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The map label for this gene is murC

Identifier: 146299571

GI number: 146299571

Start: 2093613

End: 2094962

Strand: Direct

Name: murC

Synonym: Fjoh_1811

Alternate gene names: 146299571

Gene position: 2093613-2094962 (Clockwise)

Preceding gene: 146299570

Following gene: 146299572

Centisome position: 34.34

GC content: 36.52

Gene sequence:

>1350_bases
ATGAATTTAAATCAAATAGAAAACGTTTATTTTATAGGTATCGGAGGCATCGGAATGAGTGCTTTGGCCCGTTATTTCAA
ATACATCGGAAAAAAAGTTTCCGGTTATGATAAAACGCCTTCTATGCTTACAAGTGAATTGATTGAAAGCGGTATTGATA
TTCATTTTGAAGACAACATCAATTTAATTCCATCTAATTATTATGTAGAGAATACGCTGGTAATTTTTACGCCTGCGGTT
CCAGCCTCACATTCAGAATGGCATTATTTTATTGAAAGAAATTACCAAATTAAAAAACGAGCAGAGGTTTTAGGAATTAT
CACTAAGGATACTTTTAGTTTTGCAGTTGCCGGAACACACGGTAAAACCACAACATCTAGTATTTTAGGACATATTCTAC
ACCAAAGCGGGGCAGATGTTACAGCCTTTGTAGGTGGTATTGTAGAAAATTACAATTCAAACTTAATTGGAACCGGAAAA
ACGGTAACCGTTGTAGAGGCTGATGAATTTGATCGTTCATTCCTTCATTTGCATCCTGATATTGCCTGCGTTACCTCAAT
GGATGCAGATCATTTGGATATTTATGGAACAAGTGATGCAATTCAGGCTTCGTTTATTGAATTTGCCTCGAAAGTAGAAG
ATAAAAGCAAATTGTTTATAACCAAAGAATTACCTCTTGAAGGTGTTCAATGTGCTATAAATGAAGATGCAGTGTATAAA
GCCTATAATGTTCGAATTGAAGATGGAAATTATGTTTTTGATGTGCAGACGCCGTCAGAAATTATGAAAGACCTTCGTTT
TGGACTTCCGGGAAAACACAATTTAATGAATGGGTTAATGGCTATTGCGATGGCGAAAACGTATGGCACCCCGACCGACG
CCATTGCAAAAGCTATTGCCTCATTTAATGGAATCAGAAGACGTTTTTCTTATCAAATTAAATCAGATAAGTTAGTTTAT
ATAGATGATTATGCACATCATCCAACAGAAATAAATGCTGTTCATCAGGCAGTTAGAGAGTTGTATCCGGGACGTAAAGT
TCTGGCAGTTTTTCAGCCGCATTTGTTTAGCAGAACTAGAGATTTTGCCGACGGATTTGCCGAAAGCCTGTCTCAGTTTG
ATGAAGTGTTTTTGATGGATATTTATCCGGCACGCGAATTACCAATGGAAGGAATTACATCGCAATGGCTGCTGGATAAA
ATGACAAACCCGAACAGAAAAATTGTTGCAAAAGAAGATTTATTAGCGGAAATCAAAGCCAGTGATGCGCCAATAATTGT
AACAATAGGGGCTGGTGATATTGGTGAAATGGTACCATCAATTAAAAAAATGCTGAATGAAAATATTTAA

Upstream 100 bases:

>100_bases
CAATTTAGGCTTGAAAAGACTTCATAAAACGCAAAGGATTAATTGTTAGTTTCTTACAAAAAAGTAAGAGGCAGTCAAGT
CGAAAAAAACATATTTTAAA

Downstream 100 bases:

>100_bases
TTGGACAAATATTCGATTAGTACTCATTTTAGGGCTTGTTCTTTTTCTATATTCTTTCGCGCAGCACCGAAATGGAGATA
GAAAATTGAAAAAATCTATG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MNLNQIENVYFIGIGGIGMSALARYFKYIGKKVSGYDKTPSMLTSELIESGIDIHFEDNINLIPSNYYVENTLVIFTPAV
PASHSEWHYFIERNYQIKKRAEVLGIITKDTFSFAVAGTHGKTTTSSILGHILHQSGADVTAFVGGIVENYNSNLIGTGK
TVTVVEADEFDRSFLHLHPDIACVTSMDADHLDIYGTSDAIQASFIEFASKVEDKSKLFITKELPLEGVQCAINEDAVYK
AYNVRIEDGNYVFDVQTPSEIMKDLRFGLPGKHNLMNGLMAIAMAKTYGTPTDAIAKAIASFNGIRRRFSYQIKSDKLVY
IDDYAHHPTEINAVHQAVRELYPGRKVLAVFQPHLFSRTRDFADGFAESLSQFDEVFLMDIYPARELPMEGITSQWLLDK
MTNPNRKIVAKEDLLAEIKASDAPIIVTIGAGDIGEMVPSIKKMLNENI

Sequences:

>Translated_449_residues
MNLNQIENVYFIGIGGIGMSALARYFKYIGKKVSGYDKTPSMLTSELIESGIDIHFEDNINLIPSNYYVENTLVIFTPAV
PASHSEWHYFIERNYQIKKRAEVLGIITKDTFSFAVAGTHGKTTTSSILGHILHQSGADVTAFVGGIVENYNSNLIGTGK
TVTVVEADEFDRSFLHLHPDIACVTSMDADHLDIYGTSDAIQASFIEFASKVEDKSKLFITKELPLEGVQCAINEDAVYK
AYNVRIEDGNYVFDVQTPSEIMKDLRFGLPGKHNLMNGLMAIAMAKTYGTPTDAIAKAIASFNGIRRRFSYQIKSDKLVY
IDDYAHHPTEINAVHQAVRELYPGRKVLAVFQPHLFSRTRDFADGFAESLSQFDEVFLMDIYPARELPMEGITSQWLLDK
MTNPNRKIVAKEDLLAEIKASDAPIIVTIGAGDIGEMVPSIKKMLNENI
>Mature_449_residues
MNLNQIENVYFIGIGGIGMSALARYFKYIGKKVSGYDKTPSMLTSELIESGIDIHFEDNINLIPSNYYVENTLVIFTPAV
PASHSEWHYFIERNYQIKKRAEVLGIITKDTFSFAVAGTHGKTTTSSILGHILHQSGADVTAFVGGIVENYNSNLIGTGK
TVTVVEADEFDRSFLHLHPDIACVTSMDADHLDIYGTSDAIQASFIEFASKVEDKSKLFITKELPLEGVQCAINEDAVYK
AYNVRIEDGNYVFDVQTPSEIMKDLRFGLPGKHNLMNGLMAIAMAKTYGTPTDAIAKAIASFNGIRRRFSYQIKSDKLVY
IDDYAHHPTEINAVHQAVRELYPGRKVLAVFQPHLFSRTRDFADGFAESLSQFDEVFLMDIYPARELPMEGITSQWLLDK
MTNPNRKIVAKEDLLAEIKASDAPIIVTIGAGDIGEMVPSIKKMLNENI

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=485, Percent_Identity=32.3711340206186, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1790680, Length=395, Percent_Identity=29.1139240506329, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_FLAJ1 (A5FIY4)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001194162.1
- ProteinModelPortal:   A5FIY4
- STRING:   A5FIY4
- GeneID:   5091436
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_1811
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   FJOH376686:FJOH_1811-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50006; Mature: 50006

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLNQIENVYFIGIGGIGMSALARYFKYIGKKVSGYDKTPSMLTSELIESGIDIHFEDNI
CCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEECCCC
NLIPSNYYVENTLVIFTPAVPASHSEWHYFIERNYQIKKRAEVLGIITKDTFSFAVAGTH
EECCCCEEEEEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHEEEEEEECCEEEEEECCC
GKTTTSSILGHILHQSGADVTAFVGGIVENYNSNLIGTGKTVTVVEADEFDRSFLHLHPD
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCCHHEEECCC
IACVTSMDADHLDIYGTSDAIQASFIEFASKVEDKSKLFITKELPLEGVQCAINEDAVYK
EEEEECCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCEEE
AYNVRIEDGNYVFDVQTPSEIMKDLRFGLPGKHNLMNGLMAIAMAKTYGTPTDAIAKAIA
EEEEEEECCCEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SFNGIRRRFSYQIKSDKLVYIDDYAHHPTEINAVHQAVRELYPGRKVLAVFQPHLFSRTR
HHHHHHHHHEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
DFADGFAESLSQFDEVFLMDIYPARELPMEGITSQWLLDKMTNPNRKIVAKEDLLAEIKA
HHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHC
SDAPIIVTIGAGDIGEMVPSIKKMLNENI
CCCCEEEEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLNQIENVYFIGIGGIGMSALARYFKYIGKKVSGYDKTPSMLTSELIESGIDIHFEDNI
CCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEECCCC
NLIPSNYYVENTLVIFTPAVPASHSEWHYFIERNYQIKKRAEVLGIITKDTFSFAVAGTH
EECCCCEEEEEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHEEEEEEECCEEEEEECCC
GKTTTSSILGHILHQSGADVTAFVGGIVENYNSNLIGTGKTVTVVEADEFDRSFLHLHPD
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCCHHEEECCC
IACVTSMDADHLDIYGTSDAIQASFIEFASKVEDKSKLFITKELPLEGVQCAINEDAVYK
EEEEECCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCEEE
AYNVRIEDGNYVFDVQTPSEIMKDLRFGLPGKHNLMNGLMAIAMAKTYGTPTDAIAKAIA
EEEEEEECCCEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SFNGIRRRFSYQIKSDKLVYIDDYAHHPTEINAVHQAVRELYPGRKVLAVFQPHLFSRTR
HHHHHHHHHEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
DFADGFAESLSQFDEVFLMDIYPARELPMEGITSQWLLDKMTNPNRKIVAKEDLLAEIKA
HHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHC
SDAPIIVTIGAGDIGEMVPSIKKMLNENI
CCCCEEEEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA