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The map label for this gene is macA [H]

Identifier: 146299430

GI number: 146299430

Start: 1938877

End: 1939992

Strand: Direct

Name: macA [H]

Synonym: Fjoh_1670

Alternate gene names: 146299430

Gene position: 1938877-1939992 (Clockwise)

Preceding gene: 146299429

Following gene: 146299431

Centisome position: 31.8

GC content: 32.35

Gene sequence:

>1116_bases
ATGAAAAAAGGAGTAACCGTAACCATTTTAATTTTAATTGCTGTAGTGTTTTTTGGCGCACTTTACTATTTGTATGCGAA
GAATCAGGAATCACCAATTGTTTTTAAAACGGAGAAAGCAGAAATCAAAACAATAGTAAAAAATACAATTGCTACTGGTA
ACATTCAGCCTGATGAAGAGGTACTAATCAAACCGAACATTTCAGGTATTATTGAGCAGGTTTACATTAAAGCCGGAGAA
AAAATCAAAGCCGGAGATATGATTGCTAAAATTAGAGTTGTAGCCAATGTATCTAATGTAAGCAGTACTCAAAATCAAGT
ACAAACTGCTAAAATTGCTTTAGACAATCAGGAGAAAATTTATCAAAGACAAAAAACACTTTTTGAAAAAGATGTAATTT
CTGCCAATGATTTTGATGCAGCTCAATTAGCTTATAAACAAGCCAAACAAAACTATGCATCAGCATTACAAAGTTTAGAT
ATTGTAAAAACAGGAACAACTTCGTCGTTAGGAAGTTATGCGAATACTTTGATTCGTTCTACAGTAAACGGAATGGTTTT
ACAGGTTCCGGTAAAAGTAGGAAATCAGGTTATTGAAAGTAATAACTTTAATGAAGGAACTACAATAGCAAGCGTTGCCG
ATGTGGGAAGAATGATTTTTATTGGAAAAATTGACGAATCTGAAGTGGGAAAAATCAAAGAAAAAATGCCAATTGAAATT
ACTGTAGGTGCTATCGAAAACAAAAAATTTGAAGCAGTTCTTACTGATATTGCACCAAAAGGAGTTACAGAAAACGGAGC
AATTCAGTTTGAAATAAAAGCTAGATTAGAAAATAGAGACGAAACATTTATTAGAGCCGGATTAAGTGCAAATGCTTCTA
TTATTCTTGAAAAAGCCGATAAAGTTATGGCTATAAAAGAATCATTAGTACAATTTGACAAAAAAACTCAAAAACCCTAT
GTAGAAGTTGAAACAACACCTCAGAAATTTGAAAGAAGAGATTTAGTTTTAGGTGTAAGCGACGGAATCTACGTTCAGGT
AAAAAGCGGGATCAAAAACACAGATAAAATTAAAATCTGGAATCAGGGTTTGATCGATGAAAAAGAGAAAAAATAA

Upstream 100 bases:

>100_bases
TTTATTCCGGCGCAGACCGCAATTAATGTGAAGCCTGTAGACGCTTTGCGAACAGAATAAATTATCAATCAAAAAAATAA
TCGATTAAACCGAAAACAAA

Downstream 100 bases:

>100_bases
TTGAAATCGTAAAGAGTTTTTTTGGTTTTAAAAAATGTTAAATTTGCGCAGCATCGACTGCGCCATCAATCAAAATATAT
GAAAATAAATAAATATAATA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MKKGVTVTILILIAVVFFGALYYLYAKNQESPIVFKTEKAEIKTIVKNTIATGNIQPDEEVLIKPNISGIIEQVYIKAGE
KIKAGDMIAKIRVVANVSNVSSTQNQVQTAKIALDNQEKIYQRQKTLFEKDVISANDFDAAQLAYKQAKQNYASALQSLD
IVKTGTTSSLGSYANTLIRSTVNGMVLQVPVKVGNQVIESNNFNEGTTIASVADVGRMIFIGKIDESEVGKIKEKMPIEI
TVGAIENKKFEAVLTDIAPKGVTENGAIQFEIKARLENRDETFIRAGLSANASIILEKADKVMAIKESLVQFDKKTQKPY
VEVETTPQKFERRDLVLGVSDGIYVQVKSGIKNTDKIKIWNQGLIDEKEKK

Sequences:

>Translated_371_residues
MKKGVTVTILILIAVVFFGALYYLYAKNQESPIVFKTEKAEIKTIVKNTIATGNIQPDEEVLIKPNISGIIEQVYIKAGE
KIKAGDMIAKIRVVANVSNVSSTQNQVQTAKIALDNQEKIYQRQKTLFEKDVISANDFDAAQLAYKQAKQNYASALQSLD
IVKTGTTSSLGSYANTLIRSTVNGMVLQVPVKVGNQVIESNNFNEGTTIASVADVGRMIFIGKIDESEVGKIKEKMPIEI
TVGAIENKKFEAVLTDIAPKGVTENGAIQFEIKARLENRDETFIRAGLSANASIILEKADKVMAIKESLVQFDKKTQKPY
VEVETTPQKFERRDLVLGVSDGIYVQVKSGIKNTDKIKIWNQGLIDEKEKK
>Mature_371_residues
MKKGVTVTILILIAVVFFGALYYLYAKNQESPIVFKTEKAEIKTIVKNTIATGNIQPDEEVLIKPNISGIIEQVYIKAGE
KIKAGDMIAKIRVVANVSNVSSTQNQVQTAKIALDNQEKIYQRQKTLFEKDVISANDFDAAQLAYKQAKQNYASALQSLD
IVKTGTTSSLGSYANTLIRSTVNGMVLQVPVKVGNQVIESNNFNEGTTIASVADVGRMIFIGKIDESEVGKIKEKMPIEI
TVGAIENKKFEAVLTDIAPKGVTENGAIQFEIKARLENRDETFIRAGLSANASIILEKADKVMAIKESLVQFDKKTQKPY
VEVETTPQKFERRDLVLGVSDGIYVQVKSGIKNTDKIKIWNQGLIDEKEKK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40954; Mature: 40954

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGVTVTILILIAVVFFGALYYLYAKNQESPIVFKTEKAEIKTIVKNTIATGNIQPDEE
CCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCC
VLIKPNISGIIEQVYIKAGEKIKAGDMIAKIRVVANVSNVSSTQNQVQTAKIALDNQEKI
EEECCCHHHHHHHHHHHCCCEEECCCCEEEEEEEEECHHHHHHHHHHEEEEEEECCHHHH
YQRQKTLFEKDVISANDFDAAQLAYKQAKQNYASALQSLDIVKTGTTSSLGSYANTLIRS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHH
TVNGMVLQVPVKVGNQVIESNNFNEGTTIASVADVGRMIFIGKIDESEVGKIKEKMPIEI
HHCCEEEEEEHHHCCHHHCCCCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHCCCEEE
TVGAIENKKFEAVLTDIAPKGVTENGAIQFEIKARLENRDETFIRAGLSANASIILEKAD
EEEECCCCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCEEEEECHH
KVMAIKESLVQFDKKTQKPYVEVETTPQKFERRDLVLGVSDGIYVQVKSGIKNTDKIKIW
HHHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCEEEEECCCEEEEEECCCCCCCEEEEE
NQGLIDEKEKK
CCCCCCCCCCC
>Mature Secondary Structure
MKKGVTVTILILIAVVFFGALYYLYAKNQESPIVFKTEKAEIKTIVKNTIATGNIQPDEE
CCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCC
VLIKPNISGIIEQVYIKAGEKIKAGDMIAKIRVVANVSNVSSTQNQVQTAKIALDNQEKI
EEECCCHHHHHHHHHHHCCCEEECCCCEEEEEEEEECHHHHHHHHHHEEEEEEECCHHHH
YQRQKTLFEKDVISANDFDAAQLAYKQAKQNYASALQSLDIVKTGTTSSLGSYANTLIRS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHH
TVNGMVLQVPVKVGNQVIESNNFNEGTTIASVADVGRMIFIGKIDESEVGKIKEKMPIEI
HHCCEEEEEEHHHCCHHHCCCCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHCCCEEE
TVGAIENKKFEAVLTDIAPKGVTENGAIQFEIKARLENRDETFIRAGLSANASIILEKAD
EEEECCCCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCEEEEECHH
KVMAIKESLVQFDKKTQKPYVEVETTPQKFERRDLVLGVSDGIYVQVKSGIKNTDKIKIW
HHHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCEEEEECCCEEEEEECCCCCCCEEEEE
NQGLIDEKEKK
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]