Click here to switch to the map view.

The map label for this gene is czcA [H]

Identifier: 146302191

GI number: 146302191

Start: 5378795

End: 5383135

Strand: Direct

Name: czcA [H]

Synonym: Fjoh_4462

Alternate gene names: 146302191

Gene position: 5378795-5383135 (Clockwise)

Preceding gene: 146302190

Following gene: 146302192

Centisome position: 88.22

GC content: 42.46

Gene sequence:

>4341_bases
ATGCTTACTAAAATCATTGAGTTTTCCGTAAGGAATAAACTCATCATAGGGCTTTTGGTCATTGCGCTCATTGGAATTGG
CACCTACCAAACCACAAAATTACCAATTGATGCTGTGCCCGACATCACCAATAACCAGGTACAGGTCATCACGATAGCAC
CTTCTTTTGGTGCGACGGATATAGAACGCCTGGTTACCTTCCCCATAGAACAAGCAACGGGCAACATTTCCGGCACCAAA
GAAATACGCAGCTTTTCCCGTTTTGGACTCTCGCTCGTTACCATTGTTTTTGATGATGATATAGATGTTTATTGGGCAAG
ACAACAGGTGGCTGAACGTTTGCAGCAAGTGCAAAGTCAAATCCCCCAGGGGATCGGCACACCGGCATTAGGACCAATTT
CTACCGGCTTGGGCGAAATATATCAATATGTAGTCCGTCCCAAAAAAGGTTACGAACAAAAATATGACATCGCCGAACTG
CGTACCATTCAGGACTGGATTGTGCGCAGGCAGTTATTAAGCGTAAAGGGGGTTGCTGAAGTGAGTAGTTTCGGTGGCAA
ACTCAAGCAATATGAAATTGCAGTAAACCCTGACAAACTCAATGCCTACGGGATTAGCATCAACGATATTTTTTTGGCTT
TGGAAGAAAACAATCAAAATACCGGTGGTGCATATATCGAAAAAGGGCCTACCGTTTTATATGTCCGCAGCGAAGGCCTG
ATAGGCAGCCTGGAAGATATCGGCAATATTTCCATTGCCAATAAAAACAACGAAACACCTTTGTTTATCCGTGATGTGGC
AAACGTGAAAATGGGTTATGCCACTCGTTATGGGGCTATGACTTACAACGATCAGGGCGAAGTTTCGGGTGCCGTAGTGA
TGATGCTGAAAGGTGCAAACAGCAGCGAAGTCATCAAGAATGTAAAAGCTAAAGTAGCGCAAATACAGAAAACCCTACCC
GAAGGCGTAGTTGTTGAGCCTTTCCTGGATCGTACCAAAATGGTCAATAATGCCATCAGTACAGTCGAAAAAAACCTGAT
GGAAGGCGCACTGATTGTAGTGCTCGTTTTGGTTTTGTTCCTTGGGAATTTCAGGGCGGGATTGTTGGTTGCTTCGGTTA
TTCCACTGGCCATGCTTTTTGCCATCTGTATGATGAATTTGTTTGGGGTAAGCGGCAACCTGATGAGCCTTGGAGCCTTG
GATTTCGGACTGATTATAGACGGTGCAGTCATCATTGTGGAATCGGTGATGCACCAACTGTCGCATAACGCCAGATTTCA
GCAAATGACCAATTTATCCAAAAAGGAAATGAATAATACGGTAATTGGTTCTGCGGGAAAAATGATGAACAGTGCTGTAT
TCGGGCAGATCATCATTCTGATCGTTTACCTTCCCATCCTAAGTTTGCAAGGTATAGAAGGCAAAATGTTCCGACCGATG
GCACAGACCGTAGCCTTTGCTTTATTGGGCGCATTTTTATTATCGCTTACCTATATCCCAATGATGAGTTCCTGGGTACT
GAGCAGGAAAATCAGCCATAAACACAATCTTTCAGACAGGGTTATGCGTCGTGTAGAAGCCTTCTACCAAAAATTTTTGT
TAAAAGCCATCCGCATCCCCAAACGCATTATTGCTGTTGTTTCGGTTTTATTTATTGTGGCCATTTTCGTGATGTCGAGA
TTGGGAGGCGAGTTTATCCCCTCTTTGGAAGAAGGCGATTTTGCAGTGGATACCAGGGTCTTAACGGGAAGTAACCTTAA
TACGACCATTGCAAGTACCCAAAAGGCTGCTCACATCCTAAAAACACGCTTTCCTGAAGTGATAAAAGTAGTAACCAAAA
TAGGTAGCGGCGAGGTACCCACAGACCCGATGCCGATGGACGCCAGCGATATGATGGTGATTCTGAAAGACAAAAGCGAA
TGGACATCTGCCAAAACTTTTCCGGAACTATCCGAGAAAATGAGCAAGGCCTTGGAAGATGTACCGGGAATTACCGCAGG
TTTTCAATATCCAGTAAATATGCGGTTCAATGAACTGATGACGGGTGCAAGACAGGATGTGGTACTGAAAATTTTTGGGG
ATGATTTGGATTCCCTGGCAGCGACGGCTGACAAATTAGGCAAAATAATCAATACGGTTGATGGCGTACAAAACCTTTAT
GTAGAACCTATAACCGGAATGCCTCAGGTTATTATTACCTATAACCGCCCAATGATTGCCCAATACCATTTGTCTGTAGC
CGGCATCAACAAGGTGGTCAATACAGCATTTGCCGGACAAAGCACCGGTTTGGTTTTCGAAGGCGAAAAACGTTTTGATA
TGGTTGTAAAACTAAATGCCGACGTGCGGAAGAATCTGGAAGACGTACAGAATTTATTGATTCCTATACCTTCTGGCAAT
CAGATTCCACTTTCACAGTTGGCAGAAGTGCAGATCAAAGATGGTCCCAATCAAATTCAGCGGGAGAATACACAACGCAG
GATTATTGTCGGCTTCAACATAAAAGGCCGGGATGTGCAAAGTATTGTTCAGGAATTGCAAGCCAAAGTGAATGCGCAAA
TCAAGCTTCCGGCCGGGTATTCTATTACTTATGGCGGTTCGTTCGAGAATCTGAACCAGGCAAAAAGCCGTTTGATGGTT
GCGGTGCCTATCTCATTGGCTTTGATATTCATTCTCTTATTTTTTGCTTTTAAATCGGTGAAGGAAAGTTTATTGATTTA
TACCGCAATCCCATTATCCACCATTGGCGGAATTTTCTTTTTAGCGCTTCGGGGAATGCCTTTTAGCATAAGTGCCGGTA
TAGGTTTCATTGCACTGTTCGGCGTGGCTGTTTTAAATGGAATTGTTTTGGTCGCCGAATTCAACCGTTTAAAAAAATCA
GGAATCAAAAACATTGTCCGCATCGTGGTAGACGGAACAGAATCCCGTTTGCGCCCCGTGCTGATGACCGCATTTGTGGC
TTCATTGGGTTTTATTCCAATGGCGCTGAGCAATGGTGCAGGTGCAGAGGTACAACGTCCGCTGGCAACAGTAGTTATTG
GTGGACTGATGGGGGCTACTTTACTCACATTATTCGTTCTTCCTTTATTGTTCATCGCATTTGAAAAAGGTTTTACAATG
AATCCATTCAAGAAAAAAGCAATCACATTATTGATCGTTTCAGGGATTTCTTTAATGGGAATGGGTTCTGTTAAAGCACA
GGAAAAAATCACTTTAGACAGGGCTATTGCATTGGCTGTTCAAAATAATCAAAATTTAAGAACTGAAAAACTAAAAGCAG
ATTATGCCAAGGCCATAATCAAAACTTCGGCTGATATTCCGCAGACCGGTATCACGGCTGATTACGGTCAGATCAACAGT
GCATACAACGATACCAAGTTCGGAATTTCACAGAATATCGCATTTCCAACGGTTTATAAAAGGCAGAAAGAATTGTTTAC
ACAGGAATGGAAATACAGTTTGCTGAATGTTTCGTTGAAAGAATTTGAATTAAAAAAAGCCGTTACCCAAACTTTTTATG
CCATCCTGTTCTGGCAGGAAAAGGAAAGGCTGCTACTAAAAGCAGATTCCTTATACGCTGATTTTTATGCCAAATCCTTG
TTGCGCCTGCAAAAAGGAGAAAGCAATATTTTGGAAAAAATCACTGCACAGAATCAAAAGGCTGCTATCAATATCCAGTT
GAAACAGGTGCAGCGAGAATTAGAAACAGCGAAGTTGCAGTGGCAATGGTTGTTAAATTCGGATACGGTCTATAAAGTGG
AATCCCCTGAAAAAATAATTCCGCTACAGGTGGATGAAACCAGCAAAAATCCTGTTATACAGGTTTTGGAACAGCAGAAA
AATATTGCAGCGAGCCAAACCAAAGTAGAAAAATCCAAGTTGCTGCCCGGTTTGATGATTGGTTACAATCTCAACAGTTT
CAAGGGAACCGGAGCCGATGATAAGTTATACAACGCTTCCCCTCAATTCCATTCTGTACAGGTTGGTTTTTCCATTCCTG
TTTTTTCGCAGTCGCAAAGAGCGAGAATCAATGCTTCCAAAATCACGGAAAGTATTACCGAAAACCAATTGCAGGCTACA
AGTGCTTATTTGCAGAACCGGTATAAACAACTCTCGGAAAACTATCAGCGCAATTTGGAAATTGTAAACTATTATGAAAG
TGAAGGGCTAAAAAATGCGGCAGTCGTTACCGAAACAATACAAAAGCAGTTCACCAACGGGGAAATCAATTACCTGGACT
TTGTAATGCTCATAAATCAAGCCATCAGTATTCAAAGTAATTACGCTGATGCTGTCAAAATGCTGAACGATACTATTATA
CAAATCAATTATCTCAATTAA

Upstream 100 bases:

>100_bases
GTGATTGTCAATTGGTTAATCCTGTTATTTTATTTACGATAAATACTGCTGTATCTATTTGTAATTGTATTGAATAATAA
TTTGATTAACAAGTAAAACT

Downstream 100 bases:

>100_bases
ATTCTTATGACAATGTATTCATTCGATATAAAAAATAAAAACCGGGGCAAGCTGAAAATACTGCTCCCCGTTCTGGGAAT
ATTGTTGCTGGTTCAATGCC

Product: CzcA family heavy metal efflux protein

Products: Proton [Cytoplasm]; silver [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 1446; Mature: 1446

Protein sequence:

>1446_residues
MLTKIIEFSVRNKLIIGLLVIALIGIGTYQTTKLPIDAVPDITNNQVQVITIAPSFGATDIERLVTFPIEQATGNISGTK
EIRSFSRFGLSLVTIVFDDDIDVYWARQQVAERLQQVQSQIPQGIGTPALGPISTGLGEIYQYVVRPKKGYEQKYDIAEL
RTIQDWIVRRQLLSVKGVAEVSSFGGKLKQYEIAVNPDKLNAYGISINDIFLALEENNQNTGGAYIEKGPTVLYVRSEGL
IGSLEDIGNISIANKNNETPLFIRDVANVKMGYATRYGAMTYNDQGEVSGAVVMMLKGANSSEVIKNVKAKVAQIQKTLP
EGVVVEPFLDRTKMVNNAISTVEKNLMEGALIVVLVLVLFLGNFRAGLLVASVIPLAMLFAICMMNLFGVSGNLMSLGAL
DFGLIIDGAVIIVESVMHQLSHNARFQQMTNLSKKEMNNTVIGSAGKMMNSAVFGQIIILIVYLPILSLQGIEGKMFRPM
AQTVAFALLGAFLLSLTYIPMMSSWVLSRKISHKHNLSDRVMRRVEAFYQKFLLKAIRIPKRIIAVVSVLFIVAIFVMSR
LGGEFIPSLEEGDFAVDTRVLTGSNLNTTIASTQKAAHILKTRFPEVIKVVTKIGSGEVPTDPMPMDASDMMVILKDKSE
WTSAKTFPELSEKMSKALEDVPGITAGFQYPVNMRFNELMTGARQDVVLKIFGDDLDSLAATADKLGKIINTVDGVQNLY
VEPITGMPQVIITYNRPMIAQYHLSVAGINKVVNTAFAGQSTGLVFEGEKRFDMVVKLNADVRKNLEDVQNLLIPIPSGN
QIPLSQLAEVQIKDGPNQIQRENTQRRIIVGFNIKGRDVQSIVQELQAKVNAQIKLPAGYSITYGGSFENLNQAKSRLMV
AVPISLALIFILLFFAFKSVKESLLIYTAIPLSTIGGIFFLALRGMPFSISAGIGFIALFGVAVLNGIVLVAEFNRLKKS
GIKNIVRIVVDGTESRLRPVLMTAFVASLGFIPMALSNGAGAEVQRPLATVVIGGLMGATLLTLFVLPLLFIAFEKGFTM
NPFKKKAITLLIVSGISLMGMGSVKAQEKITLDRAIALAVQNNQNLRTEKLKADYAKAIIKTSADIPQTGITADYGQINS
AYNDTKFGISQNIAFPTVYKRQKELFTQEWKYSLLNVSLKEFELKKAVTQTFYAILFWQEKERLLLKADSLYADFYAKSL
LRLQKGESNILEKITAQNQKAAINIQLKQVQRELETAKLQWQWLLNSDTVYKVESPEKIIPLQVDETSKNPVIQVLEQQK
NIAASQTKVEKSKLLPGLMIGYNLNSFKGTGADDKLYNASPQFHSVQVGFSIPVFSQSQRARINASKITESITENQLQAT
SAYLQNRYKQLSENYQRNLEIVNYYESEGLKNAAVVTETIQKQFTNGEINYLDFVMLINQAISIQSNYADAVKMLNDTII
QINYLN

Sequences:

>Translated_1446_residues
MLTKIIEFSVRNKLIIGLLVIALIGIGTYQTTKLPIDAVPDITNNQVQVITIAPSFGATDIERLVTFPIEQATGNISGTK
EIRSFSRFGLSLVTIVFDDDIDVYWARQQVAERLQQVQSQIPQGIGTPALGPISTGLGEIYQYVVRPKKGYEQKYDIAEL
RTIQDWIVRRQLLSVKGVAEVSSFGGKLKQYEIAVNPDKLNAYGISINDIFLALEENNQNTGGAYIEKGPTVLYVRSEGL
IGSLEDIGNISIANKNNETPLFIRDVANVKMGYATRYGAMTYNDQGEVSGAVVMMLKGANSSEVIKNVKAKVAQIQKTLP
EGVVVEPFLDRTKMVNNAISTVEKNLMEGALIVVLVLVLFLGNFRAGLLVASVIPLAMLFAICMMNLFGVSGNLMSLGAL
DFGLIIDGAVIIVESVMHQLSHNARFQQMTNLSKKEMNNTVIGSAGKMMNSAVFGQIIILIVYLPILSLQGIEGKMFRPM
AQTVAFALLGAFLLSLTYIPMMSSWVLSRKISHKHNLSDRVMRRVEAFYQKFLLKAIRIPKRIIAVVSVLFIVAIFVMSR
LGGEFIPSLEEGDFAVDTRVLTGSNLNTTIASTQKAAHILKTRFPEVIKVVTKIGSGEVPTDPMPMDASDMMVILKDKSE
WTSAKTFPELSEKMSKALEDVPGITAGFQYPVNMRFNELMTGARQDVVLKIFGDDLDSLAATADKLGKIINTVDGVQNLY
VEPITGMPQVIITYNRPMIAQYHLSVAGINKVVNTAFAGQSTGLVFEGEKRFDMVVKLNADVRKNLEDVQNLLIPIPSGN
QIPLSQLAEVQIKDGPNQIQRENTQRRIIVGFNIKGRDVQSIVQELQAKVNAQIKLPAGYSITYGGSFENLNQAKSRLMV
AVPISLALIFILLFFAFKSVKESLLIYTAIPLSTIGGIFFLALRGMPFSISAGIGFIALFGVAVLNGIVLVAEFNRLKKS
GIKNIVRIVVDGTESRLRPVLMTAFVASLGFIPMALSNGAGAEVQRPLATVVIGGLMGATLLTLFVLPLLFIAFEKGFTM
NPFKKKAITLLIVSGISLMGMGSVKAQEKITLDRAIALAVQNNQNLRTEKLKADYAKAIIKTSADIPQTGITADYGQINS
AYNDTKFGISQNIAFPTVYKRQKELFTQEWKYSLLNVSLKEFELKKAVTQTFYAILFWQEKERLLLKADSLYADFYAKSL
LRLQKGESNILEKITAQNQKAAINIQLKQVQRELETAKLQWQWLLNSDTVYKVESPEKIIPLQVDETSKNPVIQVLEQQK
NIAASQTKVEKSKLLPGLMIGYNLNSFKGTGADDKLYNASPQFHSVQVGFSIPVFSQSQRARINASKITESITENQLQAT
SAYLQNRYKQLSENYQRNLEIVNYYESEGLKNAAVVTETIQKQFTNGEINYLDFVMLINQAISIQSNYADAVKMLNDTII
QINYLN
>Mature_1446_residues
MLTKIIEFSVRNKLIIGLLVIALIGIGTYQTTKLPIDAVPDITNNQVQVITIAPSFGATDIERLVTFPIEQATGNISGTK
EIRSFSRFGLSLVTIVFDDDIDVYWARQQVAERLQQVQSQIPQGIGTPALGPISTGLGEIYQYVVRPKKGYEQKYDIAEL
RTIQDWIVRRQLLSVKGVAEVSSFGGKLKQYEIAVNPDKLNAYGISINDIFLALEENNQNTGGAYIEKGPTVLYVRSEGL
IGSLEDIGNISIANKNNETPLFIRDVANVKMGYATRYGAMTYNDQGEVSGAVVMMLKGANSSEVIKNVKAKVAQIQKTLP
EGVVVEPFLDRTKMVNNAISTVEKNLMEGALIVVLVLVLFLGNFRAGLLVASVIPLAMLFAICMMNLFGVSGNLMSLGAL
DFGLIIDGAVIIVESVMHQLSHNARFQQMTNLSKKEMNNTVIGSAGKMMNSAVFGQIIILIVYLPILSLQGIEGKMFRPM
AQTVAFALLGAFLLSLTYIPMMSSWVLSRKISHKHNLSDRVMRRVEAFYQKFLLKAIRIPKRIIAVVSVLFIVAIFVMSR
LGGEFIPSLEEGDFAVDTRVLTGSNLNTTIASTQKAAHILKTRFPEVIKVVTKIGSGEVPTDPMPMDASDMMVILKDKSE
WTSAKTFPELSEKMSKALEDVPGITAGFQYPVNMRFNELMTGARQDVVLKIFGDDLDSLAATADKLGKIINTVDGVQNLY
VEPITGMPQVIITYNRPMIAQYHLSVAGINKVVNTAFAGQSTGLVFEGEKRFDMVVKLNADVRKNLEDVQNLLIPIPSGN
QIPLSQLAEVQIKDGPNQIQRENTQRRIIVGFNIKGRDVQSIVQELQAKVNAQIKLPAGYSITYGGSFENLNQAKSRLMV
AVPISLALIFILLFFAFKSVKESLLIYTAIPLSTIGGIFFLALRGMPFSISAGIGFIALFGVAVLNGIVLVAEFNRLKKS
GIKNIVRIVVDGTESRLRPVLMTAFVASLGFIPMALSNGAGAEVQRPLATVVIGGLMGATLLTLFVLPLLFIAFEKGFTM
NPFKKKAITLLIVSGISLMGMGSVKAQEKITLDRAIALAVQNNQNLRTEKLKADYAKAIIKTSADIPQTGITADYGQINS
AYNDTKFGISQNIAFPTVYKRQKELFTQEWKYSLLNVSLKEFELKKAVTQTFYAILFWQEKERLLLKADSLYADFYAKSL
LRLQKGESNILEKITAQNQKAAINIQLKQVQRELETAKLQWQWLLNSDTVYKVESPEKIIPLQVDETSKNPVIQVLEQQK
NIAASQTKVEKSKLLPGLMIGYNLNSFKGTGADDKLYNASPQFHSVQVGFSIPVFSQSQRARINASKITESITENQLQAT
SAYLQNRYKQLSENYQRNLEIVNYYESEGLKNAAVVTETIQKQFTNGEINYLDFVMLINQAISIQSNYADAVKMLNDTII
QINYLN

Specific function: Has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance. CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete CZC efflux system (CzcABC) [H]

COG id: COG3696

COG function: function code P; Putative silver efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AcrB/AcrD/AcrF (TC 2.A.6) family [H]

Homologues:

Organism=Escherichia coli, GI1786788, Length=1044, Percent_Identity=31.6091954022989, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI1788814, Length=1077, Percent_Identity=24.0482822655525, Blast_Score=258, Evalue=2e-69,
Organism=Escherichia coli, GI1788391, Length=1042, Percent_Identity=22.2648752399232, Blast_Score=219, Evalue=9e-58,
Organism=Escherichia coli, GI1788390, Length=1040, Percent_Identity=22.3076923076923, Blast_Score=201, Evalue=3e-52,
Organism=Escherichia coli, GI1786667, Length=1070, Percent_Identity=22.5233644859813, Blast_Score=200, Evalue=6e-52,
Organism=Escherichia coli, GI1789930, Length=1047, Percent_Identity=23.1136580706781, Blast_Score=197, Evalue=3e-51,
Organism=Escherichia coli, GI1789666, Length=1067, Percent_Identity=23.805060918463, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001036
- InterPro:   IPR004763 [H]

Pfam domain/function: PF00873 ACR_tran [H]

EC number: NA

Molecular weight: Translated: 159702; Mature: 159702

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKIIEFSVRNKLIIGLLVIALIGIGTYQTTKLPIDAVPDITNNQVQVITIAPSFGATD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCEEEEEEECCCCCHH
IERLVTFPIEQATGNISGTKEIRSFSRFGLSLVTIVFDDDIDVYWARQQVAERLQQVQSQ
HHHHHHCCHHHCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCEEHHHHHHHHHHHHHHH
IPQGIGTPALGPISTGLGEIYQYVVRPKKGYEQKYDIAELRTIQDWIVRRQLLSVKGVAE
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VSSFGGKLKQYEIAVNPDKLNAYGISINDIFLALEENNQNTGGAYIEKGPTVLYVRSEGL
HHHHCCCCEEEEEEECCCCCEEEEEEHEEEEEEEECCCCCCCCCEEECCCEEEEEECCCC
IGSLEDIGNISIANKNNETPLFIRDVANVKMGYATRYGAMTYNDQGEVSGAVVMMLKGAN
EECHHHCCCEEEECCCCCCCEEEEEHHCCCCCCEEECCCEEECCCCCCCCEEEEEEECCC
SSEVIKNVKAKVAQIQKTLPEGVVVEPFLDRTKMVNNAISTVEKNLMEGALIVVLVLVLF
HHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGNFRAGLLVASVIPLAMLFAICMMNLFGVSGNLMSLGALDFGLIIDGAVIIVESVMHQL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
SHNARFQQMTNLSKKEMNNTVIGSAGKMMNSAVFGQIIILIVYLPILSLQGIEGKMFRPM
HCCHHHHHHHCCHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AQTVAFALLGAFLLSLTYIPMMSSWVLSRKISHKHNLSDRVMRRVEAFYQKFLLKAIRIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCH
KRIIAVVSVLFIVAIFVMSRLGGEFIPSLEEGDFAVDTRVLTGSNLNTTIASTQKAAHIL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHH
KTRFPEVIKVVTKIGSGEVPTDPMPMDASDMMVILKDKSEWTSAKTFPELSEKMSKALED
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
VPGITAGFQYPVNMRFNELMTGARQDVVLKIFGDDLDSLAATADKLGKIINTVDGVQNLY
CCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHE
VEPITGMPQVIITYNRPMIAQYHLSVAGINKVVNTAFAGQSTGLVFEGEKRFDMVVKLNA
ECCCCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECC
DVRKNLEDVQNLLIPIPSGNQIPLSQLAEVQIKDGPNQIQRENTQRRIIVGFNIKGRDVQ
HHHCCHHHHHHHEEECCCCCCCCHHHHHEEEECCCCHHHHHCCCCEEEEEEECCCCCHHH
SIVQELQAKVNAQIKLPAGYSITYGGSFENLNQAKSRLMVAVPISLALIFILLFFAFKSV
HHHHHHHHHHCCEEEECCCCEEEECCCHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHH
KESLLIYTAIPLSTIGGIFFLALRGMPFSISAGIGFIALFGVAVLNGIVLVAEFNRLKKS
HHHEEEEEECCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHEEEEHHHHHHHHH
GIKNIVRIVVDGTESRLRPVLMTAFVASLGFIPMALSNGAGAEVQRPLATVVIGGLMGAT
HHHHHHHHEECCCHHHHHHHHHHHHHHHHCCHHHEECCCCCCHHHHHHHHHHHHHHHHHH
LLTLFVLPLLFIAFEKGFTMNPFKKKAITLLIVSGISLMGMGSVKAQEKITLDRAIALAV
HHHHHHHHHHHHHHHCCCCCCCHHHHHEEEEEECCCHHCCCCCCCHHHHHHHHHEEEEEE
QNNQNLRTEKLKADYAKAIIKTSADIPQTGITADYGQINSAYNDTKFGISQNIAFPTVYK
ECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RQKELFTQEWKYSLLNVSLKEFELKKAVTQTFYAILFWQEKERLLLKADSLYADFYAKSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEHHHHHHHHHHHHH
LRLQKGESNILEKITAQNQKAAINIQLKQVQRELETAKLQWQWLLNSDTVYKVESPEKII
HHHHCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHEEEEEEECCCEEEEECCCCEEE
PLQVDETSKNPVIQVLEQQKNIAASQTKVEKSKLLPGLMIGYNLNSFKGTGADDKLYNAS
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCC
PQFHSVQVGFSIPVFSQSQRARINASKITESITENQLQATSAYLQNRYKQLSENYQRNLE
CCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IVNYYESEGLKNAAVVTETIQKQFTNGEINYLDFVMLINQAISIQSNYADAVKMLNDTII
EEEEEHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEE
QINYLN
EEEECC
>Mature Secondary Structure
MLTKIIEFSVRNKLIIGLLVIALIGIGTYQTTKLPIDAVPDITNNQVQVITIAPSFGATD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCEEEEEEECCCCCHH
IERLVTFPIEQATGNISGTKEIRSFSRFGLSLVTIVFDDDIDVYWARQQVAERLQQVQSQ
HHHHHHCCHHHCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCEEHHHHHHHHHHHHHHH
IPQGIGTPALGPISTGLGEIYQYVVRPKKGYEQKYDIAELRTIQDWIVRRQLLSVKGVAE
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VSSFGGKLKQYEIAVNPDKLNAYGISINDIFLALEENNQNTGGAYIEKGPTVLYVRSEGL
HHHHCCCCEEEEEEECCCCCEEEEEEHEEEEEEEECCCCCCCCCEEECCCEEEEEECCCC
IGSLEDIGNISIANKNNETPLFIRDVANVKMGYATRYGAMTYNDQGEVSGAVVMMLKGAN
EECHHHCCCEEEECCCCCCCEEEEEHHCCCCCCEEECCCEEECCCCCCCCEEEEEEECCC
SSEVIKNVKAKVAQIQKTLPEGVVVEPFLDRTKMVNNAISTVEKNLMEGALIVVLVLVLF
HHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGNFRAGLLVASVIPLAMLFAICMMNLFGVSGNLMSLGALDFGLIIDGAVIIVESVMHQL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
SHNARFQQMTNLSKKEMNNTVIGSAGKMMNSAVFGQIIILIVYLPILSLQGIEGKMFRPM
HCCHHHHHHHCCHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AQTVAFALLGAFLLSLTYIPMMSSWVLSRKISHKHNLSDRVMRRVEAFYQKFLLKAIRIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCH
KRIIAVVSVLFIVAIFVMSRLGGEFIPSLEEGDFAVDTRVLTGSNLNTTIASTQKAAHIL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHH
KTRFPEVIKVVTKIGSGEVPTDPMPMDASDMMVILKDKSEWTSAKTFPELSEKMSKALED
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
VPGITAGFQYPVNMRFNELMTGARQDVVLKIFGDDLDSLAATADKLGKIINTVDGVQNLY
CCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHE
VEPITGMPQVIITYNRPMIAQYHLSVAGINKVVNTAFAGQSTGLVFEGEKRFDMVVKLNA
ECCCCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECC
DVRKNLEDVQNLLIPIPSGNQIPLSQLAEVQIKDGPNQIQRENTQRRIIVGFNIKGRDVQ
HHHCCHHHHHHHEEECCCCCCCCHHHHHEEEECCCCHHHHHCCCCEEEEEEECCCCCHHH
SIVQELQAKVNAQIKLPAGYSITYGGSFENLNQAKSRLMVAVPISLALIFILLFFAFKSV
HHHHHHHHHHCCEEEECCCCEEEECCCHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHH
KESLLIYTAIPLSTIGGIFFLALRGMPFSISAGIGFIALFGVAVLNGIVLVAEFNRLKKS
HHHEEEEEECCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHEEEEHHHHHHHHH
GIKNIVRIVVDGTESRLRPVLMTAFVASLGFIPMALSNGAGAEVQRPLATVVIGGLMGAT
HHHHHHHHEECCCHHHHHHHHHHHHHHHHCCHHHEECCCCCCHHHHHHHHHHHHHHHHHH
LLTLFVLPLLFIAFEKGFTMNPFKKKAITLLIVSGISLMGMGSVKAQEKITLDRAIALAV
HHHHHHHHHHHHHHHCCCCCCCHHHHHEEEEEECCCHHCCCCCCCHHHHHHHHHEEEEEE
QNNQNLRTEKLKADYAKAIIKTSADIPQTGITADYGQINSAYNDTKFGISQNIAFPTVYK
ECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RQKELFTQEWKYSLLNVSLKEFELKKAVTQTFYAILFWQEKERLLLKADSLYADFYAKSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEHHHHHHHHHHHHH
LRLQKGESNILEKITAQNQKAAINIQLKQVQRELETAKLQWQWLLNSDTVYKVESPEKII
HHHHCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHEEEEEEECCCEEEEECCCCEEE
PLQVDETSKNPVIQVLEQQKNIAASQTKVEKSKLLPGLMIGYNLNSFKGTGADDKLYNAS
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCC
PQFHSVQVGFSIPVFSQSQRARINASKITESITENQLQATSAYLQNRYKQLSENYQRNLE
CCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IVNYYESEGLKNAAVVTETIQKQFTNGEINYLDFVMLINQAISIQSNYADAVKMLNDTII
EEEEEHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEE
QINYLN
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; silver [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + silver [Cytoplasm] = Proton [Cytoplasm] + silver [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8829543 [H]