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The map label for this gene is kbl [C]

Identifier: 146300174

GI number: 146300174

Start: 2894165

End: 2895424

Strand: Direct

Name: kbl [C]

Synonym: Fjoh_2419

Alternate gene names: 146300174

Gene position: 2894165-2895424 (Clockwise)

Preceding gene: 146300170

Following gene: 146300175

Centisome position: 47.47

GC content: 34.92

Gene sequence:

>1260_bases
ATGGTAAAAGATTTATTCGAAAGAATTCAGGACAATAAGGGACCTTTAGGAAAATGGGCTTCTCAGGCAGAAGGTTATTA
CGTTTTCCCAAAGTTAGAAGGAGAGTTGGGTCCTAGAATGCAATTTCATGGAAAAAATATCCTAAACTGGAGTTTAAATG
ATTATTTAGGTTTAGCTAATCATCCAGAAGTTCGTAAGGCTGATACAGATGCAGCAGCTCAGTTTGGTGCAGCTTACCCA
ATGGGTGCTCGTATGATGTCTGGACACACTACTTATCATGAGCAATTAGAAAATGAACTGGCTTCTTTTGTAATGAAAGA
ATCAGCTTATTTATTGAATTTTGGTTACCAGGGAATGGTTTCTATTATTGATGCTTTGGTTACAAAAAATGATATCATTG
TTTATGATGTAGATTCACATGCTTGTATTATTGATGGTGTTCGTTTGCACATGGGTAAACGTTTTACTTACAAACACAAT
GATCTTGAAAGTATGGAAAAAAACCTGCAGCGTGCTACTAAAATGGCTGAAGAAACAGGTGGAGGTATTTTATTTATTAC
CGAAGGTGTTTTTGGAATGCGCGGACAGCAGGGAAAATTAAAAGAAATTGTTGCGTTAAAGCAAAAATACAATTTCCGTT
TATTAGTTGATGATGCACACGGTTTTGGTACACTTGGTAAAACAGGTGCAGGAGCAGGTGAGGAGCAGGGAGTTCAGGCA
GATATTGATGTTTATTTCTCTACTTTTGCAAAATCTATGGCTAATATTGGTGCTTTCGTAGCAGCAGATAAAACAGTTAT
TGATTACTTAAAATATAACTTACGTTCTCAGATGTTTGCAAAAGCATTACCAATGATTCAAACAATTGGTTCTTTGAAAC
GTTTAGAGTTATTACGCCAGTCTTCTGCAATTAAAGACAAACTTTGGGAAAACGTAAATGCTTTACAAAGCGGTCTTAAA
GAAAGAGGATTTAATATTGGAGATACAAATACTTGTATTACACCAGTTTATTTAGAAGGAAGTATTCCAGAAGCAATGGT
AATGGTTAACGATTTAAGAGAAAATTACGGTATTTTCCTTTCTATTGTTGTATATCCTGTTATTCCAAAAGGAATTATTT
TGTTAAGAATGATTCCAACAGCTTCTCATACATTAGAAGATATCAAAGAAACATTAGCAGCTTTTGAAGCAATTCGTGAG
AAACTGGTAAACGGAACGTATAAAGAAATTGCAGAACGTACAACAGTAGACGTTTCGTAA

Upstream 100 bases:

>100_bases
TTGATTATTTTTTAATAAAAATAAATGACTGTCTGAATTTTAGAATAATAATGATTATTTTTGCTCGCTGATTAAGTTAA
AAAAATTACTACACTATATT

Downstream 100 bases:

>100_bases
TTGATTTAAAAATAAATTCTCACATGGGAATTATGTAAAAAAATCCATTCGTTATGCGAATGGATTTTTTTTATTTGAGG
TAACTTTATTTCATAATCAC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MVKDLFERIQDNKGPLGKWASQAEGYYVFPKLEGELGPRMQFHGKNILNWSLNDYLGLANHPEVRKADTDAAAQFGAAYP
MGARMMSGHTTYHEQLENELASFVMKESAYLLNFGYQGMVSIIDALVTKNDIIVYDVDSHACIIDGVRLHMGKRFTYKHN
DLESMEKNLQRATKMAEETGGGILFITEGVFGMRGQQGKLKEIVALKQKYNFRLLVDDAHGFGTLGKTGAGAGEEQGVQA
DIDVYFSTFAKSMANIGAFVAADKTVIDYLKYNLRSQMFAKALPMIQTIGSLKRLELLRQSSAIKDKLWENVNALQSGLK
ERGFNIGDTNTCITPVYLEGSIPEAMVMVNDLRENYGIFLSIVVYPVIPKGIILLRMIPTASHTLEDIKETLAAFEAIRE
KLVNGTYKEIAERTTVDVS

Sequences:

>Translated_419_residues
MVKDLFERIQDNKGPLGKWASQAEGYYVFPKLEGELGPRMQFHGKNILNWSLNDYLGLANHPEVRKADTDAAAQFGAAYP
MGARMMSGHTTYHEQLENELASFVMKESAYLLNFGYQGMVSIIDALVTKNDIIVYDVDSHACIIDGVRLHMGKRFTYKHN
DLESMEKNLQRATKMAEETGGGILFITEGVFGMRGQQGKLKEIVALKQKYNFRLLVDDAHGFGTLGKTGAGAGEEQGVQA
DIDVYFSTFAKSMANIGAFVAADKTVIDYLKYNLRSQMFAKALPMIQTIGSLKRLELLRQSSAIKDKLWENVNALQSGLK
ERGFNIGDTNTCITPVYLEGSIPEAMVMVNDLRENYGIFLSIVVYPVIPKGIILLRMIPTASHTLEDIKETLAAFEAIRE
KLVNGTYKEIAERTTVDVS
>Mature_419_residues
MVKDLFERIQDNKGPLGKWASQAEGYYVFPKLEGELGPRMQFHGKNILNWSLNDYLGLANHPEVRKADTDAAAQFGAAYP
MGARMMSGHTTYHEQLENELASFVMKESAYLLNFGYQGMVSIIDALVTKNDIIVYDVDSHACIIDGVRLHMGKRFTYKHN
DLESMEKNLQRATKMAEETGGGILFITEGVFGMRGQQGKLKEIVALKQKYNFRLLVDDAHGFGTLGKTGAGAGEEQGVQA
DIDVYFSTFAKSMANIGAFVAADKTVIDYLKYNLRSQMFAKALPMIQTIGSLKRLELLRQSSAIKDKLWENVNALQSGLK
ERGFNIGDTNTCITPVYLEGSIPEAMVMVNDLRENYGIFLSIVVYPVIPKGIILLRMIPTASHTLEDIKETLAAFEAIRE
KLVNGTYKEIAERTTVDVS

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=362, Percent_Identity=32.5966850828729, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI284448556, Length=352, Percent_Identity=32.6704545454545, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI83977440, Length=355, Percent_Identity=27.887323943662, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI83977442, Length=355, Percent_Identity=27.887323943662, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI83977444, Length=355, Percent_Identity=27.887323943662, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI4758668, Length=367, Percent_Identity=30.7901907356948, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI119220554, Length=421, Percent_Identity=28.7410926365796, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4502025, Length=344, Percent_Identity=27.0348837209302, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI40316939, Length=344, Percent_Identity=27.0348837209302, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI5454084, Length=295, Percent_Identity=28.4745762711864, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1790046, Length=364, Percent_Identity=33.5164835164835, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1786993, Length=350, Percent_Identity=31.4285714285714, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71994529, Length=361, Percent_Identity=32.9639889196676, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI32566772, Length=373, Percent_Identity=27.6139410187668, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17560914, Length=369, Percent_Identity=27.6422764227642, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17560912, Length=369, Percent_Identity=27.6422764227642, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71982617, Length=319, Percent_Identity=23.5109717868339, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71982625, Length=319, Percent_Identity=23.5109717868339, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320267, Length=371, Percent_Identity=29.6495956873315, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320438, Length=365, Percent_Identity=26.5753424657534, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323954, Length=261, Percent_Identity=26.8199233716475, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24662918, Length=357, Percent_Identity=31.6526610644258, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI17137420, Length=346, Percent_Identity=28.9017341040462, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=25.8760107816712, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653280, Length=317, Percent_Identity=26.4984227129338, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24653276, Length=317, Percent_Identity=26.4984227129338, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24653278, Length=317, Percent_Identity=26.4984227129338, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 46654; Mature: 46654

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKDLFERIQDNKGPLGKWASQAEGYYVFPKLEGELGPRMQFHGKNILNWSLNDYLGLAN
CCHHHHHHHHCCCCCCCHHHHCCCCEEEEEEECCCCCCCEEECCCCEEEECHHHHCCCCC
HPEVRKADTDAAAQFGAAYPMGARMMSGHTTYHEQLENELASFVMKESAYLLNFGYQGMV
CCCCCCCCCHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCHHEEECCCHHHH
SIIDALVTKNDIIVYDVDSHACIIDGVRLHMGKRFTYKHNDLESMEKNLQRATKMAEETG
HHHHHHHCCCCEEEEECCCCEEEEECHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCC
GGILFITEGVFGMRGQQGKLKEIVALKQKYNFRLLVDDAHGFGTLGKTGAGAGEEQGVQA
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCH
DIDVYFSTFAKSMANIGAFVAADKTVIDYLKYNLRSQMFAKALPMIQTIGSLKRLELLRQ
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSAIKDKLWENVNALQSGLKERGFNIGDTNTCITPVYLEGSIPEAMVMVNDLRENYGIFL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEE
SIVVYPVIPKGIILLRMIPTASHTLEDIKETLAAFEAIREKLVNGTYKEIAERTTVDVS
EHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MVKDLFERIQDNKGPLGKWASQAEGYYVFPKLEGELGPRMQFHGKNILNWSLNDYLGLAN
CCHHHHHHHHCCCCCCCHHHHCCCCEEEEEEECCCCCCCEEECCCCEEEECHHHHCCCCC
HPEVRKADTDAAAQFGAAYPMGARMMSGHTTYHEQLENELASFVMKESAYLLNFGYQGMV
CCCCCCCCCHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCHHEEECCCHHHH
SIIDALVTKNDIIVYDVDSHACIIDGVRLHMGKRFTYKHNDLESMEKNLQRATKMAEETG
HHHHHHHCCCCEEEEECCCCEEEEECHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCC
GGILFITEGVFGMRGQQGKLKEIVALKQKYNFRLLVDDAHGFGTLGKTGAGAGEEQGVQA
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCH
DIDVYFSTFAKSMANIGAFVAADKTVIDYLKYNLRSQMFAKALPMIQTIGSLKRLELLRQ
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSAIKDKLWENVNALQSGLKERGFNIGDTNTCITPVYLEGSIPEAMVMVNDLRENYGIFL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEE
SIVVYPVIPKGIILLRMIPTASHTLEDIKETLAAFEAIREKLVNGTYKEIAERTTVDVS
EHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA