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The map label for this gene is hisI [H]

Identifier: 146300620

GI number: 146300620

Start: 3408271

End: 3408867

Strand: Reverse

Name: hisI [H]

Synonym: Fjoh_2871

Alternate gene names: 146300620

Gene position: 3408867-3408271 (Counterclockwise)

Preceding gene: 146300621

Following gene: 146300619

Centisome position: 55.91

GC content: 36.18

Gene sequence:

>597_bases
ATGGATATCGATATCAAAAGCGCACACGGATTAATTCCGGCTATAATTCAGGATTCTGAAACAAAAAATGTTTTGATGCT
GGGTTATATGAACGAAGAATCGCTTCAAAAAACAATAGAAACTCAAAAAGTAACTTTCTTTAGTCGCTCTAAGCAAAGAC
TTTGGACAAAAGGCGAGGAGAGCGGTAACTTTTTAAATCTGGTAAGCATTAAAAATGATTGTGACGGCGATACGCTATTA
ATTCAGGCAAAACCAGTTGGACCAACGTGCCACACAGGCGCAGATACATGTTGGCAAGAACCCAATGATGCGAATTACGG
TTTTATTTCACAATTAGAAAATACAATCAAAACCCGTAGAGAAAATGCTGATTCTGAACAGAGTTATGTAGCTTCTTTAT
TTGCAAAAGGAATCAATAAAATTGCCCAAAAAGTTGGTGAAGAGGCAGTAGAAGTAGTTATTGAAGCAAAAGATAACAAC
GATGATTTATTCCTCAGCGAAAGCGCCGATTTACTTTTTCATTATCTGATTTTACTGCAGGCAAAAGGTTATCAGTTAAA
TGATGTTGTAGAAGTTTTAAAGAAACGTCAGAAGTAG

Upstream 100 bases:

>100_bases
AGACTTTAAGAGAAGCAGGAAACAAGAAGAAAGAGAAGATTTAATCTAAAATAAAAGAGTTCAGCAATCTAAAATCTGAA
TTCTAAAATCTAAAATAATT

Downstream 100 bases:

>100_bases
TTATACTCAATATTTTCAATCTGAGTGAATTTGAAATACTGTAAAGTGATTTAATAAACTTGATTTCAACTTCGCTCAGT
CTGATAAAAATATTTACTTT

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MDIDIKSAHGLIPAIIQDSETKNVLMLGYMNEESLQKTIETQKVTFFSRSKQRLWTKGEESGNFLNLVSIKNDCDGDTLL
IQAKPVGPTCHTGADTCWQEPNDANYGFISQLENTIKTRRENADSEQSYVASLFAKGINKIAQKVGEEAVEVVIEAKDNN
DDLFLSESADLLFHYLILLQAKGYQLNDVVEVLKKRQK

Sequences:

>Translated_198_residues
MDIDIKSAHGLIPAIIQDSETKNVLMLGYMNEESLQKTIETQKVTFFSRSKQRLWTKGEESGNFLNLVSIKNDCDGDTLL
IQAKPVGPTCHTGADTCWQEPNDANYGFISQLENTIKTRRENADSEQSYVASLFAKGINKIAQKVGEEAVEVVIEAKDNN
DDLFLSESADLLFHYLILLQAKGYQLNDVVEVLKKRQK
>Mature_198_residues
MDIDIKSAHGLIPAIIQDSETKNVLMLGYMNEESLQKTIETQKVTFFSRSKQRLWTKGEESGNFLNLVSIKNDCDGDTLL
IQAKPVGPTCHTGADTCWQEPNDANYGFISQLENTIKTRRENADSEQSYVASLFAKGINKIAQKVGEEAVEVVIEAKDNN
DDLFLSESADLLFHYLILLQAKGYQLNDVVEVLKKRQK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=197, Percent_Identity=50.761421319797, Blast_Score=207, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6319819, Length=183, Percent_Identity=34.4262295081967, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 22230; Mature: 22230

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDIKSAHGLIPAIIQDSETKNVLMLGYMNEESLQKTIETQKVTFFSRSKQRLWTKGEE
CCCCCCCCCCCHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SGNFLNLVSIKNDCDGDTLLIQAKPVGPTCHTGADTCWQEPNDANYGFISQLENTIKTRR
CCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHH
ENADSEQSYVASLFAKGINKIAQKVGEEAVEVVIEAKDNNDDLFLSESADLLFHYLILLQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEECCHHHHHHHHHHHH
AKGYQLNDVVEVLKKRQK
CCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDIDIKSAHGLIPAIIQDSETKNVLMLGYMNEESLQKTIETQKVTFFSRSKQRLWTKGEE
CCCCCCCCCCCHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SGNFLNLVSIKNDCDGDTLLIQAKPVGPTCHTGADTCWQEPNDANYGFISQLENTIKTRR
CCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHH
ENADSEQSYVASLFAKGINKIAQKVGEEAVEVVIEAKDNNDDLFLSESADLLFHYLILLQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEECCHHHHHHHHHHHH
AKGYQLNDVVEVLKKRQK
CCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]