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The map label for this gene is pgi [H]

Identifier: 146298498

GI number: 146298498

Start: 811591

End: 813234

Strand: Direct

Name: pgi [H]

Synonym: Fjoh_0735

Alternate gene names: 146298498

Gene position: 811591-813234 (Clockwise)

Preceding gene: 146298497

Following gene: 146298499

Centisome position: 13.31

GC content: 34.18

Gene sequence:

>1644_bases
ATGGCTTTAAACACAACAAACCCAACCGGGACTGAAGCGTGGAAAAATCTGCAAAACCACTATAATGCAATTCACGAAAC
CACAATTCAAGAATTGTTTCAACAAGATAATGCTCGTGCTGAAAAATTCAACTTGCAATGGAATGACTTTTTAGTAGATT
ATTCTAAAAATAATATTAGTCAGGAAACAATTTCTCTTTTATTAGAATTAGCAAATTCTATCGGATTAAAAGATGCCGTT
GCTCAATATTTTGGCGGAGCATTAATTAACCAGACTGAAAATCGCGCTGTTCTTCATACTGCATTGCGTGCTCCGGAATC
GGCAGTAATTAATATTGATGGAGAAAACGTAATCCCGGAAGTTTATGAAGTAAAAAACAAAATCAAAAATTTCACAAACG
AAGTTATTTCGGGAGAAAGAAAAGGTTTTACCGGGAAAGCTTTTACAGATATTGTAAATATTGGAATTGGAGGCTCAGAT
CTTGGACCAGTTATGGCCGTTGAAGCTTTACAATTTTACAAAAACCATTTAAAAACTCATTTCGTTTCAAATGTTGATGG
TGATCACGTAAACGAAATAATTAAAAAGTTAAACCCTGAAACTACACTTTTCTTAATCGTTTCTAAAACTTTTACAACTC
AGGAAACGTTATCAAATTCTGAAACTATTAAAGAATGGTTTTTGAAATCAGGTTCTCAGGAAGATATTGCAAAACACTTC
GTGGCAGTTTCTACAAACATCCAAAAAGTAACTGAGTTTGGAATTAATCCAGACAATGTTTTCCCTATGTGGGATTGGGT
TGGAGGAAGATTTTCTCTTTGGAGTGCAGTTGGATTAAGTATTGCTCTAGCAATTGGATTTGATAATTACAACCAATTAT
TAGTGGGAGCAAATGAAATGGACGAACATTTCAAATCGGCAGAATTTAACGAAAACATTCCGGTAATTTTAGCTTTATTA
AGCGTTTGGTACAATAATTTCTTTGGTGCCGAAAGTGAAGCATTAATTCCGTACACACAATATTTATCAAAACTGGCTCC
ATATTTACAACAGGCAACTATGGAAAGTAATGGAAAAAGTGTTGGCCGTGACGGAAAACCGGTTAACTACCAAACTGGAA
CTATTATCTGGGGTGAGCCTGGAACAAATTCACAGCATGCCTTTTTCCAATTGATTCACCAAGGGACTAAGAGAATCCCA
ACAGATTTTATAGGATTCGTAAAACCACTTTACGGAAACGAAGATCATCACAATAAACTGATGTCGAACTTTTTTGCACA
GACTGAAGCTTTAATGAACGGAAAAACTCCTGCACAAGTTCAGGCTGAGTTTGACAAACAAGGACTTTCTGCAGAAAAAG
CTTCTTATTTATTACCATTTAAAGTTTTCACAGGAAACAAACCAACCAATACAATTTTGATCCAAAAACTTACTCCAAAA
AGCTTAGGTTCTTTAATTGCATTGTATGAGCATAAAATATTTGTTCAGGGTGTAATTTGGAACATTTTTAGTTTTGATCA
ATGGGGAGTTGAGTTAGGAAAACAGTTAGCAAACTCAATTTTAGATGAGATAAATTCTAAAACTGTTAAGAATCATGACA
GCTCAACTTCATTCTTATTGAATCACTTTTTAAAGAATAAATAA

Upstream 100 bases:

>100_bases
GTAACTAATTGTTATATAATCATCAACCGTTACCCTTTTAAAAGTTATTTCAGTATTTTTGTGTTTCTAAAAAAAACAAA
ATCTTCAATAAAAAATACAA

Downstream 100 bases:

>100_bases
AATTTAACTAAAAGTTTAATTTTGTAAAACACTGAAACGTCTTAATTTAACAAAAATTAAGGCGTTTTTTCGTATAGAAC
AAGTCGCAAAACCTGTCTTT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MALNTTNPTGTEAWKNLQNHYNAIHETTIQELFQQDNARAEKFNLQWNDFLVDYSKNNISQETISLLLELANSIGLKDAV
AQYFGGALINQTENRAVLHTALRAPESAVINIDGENVIPEVYEVKNKIKNFTNEVISGERKGFTGKAFTDIVNIGIGGSD
LGPVMAVEALQFYKNHLKTHFVSNVDGDHVNEIIKKLNPETTLFLIVSKTFTTQETLSNSETIKEWFLKSGSQEDIAKHF
VAVSTNIQKVTEFGINPDNVFPMWDWVGGRFSLWSAVGLSIALAIGFDNYNQLLVGANEMDEHFKSAEFNENIPVILALL
SVWYNNFFGAESEALIPYTQYLSKLAPYLQQATMESNGKSVGRDGKPVNYQTGTIIWGEPGTNSQHAFFQLIHQGTKRIP
TDFIGFVKPLYGNEDHHNKLMSNFFAQTEALMNGKTPAQVQAEFDKQGLSAEKASYLLPFKVFTGNKPTNTILIQKLTPK
SLGSLIALYEHKIFVQGVIWNIFSFDQWGVELGKQLANSILDEINSKTVKNHDSSTSFLLNHFLKNK

Sequences:

>Translated_547_residues
MALNTTNPTGTEAWKNLQNHYNAIHETTIQELFQQDNARAEKFNLQWNDFLVDYSKNNISQETISLLLELANSIGLKDAV
AQYFGGALINQTENRAVLHTALRAPESAVINIDGENVIPEVYEVKNKIKNFTNEVISGERKGFTGKAFTDIVNIGIGGSD
LGPVMAVEALQFYKNHLKTHFVSNVDGDHVNEIIKKLNPETTLFLIVSKTFTTQETLSNSETIKEWFLKSGSQEDIAKHF
VAVSTNIQKVTEFGINPDNVFPMWDWVGGRFSLWSAVGLSIALAIGFDNYNQLLVGANEMDEHFKSAEFNENIPVILALL
SVWYNNFFGAESEALIPYTQYLSKLAPYLQQATMESNGKSVGRDGKPVNYQTGTIIWGEPGTNSQHAFFQLIHQGTKRIP
TDFIGFVKPLYGNEDHHNKLMSNFFAQTEALMNGKTPAQVQAEFDKQGLSAEKASYLLPFKVFTGNKPTNTILIQKLTPK
SLGSLIALYEHKIFVQGVIWNIFSFDQWGVELGKQLANSILDEINSKTVKNHDSSTSFLLNHFLKNK
>Mature_546_residues
ALNTTNPTGTEAWKNLQNHYNAIHETTIQELFQQDNARAEKFNLQWNDFLVDYSKNNISQETISLLLELANSIGLKDAVA
QYFGGALINQTENRAVLHTALRAPESAVINIDGENVIPEVYEVKNKIKNFTNEVISGERKGFTGKAFTDIVNIGIGGSDL
GPVMAVEALQFYKNHLKTHFVSNVDGDHVNEIIKKLNPETTLFLIVSKTFTTQETLSNSETIKEWFLKSGSQEDIAKHFV
AVSTNIQKVTEFGINPDNVFPMWDWVGGRFSLWSAVGLSIALAIGFDNYNQLLVGANEMDEHFKSAEFNENIPVILALLS
VWYNNFFGAESEALIPYTQYLSKLAPYLQQATMESNGKSVGRDGKPVNYQTGTIIWGEPGTNSQHAFFQLIHQGTKRIPT
DFIGFVKPLYGNEDHHNKLMSNFFAQTEALMNGKTPAQVQAEFDKQGLSAEKASYLLPFKVFTGNKPTNTILIQKLTPKS
LGSLIALYEHKIFVQGVIWNIFSFDQWGVELGKQLANSILDEINSKTVKNHDSSTSFLLNHFLKNK

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=557, Percent_Identity=52.4236983842011, Blast_Score=578, Evalue=1e-165,
Organism=Homo sapiens, GI296080693, Length=557, Percent_Identity=49.0125673249551, Blast_Score=525, Evalue=1e-149,
Organism=Escherichia coli, GI1790457, Length=544, Percent_Identity=58.2720588235294, Blast_Score=662, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=530, Percent_Identity=57.1698113207547, Blast_Score=600, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI71996708, Length=540, Percent_Identity=56.6666666666667, Blast_Score=599, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319673, Length=546, Percent_Identity=52.7472527472528, Blast_Score=538, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24651916, Length=544, Percent_Identity=55.8823529411765, Blast_Score=594, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24651914, Length=544, Percent_Identity=55.8823529411765, Blast_Score=594, Evalue=1e-170,
Organism=Drosophila melanogaster, GI17737445, Length=544, Percent_Identity=55.8823529411765, Blast_Score=594, Evalue=1e-170,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 61233; Mature: 61102

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNTTNPTGTEAWKNLQNHYNAIHETTIQELFQQDNARAEKFNLQWNDFLVDYSKNNIS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCHHHEEEECCCCCCC
QETISLLLELANSIGLKDAVAQYFGGALINQTENRAVLHTALRAPESAVINIDGENVIPE
HHHHHHHHHHHHHCCHHHHHHHHHCCHHHCCCCCHHHHHHHHCCCCCEEEEECCCCCCHH
VYEVKNKIKNFTNEVISGERKGFTGKAFTDIVNIGIGGSDLGPVMAVEALQFYKNHLKTH
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
FVSNVDGDHVNEIIKKLNPETTLFLIVSKTFTTQETLSNSETIKEWFLKSGSQEDIAKHF
HHCCCCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHH
VAVSTNIQKVTEFGINPDNVFPMWDWVGGRFSLWSAVGLSIALAIGFDNYNQLLVGANEM
HHHHCCHHHHHHCCCCCCCCCCCHHCCCCCHHHHHHHHHHEEEEECCCCCCCEEECCHHH
DEHFKSAEFNENIPVILALLSVWYNNFFGAESEALIPYTQYLSKLAPYLQQATMESNGKS
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
VGRDGKPVNYQTGTIIWGEPGTNSQHAFFQLIHQGTKRIPTDFIGFVKPLYGNEDHHNKL
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHH
MSNFFAQTEALMNGKTPAQVQAEFDKQGLSAEKASYLLPFKVFTGNKPTNTILIQKLTPK
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHCCEEEEEEEECCCCCCCEEEEEECCHH
SLGSLIALYEHKIFVQGVIWNIFSFDQWGVELGKQLANSILDEINSKTVKNHDSSTSFLL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHH
NHFLKNK
HHHHCCC
>Mature Secondary Structure 
ALNTTNPTGTEAWKNLQNHYNAIHETTIQELFQQDNARAEKFNLQWNDFLVDYSKNNIS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCHHHEEEECCCCCCC
QETISLLLELANSIGLKDAVAQYFGGALINQTENRAVLHTALRAPESAVINIDGENVIPE
HHHHHHHHHHHHHCCHHHHHHHHHCCHHHCCCCCHHHHHHHHCCCCCEEEEECCCCCCHH
VYEVKNKIKNFTNEVISGERKGFTGKAFTDIVNIGIGGSDLGPVMAVEALQFYKNHLKTH
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
FVSNVDGDHVNEIIKKLNPETTLFLIVSKTFTTQETLSNSETIKEWFLKSGSQEDIAKHF
HHCCCCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHH
VAVSTNIQKVTEFGINPDNVFPMWDWVGGRFSLWSAVGLSIALAIGFDNYNQLLVGANEM
HHHHCCHHHHHHCCCCCCCCCCCHHCCCCCHHHHHHHHHHEEEEECCCCCCCEEECCHHH
DEHFKSAEFNENIPVILALLSVWYNNFFGAESEALIPYTQYLSKLAPYLQQATMESNGKS
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
VGRDGKPVNYQTGTIIWGEPGTNSQHAFFQLIHQGTKRIPTDFIGFVKPLYGNEDHHNKL
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHH
MSNFFAQTEALMNGKTPAQVQAEFDKQGLSAEKASYLLPFKVFTGNKPTNTILIQKLTPK
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHCCEEEEEEEECCCCCCCEEEEEECCHH
SLGSLIALYEHKIFVQGVIWNIFSFDQWGVELGKQLANSILDEINSKTVKNHDSSTSFLL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHH
NHFLKNK
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA