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The map label for this gene is lytR [H]

Identifier: 146301739

GI number: 146301739

Start: 4783860

End: 4784627

Strand: Reverse

Name: lytR [H]

Synonym: Fjoh_4001

Alternate gene names: 146301739

Gene position: 4784627-4783860 (Counterclockwise)

Preceding gene: 146301740

Following gene: 146301735

Centisome position: 78.48

GC content: 34.24

Gene sequence:

>768_bases
ATGACTATCATAATAATTGAAGATGAAGTAAAAACGGACAAAGCGCTTGGTCAGCTTATTTTGAGTATCAGACCCGATGC
TCAGATTTTGTCGTATATTCAAAGTATAGACGGTGCTGTGAGTTATCTTTTAGAAAACGATCAGCCCGATTTAATTTTTA
TGGATATTCAGCTGGCGGATGGTTTGAGTTTTGAAATTTTCAAAAACGTTGAGGTTTTATCGCCGGTTATTTTCTGCACC
GCTTTTGATGATTATGCAATCGACGCTTTTAAATCAAACGGAATCGATTATGTATTAAAACCTTTTTCAAGAGAAAGTAT
TTCGCAGGCCATTAAAAAAGCAGGCGAACTGAAAAATTTCTTCCAAAGAAACAAAAAAATGATGCCCGATTTCGATTATC
TCTTAACAAGAACGGGCGAAAACAAAGGTAAAAGCAGTTTTTTGGTTTTTAAAAACAATAAATACCAAACCATCCAAACA
GAAAATATTGCTTTTTTCTACATCAAAAACGAAACACCAACCATCGTAACTTTTGATAAAACAGAATATCAAATTACACA
ATCTCTGGATGAGGTTCATAAGCTGTTATCTCCCATTCAGTTTTTCAGAATCAACAGACAATATTTGGTGAACTTTTCGG
CAATTAGAGAAGCAGAACATTATTTCTCAAGAAAATTGATTCTAAAACTGACCATTCCAACAGAAGAAAAATTATTAGTT
GGGAAAGAGAAAGCAACGGCGTTTTTAAGCTGGCTGGAGAATCGATAG

Upstream 100 bases:

>100_bases
GGACTGAACAATATCAATCAGCGATTCCTTCATTTGGTGAACAAAGAAATTGAAATTGACAAAACCGAAACCCATTTTAA
AGTTAAAATACCACTAATTT

Downstream 100 bases:

>100_bases
GTAAGGATTTAACCGCAAAGCTCGCTAAGTTTTTTAAAGCAGCAATTCTATAAAAACGCAAAGGTCGCAAAGCTATATGA
ATAATAGCTTTACGATCTTT

Product: LytTR family two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MTIIIIEDEVKTDKALGQLILSIRPDAQILSYIQSIDGAVSYLLENDQPDLIFMDIQLADGLSFEIFKNVEVLSPVIFCT
AFDDYAIDAFKSNGIDYVLKPFSRESISQAIKKAGELKNFFQRNKKMMPDFDYLLTRTGENKGKSSFLVFKNNKYQTIQT
ENIAFFYIKNETPTIVTFDKTEYQITQSLDEVHKLLSPIQFFRINRQYLVNFSAIREAEHYFSRKLILKLTIPTEEKLLV
GKEKATAFLSWLENR

Sequences:

>Translated_255_residues
MTIIIIEDEVKTDKALGQLILSIRPDAQILSYIQSIDGAVSYLLENDQPDLIFMDIQLADGLSFEIFKNVEVLSPVIFCT
AFDDYAIDAFKSNGIDYVLKPFSRESISQAIKKAGELKNFFQRNKKMMPDFDYLLTRTGENKGKSSFLVFKNNKYQTIQT
ENIAFFYIKNETPTIVTFDKTEYQITQSLDEVHKLLSPIQFFRINRQYLVNFSAIREAEHYFSRKLILKLTIPTEEKLLV
GKEKATAFLSWLENR
>Mature_254_residues
TIIIIEDEVKTDKALGQLILSIRPDAQILSYIQSIDGAVSYLLENDQPDLIFMDIQLADGLSFEIFKNVEVLSPVIFCTA
FDDYAIDAFKSNGIDYVLKPFSRESISQAIKKAGELKNFFQRNKKMMPDFDYLLTRTGENKGKSSFLVFKNNKYQTIQTE
NIAFFYIKNETPTIVTFDKTEYQITQSLDEVHKLLSPIQFFRINRQYLVNFSAIREAEHYFSRKLILKLTIPTEEKLLVG
KEKATAFLSWLENR

Specific function: Member of the two-component regulatory system lytR/lytS that regulates genes involved in autolysis and cell wall metabolism. Regulates the activity of the cell wall-associated murein hydrolase through regulation of lrgA and lrgB [H]

COG id: COG3279

COG function: function code KT; Response regulator of the LytR/AlgR family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788724, Length=241, Percent_Identity=26.1410788381743, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082052, Length=218, Percent_Identity=25.6880733944954, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR007492
- InterPro:   IPR001789 [H]

Pfam domain/function: PF04397 LytTR; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 29535; Mature: 29404

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50930 HTH_LYTTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIIIIEDEVKTDKALGQLILSIRPDAQILSYIQSIDGAVSYLLENDQPDLIFMDIQLAD
CEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
GLSFEIFKNVEVLSPVIFCTAFDDYAIDAFKSNGIDYVLKPFSRESISQAIKKAGELKNF
CCCCHHHCCHHHHHHEEEEEECCCHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHH
FQRNKKMMPDFDYLLTRTGENKGKSSFLVFKNNKYQTIQTENIAFFYIKNETPTIVTFDK
HHHCCCCCCCHHHHHEECCCCCCCCEEEEEECCCEEEEEECCEEEEEEECCCCEEEEECC
TEYQITQSLDEVHKLLSPIQFFRINRQYLVNFSAIREAEHYFSRKLILKLTIPTEEKLLV
CHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHHHHHHHHHHCEEEEEEEECCCCCCEEE
GKEKATAFLSWLENR
CCHHHHHHHHHHHCC
>Mature Secondary Structure 
TIIIIEDEVKTDKALGQLILSIRPDAQILSYIQSIDGAVSYLLENDQPDLIFMDIQLAD
EEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
GLSFEIFKNVEVLSPVIFCTAFDDYAIDAFKSNGIDYVLKPFSRESISQAIKKAGELKNF
CCCCHHHCCHHHHHHEEEEEECCCHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHH
FQRNKKMMPDFDYLLTRTGENKGKSSFLVFKNNKYQTIQTENIAFFYIKNETPTIVTFDK
HHHCCCCCCCHHHHHEECCCCCCCCEEEEEECCCEEEEEECCEEEEEEECCCCEEEEECC
TEYQITQSLDEVHKLLSPIQFFRINRQYLVNFSAIREAEHYFSRKLILKLTIPTEEKLLV
CHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHHHHHHHHHHCEEEEEEEECCCCCCEEE
GKEKATAFLSWLENR
CCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA