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The map label for this gene is mro [H]

Identifier: 146299785

GI number: 146299785

Start: 2376502

End: 2377680

Strand: Direct

Name: mro [H]

Synonym: Fjoh_2026

Alternate gene names: 146299785

Gene position: 2376502-2377680 (Clockwise)

Preceding gene: 146299784

Following gene: 146299786

Centisome position: 38.98

GC content: 34.86

Gene sequence:

>1179_bases
ATGAAAAATATCCAAATAGCAGCTGTCGTTTTACTGGCGCTTTTTCAGTTTAATTGTAAGGACAATAAAAAAGAAAATTC
CACTTCAAAAGAAACTGCTGCAATACAATCAGATTCAACAAAAACTGTTTTACAAACTAAAAATTTCGATACGATAATCG
ACGGAAAAAAAGTTGGCTTATACTGGATCGAAAACAAAGGTATTAAAGCCGCTTTTACCAATTACGGCGGAAGACTAATC
GGACTTTGGGTAAACGATAAAAATGGAAAATCAACCGATGTTGTTGTGGGAATGAACAGTGCAAAAGGTTTTAAAACCTC
AACAGAACCTTACTTTGGAGCTACAATTGGAAGAGTTGGAAACCGAATAGGAAAAGGGAAATTTACATTAGAAGGAAAAC
AATATCAAGTTCCGTTAAATAATGGGAAAAATGCCTTGCATGGTGGTGTAAAAGGTTTTCAGGATGTAGTTTGGAATGCC
GAAAAAACAAACGAAAACATTCTGGTTTTTACCTATGTTTCACCAGACGGCGAACAAGGTTTTCCTGGAAATTTATCTGT
AAAAGTAACCTATACGATTACTGATGATAATTCGGTTCAAATGGAGTATGAAGCAACTACAGATAAAACAACAATTGTCA
ATTTAACCAATCATGCTTTTTTAAATTTAAACGGAGAAGGAAGCGGTACAATCTTAAATCACGAATTACAGATCTATGCC
AACGAATTTACTCCCGTTGACGAAGGTTTGATTCCAAACGGTGAATTAAAACCAGTAAAAAATACGCCTTTCGATTTTAC
TTCAAAACATACCATTGGCGAAAGAATTGAAACGAAAGATGAACAGTTGAAATTTGGAAAAGGCTACGACCACAATTACG
TTTTAAACGGAACTAAGAAAAACGGATTAAATCATGCTGCAACAATTTCTGGTGATAAATCGGGAATCACGCTTGATATT
TTTACACAAGAACCGGGATTACAGTTTTACAGCGGGAATTTCATGCAGTCAAAAAACACCTTTAAAAGTGGTGCAAAAGA
CGATTTTAGAACTGCTTTTGCTTTAGAAACACAGCATTTTCCAGACGCGCCAAATCAGCCAAAATTTGCTCCGATTGTTT
TAAAACCCGGAGAAAAATATCATACAGTTTCTTATTATCAGTTTTCTGTAAAAAAGTAG

Upstream 100 bases:

>100_bases
TTGGGATGCCAACGGATTTCCAGTTTTGGGAGAACCGGTAAGTGAAGAAACCAAACTGGCAATTCCTTCAAAATAATACA
AACATTTTAAAATTCACAAA

Downstream 100 bases:

>100_bases
TTTAACCGCAAAGTTTTTTTACCGCAAAGAGCGCTAAGAATTACGCAAAGGTCGCAAAGTTTTTTTTCTCACTTTTGTCA
CCCTGAGCGAAGTCGAAGGA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKNIQIAAVVLLALFQFNCKDNKKENSTSKETAAIQSDSTKTVLQTKNFDTIIDGKKVGLYWIENKGIKAAFTNYGGRLI
GLWVNDKNGKSTDVVVGMNSAKGFKTSTEPYFGATIGRVGNRIGKGKFTLEGKQYQVPLNNGKNALHGGVKGFQDVVWNA
EKTNENILVFTYVSPDGEQGFPGNLSVKVTYTITDDNSVQMEYEATTDKTTIVNLTNHAFLNLNGEGSGTILNHELQIYA
NEFTPVDEGLIPNGELKPVKNTPFDFTSKHTIGERIETKDEQLKFGKGYDHNYVLNGTKKNGLNHAATISGDKSGITLDI
FTQEPGLQFYSGNFMQSKNTFKSGAKDDFRTAFALETQHFPDAPNQPKFAPIVLKPGEKYHTVSYYQFSVKK

Sequences:

>Translated_392_residues
MKNIQIAAVVLLALFQFNCKDNKKENSTSKETAAIQSDSTKTVLQTKNFDTIIDGKKVGLYWIENKGIKAAFTNYGGRLI
GLWVNDKNGKSTDVVVGMNSAKGFKTSTEPYFGATIGRVGNRIGKGKFTLEGKQYQVPLNNGKNALHGGVKGFQDVVWNA
EKTNENILVFTYVSPDGEQGFPGNLSVKVTYTITDDNSVQMEYEATTDKTTIVNLTNHAFLNLNGEGSGTILNHELQIYA
NEFTPVDEGLIPNGELKPVKNTPFDFTSKHTIGERIETKDEQLKFGKGYDHNYVLNGTKKNGLNHAATISGDKSGITLDI
FTQEPGLQFYSGNFMQSKNTFKSGAKDDFRTAFALETQHFPDAPNQPKFAPIVLKPGEKYHTVSYYQFSVKK
>Mature_392_residues
MKNIQIAAVVLLALFQFNCKDNKKENSTSKETAAIQSDSTKTVLQTKNFDTIIDGKKVGLYWIENKGIKAAFTNYGGRLI
GLWVNDKNGKSTDVVVGMNSAKGFKTSTEPYFGATIGRVGNRIGKGKFTLEGKQYQVPLNNGKNALHGGVKGFQDVVWNA
EKTNENILVFTYVSPDGEQGFPGNLSVKVTYTITDDNSVQMEYEATTDKTTIVNLTNHAFLNLNGEGSGTILNHELQIYA
NEFTPVDEGLIPNGELKPVKNTPFDFTSKHTIGERIETKDEQLKFGKGYDHNYVLNGTKKNGLNHAATISGDKSGITLDI
FTQEPGLQFYSGNFMQSKNTFKSGAKDDFRTAFALETQHFPDAPNQPKFAPIVLKPGEKYHTVSYYQFSVKK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=336, Percent_Identity=40.7738095238095, Blast_Score=270, Evalue=2e-72,
Organism=Escherichia coli, GI1786971, Length=326, Percent_Identity=37.7300613496933, Blast_Score=230, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17557428, Length=335, Percent_Identity=34.3283582089552, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI115533334, Length=335, Percent_Identity=34.3283582089552, Blast_Score=173, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319493, Length=337, Percent_Identity=32.9376854599407, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6322004, Length=346, Percent_Identity=28.9017341040462, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324399, Length=344, Percent_Identity=27.3255813953488, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24659048, Length=333, Percent_Identity=35.7357357357357, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24668278, Length=333, Percent_Identity=34.2342342342342, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24668282, Length=336, Percent_Identity=33.6309523809524, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24583720, Length=342, Percent_Identity=34.5029239766082, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24641876, Length=336, Percent_Identity=30.6547619047619, Blast_Score=165, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 43322; Mature: 43322

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIQIAAVVLLALFQFNCKDNKKENSTSKETAAIQSDSTKTVLQTKNFDTIIDGKKVGL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEECCCCEEEEEECCCCEEECCCEEEE
YWIENKGIKAAFTNYGGRLIGLWVNDKNGKSTDVVVGMNSAKGFKTSTEPYFGATIGRVG
EEEECCCEEEEEECCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHC
NRIGKGKFTLEGKQYQVPLNNGKNALHGGVKGFQDVVWNAEKTNENILVFTYVSPDGEQG
CCCCCCEEEECCCEEEEECCCCCHHHHCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCCC
FPGNLSVKVTYTITDDNSVQMEYEATTDKTTIVNLTNHAFLNLNGEGSGTILNHELQIYA
CCCCEEEEEEEEEECCCCEEEEEECCCCCEEEEEECCEEEEEECCCCCCEEEEEEEEEEE
NEFTPVDEGLIPNGELKPVKNTPFDFTSKHTIGERIETKDEQLKFGKGYDHNYVLNGTKK
ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHEECCCCCCCCEEEECCCC
NGLNHAATISGDKSGITLDIFTQEPGLQFYSGNFMQSKNTFKSGAKDDFRTAFALETQHF
CCCCEEEEECCCCCCEEEEEEECCCCCEEEECCEEECCCHHCCCCCCCCEEEEEEECCCC
PDAPNQPKFAPIVLKPGEKYHTVSYYQFSVKK
CCCCCCCCEEEEEECCCCCEEEEEEEEEEECC
>Mature Secondary Structure
MKNIQIAAVVLLALFQFNCKDNKKENSTSKETAAIQSDSTKTVLQTKNFDTIIDGKKVGL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEECCCCEEEEEECCCCEEECCCEEEE
YWIENKGIKAAFTNYGGRLIGLWVNDKNGKSTDVVVGMNSAKGFKTSTEPYFGATIGRVG
EEEECCCEEEEEECCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHC
NRIGKGKFTLEGKQYQVPLNNGKNALHGGVKGFQDVVWNAEKTNENILVFTYVSPDGEQG
CCCCCCEEEECCCEEEEECCCCCHHHHCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCCC
FPGNLSVKVTYTITDDNSVQMEYEATTDKTTIVNLTNHAFLNLNGEGSGTILNHELQIYA
CCCCEEEEEEEEEECCCCEEEEEECCCCCEEEEEECCEEEEEECCCCCCEEEEEEEEEEE
NEFTPVDEGLIPNGELKPVKNTPFDFTSKHTIGERIETKDEQLKFGKGYDHNYVLNGTKK
ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHEECCCCCCCCEEEECCCC
NGLNHAATISGDKSGITLDIFTQEPGLQFYSGNFMQSKNTFKSGAKDDFRTAFALETQHF
CCCCEEEEECCCCCCEEEEEEECCCCCEEEECCEEECCCHHCCCCCCCCEEEEEEECCCC
PDAPNQPKFAPIVLKPGEKYHTVSYYQFSVKK
CCCCCCCCEEEEEECCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]