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The map label for this gene is hemC [H]

Identifier: 146298706

GI number: 146298706

Start: 1056762

End: 1057685

Strand: Direct

Name: hemC [H]

Synonym: Fjoh_0944

Alternate gene names: 146298706

Gene position: 1056762-1057685 (Clockwise)

Preceding gene: 146298705

Following gene: 146298707

Centisome position: 17.33

GC content: 38.31

Gene sequence:

>924_bases
ATGGCTGAAAAAACAATCAGAATTGGAACGCGTGACAGCGAATTAGCACTTTGGCAGGCACATAATGTCGAGAAAAAACT
AAACGATTTAGGTTATAAAACCTCAATTGTTGCGGTTAAATCTCAGGGCGATATTATTCTGGATAAACCTCTTTACGAAT
TAGGGATTACCGGAATTTTTACCAAAACGCTTGACATTGCTATGATCAATGGCGATATTGATATTGCGGTGCATTCTATG
AAAGATGTTCCAACGGCTTTACCAAAAGGTATCGTTCAGGGTGCTGTTTTACCACGAGCCAATGTTCTGGATATTTTAGT
TCATAAAGGAAATCCTGATTTTACAAATCCAAGTACCATCGCAACAGGAAGTTTGCGTCGTCAGGCACAATGGTTTAATA
AATACCCAAATCATACGGTTGTTGATTTACGCGGAAACGTGAATACACGCATGCAAAAATTACAAGACAATAATTGGGAC
GGAGCTGTTTTTGCTGCTGCAGGTTTGGAGCGCATCAACTTAAAACCAGAAAATTATATCAATTTAGATTGGATGATTCC
GGCACCGGCACAAGGAGCAATGCTTGTGGTGGGAATGGAAAATGACAATTATACATTGGATGCTCTTTCTCAGCTAAATG
ATATTGAAACAGAAATCTGTACACATATCGAACGTCAGTTTTTAAGAACACTTGAAGGCGGATGTACAGCCCCAATTGGA
GCTTTAGTAACGTATAACGAGGACGAAGATACTTTGCATTTTCAAGGTGTTTTACTTTCTATTGACGGAAAACAAAAACT
GGAAATCAACAAAACCGTTGATATTTCGGAGTGGAAAAAACTAGGTTTCAACTCAGCTCAGGAAATCTTGAACAATGGCG
GAACGGAATTAATGCAAAAGATTAAAGAATCCCTGAAAAAATAA

Upstream 100 bases:

>100_bases
AATCTTAAATTCATACAAAGCTTAATTTTCTTAATGGTAAGAAAAAAATCAACGTAAAGCTTAATGAACCTTAATACCTT
AATGGTAAAAATAAAAAAAC

Downstream 100 bases:

>100_bases
TGGCAAACCCAATTCAGATATTATCTACTAAAATACTATCGCCTCTTCATAAACAAGAGTTGGTTAAAATTGGCATCGAA
GTAATCGAAGCTGATTTCAT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MAEKTIRIGTRDSELALWQAHNVEKKLNDLGYKTSIVAVKSQGDIILDKPLYELGITGIFTKTLDIAMINGDIDIAVHSM
KDVPTALPKGIVQGAVLPRANVLDILVHKGNPDFTNPSTIATGSLRRQAQWFNKYPNHTVVDLRGNVNTRMQKLQDNNWD
GAVFAAAGLERINLKPENYINLDWMIPAPAQGAMLVVGMENDNYTLDALSQLNDIETEICTHIERQFLRTLEGGCTAPIG
ALVTYNEDEDTLHFQGVLLSIDGKQKLEINKTVDISEWKKLGFNSAQEILNNGGTELMQKIKESLKK

Sequences:

>Translated_307_residues
MAEKTIRIGTRDSELALWQAHNVEKKLNDLGYKTSIVAVKSQGDIILDKPLYELGITGIFTKTLDIAMINGDIDIAVHSM
KDVPTALPKGIVQGAVLPRANVLDILVHKGNPDFTNPSTIATGSLRRQAQWFNKYPNHTVVDLRGNVNTRMQKLQDNNWD
GAVFAAAGLERINLKPENYINLDWMIPAPAQGAMLVVGMENDNYTLDALSQLNDIETEICTHIERQFLRTLEGGCTAPIG
ALVTYNEDEDTLHFQGVLLSIDGKQKLEINKTVDISEWKKLGFNSAQEILNNGGTELMQKIKESLKK
>Mature_306_residues
AEKTIRIGTRDSELALWQAHNVEKKLNDLGYKTSIVAVKSQGDIILDKPLYELGITGIFTKTLDIAMINGDIDIAVHSMK
DVPTALPKGIVQGAVLPRANVLDILVHKGNPDFTNPSTIATGSLRRQAQWFNKYPNHTVVDLRGNVNTRMQKLQDNNWDG
AVFAAAGLERINLKPENYINLDWMIPAPAQGAMLVVGMENDNYTLDALSQLNDIETEICTHIERQFLRTLEGGCTAPIGA
LVTYNEDEDTLHFQGVLLSIDGKQKLEINKTVDISEWKKLGFNSAQEILNNGGTELMQKIKESLKK

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=284, Percent_Identity=35.5633802816901, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI20149500, Length=284, Percent_Identity=35.5633802816901, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI48994974, Length=309, Percent_Identity=35.2750809061489, Blast_Score=180, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319996, Length=288, Percent_Identity=34.7222222222222, Blast_Score=161, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20130425, Length=296, Percent_Identity=37.8378378378378, Blast_Score=164, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34064; Mature: 33933

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKTIRIGTRDSELALWQAHNVEKKLNDLGYKTSIVAVKSQGDIILDKPLYELGITGIF
CCCCEEEECCCCCCEEEEEHHCHHHHHHHCCCEEEEEEEECCCCEEECCCHHHHCCHHEE
TKTLDIAMINGDIDIAVHSMKDVPTALPKGIVQGAVLPRANVLDILVHKGNPDFTNPSTI
EEEEEEEEECCCEEEEEECCHHCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCE
ATGSLRRQAQWFNKYPNHTVVDLRGNVNTRMQKLQDNNWDGAVFAAAGLERINLKPENYI
ECHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCEEEEECCCEEECCCCCCEE
NLDWMIPAPAQGAMLVVGMENDNYTLDALSQLNDIETEICTHIERQFLRTLEGGCTAPIG
EEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ALVTYNEDEDTLHFQGVLLSIDGKQKLEINKTVDISEWKKLGFNSAQEILNNGGTELMQK
EEEEECCCCCEEEEEEEEEEECCCCEEEECCCCCHHHHHHCCCCHHHHHHHCCCHHHHHH
IKESLKK
HHHHHCC
>Mature Secondary Structure 
AEKTIRIGTRDSELALWQAHNVEKKLNDLGYKTSIVAVKSQGDIILDKPLYELGITGIF
CCCEEEECCCCCCEEEEEHHCHHHHHHHCCCEEEEEEEECCCCEEECCCHHHHCCHHEE
TKTLDIAMINGDIDIAVHSMKDVPTALPKGIVQGAVLPRANVLDILVHKGNPDFTNPSTI
EEEEEEEEECCCEEEEEECCHHCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCE
ATGSLRRQAQWFNKYPNHTVVDLRGNVNTRMQKLQDNNWDGAVFAAAGLERINLKPENYI
ECHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCEEEEECCCEEECCCCCCEE
NLDWMIPAPAQGAMLVVGMENDNYTLDALSQLNDIETEICTHIERQFLRTLEGGCTAPIG
EEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ALVTYNEDEDTLHFQGVLLSIDGKQKLEINKTVDISEWKKLGFNSAQEILNNGGTELMQK
EEEEECCCCCEEEEEEEEEEECCCCEEEECCCCCHHHHHHCCCCHHHHHHHCCCHHHHHH
IKESLKK
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA