPVEGIALILPIDHFCDMFRSATN
VLGNALATSVVGQWEGNDTAENVIEN
>Mature_426_residues
MQVTETKKKSFLTGLTGQILIAMVLGATLGIILHNSISPEAAQSFSTKIKMLATIFIRLVQMIISPLVFTTLIVGIAKLG
DIKTVGRIGGKALGWFFTASFISLLIGLFYVNILEPGVGLKLSHVDMASASEVTAKTQNLSFENFVEHIVPKSIIEAMAT
NEILQIVIFSIFFGLAAASLGNTVKPVIGALDKISHIVLKMVNYVMNFAPIGVFGAIAAVFAIRDAEELLITYFKFFGSF
LLGIGTLWVVLIAVGFIFLGRRMVELLRRIIGPLAIAFGTTSSEAVFPKLTEELESFGVKDRIVSFMLPLGYSFNLDGSM
MYMTFASIFIAQFYNVHLDLGTQMAMLLVLMLTSKGIAGVPRASLVVVAATCGMFDIPVEGIALILPIDHFCDMFRSATN
VLGNALATSVVGQWEGNDTAENVIEN

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=423, Percent_Identity=26.9503546099291, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI194239697, Length=466, Percent_Identity=24.8927038626609, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI169790839, Length=464, Percent_Identity=24.7844827586207, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI66773030, Length=443, Percent_Identity=25.5079006772009, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI40254478, Length=471, Percent_Identity=25.2653927813163, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4827012, Length=430, Percent_Identity=25.1162790697674, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI5032093, Length=399, Percent_Identity=29.0726817042606, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI223468566, Length=271, Percent_Identity=30.9963099630996, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI223468564, Length=272, Percent_Identity=30.8823529411765, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI262359914, Length=389, Percent_Identity=24.4215938303342, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI301601644, Length=117, Percent_Identity=34.1880341880342, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790514, Length=416, Percent_Identity=38.9423076923077, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1789947, Length=416, Percent_Identity=34.6153846153846, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI1788024, Length=382, Percent_Identity=26.1780104712042, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1789473, Length=291, Percent_Identity=27.4914089347079, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71983106, Length=443, Percent_Identity=25.9593679458239, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193206505, Length=425, Percent_Identity=26.5882352941176, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71983099, Length=443, Percent_Identity=25.9593679458239, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17537407, Length=406, Percent_Identity=26.1083743842365, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193206654, Length=441, Percent_Identity=25.3968253968254, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71996953, Length=446, Percent_Identity=25.3363228699552, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17541374, Length=401, Percent_Identity=23.1920199501247, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583025, Length=456, Percent_Identity=26.9736842105263, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI17137668, Length=456, Percent_Identity=26.9736842105263, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24583023, Length=456, Percent_Identity=26.9736842105263, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI281360483, Length=454, Percent_Identity=27.0925110132159, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17137666, Length=454, Percent_Identity=27.0925110132159, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281360481, Length=454, Percent_Identity=27.0925110132159, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46046; Mature: 46046

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCC
>Mature Secondary Structure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HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA