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The map label for this gene is lig [H]

Identifier: 146299515

GI number: 146299515

Start: 2029372

End: 2030973

Strand: Direct

Name: lig [H]

Synonym: Fjoh_1755

Alternate gene names: 146299515

Gene position: 2029372-2030973 (Clockwise)

Preceding gene: 146299514

Following gene: 146299516

Centisome position: 33.29

GC content: 36.83

Gene sequence:

>1602_bases
ATGAAAAATTTCGCCCAACTTATAAAAACACTCGACAGTTCTAATAAAACGAACGTAAAAGTCGATGCGCTGACGACGTA
TTTTAAAAATGCATCGCCGGAAGATAAAGTATGGACTATTGCTATTCTTTCGCATCGTCGTCCGGCAAGACCTGTCAATA
CAACATTATTGCGTCTTTGGGCAAATGAACTGGCGAATATTCCGTTATGGCTTTTTGAAGAAAGTTACCATATTGTAGGC
GATCTGGCCGAAACTATTGCTTTGATAATTCCAACAACCAAAGAACATTCCGATAAAAGTTTAACCGAATTTCTACAGGA
AATCATTGCCTTAAAAAAGAAAACCGATCCAGAGAAAAAAGAATATCTGCACGCAAACTGGATGGCTTTAAATTATTACG
AACGTTTCGTTTTTACCAAACTAATTACTGGAAGCTTCAGAATCGGCGTAAGCCAAAAATTAATGACACGAGCTTTATCA
AAAGCAGAAAATGTAGATGAAGATGCGCTGGCTTATAAATTAATGGGAAATTGGAATCCCAATACAATTACGTTTCAGGA
ATTGATTTTGGATGAAAAAAGTTCCGATTATTTATCAAAACCATATCCATTTTATCTCGCGTATCCAATTGAAGGCGATA
TCGAAGATTTAGGAAATCCAGAAGATTGGTCCATTGAACACAAATGGGACGGAATCCGATCGCAAACTATTATCCGCGAT
GACGAAATTTATGTTTGGTCAAGAGGCGAGGAGCTGGTTACCGATAAATATCCTGAGTTTAAATCCTTTGTAGGACTTAT
TCCAAACGGGACCGTAATCGATGCAGAGATTTTAGCTTTTCCCGGAAATGAAATCGGAACTTTTAATGATTTACAAGCGA
GAATTGGGCGTAAAACCATATCGGCAAATCTGCTGGAAAAAGTTCCCGTAATTCTAAAAGCGTATGATATTTTAGAATGG
GAAGGAAAAGACATTCGAAATTTACCGTATATAGAAAGAAGAAAATTATTAGAAGATTTATACAACGAGATTAAAGACTT
AACAAGATCATTTCGACTTTCAGAAAGAGTTTCCTTAACTTCATGGGAAGATGTTGCGAAAGAAAGAGAACGAGCCCGCG
AAATGAAAAGCGAAGGTTTGATGTTAAAACGAAACAAGTCGCCATATCAGGTGGGAAGAAAAAAAGGCGATTGGTGGAAA
TGGAAAATAGAACCTCTGGTAATTGATGCCGTTTTAACTTACGCTATGCGCGGACACGGCCGACGCTCGAATTTATTTAC
TGATTACACTTTTGCGCTTTGGCAGAATAATGAAAATGGAGAAAAAGAACTAGTCACTTTTGCAAAAGCCTATTCTGGTT
TAACCGATGCAGAATTCAGAAAAGTAGATGATTTTATAAAAAAGAATACTTTAGAACGATTTGGTCCGGTTCGAAGCGTA
ACACCAAAACTGGTTTTTGAAATTGGTTTTGAAGGAATTTCACTTTCGAAAAGACATAAAAGCGGCATAGCTACCCGTTT
TCCAAGAATTCTAAGATGGCGTCAGGATAAAAAAATAGAAGAAGCCAATTCTATTGAAGATCTAAAAGATATGATTTCGT
AA

Upstream 100 bases:

>100_bases
CATAGCTATGTGAATTTAAACAAAGTGAAACGCCTTTAATAGCAAAGAGAAGCTATGTTTCTATGTGTTAAATAAATTAT
GCGGTTTAAAAGAAATGTAA

Downstream 100 bases:

>100_bases
ATACGGTACAATTTTTAAACACATAGAAACATAGGTTAAAATGTGTGTAAAAAGAATTTAAAAGAAACAAGTTTCTACTC
ATAGCTATGTTTGTTAATGC

Product: ATP dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MKNFAQLIKTLDSSNKTNVKVDALTTYFKNASPEDKVWTIAILSHRRPARPVNTTLLRLWANELANIPLWLFEESYHIVG
DLAETIALIIPTTKEHSDKSLTEFLQEIIALKKKTDPEKKEYLHANWMALNYYERFVFTKLITGSFRIGVSQKLMTRALS
KAENVDEDALAYKLMGNWNPNTITFQELILDEKSSDYLSKPYPFYLAYPIEGDIEDLGNPEDWSIEHKWDGIRSQTIIRD
DEIYVWSRGEELVTDKYPEFKSFVGLIPNGTVIDAEILAFPGNEIGTFNDLQARIGRKTISANLLEKVPVILKAYDILEW
EGKDIRNLPYIERRKLLEDLYNEIKDLTRSFRLSERVSLTSWEDVAKERERAREMKSEGLMLKRNKSPYQVGRKKGDWWK
WKIEPLVIDAVLTYAMRGHGRRSNLFTDYTFALWQNNENGEKELVTFAKAYSGLTDAEFRKVDDFIKKNTLERFGPVRSV
TPKLVFEIGFEGISLSKRHKSGIATRFPRILRWRQDKKIEEANSIEDLKDMIS

Sequences:

>Translated_533_residues
MKNFAQLIKTLDSSNKTNVKVDALTTYFKNASPEDKVWTIAILSHRRPARPVNTTLLRLWANELANIPLWLFEESYHIVG
DLAETIALIIPTTKEHSDKSLTEFLQEIIALKKKTDPEKKEYLHANWMALNYYERFVFTKLITGSFRIGVSQKLMTRALS
KAENVDEDALAYKLMGNWNPNTITFQELILDEKSSDYLSKPYPFYLAYPIEGDIEDLGNPEDWSIEHKWDGIRSQTIIRD
DEIYVWSRGEELVTDKYPEFKSFVGLIPNGTVIDAEILAFPGNEIGTFNDLQARIGRKTISANLLEKVPVILKAYDILEW
EGKDIRNLPYIERRKLLEDLYNEIKDLTRSFRLSERVSLTSWEDVAKERERAREMKSEGLMLKRNKSPYQVGRKKGDWWK
WKIEPLVIDAVLTYAMRGHGRRSNLFTDYTFALWQNNENGEKELVTFAKAYSGLTDAEFRKVDDFIKKNTLERFGPVRSV
TPKLVFEIGFEGISLSKRHKSGIATRFPRILRWRQDKKIEEANSIEDLKDMIS
>Mature_533_residues
MKNFAQLIKTLDSSNKTNVKVDALTTYFKNASPEDKVWTIAILSHRRPARPVNTTLLRLWANELANIPLWLFEESYHIVG
DLAETIALIIPTTKEHSDKSLTEFLQEIIALKKKTDPEKKEYLHANWMALNYYERFVFTKLITGSFRIGVSQKLMTRALS
KAENVDEDALAYKLMGNWNPNTITFQELILDEKSSDYLSKPYPFYLAYPIEGDIEDLGNPEDWSIEHKWDGIRSQTIIRD
DEIYVWSRGEELVTDKYPEFKSFVGLIPNGTVIDAEILAFPGNEIGTFNDLQARIGRKTISANLLEKVPVILKAYDILEW
EGKDIRNLPYIERRKLLEDLYNEIKDLTRSFRLSERVSLTSWEDVAKERERAREMKSEGLMLKRNKSPYQVGRKKGDWWK
WKIEPLVIDAVLTYAMRGHGRRSNLFTDYTFALWQNNENGEKELVTFAKAYSGLTDAEFRKVDDFIKKNTLERFGPVRSV
TPKLVFEIGFEGISLSKRHKSGIATRFPRILRWRQDKKIEEANSIEDLKDMIS

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=359, Percent_Identity=27.8551532033426, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71985269, Length=509, Percent_Identity=26.3261296660118, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320038, Length=525, Percent_Identity=24, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24762424, Length=588, Percent_Identity=23.8095238095238, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI85815841, Length=374, Percent_Identity=27.807486631016, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 61989; Mature: 61989

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFAQLIKTLDSSNKTNVKVDALTTYFKNASPEDKVWTIAILSHRRPARPVNTTLLRLW
CCHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHH
ANELANIPLWLFEESYHIVGDLAETIALIIPTTKEHSDKSLTEFLQEIIALKKKTDPEKK
HHHHCCCCEEEEECCHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
EYLHANWMALNYYERFVFTKLITGSFRIGVSQKLMTRALSKAENVDEDALAYKLMGNWNP
HHHHHCEEEHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCHHHHEEEEECCCCC
NTITFQELILDEKSSDYLSKPYPFYLAYPIEGDIEDLGNPEDWSIEHKWDGIRSQTIIRD
CEEEHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHCCCCCCCCEECCCCCCCCCEEEEC
DEIYVWSRGEELVTDKYPEFKSFVGLIPNGTVIDAEILAFPGNEIGTFNDLQARIGRKTI
CCEEEEECCCHHHHCCCCCHHHHHCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHH
SANLLEKVPVILKAYDILEWEGKDIRNLPYIERRKLLEDLYNEIKDLTRSFRLSERVSLT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SWEDVAKERERAREMKSEGLMLKRNKSPYQVGRKKGDWWKWKIEPLVIDAVLTYAMRGHG
CHHHHHHHHHHHHHHHHCCEEEECCCCHHHHCCCCCCEEEEEECHHHHHHHHHHHHHCCC
RRSNLFTDYTFALWQNNENGEKELVTFAKAYSGLTDAEFRKVDDFIKKNTLERFGPVRSV
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
TPKLVFEIGFEGISLSKRHKSGIATRFPRILRWRQDKKIEEANSIEDLKDMIS
CHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHC
>Mature Secondary Structure
MKNFAQLIKTLDSSNKTNVKVDALTTYFKNASPEDKVWTIAILSHRRPARPVNTTLLRLW
CCHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHH
ANELANIPLWLFEESYHIVGDLAETIALIIPTTKEHSDKSLTEFLQEIIALKKKTDPEKK
HHHHCCCCEEEEECCHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
EYLHANWMALNYYERFVFTKLITGSFRIGVSQKLMTRALSKAENVDEDALAYKLMGNWNP
HHHHHCEEEHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCHHHHEEEEECCCCC
NTITFQELILDEKSSDYLSKPYPFYLAYPIEGDIEDLGNPEDWSIEHKWDGIRSQTIIRD
CEEEHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHCCCCCCCCEECCCCCCCCCEEEEC
DEIYVWSRGEELVTDKYPEFKSFVGLIPNGTVIDAEILAFPGNEIGTFNDLQARIGRKTI
CCEEEEECCCHHHHCCCCCHHHHHCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHH
SANLLEKVPVILKAYDILEWEGKDIRNLPYIERRKLLEDLYNEIKDLTRSFRLSERVSLT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SWEDVAKERERAREMKSEGLMLKRNKSPYQVGRKKGDWWKWKIEPLVIDAVLTYAMRGHG
CHHHHHHHHHHHHHHHHCCEEEECCCCHHHHCCCCCCEEEEEECHHHHHHHHHHHHHCCC
RRSNLFTDYTFALWQNNENGEKELVTFAKAYSGLTDAEFRKVDDFIKKNTLERFGPVRSV
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
TPKLVFEIGFEGISLSKRHKSGIATRFPRILRWRQDKKIEEANSIEDLKDMIS
CHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA