| Definition | Flavobacterium johnsoniae UW101 chromosome, complete genome. |
|---|---|
| Accession | NC_009441 |
| Length | 6,096,872 |
Click here to switch to the map view.
The map label for this gene is parC [H]
Identifier: 146300230
GI number: 146300230
Start: 2962784
End: 2965504
Strand: Direct
Name: parC [H]
Synonym: Fjoh_2475
Alternate gene names: 146300230
Gene position: 2962784-2965504 (Clockwise)
Preceding gene: 146300229
Following gene: 146300231
Centisome position: 48.6
GC content: 36.2
Gene sequence:
>2721_bases ATGAAAGACGAAGAAGACGATAACATAATTCCAAACGACGACGAGAATAATCAAGATGAAAACCTGATGGATGACAATCA GGATGGAGATGACGAGGATATTATAAACGTAGATGCGAAGCATTTCGAGGGACAGCATTTTTACGAAAATCAGGAAGAAG AAGGCGAGGACGTTATTACTAAAGTAACGGGAATGTACAAGGACTGGTTTTTGGATTATGCTTCGTATGTAATTCTGGAA CGTGCAGTTCCTGCTATCGAGGACGGATTTAAGCCTGTTCAGCGTCGTATTATGCACTCTTTAAAAGAGCTGGACGATGG TCGTTATAATAAAGTTGCCAATGTTGTAGGTCACACCATGCAGTATCACCCACACGGAGATGCGAGTATTGGTGATGCCA TGGTGCAGATTGGTCAGAAAGATTTATTAATTGACTGCCAGGGTAACTGGGGAAATATCTTAACGGGCGACGGTGCAGCT GCACCCCGTTATATTGAGGCACGTTTATCTAAATTTGCTTTAGAAGTTTTATATTCTCCAAAAATTACAGAATGGGGACT ATCATATGACGGTAGAAAAGCCGAACCGATTAATCTTCCGGTAAAATTCCCAATGCTTTTAGCGCAGGGAGCAGAAGGTA TTGCGGTTGGACTTTCTACAAAAGTACTGCCTCATAACTTTAACGAATTAATCGATGCTTCGATTAAAATCTTAAAAGGA AAACCGTTTACGCTTTATCCTGATTTTATGACGCAGGGTATTGCCGACGTTTCAAATTATAACGACGGAATGCGCGGCGG ACGTGTGCGTGTACGTGCTAAAATTTCGCAATTAGACAAAAATACATTGGTAATTACACAGATTCCGTTTTCTACCAATA CATCGAGTTTAATTGATAGTATTTTGAAAGCCAATGATAAAGGTAAAATCAAAATCAAAAAAATTGAAGATAATACGGCT GCTGATGTTGAGATTTTAATCCATCTTTTCCCAGGCGTTTCACCAGACAAAACAATTGATGCTTTGTTTGCTTTTACAGC CTGCGAAACTTCTGTAGCGCCTTTAGGATGTGTTATCGAAGACAATAAACCGTTGTTTATTGGTGTTTCCCAAATGTTGA AAATTTCAACACACAGAACAGTTGATTTACTTCGTCAGGAATTAGAAATTCAGTTAGAAGAATTAAAAAATAAGTGGCAC TTTTCTACTTTGGAGAAAATATTCATTCGTGAAGAAATGTATATCGACTTCAAATTATACGGAGACAGAGAATCACTTTA CAAATATTTATACGATCGTTTTGAGCCTTTCAAAAAATCATTTGTCAGAGAAATTAATGACGACGATTTACAAAGACTGA CTCAAATCCCGATGATTCGTATTACACGTTTCGACTCTGATAAAGCTGATGATTTAATCGCGAAGTTAGAAGACGAAATG AAAGAAGTAGAGCATAATCTGGAACATTTAACAGATTTTGCAATTGCTTACTTTACTAAATTAAAAGAGAAATACGGAAA AGGCCGCGAACGTCAGACAGAGCTTCGTGTTTTTGATAACGTTGAGGCTACAAAAGTAGTTTTACGTAATACAAAACTTT ACGTAAACCGCGAAGAAGGTTTCGTAGGAACGAGTTTAAAGAAAGATGAATACGTTGGCGATTGTTCGGATATTGATGAT GTTATTGTGTTTTTACGAGACGGAACATTGATGATAACCAAAGTCGACGCCAAAACTTTTATTGGAAAAGACATTATACA CGTTGCAGTTTTTGATAAAAACGATAAACGTACCATTTATAACATGATGTACCGTGATGGTAAATCAGGGCCGTCTTATA