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The map label for this gene is mro [H]

Identifier: 146298883

GI number: 146298883

Start: 1268151

End: 1269329

Strand: Direct

Name: mro [H]

Synonym: Fjoh_1122

Alternate gene names: 146298883

Gene position: 1268151-1269329 (Clockwise)

Preceding gene: 146298882

Following gene: 146298884

Centisome position: 20.8

GC content: 33.76

Gene sequence:

>1179_bases
ATGAATGTATTAAAACGTTGTATTTTTGGAATCGGCCTGTTAAGTCTGGCTTTGGTTTCAGTTCAATGCAAAAACGATAA
AAAAATGGATTCGACAGTTTCAGATCAAAAAGCAGCAGTAACAATTGAAAAATCTTCTTATGGAACAACTTCAAAAGGAG
AAAAAGTAGATAGTTATAAATTGAAAAACCAAAATGGGATGGAGGTTGACATCATCACTTTTGGCGGAAGAATTACAGAT
TTAAAAGTACCAAATAAAGAGGGTGTTTCAGAAAATGTTGTAATTGGATTTAGTTCTTTGGCACAATACGAAAAAGAAAA
CCCGTTTTTTGGAGCTTTAATTGGAAGATACGGAAACCGAATTGCTAAAGGTAAATTTACTTTAGAAGGAAAAGAATATC
AATTAGCGATAAACAATGCGCCAAATGCTTTGCACGGTGGACCTCAGGGATATTTCAATGTGGTTTGGAAAGCAGATGAG
GTTAAATCTGGCGAAACAGCTTCTTTAAAATTATCTTATTTAAGTAAAGATATGGAAGAAGGATATCCTGGAAACCTTAA
AGTTTTTGTGACTTATACATTAACAAATGATAATCAGTTAGAAGTTTTATATGAAGCGACGACTGATAAAACAACGGTTG
TGAACTTAACACAGCATTCATATTTCAATTTATCAGGAGATTTTACAAAAACAATCTTAGATCACGAATTGACTTTAAAT
GCAGATAAAATTGTTCCGGTTGATGCGACTTTGATTCCAACAGGAAAATTAGAAGATGTTGCTAATACACCTTTCGATTT
TAGAAAACCAAAGTTAATTGGAAAAGATATCGAAGCTAAAAACGAACAATTAGAAAAAGGAAAAGGTTACGATCATTGCT
GGGTATTAAATAATCCGGAAAAAGGAAAAACAATTATTGCAAAAGTATACCACGCACCAAGCGGAAGAGTTTTGGAAGTA
ACAACTGACGAACCTGGAATTCAGTTTTACTCAGGAAATTTCCTTGACGGAACTTTGCCAACGCCAAACGGAGGAACTTT
TGCTCACAGAACAGGATTGTGTCTGGAAACAGAACACTATCCAGATTCTCCAAACCAGAAAAATTTCCCAACAACGGTTT
TAAACCCGGGAGAAAATTATAAAACTAAAACTACTTTTAAATTCTCGGTAAAAAAATAG

Upstream 100 bases:

>100_bases
AAAAGCCGAAAGTCATAAAGTCCGAAAGTTTTAGTTACTTTGGAGAAAAGACTTATGACTTTTGATTTTAAGACTTTACT
AACTTAAAAAATTATCATTT

Downstream 100 bases:

>100_bases
TTTTAGAATTTGTTTATTAGTTCAATTCTCTAAGAAACCTCGAAAAGTAAGACTTTCGAGGTTTTTTTATTTGAAAACTA
TTTTGTTAGCAAAACTGTTT

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNVLKRCIFGIGLLSLALVSVQCKNDKKMDSTVSDQKAAVTIEKSSYGTTSKGEKVDSYKLKNQNGMEVDIITFGGRITD
LKVPNKEGVSENVVIGFSSLAQYEKENPFFGALIGRYGNRIAKGKFTLEGKEYQLAINNAPNALHGGPQGYFNVVWKADE
VKSGETASLKLSYLSKDMEEGYPGNLKVFVTYTLTNDNQLEVLYEATTDKTTVVNLTQHSYFNLSGDFTKTILDHELTLN
ADKIVPVDATLIPTGKLEDVANTPFDFRKPKLIGKDIEAKNEQLEKGKGYDHCWVLNNPEKGKTIIAKVYHAPSGRVLEV
TTDEPGIQFYSGNFLDGTLPTPNGGTFAHRTGLCLETEHYPDSPNQKNFPTTVLNPGENYKTKTTFKFSVKK

Sequences:

>Translated_392_residues
MNVLKRCIFGIGLLSLALVSVQCKNDKKMDSTVSDQKAAVTIEKSSYGTTSKGEKVDSYKLKNQNGMEVDIITFGGRITD
LKVPNKEGVSENVVIGFSSLAQYEKENPFFGALIGRYGNRIAKGKFTLEGKEYQLAINNAPNALHGGPQGYFNVVWKADE
VKSGETASLKLSYLSKDMEEGYPGNLKVFVTYTLTNDNQLEVLYEATTDKTTVVNLTQHSYFNLSGDFTKTILDHELTLN
ADKIVPVDATLIPTGKLEDVANTPFDFRKPKLIGKDIEAKNEQLEKGKGYDHCWVLNNPEKGKTIIAKVYHAPSGRVLEV
TTDEPGIQFYSGNFLDGTLPTPNGGTFAHRTGLCLETEHYPDSPNQKNFPTTVLNPGENYKTKTTFKFSVKK
>Mature_392_residues
MNVLKRCIFGIGLLSLALVSVQCKNDKKMDSTVSDQKAAVTIEKSSYGTTSKGEKVDSYKLKNQNGMEVDIITFGGRITD
LKVPNKEGVSENVVIGFSSLAQYEKENPFFGALIGRYGNRIAKGKFTLEGKEYQLAINNAPNALHGGPQGYFNVVWKADE
VKSGETASLKLSYLSKDMEEGYPGNLKVFVTYTLTNDNQLEVLYEATTDKTTVVNLTQHSYFNLSGDFTKTILDHELTLN
ADKIVPVDATLIPTGKLEDVANTPFDFRKPKLIGKDIEAKNEQLEKGKGYDHCWVLNNPEKGKTIIAKVYHAPSGRVLEV
TTDEPGIQFYSGNFLDGTLPTPNGGTFAHRTGLCLETEHYPDSPNQKNFPTTVLNPGENYKTKTTFKFSVKK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=352, Percent_Identity=47.1590909090909, Blast_Score=315, Evalue=5e-86,
Organism=Escherichia coli, GI1786971, Length=332, Percent_Identity=38.855421686747, Blast_Score=234, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17557428, Length=332, Percent_Identity=31.6265060240964, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI115533334, Length=332, Percent_Identity=31.6265060240964, Blast_Score=183, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319493, Length=332, Percent_Identity=33.433734939759, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322004, Length=345, Percent_Identity=31.304347826087, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324399, Length=351, Percent_Identity=28.4900284900285, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24659048, Length=352, Percent_Identity=39.2045454545455, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24668278, Length=366, Percent_Identity=36.8852459016393, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24583720, Length=368, Percent_Identity=36.6847826086957, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24668282, Length=349, Percent_Identity=36.3896848137536, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24641876, Length=358, Percent_Identity=31.5642458100559, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 43325; Mature: 43325

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLKRCIFGIGLLSLALVSVQCKNDKKMDSTVSDQKAAVTIEKSSYGTTSKGEKVDSYK
CCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEE
LKNQNGMEVDIITFGGRITDLKVPNKEGVSENVVIGFSSLAQYEKENPFFGALIGRYGNR
ECCCCCCEEEEEEECCEEEEEECCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHHCCE
IAKGKFTLEGKEYQLAINNAPNALHGGPQGYFNVVWKADEVKSGETASLKLSYLSKDMEE
EECCEEEECCCEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEHHHHHHHHC
GYPGNLKVFVTYTLTNDNQLEVLYEATTDKTTVVNLTQHSYFNLSGDFTKTILDHELTLN
CCCCCEEEEEEEEECCCCEEEEEEEECCCCEEEEEEECCCEEECCCCHHHHHCCCEEEEC
ADKIVPVDATLIPTGKLEDVANTPFDFRKPKLIGKDIEAKNEQLEKGKGYDHCWVLNNPE
CCEEEECCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCC
KGKTIIAKVYHAPSGRVLEVTTDEPGIQFYSGNFLDGTLPTPNGGTFAHRTGLCLETEHY
CCCEEEEEEEECCCCCEEEEECCCCCEEEEECCEECCCCCCCCCCCEEECCCCEEEECCC
PDSPNQKNFPTTVLNPGENYKTKTTFKFSVKK
CCCCCCCCCCEEEECCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MNVLKRCIFGIGLLSLALVSVQCKNDKKMDSTVSDQKAAVTIEKSSYGTTSKGEKVDSYK
CCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEE
LKNQNGMEVDIITFGGRITDLKVPNKEGVSENVVIGFSSLAQYEKENPFFGALIGRYGNR
ECCCCCCEEEEEEECCEEEEEECCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHHCCE
IAKGKFTLEGKEYQLAINNAPNALHGGPQGYFNVVWKADEVKSGETASLKLSYLSKDMEE
EECCEEEECCCEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEHHHHHHHHC
GYPGNLKVFVTYTLTNDNQLEVLYEATTDKTTVVNLTQHSYFNLSGDFTKTILDHELTLN
CCCCCEEEEEEEEECCCCEEEEEEEECCCCEEEEEEECCCEEECCCCHHHHHCCCEEEEC
ADKIVPVDATLIPTGKLEDVANTPFDFRKPKLIGKDIEAKNEQLEKGKGYDHCWVLNNPE
CCEEEECCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCC
KGKTIIAKVYHAPSGRVLEVTTDEPGIQFYSGNFLDGTLPTPNGGTFAHRTGLCLETEHY
CCCEEEEEEEECCCCCEEEEECCCCCEEEEECCEECCCCCCCCCCCEEECCCCEEEECCC
PDSPNQKNFPTTVLNPGENYKTKTTFKFSVKK
CCCCCCCCCCEEEECCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]