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The map label for this gene is dnaX [H]

Identifier: 146302257

GI number: 146302257

Start: 5469225

End: 5470310

Strand: Direct

Name: dnaX [H]

Synonym: Fjoh_4530

Alternate gene names: 146302257

Gene position: 5469225-5470310 (Clockwise)

Preceding gene: 146302251

Following gene: 146302258

Centisome position: 89.71

GC content: 36.65

Gene sequence:

>1086_bases
ATGGAACAATTTGTAGTATCGGCTCGTAAATACCGTCCGCAGACATTTAAGGATGTTGTGGGACAAAAAGCCATTACCAA
CACTTTGTTGAACGCTATCGAAAGCAATCACCTGGCTTCGGCTCTTTTATTTACGGGACCTCGTGGAGTTGGTAAAACAA
CCTGCGCTCGTATTTTGGCTCGAAAAATAAATCAGCCTGGATATGATGATCCTACAGAAGATTTTGCTTTTAACGTTTTT
GAGCTGGATGCTGCTTCAAACAACTCGGTTGATGATATTCGTAATCTTATCGATCAGGTTAGAATTCCGCCGCAAACAGG
ACAATATAAAGTATATATCATTGACGAGGTTCATATGTTGTCTTCTGCCGCTTTTAATGCTTTCCTTAAAACATTAGAAG
AGCCGCCAAAGCACGCTATTTTCATTTTAGCTACAACAGAAAAACACAAAATCCTTCCAACGATTTTATCACGTTGTCAG
ATTTTTGATTTTAAACGAATTACAGTTAAAGATGCTAAAGAACATTTAGCAGATGTTGCTGAAAGTCAAGGAATCAATTT
TGAAGACGATGCATTACACATTATTGCTCAAAAAGCAGATGGTGCAATGCGTGATGCGTTATCTATTTTTGACCGTGTCG
TTTCGTATTGCGGTACTAACCTGACACGTCAGGCTGTAACGGAAAACTTAAATGTTTTAGATTACGAAACCTATATTACA
GTTACAGATTTAATTCTTGAAAATAAAATTCCGGATCTTTTAATTGCTTACAACGATATTCTTGCAAAAGGTTTTGACGG
GCATCATTTTATTGCCGGATTAGCGTCTCATTTTAGAGATTTATTAGTCAGCAAAACACCTTCGACTATTGCTTTATTAG
AAGTTGGAGAACAAGCACAGCAGATGTACGGAGTACAATCTCAAAAGTGTTCTCAGGAATTTCTATTAAAAGGAATTGAC
ATTGCAAACGACTGCGACCTAAAATACAAATTGAGTCAAAATCAGCGTCTTTTAGTTGAATTATGTTTGATGCAATTGGC
CTCTATCAACTTTGATGGAGAAAAAAAAAAGTTGAGCAATTCATAA

Upstream 100 bases:

>100_bases
CTCAGATTCAAACTACTCAAAATCTTCTCTAAGATTTATGATTTTCAGATTTGTGATTTGGTAATTTTCAGCCTATATTT
GCTATCGAATAAAAAAGAAT

Downstream 100 bases:

>100_bases
TTCCGCCCACTTATTATAAAAATGGAAGTTTTTCAATTGTTGAAGTTCCAAATTTAAAATCTCAAACTCCAAATAAGGAA
GAAAATAGCAATGTCACTCA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MEQFVVSARKYRPQTFKDVVGQKAITNTLLNAIESNHLASALLFTGPRGVGKTTCARILARKINQPGYDDPTEDFAFNVF
ELDAASNNSVDDIRNLIDQVRIPPQTGQYKVYIIDEVHMLSSAAFNAFLKTLEEPPKHAIFILATTEKHKILPTILSRCQ
IFDFKRITVKDAKEHLADVAESQGINFEDDALHIIAQKADGAMRDALSIFDRVVSYCGTNLTRQAVTENLNVLDYETYIT
VTDLILENKIPDLLIAYNDILAKGFDGHHFIAGLASHFRDLLVSKTPSTIALLEVGEQAQQMYGVQSQKCSQEFLLKGID
IANDCDLKYKLSQNQRLLVELCLMQLASINFDGEKKKLSNS

Sequences:

>Translated_361_residues
MEQFVVSARKYRPQTFKDVVGQKAITNTLLNAIESNHLASALLFTGPRGVGKTTCARILARKINQPGYDDPTEDFAFNVF
ELDAASNNSVDDIRNLIDQVRIPPQTGQYKVYIIDEVHMLSSAAFNAFLKTLEEPPKHAIFILATTEKHKILPTILSRCQ
IFDFKRITVKDAKEHLADVAESQGINFEDDALHIIAQKADGAMRDALSIFDRVVSYCGTNLTRQAVTENLNVLDYETYIT
VTDLILENKIPDLLIAYNDILAKGFDGHHFIAGLASHFRDLLVSKTPSTIALLEVGEQAQQMYGVQSQKCSQEFLLKGID
IANDCDLKYKLSQNQRLLVELCLMQLASINFDGEKKKLSNS
>Mature_361_residues
MEQFVVSARKYRPQTFKDVVGQKAITNTLLNAIESNHLASALLFTGPRGVGKTTCARILARKINQPGYDDPTEDFAFNVF
ELDAASNNSVDDIRNLIDQVRIPPQTGQYKVYIIDEVHMLSSAAFNAFLKTLEEPPKHAIFILATTEKHKILPTILSRCQ
IFDFKRITVKDAKEHLADVAESQGINFEDDALHIIAQKADGAMRDALSIFDRVVSYCGTNLTRQAVTENLNVLDYETYIT
VTDLILENKIPDLLIAYNDILAKGFDGHHFIAGLASHFRDLLVSKTPSTIALLEVGEQAQQMYGVQSQKCSQEFLLKGID
IANDCDLKYKLSQNQRLLVELCLMQLASINFDGEKKKLSNS

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=288, Percent_Identity=25, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI31881687, Length=288, Percent_Identity=25, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI6677723, Length=248, Percent_Identity=29.8387096774194, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI194306571, Length=248, Percent_Identity=29.8387096774194, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI194306567, Length=248, Percent_Identity=29.8387096774194, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI31563534, Length=203, Percent_Identity=31.0344827586207, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1786676, Length=280, Percent_Identity=38.9285714285714, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1787119, Length=216, Percent_Identity=29.1666666666667, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17541988, Length=257, Percent_Identity=28.0155642023346, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17554730, Length=206, Percent_Identity=27.6699029126214, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71986063, Length=231, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324478, Length=263, Percent_Identity=25.8555133079848, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324039, Length=203, Percent_Identity=29.5566502463054, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322528, Length=290, Percent_Identity=21.3793103448276, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17647857, Length=202, Percent_Identity=31.1881188118812, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI18859927, Length=212, Percent_Identity=28.7735849056604, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921076, Length=209, Percent_Identity=26.7942583732057, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 40373; Mature: 40373

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQFVVSARKYRPQTFKDVVGQKAITNTLLNAIESNHLASALLFTGPRGVGKTTCARILA
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RKINQPGYDDPTEDFAFNVFELDAASNNSVDDIRNLIDQVRIPPQTGQYKVYIIDEVHML
HHCCCCCCCCCCHHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECHHHHH
SSAAFNAFLKTLEEPPKHAIFILATTEKHKILPTILSRCQIFDFKRITVKDAKEHLADVA
HHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ESQGINFEDDALHIIAQKADGAMRDALSIFDRVVSYCGTNLTRQAVTENLNVLDYETYIT
HHCCCCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEHHHHH
VTDLILENKIPDLLIAYNDILAKGFDGHHFIAGLASHFRDLLVSKTPSTIALLEVGEQAQ
HHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHH
QMYGVQSQKCSQEFLLKGIDIANDCDLKYKLSQNQRLLVELCLMQLASINFDGEKKKLSN
HHHCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHCCC
S
C
>Mature Secondary Structure
MEQFVVSARKYRPQTFKDVVGQKAITNTLLNAIESNHLASALLFTGPRGVGKTTCARILA
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RKINQPGYDDPTEDFAFNVFELDAASNNSVDDIRNLIDQVRIPPQTGQYKVYIIDEVHML
HHCCCCCCCCCCHHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECHHHHH
SSAAFNAFLKTLEEPPKHAIFILATTEKHKILPTILSRCQIFDFKRITVKDAKEHLADVA
HHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ESQGINFEDDALHIIAQKADGAMRDALSIFDRVVSYCGTNLTRQAVTENLNVLDYETYIT
HHCCCCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEHHHHH
VTDLILENKIPDLLIAYNDILAKGFDGHHFIAGLASHFRDLLVSKTPSTIALLEVGEQAQ
HHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHH
QMYGVQSQKCSQEFLLKGIDIANDCDLKYKLSQNQRLLVELCLMQLASINFDGEKKKLSN
HHHCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]