TAAAACGTTTCAATGTTACCGGTGTAACCCGTGATAAAGCTTACGACTTAACAAATGGTACAAACGGTTCTCAGGTAGTT TATTTTTCACATAATCCAAATGGTGAAGCTGAGGTAGTTACTATATTGCTGCGTCAGGTTGGAACGATTAAGAAACTGAA ATTCGATATTGATTTTGCTAAGTTAGCAATTAAAGGACGTGGTTCTAAAGGAAATTTGGTGACCAAATATCCAATTAAGA AAATCGAATTGAAAGAAAAAGGAATTTCGACATTACTGCCAAGAAAAGTTTGGTTTGATGATACTGTAAAACGTTTAAAT GTTGATGCAAGAGGAGAGTTGTTAGGTGAATTTAAACCAACAGACAAAATCTTAATAATTAATCAGTCAGGTAAATTAAA AGTAATAATCCCTGAATTATCAACTCATTTTGATGAAGACATGATTGTTCTGGAAAAATGGAAACCTAAAAAACCAATTT CTGCGATTTATTATGATGGGGAAAAAGAGCGTTATTTCTTAAAACGTTTCCTTGTTGAAAATGAAGGAAAAGAAGAAAGC TTTATTACAGACCATCCAAATTCGCAGTTAGAGATTGTATCGACTGATTATCGTCCGGTAGCACAATTGGTTTTTGCCAA AGTAAAAGGCGTTCAAAAAGACGATTTGCATATTGATGTAGAAGACTTTATAGCTGTAAAAGGTTTCAAAGCTCTAGGAA ATCAATTAACAACAGATAAATTAAAACAAGTAAATCTCTTAGATCCGCTTCCTTACGAAGAGCCGATTGAAGAAATTCCT GAAAAACCGGAAATATCAGAAGATGATCCTGTAGAAACAGAATTAGACGACGACGGCCAAATAGGATTGGTTTTAGAATA A
Upstream 100 bases:
>100_bases GTGGTGATGAAAAAAGAGTAAAGGAAGAAATTGATTTTATAGAAAATATTCGAAAATCTAAATAGAAAAATAGAAAATAC TGAAATAATTCAGCATAAAA
Downstream 100 bases:
>100_bases TATAAATAAGACGCTAAGAAATAACTCTTAGCGTTTTTTTTATGTTATTAAAAAAGGCTTATTGTTATAGTTTTAAAACC TATACTAGACTTTTTCTCAA
Product: DNA topoisomerase IV subunit A
Products: NA
Alternate protein names: Topoisomerase IV subunit A [H]
Number of amino acids: Translated: 906; Mature: 906
Protein sequence:
>906_residues MKDEEDDNIIPNDDENNQDENLMDDNQDGDDEDIINVDAKHFEGQHFYENQEEEGEDVITKVTGMYKDWFLDYASYVILE RAVPAIEDGFKPVQRRIMHSLKELDDGRYNKVANVVGHTMQYHPHGDASIGDAMVQIGQKDLLIDCQGNWGNILTGDGAA APRYIEARLSKFALEVLYSPKITEWGLSYDGRKAEPINLPVKFPMLLAQGAEGIAVGLSTKVLPHNFNELIDASIKILKG KPFTLYPDFMTQGIADVSNYNDGMRGGRVRVRAKISQLDKNTLVITQIPFSTNTSSLIDSILKANDKGKIKIKKIEDNTA ADVEILIHLFPGVSPDKTIDALFAFTACETSVAPLGCVIEDNKPLFIGVSQMLKISTHRTVDLLRQELEIQLEELKNKWH FSTLEKIFIREEMYIDFKLYGDRESLYKYLYDRFEPFKKSFVREINDDDLQRLTQIPMIRITRFDSDKADDLIAKLEDEM KEVEHNLEHLTDFAIAYFTKLKEKYGKGRERQTELRVFDNVEATKVVLRNTKLYVNREEGFVGTSLKKDEYVGDCSDIDD VIVFLRDGTLMITKVDAKTFIGKDIIHVAVFDKNDKRTIYNMMYRDGKSGPSYIKRFNVTGVTRDKAYDLTNGTNGSQVV YFSHNPNGEAEVVTILLRQVGTIKKLKFDIDFAKLAIKGRGSKGNLVTKYPIKKIELKEKGISTLLPRKVWFDDTVKRLN VDARGELLGEFKPTDKILIINQSGKLKVIIPELSTHFDEDMIVLEKWKPKKPISAIYYDGEKERYFLKRFLVENEGKEES FITDHPNSQLEIVSTDYRPVAQLVFAKVKGVQKDDLHIDVEDFIAVKGFKALGNQLTTDKLKQVNLLDPLPYEEPIEEIP EKPEISEDDPVETELDDDGQIGLVLE
Sequences:
>Translated_906_residues MKDEEDDNIIPNDDENNQDENLMDDNQDGDDEDIINVDAKHFEGQHFYENQEEEGEDVITKVTGMYKDWFLDYASYVILE RAVPAIEDGFKPVQRRIMHSLKELDDGRYNKVANVVGHTMQYHPHGDASIGDAMVQIGQKDLLIDCQGNWGNILTGDGAA APRYIEARLSKFALEVLYSPKITEWGLSYDGRKAEPINLPVKFPMLLAQGAEGIAVGLSTKVLPHNFNELIDASIKILKG KPFTLYPDFMTQGIADVSNYNDGMRGGRVRVRAKISQLDKNTLVITQIPFSTNTSSLIDSILKANDKGKIKIKKIEDNTA ADVEILIHLFPGVSPDKTIDALFAFTACETSVAPLGCVIEDNKPLFIGVSQMLKISTHRTVDLLRQELEIQLEELKNKWH FSTLEKIFIREEMYIDFKLYGDRESLYKYLYDRFEPFKKSFVREINDDDLQRLTQIPMIRITRFDSDKADDLIAKLEDEM KEVEHNLEHLTDFAIAYFTKLKEKYGKGRERQTELRVFDNVEATKVVLRNTKLYVNREEGFVGTSLKKDEYVGDCSDIDD VIVFLRDGTLMITKVDAKTFIGKDIIHVAVFDKNDKRTIYNMMYRDGKSGPSYIKRFNVTGVTRDKAYDLTNGTNGSQVV YFSHNPNGEAEVVTILLRQVGTIKKLKFDIDFAKLAIKGRGSKGNLVTKYPIKKIELKEKGISTLLPRKVWFDDTVKRLN VDARGELLGEFKPTDKILIINQSGKLKVIIPELSTHFDEDMIVLEKWKPKKPISAIYYDGEKERYFLKRFLVENEGKEES FITDHPNSQLEIVSTDYRPVAQLVFAKVKGVQKDDLHIDVEDFIAVKGFKALGNQLTTDKLKQVNLLDPLPYEEPIEEIP EKPEISEDDPVETELDDDGQIGLVLE >Mature_906_residues MKDEEDDNIIPNDDENNQDENLMDDNQDGDDEDIINVDAKHFEGQHFYENQEEEGEDVITKVTGMYKDWFLDYASYVILE RAVPAIEDGFKPVQRRIMHSLKELDDGRYNKVANVVGHTMQYHPHGDASIGDAMVQIGQKDLLIDCQGNWGNILTGDGAA APRYIEARLSKFALEVLYSPKITEWGLSYDGRKAEPINLPVKFPMLLAQGAEGIAVGLSTKVLPHNFNELIDASIKILKG KPFTLYPDFMTQGIADVSNYNDGMRGGRVRVRAKISQLDKNTLVITQIPFSTNTSSLIDSILKANDKGKIKIKKIEDNTA ADVEILIHLFPGVSPDKTIDALFAFTACETSVAPLGCVIEDNKPLFIGVSQMLKISTHRTVDLLRQELEIQLEELKNKWH FSTLEKIFIREEMYIDFKLYGDRESLYKYLYDRFEPFKKSFVREINDDDLQRLTQIPMIRITRFDSDKADDLIAKLEDEM KEVEHNLEHLTDFAIAYFTKLKEKYGKGRERQTELRVFDNVEATKVVLRNTKLYVNREEGFVGTSLKKDEYVGDCSDIDD VIVFLRDGTLMITKVDAKTFIGKDIIHVAVFDKNDKRTIYNMMYRDGKSGPSYIKRFNVTGVTRDKAYDLTNGTNGSQVV YFSHNPNGEAEVVTILLRQVGTIKKLKFDIDFAKLAIKGRGSKGNLVTKYPIKKIELKEKGISTLLPRKVWFDDTVKRLN VDARGELLGEFKPTDKILIINQSGKLKVIIPELSTHFDEDMIVLEKWKPKKPISAIYYDGEKERYFLKRFLVENEGKEES FITDHPNSQLEIVSTDYRPVAQLVFAKVKGVQKDDLHIDVEDFIAVKGFKALGNQLTTDKLKQVNLLDPLPYEEPIEEIP EKPEISEDDPVETELDDDGQIGLVLE
Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=247, Percent_Identity=29.1497975708502, Blast_Score=87, Evalue=5e-17, Organism=Homo sapiens, GI19913406, Length=237, Percent_Identity=28.6919831223629, Blast_Score=86, Evalue=2e-16, Organism=Escherichia coli, GI1788562, Length=363, Percent_Identity=28.3746556473829, Blast_Score=157, Evalue=2e-39, Organism=Escherichia coli, GI1789396, Length=373, Percent_Identity=31.6353887399464, Blast_Score=154, Evalue=3e-38, Organism=Caenorhabditis elegans, GI17535065, Length=274, Percent_Identity=26.6423357664234, Blast_Score=84, Evalue=4e-16, Organism=Caenorhabditis elegans, GI212645657, Length=272, Percent_Identity=25.3676470588235, Blast_Score=73, Evalue=5e-13, Organism=Caenorhabditis elegans, GI212645845, Length=170, Percent_Identity=31.1764705882353, Blast_Score=67, Evalue=3e-11, Organism=Saccharomyces cerevisiae, GI6324241, Length=269, Percent_Identity=29.368029739777, Blast_Score=91, Evalue=1e-18, Organism=Drosophila melanogaster, GI17136538, Length=272, Percent_Identity=30.1470588235294, Blast_Score=97, Evalue=4e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013760 [H]
Pfam domain/function: PF00521 DNA_topoisoIV [H]
EC number: 5.99.1.-
Molecular weight: Translated: 103330; Mature: 103330
Theoretical pI: Translated: 4.86; Mature: 4.86
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKDEEDDNIIPNDDENNQDENLMDDNQDGDDEDIINVDAKHFEGQHFYENQEEEGEDVIT CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHCCCCCCCCCCCCCHHHHHH KVTGMYKDWFLDYASYVILERAVPAIEDGFKPVQRRIMHSLKELDDGRYNKVANVVGHTM HHHHHHHHHHHHHHHHHHHHHHCHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCE QYHPHGDASIGDAMVQIGQKDLLIDCQGNWGNILTGDGAAAPRYIEARLSKFALEVLYSP EECCCCCCHHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCC KITEWGLSYDGRKAEPINLPVKFPMLLAQGAEGIAVGLSTKVLPHNFNELIDASIKILKG CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHEEECC KPFTLYPDFMTQGIADVSNYNDGMRGGRVRVRAKISQLDKNTLVITQIPFSTNTSSLIDS CCCEECHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHCCCCEEEEEECCCCCCHHHHHHH ILKANDKGKIKIKKIEDNTAADVEILIHLFPGVSPDKTIDALFAFTACETSVAPLGCVIE HHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE DNKPLFIGVSQMLKISTHRTVDLLRQELEIQLEELKNKWHFSTLEKIFIREEMYIDFKLY CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEEEE GDRESLYKYLYDRFEPFKKSFVREINDDDLQRLTQIPMIRITRFDSDKADDLIAKLEDEM CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH KEVEHNLEHLTDFAIAYFTKLKEKYGKGRERQTELRVFDNVEATKVVLRNTKLYVNREEG HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEECCCHHHEEEEECCEEEEECCCC FVGTSLKKDEYVGDCSDIDDVIVFLRDGTLMITKVDAKTFIGKDIIHVAVFDKNDKRTIY CCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEECHHHHHCCCEEEEEEECCCCCHHHH NMMYRDGKSGPSYIKRFNVTGVTRDKAYDLTNGTNGSQVVYFSHNPNGEAEVVTILLRQV HHHHHCCCCCHHHHHEECCCEECCCCCEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHH GTIKKLKFDIDFAKLAIKGRGSKGNLVTKYPIKKIELKEKGISTLLPRKVWFDDTVKRLN CCCEEEEEECEEEEEEEEECCCCCCEEEECCCEEEEEHHCCHHHHCCCHHHHHHHHHHCC VDARGELLGEFKPTDKILIINQSGKLKVIIPELSTHFDEDMIVLEKWKPKKPISAIYYDG CCCCHHHHCCCCCCCEEEEEECCCCEEEEECCHHCCCCCCEEEEECCCCCCCCEEEEECC EKERYFLKRFLVENEGKEESFITDHPNSQLEIVSTDYRPVAQLVFAKVKGVQKDDLHIDV CCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEEH EDFIAVKGFKALGNQLTTDKLKQVNLLDPLPYEEPIEEIPEKPEISEDDPVETELDDDGQ HHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCC IGLVLE EEEEEC >Mature Secondary Structure MKDEEDDNIIPNDDENNQDENLMDDNQDGDDEDIINVDAKHFEGQHFYENQEEEGEDVIT CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHCCCCCCCCCCCCCHHHHHH KVTGMYKDWFLDYASYVILERAVPAIEDGFKPVQRRIMHSLKELDDGRYNKVANVVGHTM HHHHHHHHHHHHHHHHHHHHHHCHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCE QYHPHGDASIGDAMVQIGQKDLLIDCQGNWGNILTGDGAAAPRYIEARLSKFALEVLYSP EECCCCCCHHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCC KITEWGLSYDGRKAEPINLPVKFPMLLAQGAEGIAVGLSTKVLPHNFNELIDASIKILKG CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHEEECC KPFTLYPDFMTQGIADVSNYNDGMRGGRVRVRAKISQLDKNTLVITQIPFSTNTSSLIDS CCCEECHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHCCCCEEEEEECCCCCCHHHHHHH ILKANDKGKIKIKKIEDNTAADVEILIHLFPGVSPDKTIDALFAFTACETSVAPLGCVIE HHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE DNKPLFIGVSQMLKISTHRTVDLLRQELEIQLEELKNKWHFSTLEKIFIREEMYIDFKLY CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEEEE GDRESLYKYLYDRFEPFKKSFVREINDDDLQRLTQIPMIRITRFDSDKADDLIAKLEDEM CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH KEVEHNLEHLTDFAIAYFTKLKEKYGKGRERQTELRVFDNVEATKVVLRNTKLYVNREEG HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEECCCHHHEEEEECCEEEEECCCC FVGTSLKKDEYVGDCSDIDDVIVFLRDGTLMITKVDAKTFIGKDIIHVAVFDKNDKRTIY CCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEECHHHHHCCCEEEEEEECCCCCHHHH NMMYRDGKSGPSYIKRFNVTGVTRDKAYDLTNGTNGSQVVYFSHNPNGEAEVVTILLRQV HHHHHCCCCCHHHHHEECCCEECCCCCEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHH GTIKKLKFDIDFAKLAIKGRGSKGNLVTKYPIKKIELKEKGISTLLPRKVWFDDTVKRLN CCCEEEEEECEEEEEEEEECCCCCCEEEECCCEEEEEHHCCHHHHCCCHHHHHHHHHHCC VDARGELLGEFKPTDKILIINQSGKLKVIIPELSTHFDEDMIVLEKWKPKKPISAIYYDG CCCCHHHHCCCCCCCEEEEEECCCCEEEEECCHHCCCCCCEEEEECCCCCCCCEEEEECC EKERYFLKRFLVENEGKEESFITDHPNSQLEIVSTDYRPVAQLVFAKVKGVQKDDLHIDV CCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEEH EDFIAVKGFKALGNQLTTDKLKQVNLLDPLPYEEPIEEIPEKPEISEDDPVETELDDDGQ HHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCC IGLVLE EEEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 9403685 [H]