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The map label for this gene is kynA [H]

Identifier: 146298494

GI number: 146298494

Start: 808262

End: 809203

Strand: Direct

Name: kynA [H]

Synonym: Fjoh_0731

Alternate gene names: 146298494

Gene position: 808262-809203 (Clockwise)

Preceding gene: 146298493

Following gene: 146298495

Centisome position: 13.26

GC content: 34.08

Gene sequence:

>942_bases
ATGAACCTAACTGATAATTCAGAATCAATTTTAAAAGAAATTGATCTTAAATTTCAAGCTATAAACCAAAAAACTGACGT
TCAGTTAGAAGGACTGCTTTGGTCAAAACCAATCACATATTGGGATTACATTCAAACAGATGCTCTTCTAAATTTACAAA
TACAACGCACCACACTTCCTGACGAAATGGTTTTTATCATGTATCATCAGGTAAATGAATTAATCTTTAAAATGATTTTG
TGGGAAATTGACCAAATCGCCGACCAACAAAATATTCAGGTTGATTTTTTCAGCGAAAGACTTTCCAGAATTACTCGTTA
TTTTGATATGCTTACCAATTCGTTCAGCATTATGGAAAACGGAATGGAAGTAGACCAGTACATGAAATTTAGAAATACGC
TTACTCCTGCAAGCGGATTTCAAAGCGCACAATATAGAATGATTGAATTTGCTTCTACTGATGTTATCAATTTAACAGAC
CGCAGATACAAAGCAAACTTTGACGAAAATACAGATCTTGAAACAAGTTTTGAACATTTATATTGGCAGGCCGCTGGAAA
AGATTACCATACCGGCGAAAAATCATATTTGCTTAATGAGTTCGAAAAAAAATACAAAGACCAGTTTTTAAAACAAATTG
CTACATTTAAACCAAAAAATATTTGGCAGAAATTTACTCAGTTACCAATTGAAGATCAGCAGAATCCTGAATTAATCAAA
GCAATGCGCCACTACGATTACACAGTAAATATTACCTGGGTAATGCAGCATTTAAATACCGCCAGAAAATATATTTTAGA
AAGCGGAAAAGGCAACGGTGAAGCAACCGGAGGAAGCGACTGGCAAAAATATATGCATCCAAAATACCAAAGACGCATCT
TTTTTCCTAAATTGTGGACCGAAGAAGAATTGTCCAATTGGGGAAATGAAAATCCACTATAA

Upstream 100 bases:

>100_bases
AAGTTCCAATTAGAATTAAAGCAGATCTTGCTGTTGGATCTCTAAAAGCAGATCTCGATGAATATAAAGGACTTCAGAGT
CCGCTTAAAGTAAAAAACAA

Downstream 100 bases:

>100_bases
TTTCCTGCAAAAAATTTAAGAGTTTGAAAAAAGCATTCGTAATTATAATAGTATTATTTTCAATATTTTCATGTAAAAAA
GCTGAAGAAAAAGTTGAAAT

Product: tryptophan 2 3-dioxygenase (vermilion)-like protein

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNLTDNSESILKEIDLKFQAINQKTDVQLEGLLWSKPITYWDYIQTDALLNLQIQRTTLPDEMVFIMYHQVNELIFKMIL
WEIDQIADQQNIQVDFFSERLSRITRYFDMLTNSFSIMENGMEVDQYMKFRNTLTPASGFQSAQYRMIEFASTDVINLTD
RRYKANFDENTDLETSFEHLYWQAAGKDYHTGEKSYLLNEFEKKYKDQFLKQIATFKPKNIWQKFTQLPIEDQQNPELIK
AMRHYDYTVNITWVMQHLNTARKYILESGKGNGEATGGSDWQKYMHPKYQRRIFFPKLWTEEELSNWGNENPL

Sequences:

>Translated_313_residues
MNLTDNSESILKEIDLKFQAINQKTDVQLEGLLWSKPITYWDYIQTDALLNLQIQRTTLPDEMVFIMYHQVNELIFKMIL
WEIDQIADQQNIQVDFFSERLSRITRYFDMLTNSFSIMENGMEVDQYMKFRNTLTPASGFQSAQYRMIEFASTDVINLTD
RRYKANFDENTDLETSFEHLYWQAAGKDYHTGEKSYLLNEFEKKYKDQFLKQIATFKPKNIWQKFTQLPIEDQQNPELIK
AMRHYDYTVNITWVMQHLNTARKYILESGKGNGEATGGSDWQKYMHPKYQRRIFFPKLWTEEELSNWGNENPL
>Mature_313_residues
MNLTDNSESILKEIDLKFQAINQKTDVQLEGLLWSKPITYWDYIQTDALLNLQIQRTTLPDEMVFIMYHQVNELIFKMIL
WEIDQIADQQNIQVDFFSERLSRITRYFDMLTNSFSIMENGMEVDQYMKFRNTLTPASGFQSAQYRMIEFASTDVINLTD
RRYKANFDENTDLETSFEHLYWQAAGKDYHTGEKSYLLNEFEKKYKDQFLKQIATFKPKNIWQKFTQLPIEDQQNPELIK
AMRHYDYTVNITWVMQHLNTARKYILESGKGNGEATGGSDWQKYMHPKYQRRIFFPKLWTEEELSNWGNENPL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=148, Percent_Identity=33.7837837837838, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32564651, Length=122, Percent_Identity=34.4262295081967, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17552370, Length=122, Percent_Identity=34.4262295081967, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17530891, Length=138, Percent_Identity=34.7826086956522, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 37438; Mature: 37438

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTDNSESILKEIDLKFQAINQKTDVQLEGLLWSKPITYWDYIQTDALLNLQIQRTTLP
CCCCCCHHHHHHHHCCHHHCCCCCCCCEEECEEECCCCCHHHHHHCCCEEEEEEEECCCC
DEMVFIMYHQVNELIFKMILWEIDQIADQQNIQVDFFSERLSRITRYFDMLTNSFSIMEN
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHC
GMEVDQYMKFRNTLTPASGFQSAQYRMIEFASTDVINLTDRRYKANFDENTDLETSFEHL
CCCHHHHHHHHHCCCCCCCCCHHHHHHEEECCCCEEECCCCCEECCCCCCCCHHHHHHHH
YWQAAGKDYHTGEKSYLLNEFEKKYKDQFLKQIATFKPKNIWQKFTQLPIEDQQNPELIK
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHH
AMRHYDYTVNITWVMQHLNTARKYILESGKGNGEATGGSDWQKYMHPKYQRRIFFPKLWT
HHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCHHHHHEEECCCCCC
EEELSNWGNENPL
HHHHHCCCCCCCC
>Mature Secondary Structure
MNLTDNSESILKEIDLKFQAINQKTDVQLEGLLWSKPITYWDYIQTDALLNLQIQRTTLP
CCCCCCHHHHHHHHCCHHHCCCCCCCCEEECEEECCCCCHHHHHHCCCEEEEEEEECCCC
DEMVFIMYHQVNELIFKMILWEIDQIADQQNIQVDFFSERLSRITRYFDMLTNSFSIMEN
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHC
GMEVDQYMKFRNTLTPASGFQSAQYRMIEFASTDVINLTDRRYKANFDENTDLETSFEHL
CCCHHHHHHHHHCCCCCCCCCHHHHHHEEECCCCEEECCCCCEECCCCCCCCHHHHHHHH
YWQAAGKDYHTGEKSYLLNEFEKKYKDQFLKQIATFKPKNIWQKFTQLPIEDQQNPELIK
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHH
AMRHYDYTVNITWVMQHLNTARKYILESGKGNGEATGGSDWQKYMHPKYQRRIFFPKLWT
HHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCHHHHHEEECCCCCC
EEELSNWGNENPL
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA