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The map label for this gene is parE [H]

Identifier: 146300228

GI number: 146300228

Start: 2960241

End: 2962109

Strand: Direct

Name: parE [H]

Synonym: Fjoh_2473

Alternate gene names: 146300228

Gene position: 2960241-2962109 (Clockwise)

Preceding gene: 146300227

Following gene: 146300229

Centisome position: 48.55

GC content: 37.29

Gene sequence:

>1869_bases
ATGCTAGAGCAAAATCAATATACCGAAGATAATATTCGTTCACTTGATTGGAAAGAACATATCCGTATGCGTCCGGGAAT
GTATATCGGAAAACTTGGAGACGGTTCTTCTCCAGATGATGGTATTTATATTCTATTAAAAGAGGTTTTAGATAACTGTA
TCGATGAGTTCGTAATGGGCTCTGGAAAAACTATTGAGGTAACGATAAAAGATAAAACGGTTTCGGTTCGTGATTACGGG
CGTGGAATTCCGTTGGGGAAAGTGGTCGATGTAGTTTCGAAAATGAACACAGGAGGAAAGTACGATTCTAAAGCTTTCCA
GAAATCAGTTGGTTTGAATGGTGTCGGAACAAAAGCGGTAAATGCGCTTTCTACCTATTTCCGTGTAGAATCGGTTCGTG
ATGATAAACAAAAAGCGGCGGAGTTTTCCGGCGGGAATTTAGTTTCAGAAGAAGATGTAATCGATACTACAAAACGTAAA
GGAACAAAAGTAACTTTTACGCCAGACGAAACGATTTTCAAAAACTATAAATTCCGTTTAGAATACGTTATCAAAATGGT
TAAAAACTATTGTTACTTAAACAATGGTTTGACAATTATTTTTAATGGAGAAAAATATTATTCAGAAAATGGACTTCGTG
ATTTATTAGAAGAAACAATCAGCGAAGAAGATTTAGAATACCCAATTATCCACTTAAAAGAGCATGATATCGAGGTTGCG
CTTACACACAGTAAAACGCAGTACAGCGAAGAATATCACTCTTTTGTGAACGGTCAGAACACAACGCAGGGTGGAACGCA
CTTAGCGGCCTATCGAGAAGCCGTTGTAAAAACGATTCGTGAGTTTTACAATAAGAATTTCGAAGCATCAGATGTTCGTA
AATCGATTGTAAGTGCGATTAGTATTAAAGTAATGGAACCGGTTTTTGAGTCTCAGACCAAAACAAAATTAGGTTCTACA
GATATGGGTTCTGATGACGGAACACCAGCAGTTTCTGTTCGTACTTTCGTAAACGATTTTATCAAAACGAAACTGGATAA
TTACCTGCATAAAAATCCAACAACTGCAGATGCTTTATTGCGTAAAATTCTGCAGGCAGAACGTGAGCGCAAAGAATTAT
CAGGAATTAGAAAACTGGCAACAGATCGTGCTAAAAAAGCGAATCTTCATAATAAAAAATTAAGAGATTGCCGCGCGCAT
CTTCCTGATACCAAAAACCCAAGAAACTTAGAAAGCACGCTTTTTATTACCGAGGGAGATTCGGCTTCCGGATCGATTAC
AAAGTCGCGTGACGTGAATACACAAGCAGTTTTCAGTTTGCGTGGTAAACCTTTGAATTCATACGGAATGACGAAGAAAA
TCGTGTATGAAAACGAAGAATTCAATTTATTGCAGGCAGCACTTGATATCGAAGACGGATTAGAAAAATTACGTTACAAC
AATATCGTAATCGCAACCGATGCCGATGTCGACGGAATGCACATTCGCTTGCTTTTAATTACATTCTTTTTACAGTTTTT
CCCTGAGTTAATAAAAGAAGGGCATTTGTATATTTTACAAACACCGCTTTTCAGGGTTCGAAACAAAAAAGAAACAATTT
ACTGTTATTCTGATGAAGAAAGAAAAGACGCTATCGAGAAACTAAAACCAAAACCGGAAATCACCCGATTTAAAGGTTTA
GGAGAGATTTCGCCAGACGAGTTCAAGAACTTTATTGGAGACACTATCCGTCTTGATCCGGTTATGATGGATAAAAATAC
TTCTATCGAGCAGTTGTTATCGTTCTACATGGGTAAAAATACGCCAGATAGACAAGAGTTTATTATTAAGAACCTGAAGG
TTGAGATTGATGAATTAGAAGAAGCTTAA

Upstream 100 bases:

>100_bases
TTAAATAGATTTTAAACTGTTATTATTCATAACAAAAAGAAAATACGCTTTCATTTTTTGCTAAGAAATGGTACATTAGC
AAAAAATCCTAAATTCATAT

Downstream 100 bases:

>100_bases
TTGAACTGGTTTTGTATGAAGAAAATCTTTTGCTTATTTATTATTGTTTTTAGTGTGATAGCTTGTTATGATAAAAAGTC
AAAGAATTTATCAATAGAAG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MLEQNQYTEDNIRSLDWKEHIRMRPGMYIGKLGDGSSPDDGIYILLKEVLDNCIDEFVMGSGKTIEVTIKDKTVSVRDYG
RGIPLGKVVDVVSKMNTGGKYDSKAFQKSVGLNGVGTKAVNALSTYFRVESVRDDKQKAAEFSGGNLVSEEDVIDTTKRK
GTKVTFTPDETIFKNYKFRLEYVIKMVKNYCYLNNGLTIIFNGEKYYSENGLRDLLEETISEEDLEYPIIHLKEHDIEVA
LTHSKTQYSEEYHSFVNGQNTTQGGTHLAAYREAVVKTIREFYNKNFEASDVRKSIVSAISIKVMEPVFESQTKTKLGST
DMGSDDGTPAVSVRTFVNDFIKTKLDNYLHKNPTTADALLRKILQAERERKELSGIRKLATDRAKKANLHNKKLRDCRAH
LPDTKNPRNLESTLFITEGDSASGSITKSRDVNTQAVFSLRGKPLNSYGMTKKIVYENEEFNLLQAALDIEDGLEKLRYN
NIVIATDADVDGMHIRLLLITFFLQFFPELIKEGHLYILQTPLFRVRNKKETIYCYSDEERKDAIEKLKPKPEITRFKGL
GEISPDEFKNFIGDTIRLDPVMMDKNTSIEQLLSFYMGKNTPDRQEFIIKNLKVEIDELEEA

Sequences:

>Translated_622_residues
MLEQNQYTEDNIRSLDWKEHIRMRPGMYIGKLGDGSSPDDGIYILLKEVLDNCIDEFVMGSGKTIEVTIKDKTVSVRDYG
RGIPLGKVVDVVSKMNTGGKYDSKAFQKSVGLNGVGTKAVNALSTYFRVESVRDDKQKAAEFSGGNLVSEEDVIDTTKRK
GTKVTFTPDETIFKNYKFRLEYVIKMVKNYCYLNNGLTIIFNGEKYYSENGLRDLLEETISEEDLEYPIIHLKEHDIEVA
LTHSKTQYSEEYHSFVNGQNTTQGGTHLAAYREAVVKTIREFYNKNFEASDVRKSIVSAISIKVMEPVFESQTKTKLGST
DMGSDDGTPAVSVRTFVNDFIKTKLDNYLHKNPTTADALLRKILQAERERKELSGIRKLATDRAKKANLHNKKLRDCRAH
LPDTKNPRNLESTLFITEGDSASGSITKSRDVNTQAVFSLRGKPLNSYGMTKKIVYENEEFNLLQAALDIEDGLEKLRYN
NIVIATDADVDGMHIRLLLITFFLQFFPELIKEGHLYILQTPLFRVRNKKETIYCYSDEERKDAIEKLKPKPEITRFKGL
GEISPDEFKNFIGDTIRLDPVMMDKNTSIEQLLSFYMGKNTPDRQEFIIKNLKVEIDELEEA
>Mature_622_residues
MLEQNQYTEDNIRSLDWKEHIRMRPGMYIGKLGDGSSPDDGIYILLKEVLDNCIDEFVMGSGKTIEVTIKDKTVSVRDYG
RGIPLGKVVDVVSKMNTGGKYDSKAFQKSVGLNGVGTKAVNALSTYFRVESVRDDKQKAAEFSGGNLVSEEDVIDTTKRK
GTKVTFTPDETIFKNYKFRLEYVIKMVKNYCYLNNGLTIIFNGEKYYSENGLRDLLEETISEEDLEYPIIHLKEHDIEVA
LTHSKTQYSEEYHSFVNGQNTTQGGTHLAAYREAVVKTIREFYNKNFEASDVRKSIVSAISIKVMEPVFESQTKTKLGST
DMGSDDGTPAVSVRTFVNDFIKTKLDNYLHKNPTTADALLRKILQAERERKELSGIRKLATDRAKKANLHNKKLRDCRAH
LPDTKNPRNLESTLFITEGDSASGSITKSRDVNTQAVFSLRGKPLNSYGMTKKIVYENEEFNLLQAALDIEDGLEKLRYN
NIVIATDADVDGMHIRLLLITFFLQFFPELIKEGHLYILQTPLFRVRNKKETIYCYSDEERKDAIEKLKPKPEITRFKGL
GEISPDEFKNFIGDTIRLDPVMMDKNTSIEQLLSFYMGKNTPDRQEFIIKNLKVEIDELEEA

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=631, Percent_Identity=29.1600633914422, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI19913406, Length=627, Percent_Identity=27.7511961722488, Blast_Score=134, Evalue=4e-31,
Organism=Escherichia coli, GI1789408, Length=600, Percent_Identity=31.5, Blast_Score=268, Evalue=8e-73,
Organism=Escherichia coli, GI48994957, Length=575, Percent_Identity=34.0869565217391, Blast_Score=258, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17535065, Length=635, Percent_Identity=26.4566929133858, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI212645845, Length=547, Percent_Identity=26.691042047532, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI212645657, Length=190, Percent_Identity=30, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=638, Percent_Identity=26.8025078369906, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17136538, Length=623, Percent_Identity=27.76886035313, Blast_Score=133, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.- [C]

Molecular weight: Translated: 70913; Mature: 70913

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQNQYTEDNIRSLDWKEHIRMRPGMYIGKLGDGSSPDDGIYILLKEVLDNCIDEFVMG
CCCCCCCCCCHHHCCCHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCC
SGKTIEVTIKDKTVSVRDYGRGIPLGKVVDVVSKMNTGGKYDSKAFQKSVGLNGVGTKAV
CCCEEEEEEECCEEEHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHH
NALSTYFRVESVRDDKQKAAEFSGGNLVSEEDVIDTTKRKGTKVTFTPDETIFKNYKFRL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
EYVIKMVKNYCYLNNGLTIIFNGEKYYSENGLRDLLEETISEEDLEYPIIHLKEHDIEVA
HHHHHHHHHHEEECCCEEEEECCCHHHCCCCHHHHHHHHHCCCCCCCCEEEEEECCEEEE
LTHSKTQYSEEYHSFVNGQNTTQGGTHLAAYREAVVKTIREFYNKNFEASDVRKSIVSAI
EECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SIKVMEPVFESQTKTKLGSTDMGSDDGTPAVSVRTFVNDFIKTKLDNYLHKNPTTADALL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RKILQAERERKELSGIRKLATDRAKKANLHNKKLRDCRAHLPDTKNPRNLESTLFITEGD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCC
SASGSITKSRDVNTQAVFSLRGKPLNSYGMTKKIVYENEEFNLLQAALDIEDGLEKLRYN
CCCCCCCCCCCCCHHHEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHC
NIVIATDADVDGMHIRLLLITFFLQFFPELIKEGHLYILQTPLFRVRNKKETIYCYSDEE
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCEEEEECCHH
RKDAIEKLKPKPEITRFKGLGEISPDEFKNFIGDTIRLDPVMMDKNTSIEQLLSFYMGKN
HHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHCCCEEECEEEECCCCCHHHHHHHHHCCC
TPDRQEFIIKNLKVEIDELEEA
CCCHHHHHHHHHHEEHHHHCCC
>Mature Secondary Structure
MLEQNQYTEDNIRSLDWKEHIRMRPGMYIGKLGDGSSPDDGIYILLKEVLDNCIDEFVMG
CCCCCCCCCCHHHCCCHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCC
SGKTIEVTIKDKTVSVRDYGRGIPLGKVVDVVSKMNTGGKYDSKAFQKSVGLNGVGTKAV
CCCEEEEEEECCEEEHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHH
NALSTYFRVESVRDDKQKAAEFSGGNLVSEEDVIDTTKRKGTKVTFTPDETIFKNYKFRL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
EYVIKMVKNYCYLNNGLTIIFNGEKYYSENGLRDLLEETISEEDLEYPIIHLKEHDIEVA
HHHHHHHHHHEEECCCEEEEECCCHHHCCCCHHHHHHHHHCCCCCCCCEEEEEECCEEEE
LTHSKTQYSEEYHSFVNGQNTTQGGTHLAAYREAVVKTIREFYNKNFEASDVRKSIVSAI
EECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SIKVMEPVFESQTKTKLGSTDMGSDDGTPAVSVRTFVNDFIKTKLDNYLHKNPTTADALL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RKILQAERERKELSGIRKLATDRAKKANLHNKKLRDCRAHLPDTKNPRNLESTLFITEGD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCC
SASGSITKSRDVNTQAVFSLRGKPLNSYGMTKKIVYENEEFNLLQAALDIEDGLEKLRYN
CCCCCCCCCCCCCHHHEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHC
NIVIATDADVDGMHIRLLLITFFLQFFPELIKEGHLYILQTPLFRVRNKKETIYCYSDEE
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCEEEEECCHH
RKDAIEKLKPKPEITRFKGLGEISPDEFKNFIGDTIRLDPVMMDKNTSIEQLLSFYMGKN
HHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHCCCEEECEEEECCCCCHHHHHHHHHCCC
TPDRQEFIIKNLKVEIDELEEA
CCCHHHHHHHHHHEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685; 7812434 [H]