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The map label for this gene is fsr [H]

Identifier: 146301843

GI number: 146301843

Start: 4935470

End: 4936684

Strand: Direct

Name: fsr [H]

Synonym: Fjoh_4107

Alternate gene names: 146301843

Gene position: 4935470-4936684 (Clockwise)

Preceding gene: 146301815

Following gene: 146301844

Centisome position: 80.95

GC content: 34.81

Gene sequence:

>1215_bases
ATGGACACTATTAAAGCAAATCCTGACATAGTTAAAAAAACCACTTATTCGATCTTATTTATCATTAGTTTTTCTCATCT
AATTAATGATCTTTTACAGGCTGTTGTTCCTTCAATTTATCCGCTTTTAAAAGATAATTTTAGTTTAAGTTTTACTCAAA
TTGGTATTATTACTTTGACTTACCAAATGGTAGCGTCTATTTTACAGCCATTTGTGGGAATGTATACCGATAAAAACTCA
AAACCATACTCGCTGATTATTGGAATGTGTTTTACAATGGTTGGACTTTTCTTTGTTTCGATCGCTTCGAGTTTTATCAA
CTTATTATTATCAGTAAGTTTAATCGGAATCGGATCTTCAATTTTCCATCCAGAATCTTCACGTGTGGCGCATTTGGCTT
CTGGCGGAAAAAGAGGTTTGGCGCAGTCTATTTTTCAATTGGGAGGAAATGCAGGAAGTGCGATCGGACCATTATTAGCT
GCTTTTATCGTTATTCCGCACGGACAATCTTATATCGCTTGGTTTTGTATTATTGCGTTAGTCGGTGTTTTTGCTTTGTA
TAAAATTGCGATTTGGTACACGGCACATTTATCGGAAAGAAATGCCAATAAAGCTTCTCATCAAATTGAAACACATCATT
TGTCTAAAAACCGAGTAATTGCTTCGTTGATTATTTTATTGGTTCTGATTTTTTCTAAATATTTCTATATGAGCAGTATT
ACGAGTTATTATACTTTCTTCTTGATAGATAAATTCCACATTACGATTCAGCAGTCACAAGTGTATTTATTCTTGTTTTC
TGGCGCTGTTGCAGCTGGAACTTTAATTGGCGGACCAATTGGAGATCGATATGGCAGAAAATATGTAATCTGGGTTTCTA
TTTTAGGTGTTGCACCGTTTACTTTAATGTTACCTTACGTTTCTTTATTCTGGGTTGGAGCTTTATCTGTAATTATCGGA
TTGATTCTTTCATCTGCATTCTCAGCAATTCTAGTTTATGCAACTGAATTAATGCCCGGAAAAGTCGGACTTGTAGCGGG
TCTTTTCTTCGGTTTTGCTTTCGGAATGGGCGGTTTAGGTTCTGCTATTTTAGGAAAAATTGCCGATGCTACAAGTATTG
AATATGTATTTAAGATTTGTGCATTTCTGCCTTTAATTGGGGTTATTACTGGATTCTTACCTAATTTGGAGAAGAAAAAG
AAAGCTCAGGAATAA

Upstream 100 bases:

>100_bases
GTCCAAATATAGCAATTCTGACATTACTATTCTTTTAATCTTTGCAAAAAATAATACAGCTGTTGTTTTTTAACCTAATT
TAAAAATCAAAAAATATCTC

Downstream 100 bases:

>100_bases
TTTTAAACACATAAAAACATAGTATTTGAATTGTCTTTAAAAGGCATTTCATTTCATAATAAAACACATAGTTTTCTCGA
TTGAAAGCTATGTGTTTTTT

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MDTIKANPDIVKKTTYSILFIISFSHLINDLLQAVVPSIYPLLKDNFSLSFTQIGIITLTYQMVASILQPFVGMYTDKNS
KPYSLIIGMCFTMVGLFFVSIASSFINLLLSVSLIGIGSSIFHPESSRVAHLASGGKRGLAQSIFQLGGNAGSAIGPLLA
AFIVIPHGQSYIAWFCIIALVGVFALYKIAIWYTAHLSERNANKASHQIETHHLSKNRVIASLIILLVLIFSKYFYMSSI
TSYYTFFLIDKFHITIQQSQVYLFLFSGAVAAGTLIGGPIGDRYGRKYVIWVSILGVAPFTLMLPYVSLFWVGALSVIIG
LILSSAFSAILVYATELMPGKVGLVAGLFFGFAFGMGGLGSAILGKIADATSIEYVFKICAFLPLIGVITGFLPNLEKKK
KAQE

Sequences:

>Translated_404_residues
MDTIKANPDIVKKTTYSILFIISFSHLINDLLQAVVPSIYPLLKDNFSLSFTQIGIITLTYQMVASILQPFVGMYTDKNS
KPYSLIIGMCFTMVGLFFVSIASSFINLLLSVSLIGIGSSIFHPESSRVAHLASGGKRGLAQSIFQLGGNAGSAIGPLLA
AFIVIPHGQSYIAWFCIIALVGVFALYKIAIWYTAHLSERNANKASHQIETHHLSKNRVIASLIILLVLIFSKYFYMSSI
TSYYTFFLIDKFHITIQQSQVYLFLFSGAVAAGTLIGGPIGDRYGRKYVIWVSILGVAPFTLMLPYVSLFWVGALSVIIG
LILSSAFSAILVYATELMPGKVGLVAGLFFGFAFGMGGLGSAILGKIADATSIEYVFKICAFLPLIGVITGFLPNLEKKK
KAQE
>Mature_404_residues
MDTIKANPDIVKKTTYSILFIISFSHLINDLLQAVVPSIYPLLKDNFSLSFTQIGIITLTYQMVASILQPFVGMYTDKNS
KPYSLIIGMCFTMVGLFFVSIASSFINLLLSVSLIGIGSSIFHPESSRVAHLASGGKRGLAQSIFQLGGNAGSAIGPLLA
AFIVIPHGQSYIAWFCIIALVGVFALYKIAIWYTAHLSERNANKASHQIETHHLSKNRVIASLIILLVLIFSKYFYMSSI
TSYYTFFLIDKFHITIQQSQVYLFLFSGAVAAGTLIGGPIGDRYGRKYVIWVSILGVAPFTLMLPYVSLFWVGALSVIIG
LILSSAFSAILVYATELMPGKVGLVAGLFFGFAFGMGGLGSAILGKIADATSIEYVFKICAFLPLIGVITGFLPNLEKKK
KAQE

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=388, Percent_Identity=60.5670103092783, Blast_Score=442, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43947; Mature: 43947

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure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HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]