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The map label for this gene is hemF2 [H]

Identifier: 146298712

GI number: 146298712

Start: 1061145

End: 1062047

Strand: Direct

Name: hemF2 [H]

Synonym: Fjoh_0950

Alternate gene names: 146298712

Gene position: 1061145-1062047 (Clockwise)

Preceding gene: 146298711

Following gene: 146298713

Centisome position: 17.4

GC content: 40.09

Gene sequence:

>903_bases
ATGAAAGATAAATTTTACGCATACATACAAAATTTACAAGACCAGATTTGCGCTGGATTAGAAGCTGTTGACGGAACTGC
AAAATTCCGTGAAGACTTATGGAAACGTCCTGAAGGCGGAGGCGGAAGAACACGCGTTATTGAAAACGGAGCCGTTTTTG
AAAAAGGCGGTGTAAACATTTCAGCCGTTCATGGAAAACTTCCTGAAACAATGCAGAAAATGTTCGGTGTTGGCGAAGCC
GATTTCTTTGCGTGCGGATTAAGTCTGGTGATTCACCCGAAAAATCCAATGGTTCCTACTGTCCACGCCAATTGGCGCTA
TTTTGAAATGTACAACGAATCTGGAAAAGTTATCGAACAATGGTTCGGCGGCGGACAGGATTTAACGCCTTATTATTTGT
TTGAAGAAGATGGCAAACATTTTCATCAAACCTGTAAAACCGCTTGTGATAAACACAATCCGGAATTTTATCCAAAATAT
AAAAAACAATGCGACTCGTATTTCTGGAACGCACACCGAAATGAAGCCCGTGGACTTGGCGGTTTATTCTTTGACTATTG
CAAGGCAAATGAGCAAATGCCAATGGAAAACTGGTACGATTTTGTAACTGAAGTTGGAAACAGTTTCCTTGAAGCCTACG
TTCCGATTGTAGAAAAAAGAAAAAACTTAGAGTATACATCAGAAAACAGAAATTGGCAGGAAATCCGCCGTGGCCGTTAT
GTTGAGTTTAATCTGGTTCATGATAAAGGAACTTTATTCGGCTTAAAAACCAACGGAAGAATCGAAAGTATTTTAATGAG
TCTGCCTCCGCATGTACAATGGGTTTACGATCATCATCCAGAAGCAGGAAGTGACGAAGAAAAATTGATTAATGTATTGC
AGAACCCGATTGATTGGATTTAA

Upstream 100 bases:

>100_bases
TTAAACAAGAAGGAATATTAAGAGACGAATTTAGAAACGGCGATGGGCAATTGCAAAATACCGTTTATTTCGGACTTCTT
AAATCAGAATATATTAAATC

Downstream 100 bases:

>100_bases
TTTTTATTAAATGAATTCGGATTAATAGATGCCGCTCCGTTGGAGCTTTTATCTAATCTTTATAAATATCTAGACATATA
ATGCTCCTCTGGAGCATTTT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase 2; Coproporphyrinogenase 2 [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKDKFYAYIQNLQDQICAGLEAVDGTAKFREDLWKRPEGGGGRTRVIENGAVFEKGGVNISAVHGKLPETMQKMFGVGEA
DFFACGLSLVIHPKNPMVPTVHANWRYFEMYNESGKVIEQWFGGGQDLTPYYLFEEDGKHFHQTCKTACDKHNPEFYPKY
KKQCDSYFWNAHRNEARGLGGLFFDYCKANEQMPMENWYDFVTEVGNSFLEAYVPIVEKRKNLEYTSENRNWQEIRRGRY
VEFNLVHDKGTLFGLKTNGRIESILMSLPPHVQWVYDHHPEAGSDEEKLINVLQNPIDWI

Sequences:

>Translated_300_residues
MKDKFYAYIQNLQDQICAGLEAVDGTAKFREDLWKRPEGGGGRTRVIENGAVFEKGGVNISAVHGKLPETMQKMFGVGEA
DFFACGLSLVIHPKNPMVPTVHANWRYFEMYNESGKVIEQWFGGGQDLTPYYLFEEDGKHFHQTCKTACDKHNPEFYPKY
KKQCDSYFWNAHRNEARGLGGLFFDYCKANEQMPMENWYDFVTEVGNSFLEAYVPIVEKRKNLEYTSENRNWQEIRRGRY
VEFNLVHDKGTLFGLKTNGRIESILMSLPPHVQWVYDHHPEAGSDEEKLINVLQNPIDWI
>Mature_300_residues
MKDKFYAYIQNLQDQICAGLEAVDGTAKFREDLWKRPEGGGGRTRVIENGAVFEKGGVNISAVHGKLPETMQKMFGVGEA
DFFACGLSLVIHPKNPMVPTVHANWRYFEMYNESGKVIEQWFGGGQDLTPYYLFEEDGKHFHQTCKTACDKHNPEFYPKY
KKQCDSYFWNAHRNEARGLGGLFFDYCKANEQMPMENWYDFVTEVGNSFLEAYVPIVEKRKNLEYTSENRNWQEIRRGRY
VEFNLVHDKGTLFGLKTNGRIESILMSLPPHVQWVYDHHPEAGSDEEKLINVLQNPIDWI

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=310, Percent_Identity=48.3870967741936, Blast_Score=293, Evalue=1e-79,
Organism=Escherichia coli, GI1788777, Length=295, Percent_Identity=50.8474576271186, Blast_Score=285, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6320249, Length=320, Percent_Identity=49.0625, Blast_Score=307, Evalue=1e-84,
Organism=Drosophila melanogaster, GI17864388, Length=310, Percent_Identity=51.6129032258064, Blast_Score=318, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34789; Mature: 34789

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKFYAYIQNLQDQICAGLEAVDGTAKFREDLWKRPEGGGGRTRVIENGAVFEKGGVNI
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEECCCEEECCCCEE
SAVHGKLPETMQKMFGVGEADFFACGLSLVIHPKNPMVPTVHANWRYFEMYNESGKVIEQ
EEECCCCHHHHHHHHCCCCHHHHHCCEEEEEECCCCCCCEEECCEEEEEEECCCCHHHHH
WFGGGQDLTPYYLFEEDGKHFHQTCKTACDKHNPEFYPKYKKQCDSYFWNAHRNEARGLG
HCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
GLFFDYCKANEQMPMENWYDFVTEVGNSFLEAYVPIVEKRKNLEYTSENRNWQEIRRGRY
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCE
VEFNLVHDKGTLFGLKTNGRIESILMSLPPHVQWVYDHHPEAGSDEEKLINVLQNPIDWI
EEEEEEECCCEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKDKFYAYIQNLQDQICAGLEAVDGTAKFREDLWKRPEGGGGRTRVIENGAVFEKGGVNI
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEECCCEEECCCCEE
SAVHGKLPETMQKMFGVGEADFFACGLSLVIHPKNPMVPTVHANWRYFEMYNESGKVIEQ
EEECCCCHHHHHHHHCCCCHHHHHCCEEEEEECCCCCCCEEECCEEEEEEECCCCHHHHH
WFGGGQDLTPYYLFEEDGKHFHQTCKTACDKHNPEFYPKYKKQCDSYFWNAHRNEARGLG
HCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
GLFFDYCKANEQMPMENWYDFVTEVGNSFLEAYVPIVEKRKNLEYTSENRNWQEIRRGRY
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCE
VEFNLVHDKGTLFGLKTNGRIESILMSLPPHVQWVYDHHPEAGSDEEKLINVLQNPIDWI
EEEEEEECCCEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]