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The map label for this gene is 146301153

Identifier: 146301153

GI number: 146301153

Start: 4074955

End: 4076238

Strand: Direct

Name: 146301153

Synonym: Fjoh_3411

Alternate gene names: NA

Gene position: 4074955-4076238 (Clockwise)

Preceding gene: 146301146

Following gene: 146301156

Centisome position: 66.84

GC content: 37.69

Gene sequence:

>1284_bases
ATGCCAATAACCGCCAACGATACAAATAGAAAATCATGGTTAGAAGTACCAGAAAATAGTGACTTCCCTATTCAAAATAT
TCCTTTCGGCGTGTTTCTTACCAAAGAAAATGTCGTTACAGTGGGAACTAGAATTGGCGATTACGCCATAGATTTAGGGG
CTTTACAACAATTAAACTATTTTGAAGGAATAGAATTAACCGATGATATGTTTATGCAGGACACGCTGAATGATTTTATT
TCTGACGGAAAAAAAACATGGCGTTTGGTGCGAAATCGTATCGCTGATATTTTCGACGAGACTAATCCACAACTAAGAGA
TTCAACAAAACACCGAGATATTGTTATATTTAAGATTGAAGATGTAGAAATGCAGCTTCCGGTTTTAATTGGTGATTATA
CAGATTTTTATTCAAGCAGAGAACATGCTACAAACGTAGGTAAAATGTTCCGCGACCCAGAAAATGCTTTACTGCCAAAC
TGGCTTCATATTCCGGTTGGGTACCATGGAAGAAGTTCTACAATTGTACCATCTGGAATTCCGGTTCACAGGCCAATGGG
ACAAACATTACCTGCGGGTCATGATACTCCTGTTTTTGGAGCTTCGCGTTTAGTAGATTTCGAATTAGAAACGGCTTTCA
TTACTACTGATGTGAATGTAATGGGAGAAAACATCTCAACTTACGAAGCAGAAGACTATATTTTTGGTATGGTTTTACTA
AATGACTGGAGCGCGCGCGATATGCAAAAATGGGAATATGTGCCTCTTGGGCCATTCTTAGCAAAAAACTTTGCAACTTC
AATTTCTCCGTGGATTGTAACTATGGATGCTTTAGAACCTTTTAGAACCAAAGGCCCAAAACAAGATCCGTCTCCGCTTC
CCTACTTACAAACAAAAGGAAAAAAAGCTTTTGATATTCATTTAGAAGTTTCTTTAAAACCAGAGAATCAGGAAGAAACT
GTGATTTCAAAATCCAACTTTAAATACATGTATTGGTCAATGGCACAGCAATTAACGCACCATACTTCTAATGGATGTCG
TGTTAATTCTGGAGACATGATGGGTTCTGGAACTATTTCTGGTCCAACTCCTGATAGTTTTGGTTCTATGCTGGAATTAA
CTTGGGGAGGAAAAAATCCGTTGAAACTAAATGACGGAAGTGAACGTAAATTTATTGAAGATAATGACACTGTTATTATT
CGTGGTTTCTGTGAAAACAACGAAGTAAGAATTGGTTTTGGTGAAGTTGCCAGCCAGCTTTTACCTCCATTTACAAGACA
ATGA

Upstream 100 bases:

>100_bases
TTTCGTTAATTTCCTGCAAAAATACAAAAAAACGTTTGTGATACTGGCAGATTATGATATATTTGACATATAATTTTTCA
ACAAATAATTAACATCAAAC

Downstream 100 bases:

>100_bases
AGAGCAGAGCAATCTGAAGATATATAGAAATAAAAAAAACCTTGGAAAGCCAAGGTTTTTTTATGCTTTATATTTAATCT
TGAAAAAATTGAAAAAAAGC

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MPITANDTNRKSWLEVPENSDFPIQNIPFGVFLTKENVVTVGTRIGDYAIDLGALQQLNYFEGIELTDDMFMQDTLNDFI
SDGKKTWRLVRNRIADIFDETNPQLRDSTKHRDIVIFKIEDVEMQLPVLIGDYTDFYSSREHATNVGKMFRDPENALLPN
WLHIPVGYHGRSSTIVPSGIPVHRPMGQTLPAGHDTPVFGASRLVDFELETAFITTDVNVMGENISTYEAEDYIFGMVLL
NDWSARDMQKWEYVPLGPFLAKNFATSISPWIVTMDALEPFRTKGPKQDPSPLPYLQTKGKKAFDIHLEVSLKPENQEET
VISKSNFKYMYWSMAQQLTHHTSNGCRVNSGDMMGSGTISGPTPDSFGSMLELTWGGKNPLKLNDGSERKFIEDNDTVII
RGFCENNEVRIGFGEVASQLLPPFTRQ

Sequences:

>Translated_427_residues
MPITANDTNRKSWLEVPENSDFPIQNIPFGVFLTKENVVTVGTRIGDYAIDLGALQQLNYFEGIELTDDMFMQDTLNDFI
SDGKKTWRLVRNRIADIFDETNPQLRDSTKHRDIVIFKIEDVEMQLPVLIGDYTDFYSSREHATNVGKMFRDPENALLPN
WLHIPVGYHGRSSTIVPSGIPVHRPMGQTLPAGHDTPVFGASRLVDFELETAFITTDVNVMGENISTYEAEDYIFGMVLL
NDWSARDMQKWEYVPLGPFLAKNFATSISPWIVTMDALEPFRTKGPKQDPSPLPYLQTKGKKAFDIHLEVSLKPENQEET
VISKSNFKYMYWSMAQQLTHHTSNGCRVNSGDMMGSGTISGPTPDSFGSMLELTWGGKNPLKLNDGSERKFIEDNDTVII
RGFCENNEVRIGFGEVASQLLPPFTRQ
>Mature_426_residues
PITANDTNRKSWLEVPENSDFPIQNIPFGVFLTKENVVTVGTRIGDYAIDLGALQQLNYFEGIELTDDMFMQDTLNDFIS
DGKKTWRLVRNRIADIFDETNPQLRDSTKHRDIVIFKIEDVEMQLPVLIGDYTDFYSSREHATNVGKMFRDPENALLPNW
LHIPVGYHGRSSTIVPSGIPVHRPMGQTLPAGHDTPVFGASRLVDFELETAFITTDVNVMGENISTYEAEDYIFGMVLLN
DWSARDMQKWEYVPLGPFLAKNFATSISPWIVTMDALEPFRTKGPKQDPSPLPYLQTKGKKAFDIHLEVSLKPENQEETV
ISKSNFKYMYWSMAQQLTHHTSNGCRVNSGDMMGSGTISGPTPDSFGSMLELTWGGKNPLKLNDGSERKFIEDNDTVIIR
GFCENNEVRIGFGEVASQLLPPFTRQ

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=413, Percent_Identity=53.0266343825666, Blast_Score=460, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17568863, Length=418, Percent_Identity=50.2392344497608, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24657182, Length=414, Percent_Identity=51.4492753623188, Blast_Score=431, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 48265; Mature: 48134

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPITANDTNRKSWLEVPENSDFPIQNIPFGVFLTKENVVTVGTRIGDYAIDLGALQQLNY
CCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCEEEEECCCCCEEECHHHHHHCCH
FEGIELTDDMFMQDTLNDFISDGKKTWRLVRNRIADIFDETNPQLRDSTKHRDIVIFKIE
HCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEEEEEEE
DVEMQLPVLIGDYTDFYSSREHATNVGKMFRDPENALLPNWLHIPVGYHGRSSTIVPSGI
CCEEEECEEEECHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCC
PVHRPMGQTLPAGHDTPVFGASRLVDFELETAFITTDVNVMGENISTYEAEDYIFGMVLL
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEHEEECCCCCCEECCCEEEEEEEE
NDWSARDMQKWEYVPLGPFLAKNFATSISPWIVTMDALEPFRTKGPKQDPSPLPYLQTKG
CCCCCCCHHCCCCCCCCHHHHHHHHCCCCCEEEEECCCCHHHHCCCCCCCCCCCHHHCCC
KKAFDIHLEVSLKPENQEETVISKSNFKYMYWSMAQQLTHHTSNGCRVNSGDMMGSGTIS
CEEEEEEEEEEECCCCCCCEEEECCCCEEEHHHHHHHHHHCCCCCCEECCCCCCCCCCCC
GPTPDSFGSMLELTWGGKNPLKLNDGSERKFIEDNDTVIIRGFCENNEVRIGFGEVASQL
CCCCCCCCCEEEEEECCCCCEEECCCCCCCEECCCCEEEEEEECCCCCEEEEHHHHHHHH
LPPFTRQ
CCCCCCC
>Mature Secondary Structure 
PITANDTNRKSWLEVPENSDFPIQNIPFGVFLTKENVVTVGTRIGDYAIDLGALQQLNY
CCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCEEEEECCCCCEEECHHHHHHCCH
FEGIELTDDMFMQDTLNDFISDGKKTWRLVRNRIADIFDETNPQLRDSTKHRDIVIFKIE
HCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEEEEEEE
DVEMQLPVLIGDYTDFYSSREHATNVGKMFRDPENALLPNWLHIPVGYHGRSSTIVPSGI
CCEEEECEEEECHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCC
PVHRPMGQTLPAGHDTPVFGASRLVDFELETAFITTDVNVMGENISTYEAEDYIFGMVLL
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEHEEECCCCCCEECCCEEEEEEEE
NDWSARDMQKWEYVPLGPFLAKNFATSISPWIVTMDALEPFRTKGPKQDPSPLPYLQTKG
CCCCCCCHHCCCCCCCCHHHHHHHHCCCCCEEEEECCCCHHHHCCCCCCCCCCCHHHCCC
KKAFDIHLEVSLKPENQEETVISKSNFKYMYWSMAQQLTHHTSNGCRVNSGDMMGSGTIS
CEEEEEEEEEEECCCCCCCEEEECCCCEEEHHHHHHHHHHCCCCCCEECCCCCCCCCCCC
GPTPDSFGSMLELTWGGKNPLKLNDGSERKFIEDNDTVIIRGFCENNEVRIGFGEVASQL
CCCCCCCCCEEEEEECCCCCEEECCCCCCCEECCCCEEEEEEECCCCCEEEEHHHHHHHH
LPPFTRQ
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA