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The map label for this gene is nhaA1

Identifier: 146298602

GI number: 146298602

Start: 951149

End: 952294

Strand: Direct

Name: nhaA1

Synonym: Fjoh_0840

Alternate gene names: 146298602

Gene position: 951149-952294 (Clockwise)

Preceding gene: 146298595

Following gene: 146298603

Centisome position: 15.6

GC content: 35.51

Gene sequence:

>1146_bases
ATGAAATTAACCAAGACTTTTAAAGCCTTCTTTGAAAACGAAAAATCAGGCGGATTACTATTATTATTTGTCACTGTAAT
TTCGTTGTGGGCTGCTAACTCATCTTATTCAGCTGGGTACATTGCTTTTTGGGAAAAAGATTTAGCAGGGCATTCGATCA
CGCATTGGATTAATGACGGATTGATGACGATTTTCTTTTTATTGATTGGTCTGGAACTGGAACGTGAAATTTATCATGGT
GAGTTATCAAATATCAAAAATGCTTCACTGCCTATTATGGCCGCTTTTGGCGGTATGCTTATTCCAGCGGCTACCTTTCT
TGCTCTAAATTTTGGAACTTCAACTCAAAACGGTGCCGGAATTCCTATGGCAACGGATATTGCTTTTGCTATTGGAATAT
TATCGCTTTTAGGCGATAAAGTCCCAGCTTCATTAAAAGTCTTTTTAACAGCACTTGCAGTAATTGACGATTTGGGAGCC
ATAATAGTTATTGCCGTATTTTATACTACTTCAATTGGGTTTGTGAATCTTGCTATTGCATTAGGAATTTGGGTTTTCCT
ATTTGTTTTAAACAGAATGAAAGTCTATAATTTGATTCCGTATTTAATTGGCGGTGTCATAATGTGGTATTTTATGTTGA
ATTCCGGAATCCATGCTACAATTACAGGAGTTATTTTGGCATTTGTAATTCCATTTGGCGACGGAGGCGAAAAATCTACT
TCATACAAATTGCAGCATTTTTTACATCAGCCTGTTGCATTTTTTATTCTTCCTCTTTTTGCGATTGCCAATACCTGCAT
TGCGATAGAATCAAACTGGCATATTGGCTTAAATCATCCCAATGCATTCGGAATTATTTTAGGTCTGGTAATAGGAAAAC
CTCTTGGCATTCTGCTTTTTTCTTCAATTGGAGTAAGTGCCGGATTATGTGCCCTGCCAAAAAACTTAAAATGGGCACAC
ATATTAGGAGCGGGAATGCTGGGTGGAATTGGTTTTACAATGTCAATTTTTATAACTCTTTTAGCTTTTAAAGATCCTGA
AATTATTGTTTTTTCTAAAATTGCAATTATTATTGCCTCAATCATTTCTGGAATTACAGGTTTCGTATATTTGCGGTATA
TTCTTACAACAAATAAAAATACCTGA

Upstream 100 bases:

>100_bases
ATGGAAGTGAAACTTTTTATTGGTCAGATTTTTTTTTAACTTTGAAAATACAAGCCTCAAAGAAATTCTGTCATTTCTAA
ATCATCTCAAACTTTCCAAA

Downstream 100 bases:

>100_bases
AATGAATTTTATAAATAAACTTATCATACCAATTTCTGCAGTTTTAATAATTTCAGCCTGTAATACAAAAAAAGAATCTG
AAGTTATCGAAACAAAAATT

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKLTKTFKAFFENEKSGGLLLLFVTVISLWAANSSYSAGYIAFWEKDLAGHSITHWINDGLMTIFFLLIGLELEREIYHG
ELSNIKNASLPIMAAFGGMLIPAATFLALNFGTSTQNGAGIPMATDIAFAIGILSLLGDKVPASLKVFLTALAVIDDLGA
IIVIAVFYTTSIGFVNLAIALGIWVFLFVLNRMKVYNLIPYLIGGVIMWYFMLNSGIHATITGVILAFVIPFGDGGEKST
SYKLQHFLHQPVAFFILPLFAIANTCIAIESNWHIGLNHPNAFGIILGLVIGKPLGILLFSSIGVSAGLCALPKNLKWAH
ILGAGMLGGIGFTMSIFITLLAFKDPEIIVFSKIAIIIASIISGITGFVYLRYILTTNKNT

Sequences:

>Translated_381_residues
MKLTKTFKAFFENEKSGGLLLLFVTVISLWAANSSYSAGYIAFWEKDLAGHSITHWINDGLMTIFFLLIGLELEREIYHG
ELSNIKNASLPIMAAFGGMLIPAATFLALNFGTSTQNGAGIPMATDIAFAIGILSLLGDKVPASLKVFLTALAVIDDLGA
IIVIAVFYTTSIGFVNLAIALGIWVFLFVLNRMKVYNLIPYLIGGVIMWYFMLNSGIHATITGVILAFVIPFGDGGEKST
SYKLQHFLHQPVAFFILPLFAIANTCIAIESNWHIGLNHPNAFGIILGLVIGKPLGILLFSSIGVSAGLCALPKNLKWAH
ILGAGMLGGIGFTMSIFITLLAFKDPEIIVFSKIAIIIASIISGITGFVYLRYILTTNKNT
>Mature_381_residues
MKLTKTFKAFFENEKSGGLLLLFVTVISLWAANSSYSAGYIAFWEKDLAGHSITHWINDGLMTIFFLLIGLELEREIYHG
ELSNIKNASLPIMAAFGGMLIPAATFLALNFGTSTQNGAGIPMATDIAFAIGILSLLGDKVPASLKVFLTALAVIDDLGA
IIVIAVFYTTSIGFVNLAIALGIWVFLFVLNRMKVYNLIPYLIGGVIMWYFMLNSGIHATITGVILAFVIPFGDGGEKST
SYKLQHFLHQPVAFFILPLFAIANTCIAIESNWHIGLNHPNAFGIILGLVIGKPLGILLFSSIGVSAGLCALPKNLKWAH
ILGAGMLGGIGFTMSIFITLLAFKDPEIIVFSKIAIIIASIISGITGFVYLRYILTTNKNT

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=386, Percent_Identity=43.0051813471503, Blast_Score=279, Evalue=3e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA1_FLAJ1 (A5FLP0)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001193193.1
- ProteinModelPortal:   A5FLP0
- SMR:   A5FLP0
- STRING:   A5FLP0
- GeneID:   5092029
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_0840
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   ITHWIND
- ProtClustDB:   CLSK839815
- BioCyc:   FJOH376686:FJOH_0840-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 41149; Mature: 41149

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x40e1b6fc)-; HASH(0x1cf2b3c0)-; HASH(0x1d5faee4)-; HASH(0xd045024)-; HASH(0xd068a14)-; HASH(0x1d2a8c64)-; HASH(0x1d5fabe4)-; HASH(0x1d605230)-; HASH(0x1d1d3198)-; HASH(0x1d03df10)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTKTFKAFFENEKSGGLLLLFVTVISLWAANSSYSAGYIAFWEKDLAGHSITHWINDG
CCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCCCEEEEECHHHCCCHHHHHHHHH
LMTIFFLLIGLELEREIYHGELSNIKNASLPIMAAFGGMLIPAATFLALNFGTSTQNGAG
HHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHHHCCHHHHHHHHHHEECCCCCCCCCC
IPMATDIAFAIGILSLLGDKVPASLKVFLTALAVIDDLGAIIVIAVFYTTSIGFVNLAIA
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGIWVFLFVLNRMKVYNLIPYLIGGVIMWYFMLNSGIHATITGVILAFVIPFGDGGEKST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCH
SYKLQHFLHQPVAFFILPLFAIANTCIAIESNWHIGLNHPNAFGIILGLVIGKPLGILLF
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEECCCCCHHHHHHHHHHCCHHHHHHH
SSIGVSAGLCALPKNLKWAHILGAGMLGGIGFTMSIFITLLAFKDPEIIVFSKIAIIIAS
HHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
IISGITGFVYLRYILTTNKNT
HHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MKLTKTFKAFFENEKSGGLLLLFVTVISLWAANSSYSAGYIAFWEKDLAGHSITHWINDG
CCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCCCEEEEECHHHCCCHHHHHHHHH
LMTIFFLLIGLELEREIYHGELSNIKNASLPIMAAFGGMLIPAATFLALNFGTSTQNGAG
HHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHHHCCHHHHHHHHHHEECCCCCCCCCC
IPMATDIAFAIGILSLLGDKVPASLKVFLTALAVIDDLGAIIVIAVFYTTSIGFVNLAIA
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGIWVFLFVLNRMKVYNLIPYLIGGVIMWYFMLNSGIHATITGVILAFVIPFGDGGEKST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCH
SYKLQHFLHQPVAFFILPLFAIANTCIAIESNWHIGLNHPNAFGIILGLVIGKPLGILLF
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEECCCCCHHHHHHHHHHCCHHHHHHH
SSIGVSAGLCALPKNLKWAHILGAGMLGGIGFTMSIFITLLAFKDPEIIVFSKIAIIIAS
HHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
IISGITGFVYLRYILTTNKNT
HHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA