Click here to switch to the map view.

The map label for this gene is guaC [H]

Identifier: 146301150

GI number: 146301150

Start: 4071565

End: 4072605

Strand: Reverse

Name: guaC [H]

Synonym: Fjoh_3408

Alternate gene names: 146301150

Gene position: 4072605-4071565 (Counterclockwise)

Preceding gene: 146301151

Following gene: 146301149

Centisome position: 66.8

GC content: 37.94

Gene sequence:

>1041_bases
ATGAGAATAGAAATGGACTTAAAACTGGGGTTTAAAGATGTAATGTTTAGGCCAAAAAGATCAACACTCAAAAGCAGGTC
TGAAGTTTCTTTAGAACAAAATTTCAAGTTTTTGCACAGTACTGCAAGTTGGACAGGAATTCCAATTATGGCTGCCAATA
TGGATACAGTCGGAACCTTTGAAATGGCTCAGGTTTTGGCTAAAGAAAAATTGTTTACCGCTATTCACAAACATTACACT
TTAGAACAATGGAACACATTTCTAAAGAACGTAACTCCGGATTTTTACGATTATATTGCCGTAAGTACAGGAACTGGAAA
AGAAGATTTCGAAAAGATTGAAAAAATAATTACTGCAAACCCGTTGCTCAAATTTATCTGTATTGATGTTGCAAACGGCT
ATTCTGAACATTTTGTACAGTTTTTAAAGAAAACCCGAAAACAATATCCTGATAAAATAATCATTGCTGGAAATGTTGTG
ACAGGCGAAATGACTGAAGAACTATTATTAGCGGGTGCTGATATTGTAAAAGTCGGAATTGGACCAGGTTCTGTTTGTAC
AACTCGTGTAAAAACAGGTGTTGGTTATCCGCAGTTATCGGCTATTATCGAATGTGCGGATGCAGCGCACGGTTTAGGCG
GCCATATTATCAGCGATGGCGGCTGCACAACACCGGGCGATGTTGCTAAAGCTTTTGGAGCAGGAGCCGATTTTGTAATG
TTGGGAGGAATGCTCGCAGGACATACAGAAAGCGGTGGTGAACTAATAGAAGTAAAAGGCGAAAAATTCAAACAATTTTA
CGGAATGAGTTCAAAAACAGCAATGGATAAACATTCTGGCGGTGTTGCAGAATACAGGGCAAGTGAAGGAAAAACTGTGC
AGGTTACGTTTAAAGGAGATGTGATTCATACTGTTTTAGATATATTAGGCGGAATAAGAAGTACTTGCACTTATGTTGGA
GCTTCAAGATTAAAAGAATTGACTAAACGAACGACTTTCATCCGCGTAAGCGAACAGGAAAATCAAGTTTTTAAAAAATA
A

Upstream 100 bases:

>100_bases
AGTAAATCAATTGTTCAAAAGTTCAAGTTTTTGTTAATCTAAAATCTAAAGTCTACAATCTAAAATTCCTTACATTTGAG
AGTAACCAAAATCTTGAAAT

Downstream 100 bases:

>100_bases
TATGATTAAAATTACCGAAGCATTTGTAGAAGATATTGCTAAAATTCAAGAAATTGCACATATAACCTGGCCAATAACCT
ATGGCGAAATTTTGACCGCA

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MRIEMDLKLGFKDVMFRPKRSTLKSRSEVSLEQNFKFLHSTASWTGIPIMAANMDTVGTFEMAQVLAKEKLFTAIHKHYT
LEQWNTFLKNVTPDFYDYIAVSTGTGKEDFEKIEKIITANPLLKFICIDVANGYSEHFVQFLKKTRKQYPDKIIIAGNVV
TGEMTEELLLAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGHIISDGGCTTPGDVAKAFGAGADFVM
LGGMLAGHTESGGELIEVKGEKFKQFYGMSSKTAMDKHSGGVAEYRASEGKTVQVTFKGDVIHTVLDILGGIRSTCTYVG
ASRLKELTKRTTFIRVSEQENQVFKK

Sequences:

>Translated_346_residues
MRIEMDLKLGFKDVMFRPKRSTLKSRSEVSLEQNFKFLHSTASWTGIPIMAANMDTVGTFEMAQVLAKEKLFTAIHKHYT
LEQWNTFLKNVTPDFYDYIAVSTGTGKEDFEKIEKIITANPLLKFICIDVANGYSEHFVQFLKKTRKQYPDKIIIAGNVV
TGEMTEELLLAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGHIISDGGCTTPGDVAKAFGAGADFVM
LGGMLAGHTESGGELIEVKGEKFKQFYGMSSKTAMDKHSGGVAEYRASEGKTVQVTFKGDVIHTVLDILGGIRSTCTYVG
ASRLKELTKRTTFIRVSEQENQVFKK
>Mature_346_residues
MRIEMDLKLGFKDVMFRPKRSTLKSRSEVSLEQNFKFLHSTASWTGIPIMAANMDTVGTFEMAQVLAKEKLFTAIHKHYT
LEQWNTFLKNVTPDFYDYIAVSTGTGKEDFEKIEKIITANPLLKFICIDVANGYSEHFVQFLKKTRKQYPDKIIIAGNVV
TGEMTEELLLAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGHIISDGGCTTPGDVAKAFGAGADFVM
LGGMLAGHTESGGELIEVKGEKFKQFYGMSSKTAMDKHSGGVAEYRASEGKTVQVTFKGDVIHTVLDILGGIRSTCTYVG
ASRLKELTKRTTFIRVSEQENQVFKK

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=344, Percent_Identity=70.9302325581395, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI50541954, Length=344, Percent_Identity=70.9302325581395, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI50541952, Length=344, Percent_Identity=70.9302325581395, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI50541948, Length=344, Percent_Identity=70.9302325581395, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI156104880, Length=343, Percent_Identity=68.8046647230321, Blast_Score=510, Evalue=1e-145,
Organism=Homo sapiens, GI66933016, Length=233, Percent_Identity=31.7596566523605, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI217035150, Length=233, Percent_Identity=32.618025751073, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI217035152, Length=233, Percent_Identity=32.618025751073, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI34328930, Length=233, Percent_Identity=32.618025751073, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI217035146, Length=233, Percent_Identity=32.618025751073, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI217035148, Length=233, Percent_Identity=32.618025751073, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI34328928, Length=233, Percent_Identity=32.618025751073, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI156616279, Length=233, Percent_Identity=32.618025751073, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1786293, Length=346, Percent_Identity=71.6763005780347, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI1788855, Length=234, Percent_Identity=39.7435897435897, Blast_Score=147, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17560440, Length=343, Percent_Identity=64.7230320699708, Blast_Score=488, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI71994385, Length=184, Percent_Identity=33.695652173913, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71994389, Length=174, Percent_Identity=34.4827586206897, Blast_Score=101, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6323585, Length=235, Percent_Identity=32.3404255319149, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322012, Length=237, Percent_Identity=32.4894514767932, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323464, Length=235, Percent_Identity=32.3404255319149, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6319352, Length=120, Percent_Identity=35, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641071, Length=240, Percent_Identity=30.4166666666667, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24641073, Length=240, Percent_Identity=30.4166666666667, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28571163, Length=240, Percent_Identity=30.4166666666667, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 37850; Mature: 37850

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEMDLKLGFKDVMFRPKRSTLKSRSEVSLEQNFKFLHSTASWTGIPIMAANMDTVGTF
CEEEEEECCCHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEECCCCCCHH
EMAQVLAKEKLFTAIHKHYTLEQWNTFLKNVTPDFYDYIAVSTGTGKEDFEKIEKIITAN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHEEEEECCCCHHHHHHHHHHHHCC
PLLKFICIDVANGYSEHFVQFLKKTRKQYPDKIIIAGNVVTGEMTEELLLAGADIVKVGI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCEEEHHHHHHHHHCCCCEEEECC
GPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGHIISDGGCTTPGDVAKAFGAGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCHHH
LGGMLAGHTESGGELIEVKGEKFKQFYGMSSKTAMDKHSGGVAEYRASEGKTVQVTFKGD
HCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCCCHHCCCCCHHEECCCCCEEEEEECCC
VIHTVLDILGGIRSTCTYVGASRLKELTKRTTFIRVSEQENQVFKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHCC
>Mature Secondary Structure
MRIEMDLKLGFKDVMFRPKRSTLKSRSEVSLEQNFKFLHSTASWTGIPIMAANMDTVGTF
CEEEEEECCCHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEECCCCCCHH
EMAQVLAKEKLFTAIHKHYTLEQWNTFLKNVTPDFYDYIAVSTGTGKEDFEKIEKIITAN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHEEEEECCCCHHHHHHHHHHHHCC
PLLKFICIDVANGYSEHFVQFLKKTRKQYPDKIIIAGNVVTGEMTEELLLAGADIVKVGI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCEEEHHHHHHHHHCCCCEEEECC
GPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGHIISDGGCTTPGDVAKAFGAGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCHHH
LGGMLAGHTESGGELIEVKGEKFKQFYGMSSKTAMDKHSGGVAEYRASEGKTVQVTFKGD
HCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCCCHHCCCCCHHEECCCCCEEEEEECCC
VIHTVLDILGGIRSTCTYVGASRLKELTKRTTFIRVSEQENQVFKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA