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The map label for this gene is ptpA [H]

Identifier: 146299179

GI number: 146299179

Start: 1626932

End: 1629103

Strand: Direct

Name: ptpA [H]

Synonym: Fjoh_1419

Alternate gene names: 146299179

Gene position: 1626932-1629103 (Clockwise)

Preceding gene: 146299176

Following gene: 146299180

Centisome position: 26.68

GC content: 33.33

Gene sequence:

>2172_bases
ATGAATACAAGTAAATTTACTGCAGTACTTTTATTTTTAACTGCGGTCGTTTTTGGACAGCAAAAAATAACTGTCGAAAA
TGTTTTTGGCGGTACTTTCCGGGCTAAAGGGATGGATGAACTGCAATCGCTGAAAAATACAAATCAATATACTGTTTTAA
ATGTTGACCAGGCGAGCAGAAGTATGCAGATCGATTTATACGATTTTGCTACGCTCAAAAAAGTATCGAATCTTGTTGAT
ACTAAAAACCATAAAGAACTTGCCGACGGAATTGACAGCTACACCTTCGATGCTTCTGAAAAAAAAATCTTAATTGCTTG
TAATTCTACTAAAATCTTCCGTCACTCTTTTACTGCTGATTATTACCTTTACGATATCGCAGCAAAATCTCTGGTTAAAC
TTGTTGATTTTCAAATTCAAGAGCCAACTTTCTCACCTGACGGAACTAAAATCGCTTACGCAAAAAAAAATAACTTATAT
GTATATGATGTAGCATCAAAAAAATCTACACCAATTACTACAGACGGAAAGAAAAATGCTGTAATTAACGGTATTACTGA
CTGGGTTTACGAAGAAGAATTTGCTTTTGTGCGTGCATTTGACTGGAGCAAAGACAGTAAAAAAGTAGCTTACATTCGTT
TTGACGAAAGCCAGGTTCCTGAGTTTTCAATGTCAATTTTTCATAAAGATTTATATCCAAAAATTGAAACTTTTAAATAT
CCTAAAGCTGGAGAAAAAAACTCAGAAGTTTCATTACATATATATGATGTAGCTGCAGGAACTGCAAAAAAAGTAAATTT
AGGTAACTACAATGATTTCTATATTGCAAGAATGCAGTGGACAAATGATGCAAATGTACTTTGTGTACAGGTTTTAAACC
GTCACCAAGACAATTTAGATTTATTGTTTGTTGACGGAAATACAGCGACAGCAAAAGTAGTTTTGAATGAAAAAGATAAA
GCTTATGTAGATGTAACTGATAATTTGACTTTCTTAAAAGACAACAGTTTTATCTGGACCAGTGAAAAAGACGGTTTTAA
TCATATCTATGTGTATGATAAAAACGGAAAACTTAAAAATCAAGTTACAAAAGGAAACTGGGAAGTAGTTTCATACTATG
GTTTTGACGAAAAAACAAAAACGATTTTCTATCAGTCTACAGAAAATGGTTCTATTAACAGAGATCTTTACAGAATTGGT
TTAGACGGAAAAAATAAAGTGCGTTTGTCTTCAAAAACAGGAACAAGTGAGGCTACTTTCAGTCCAAATTTCCAATACTT
TATTACAACTTTCTCAAGTAATACACAGCCTACAACTTATACTTTAAACGAGGCTAAAACTGGAAAAGAAATTCAGGTTA
TCGAAAATAATCAGGCTCTTGCTGATAAATTAAAAGCGTATAACCTTCCTTCAAAAGAATACTTTGTTTTAAAAACTGCA
AAAGGGAATGAACTTAATGCATGGATTTTAAAACCAAAAGATTTTGACCCTTCAAAAAAATATCCAGTTTTTATGTTCCA
ATATTCAGGTCCGGGATCGCAGCAGGTGGCGAATCAATGGAATAACTCTAATGATTATTGGTTTCTTTCATTAACGCAGC
AAGGTTATATTGTGGCTTGCGTTGACGGAAGAGGTACAGGTTACAAAGGGGCTGATTTCAAAAAAGTGACTCAAAAAGAA
TTAGGAAAATACGAAGTTGAAGATCAAATCGATGCAGCAAAAGTAATTGGTGCTTATCCATATGTTGATGCTTCAAGAAT
TGGAATTTTCGGATGGAGTTATGGTGGTTTTATGGCATCTAACTGTATTTTCCAAGGAAATGATGTATTTAAAATGGCAA
TTGCTGTTGCTCCTGTAACAAACTGGAGATTCTATGATAGTGTTTACACAGAAAGATACATGCAGACTCCACAAGAAAAT
GCAAGCGGATACGATCAAAACTCTCCTATAAATCACGTTGATAAATTGAAAGGAAAGTTCTTATTGATTCATGGTTCTGG
CGATGACAATGTTCACGTTCAAAACACAATGCAGATGATGGAAGCATTAATTCAGGCAAATAAACAATTTGATTCTCAAA
TCTATCCAGATAAAGATCATGGTATTTATGGCGGAAAAACGAGAGTTCAGCTTTACAATAAAATGACCAATTTTATCAAA
GAAAATTTATAA

Upstream 100 bases:

>100_bases
TACGCAATCGTTATTTTTTTTAACATTTAACACTTAAAATGTGTATTATGTTTATTTTTTTTATTAAAATTGGGCTCTTT
TTATATTTAAAATAATTCTA

Downstream 100 bases:

>100_bases
TCTAAAACAATATTAACCTAAAAATAATAATGAAAATATGGGAGAAACTCAAGTAAAAACTGCGCATCCAAAAGGTCTTT
GGGTACTATTCGGAACGGAG

Product: peptidase S9B dipeptidylpeptidase IV subunit

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 723; Mature: 723

Protein sequence:

>723_residues
MNTSKFTAVLLFLTAVVFGQQKITVENVFGGTFRAKGMDELQSLKNTNQYTVLNVDQASRSMQIDLYDFATLKKVSNLVD
TKNHKELADGIDSYTFDASEKKILIACNSTKIFRHSFTADYYLYDIAAKSLVKLVDFQIQEPTFSPDGTKIAYAKKNNLY
VYDVASKKSTPITTDGKKNAVINGITDWVYEEEFAFVRAFDWSKDSKKVAYIRFDESQVPEFSMSIFHKDLYPKIETFKY
PKAGEKNSEVSLHIYDVAAGTAKKVNLGNYNDFYIARMQWTNDANVLCVQVLNRHQDNLDLLFVDGNTATAKVVLNEKDK
AYVDVTDNLTFLKDNSFIWTSEKDGFNHIYVYDKNGKLKNQVTKGNWEVVSYYGFDEKTKTIFYQSTENGSINRDLYRIG
LDGKNKVRLSSKTGTSEATFSPNFQYFITTFSSNTQPTTYTLNEAKTGKEIQVIENNQALADKLKAYNLPSKEYFVLKTA
KGNELNAWILKPKDFDPSKKYPVFMFQYSGPGSQQVANQWNNSNDYWFLSLTQQGYIVACVDGRGTGYKGADFKKVTQKE
LGKYEVEDQIDAAKVIGAYPYVDASRIGIFGWSYGGFMASNCIFQGNDVFKMAIAVAPVTNWRFYDSVYTERYMQTPQEN
ASGYDQNSPINHVDKLKGKFLLIHGSGDDNVHVQNTMQMMEALIQANKQFDSQIYPDKDHGIYGGKTRVQLYNKMTNFIK
ENL

Sequences:

>Translated_723_residues
MNTSKFTAVLLFLTAVVFGQQKITVENVFGGTFRAKGMDELQSLKNTNQYTVLNVDQASRSMQIDLYDFATLKKVSNLVD
TKNHKELADGIDSYTFDASEKKILIACNSTKIFRHSFTADYYLYDIAAKSLVKLVDFQIQEPTFSPDGTKIAYAKKNNLY
VYDVASKKSTPITTDGKKNAVINGITDWVYEEEFAFVRAFDWSKDSKKVAYIRFDESQVPEFSMSIFHKDLYPKIETFKY
PKAGEKNSEVSLHIYDVAAGTAKKVNLGNYNDFYIARMQWTNDANVLCVQVLNRHQDNLDLLFVDGNTATAKVVLNEKDK
AYVDVTDNLTFLKDNSFIWTSEKDGFNHIYVYDKNGKLKNQVTKGNWEVVSYYGFDEKTKTIFYQSTENGSINRDLYRIG
LDGKNKVRLSSKTGTSEATFSPNFQYFITTFSSNTQPTTYTLNEAKTGKEIQVIENNQALADKLKAYNLPSKEYFVLKTA
KGNELNAWILKPKDFDPSKKYPVFMFQYSGPGSQQVANQWNNSNDYWFLSLTQQGYIVACVDGRGTGYKGADFKKVTQKE
LGKYEVEDQIDAAKVIGAYPYVDASRIGIFGWSYGGFMASNCIFQGNDVFKMAIAVAPVTNWRFYDSVYTERYMQTPQEN
ASGYDQNSPINHVDKLKGKFLLIHGSGDDNVHVQNTMQMMEALIQANKQFDSQIYPDKDHGIYGGKTRVQLYNKMTNFIK
ENL
>Mature_723_residues
MNTSKFTAVLLFLTAVVFGQQKITVENVFGGTFRAKGMDELQSLKNTNQYTVLNVDQASRSMQIDLYDFATLKKVSNLVD
TKNHKELADGIDSYTFDASEKKILIACNSTKIFRHSFTADYYLYDIAAKSLVKLVDFQIQEPTFSPDGTKIAYAKKNNLY
VYDVASKKSTPITTDGKKNAVINGITDWVYEEEFAFVRAFDWSKDSKKVAYIRFDESQVPEFSMSIFHKDLYPKIETFKY
PKAGEKNSEVSLHIYDVAAGTAKKVNLGNYNDFYIARMQWTNDANVLCVQVLNRHQDNLDLLFVDGNTATAKVVLNEKDK
AYVDVTDNLTFLKDNSFIWTSEKDGFNHIYVYDKNGKLKNQVTKGNWEVVSYYGFDEKTKTIFYQSTENGSINRDLYRIG
LDGKNKVRLSSKTGTSEATFSPNFQYFITTFSSNTQPTTYTLNEAKTGKEIQVIENNQALADKLKAYNLPSKEYFVLKTA
KGNELNAWILKPKDFDPSKKYPVFMFQYSGPGSQQVANQWNNSNDYWFLSLTQQGYIVACVDGRGTGYKGADFKKVTQKE
LGKYEVEDQIDAAKVIGAYPYVDASRIGIFGWSYGGFMASNCIFQGNDVFKMAIAVAPVTNWRFYDSVYTERYMQTPQEN
ASGYDQNSPINHVDKLKGKFLLIHGSGDDNVHVQNTMQMMEALIQANKQFDSQIYPDKDHGIYGGKTRVQLYNKMTNFIK
ENL

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI16933540, Length=666, Percent_Identity=31.981981981982, Blast_Score=327, Evalue=3e-89,
Organism=Homo sapiens, GI18765694, Length=687, Percent_Identity=33.4788937409025, Blast_Score=322, Evalue=1e-87,
Organism=Homo sapiens, GI295842403, Length=666, Percent_Identity=29.5795795795796, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI85787627, Length=666, Percent_Identity=29.5795795795796, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI52426756, Length=666, Percent_Identity=29.5795795795796, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI295849272, Length=666, Percent_Identity=29.5795795795796, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI295842359, Length=666, Percent_Identity=29.5795795795796, Blast_Score=283, Evalue=5e-76,
Organism=Homo sapiens, GI86792778, Length=756, Percent_Identity=25.5291005291005, Blast_Score=258, Evalue=2e-68,
Organism=Homo sapiens, GI86792863, Length=756, Percent_Identity=25.5291005291005, Blast_Score=257, Evalue=3e-68,
Organism=Homo sapiens, GI86792774, Length=756, Percent_Identity=25.5291005291005, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI18450280, Length=675, Percent_Identity=25.3333333333333, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI37577089, Length=675, Percent_Identity=25.3333333333333, Blast_Score=243, Evalue=6e-64,
Organism=Homo sapiens, GI194394146, Length=570, Percent_Identity=27.8947368421053, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI37577091, Length=675, Percent_Identity=23.5555555555556, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI18450278, Length=465, Percent_Identity=21.505376344086, Blast_Score=93, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17564632, Length=606, Percent_Identity=26.5676567656766, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17564634, Length=606, Percent_Identity=26.5676567656766, Blast_Score=183, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17550672, Length=596, Percent_Identity=26.8456375838926, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17508017, Length=244, Percent_Identity=34.8360655737705, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17508019, Length=244, Percent_Identity=34.8360655737705, Blast_Score=170, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17552908, Length=253, Percent_Identity=24.5059288537549, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321817, Length=674, Percent_Identity=34.272997032641, Blast_Score=362, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6324793, Length=768, Percent_Identity=27.2135416666667, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24582032, Length=669, Percent_Identity=32.4364723467862, Blast_Score=299, Evalue=6e-81,
Organism=Drosophila melanogaster, GI45550825, Length=746, Percent_Identity=25.6032171581769, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI45553511, Length=746, Percent_Identity=25.6032171581769, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI45551969, Length=746, Percent_Identity=25.6032171581769, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17933704, Length=777, Percent_Identity=29.6010296010296, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI161083744, Length=777, Percent_Identity=29.6010296010296, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI221331178, Length=777, Percent_Identity=29.6010296010296, Blast_Score=253, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24582257, Length=276, Percent_Identity=34.7826086956522, Blast_Score=177, Evalue=3e-44,
Organism=Drosophila melanogaster, GI221372263, Length=696, Percent_Identity=22.8448275862069, Blast_Score=166, Evalue=6e-41,
Organism=Drosophila melanogaster, GI45551475, Length=667, Percent_Identity=22.7886056971514, Blast_Score=165, Evalue=8e-41,
Organism=Drosophila melanogaster, GI221372266, Length=696, Percent_Identity=22.8448275862069, Blast_Score=165, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 82266; Mature: 82266

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSKFTAVLLFLTAVVFGQQKITVENVFGGTFRAKGMDELQSLKNTNQYTVLNVDQASR
CCCHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCHHHHHHHHCCCCEEEEEECCCCC
SMQIDLYDFATLKKVSNLVDTKNHKELADGIDSYTFDASEKKILIACNSTKIFRHSFTAD
EEEEEEHHHHHHHHHHHHHCCCCHHHHHCCCCCCEECCCCCEEEEEECCCEEEEEECCCC
YYLYDIAAKSLVKLVDFQIQEPTFSPDGTKIAYAKKNNLYVYDVASKKSTPITTDGKKNA
EEEEHHHHHHHHHHHCEEECCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCC
VINGITDWVYEEEFAFVRAFDWSKDSKKVAYIRFDESQVPEFSMSIFHKDLYPKIETFKY
EEECHHHHHHHCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCHHEEEC
PKAGEKNSEVSLHIYDVAAGTAKKVNLGNYNDFYIARMQWTNDANVLCVQVLNRHQDNLD
CCCCCCCCEEEEEEEEECCCCEEEEECCCCCCEEEEEEEECCCCCEEEEEHHHCCCCCEE
LLFVDGNTATAKVVLNEKDKAYVDVTDNLTFLKDNSFIWTSEKDGFNHIYVYDKNGKLKN
EEEECCCCEEEEEEEECCCCEEEEEECCEEEEECCCEEEECCCCCCCEEEEECCCCCEEC
QVTKGNWEVVSYYGFDEKTKTIFYQSTENGSINRDLYRIGLDGKNKVRLSSKTGTSEATF
CEECCCEEEEEEECCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCEE
SPNFQYFITTFSSNTQPTTYTLNEAKTGKEIQVIENNQALADKLKAYNLPSKEYFVLKTA
CCCCEEEEEEECCCCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHCCCCCCCEEEEEEC
KGNELNAWILKPKDFDPSKKYPVFMFQYSGPGSQQVANQWNNSNDYWFLSLTQQGYIVAC
CCCCEEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCEEEEEEECCCEEEEE
VDGRGTGYKGADFKKVTQKELGKYEVEDQIDAAKVIGAYPYVDASRIGIFGWSYGGFMAS
ECCCCCCCCCCCHHHHHHHHCCCEECHHHHCHHHHHCCCCCCCCCEEEEEEECCCCHHHC
NCIFQGNDVFKMAIAVAPVTNWRFYDSVYTERYMQTPQENASGYDQNSPINHVDKLKGKF
CCEECCCCEEEEEEEEEECCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCE
LLIHGSGDDNVHVQNTMQMMEALIQANKQFDSQIYPDKDHGIYGGKTRVQLYNKMTNFIK
EEEECCCCCCEEHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHH
ENL
HCC
>Mature Secondary Structure
MNTSKFTAVLLFLTAVVFGQQKITVENVFGGTFRAKGMDELQSLKNTNQYTVLNVDQASR
CCCHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCHHHHHHHHCCCCEEEEEECCCCC
SMQIDLYDFATLKKVSNLVDTKNHKELADGIDSYTFDASEKKILIACNSTKIFRHSFTAD
EEEEEEHHHHHHHHHHHHHCCCCHHHHHCCCCCCEECCCCCEEEEEECCCEEEEEECCCC
YYLYDIAAKSLVKLVDFQIQEPTFSPDGTKIAYAKKNNLYVYDVASKKSTPITTDGKKNA
EEEEHHHHHHHHHHHCEEECCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCC
VINGITDWVYEEEFAFVRAFDWSKDSKKVAYIRFDESQVPEFSMSIFHKDLYPKIETFKY
EEECHHHHHHHCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCHHEEEC
PKAGEKNSEVSLHIYDVAAGTAKKVNLGNYNDFYIARMQWTNDANVLCVQVLNRHQDNLD
CCCCCCCCEEEEEEEEECCCCEEEEECCCCCCEEEEEEEECCCCCEEEEEHHHCCCCCEE
LLFVDGNTATAKVVLNEKDKAYVDVTDNLTFLKDNSFIWTSEKDGFNHIYVYDKNGKLKN
EEEECCCCEEEEEEEECCCCEEEEEECCEEEEECCCEEEECCCCCCCEEEEECCCCCEEC
QVTKGNWEVVSYYGFDEKTKTIFYQSTENGSINRDLYRIGLDGKNKVRLSSKTGTSEATF
CEECCCEEEEEEECCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCEE
SPNFQYFITTFSSNTQPTTYTLNEAKTGKEIQVIENNQALADKLKAYNLPSKEYFVLKTA
CCCCEEEEEEECCCCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHCCCCCCCEEEEEEC
KGNELNAWILKPKDFDPSKKYPVFMFQYSGPGSQQVANQWNNSNDYWFLSLTQQGYIVAC
CCCCEEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCEEEEEEECCCEEEEE
VDGRGTGYKGADFKKVTQKELGKYEVEDQIDAAKVIGAYPYVDASRIGIFGWSYGGFMAS
ECCCCCCCCCCCHHHHHHHHCCCEECHHHHCHHHHHCCCCCCCCCEEEEEEECCCCHHHC
NCIFQGNDVFKMAIAVAPVTNWRFYDSVYTERYMQTPQENASGYDQNSPINHVDKLKGKF
CCEECCCCEEEEEEEEEECCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCE
LLIHGSGDDNVHVQNTMQMMEALIQANKQFDSQIYPDKDHGIYGGKTRVQLYNKMTNFIK
EEEECCCCCCEEHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHH
ENL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA