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The map label for this gene is prlC [H]

Identifier: 146284467

GI number: 146284467

Start: 4508659

End: 4510881

Strand: Direct

Name: prlC [H]

Synonym: PST_4156

Alternate gene names: 146284467

Gene position: 4508659-4510881 (Clockwise)

Preceding gene: 146284465

Following gene: 146284468

Centisome position: 98.71

GC content: 67.25

Gene sequence:

>2223_bases
TTGCCGCTGCGGACCCGGGCTGAGCAGCATGCCGCCCGCCGTGGTCAGAGTAACAACCGGCCGACCGGCGTTGAAAATGC
ACGACAGCGCGTCCATCTAGGACATCTGCCTGCCACGTCCGGCCTCGCTCCAGCGAGCGGCCTGCAACCCTCTTCGTCAC
AAGGTGTCCCCGTGAGCGCGAACAATCCCCTGCTGCAACAATTCGACCTGCCGCCCTATTCCGAAATCCGTCCGGAGCAC
GTCGAGCCGGCCGTCGACACCATCCTCGGCGACAACCGCGTGGCGATCCAGGAGCTGCTCAGCCGCCCGGCCGAAAGCCT
GGACTGGCAGACCCTGGTGGTCGGGCTGGACGAGCTGAATGATCGCCTCGCCCGTGCCTGGGGGCCGGTCGGTCACCTCA
ACTCCGTGTGCAACAGCCCGGAATTGCGCACCGCGTACGAGGCCTGCCTGCCCAAGCTGTCGGCCTACTACACGGAACTC
GGGCAGAACCGCGCGCTGTTCGAGGCCTACCAGGCGCTTGCCTCCGGCCCCGCGGCGGCCGGTTTCGAGGTGGCGCAGAA
GACCATCCTCGAGCATTCGCTGCGCGACTTCCGCCTGTCCGGTATCGACCTGCCGCCGGTCGAGCAGCAGCGCTTTGGCG
CCATCCAGATGAAGCTCGCCGAGCTGGGCAGCAGGTTCTCCAACCAGCTGCTGGACGCCACGCAGGCCTGGACCCGGCAC
ATCACCGACGAGAGCCTGCTGGCCGGCATCACCGACTCGGCCAAGGCGCAGATGGCCGAGGCGGCCAAGGCCAAGGGCCT
CGACGGCTGGCTGATCACCCTGGAGTTCCCCAGCTACTACGCGGTGATGACCTATGCCGACGACCGCGGCCTGCGCGAGG
AGGTCTACACCGCCTACTGCACCCGCGCCTCGGACCAGGGCCCGAATGCCGGGCAGTTCGACAACGGCCCGGTGATGGCC
GAGATCCTCGAGCTGCGTCACGAGCTGGCCGGCCTGCTGGGCTATCGCAACTTCGCGGAGCTGTCGCTGGCGACCAAGAT
GGCCGAATCCACCGAGCAGGTACTGAGCTTTCTGCGCGACCTGGCGGTGCGCAGCAAGCCGTTCGCCGAACGCGACCTGG
CCGAACTGCGCGCCTTCGCCGCCGAGCAGGGTCTGGACGACCTGCAGAGCTGGGACCTGGGCTACTACGCCGAGAAGCTG
CGCCAGCAGCGCTACAGCCTGAACCAGGAAGAGCTGCGCGCCTACTTCCCGATCGACAAGGTACTGTCCGGGCTGTTCGG
CATCGTCCAGCGCCTGTACGGCATCCAGATCCATGAGCTGGAGCAGTTCGACGGCTGGCACCCGGATGTGCGGCTGTTCG
AGATCACCGAGAACGGCGAGCACGTCGGGCGCTTCTTCTTCGACCTCTACGCGCGGCCGAACAAGCGCGGCGGCGCCTGG
ATGGACGGCGCCCGCGACAAGCGCCGCACCGCAGACGGCACGCTGCAGACGCCGGTGGCCAACCTGGTCTGCAACTTCAC
CCCGCCGGTGGGCGAGCGCCCGGCGCTCTTGACCCATGACGAGGTCACCACGCTGTTCCACGAATTCGGCCACGGCCTGC
ACCACCTGCTGACCCAGGTCGAGCACGCTGGTGCGTCGGGCATCAACGGCGTGGCCTGGGATGCGGTGGAGCTGCCCAGC
CAGTTCATGGAGAACTGGTGCTGGGACCCCGAAGGCCTGGCGCTGATCTCCGGTCACTACCAGACCGGCGAAGCCCTGCC
ACAGGACAAACTGGACATGATGCTGGCGGCGAAGAACTTCCAGTCCGGCATGATGATGGCGCGCCAGCTGGAGTTCTCCC
TGTTCGACTTCGAACTGCACGCCACCCACGGTGACGGACGCAGCGTGCTGGAGGTGCTCGAACACATCCGCGACGAGGTT
TCGGTGATGCGGCCGCCGGCCTACAACCGCTTCCCCAACAGCTTCGCGCACATCTTCTCCGGCGGTTACGCCGCCGGTTA
CTACAGCTACAAGTGGGCCGAGGTGCTGTCGTCCGACGCCTTCTCGCGCTTCGAGGAGGAAGGGGTGTTCAACGCCGAGA
CCGGCCGCGCCTTCCGCGAGGCCATCCTGGCGCGTGGCGGCTCCCAGGAGCCGATGGTACTGTTCGTCGATTTCCGAGGC
CGCGAGCCGTCCATCGACGCCCTGCTGCGCCACCTCGGGCTGGTAGCGGAGGCCGCGGCATGA

Upstream 100 bases:

>100_bases
GCTCGCCCAGTGTCGGAGTGCTGTTTTGGTAGCTGCGTATCGCCACGATAGAAACCTCTTTGGCTGCGGGAAGGGTCGAT
TGTAATTAAGATGGCCGGCA

Downstream 100 bases:

>100_bases
GCAACGAAGTATCCCGAGTCACCACCAAGCGCTTCATCGCCGGGGCCATATGCCCGGCGTGCAGCGGTACGGACTGCATC
AAGATGTGGGATGTCGACGG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 740; Mature: 739

Protein sequence:

>740_residues
MPLRTRAEQHAARRGQSNNRPTGVENARQRVHLGHLPATSGLAPASGLQPSSSQGVPVSANNPLLQQFDLPPYSEIRPEH
VEPAVDTILGDNRVAIQELLSRPAESLDWQTLVVGLDELNDRLARAWGPVGHLNSVCNSPELRTAYEACLPKLSAYYTEL
GQNRALFEAYQALASGPAAAGFEVAQKTILEHSLRDFRLSGIDLPPVEQQRFGAIQMKLAELGSRFSNQLLDATQAWTRH
ITDESLLAGITDSAKAQMAEAAKAKGLDGWLITLEFPSYYAVMTYADDRGLREEVYTAYCTRASDQGPNAGQFDNGPVMA
EILELRHELAGLLGYRNFAELSLATKMAESTEQVLSFLRDLAVRSKPFAERDLAELRAFAAEQGLDDLQSWDLGYYAEKL
RQQRYSLNQEELRAYFPIDKVLSGLFGIVQRLYGIQIHELEQFDGWHPDVRLFEITENGEHVGRFFFDLYARPNKRGGAW
MDGARDKRRTADGTLQTPVANLVCNFTPPVGERPALLTHDEVTTLFHEFGHGLHHLLTQVEHAGASGINGVAWDAVELPS
QFMENWCWDPEGLALISGHYQTGEALPQDKLDMMLAAKNFQSGMMMARQLEFSLFDFELHATHGDGRSVLEVLEHIRDEV
SVMRPPAYNRFPNSFAHIFSGGYAAGYYSYKWAEVLSSDAFSRFEEEGVFNAETGRAFREAILARGGSQEPMVLFVDFRG
REPSIDALLRHLGLVAEAAA

Sequences:

>Translated_740_residues
MPLRTRAEQHAARRGQSNNRPTGVENARQRVHLGHLPATSGLAPASGLQPSSSQGVPVSANNPLLQQFDLPPYSEIRPEH
VEPAVDTILGDNRVAIQELLSRPAESLDWQTLVVGLDELNDRLARAWGPVGHLNSVCNSPELRTAYEACLPKLSAYYTEL
GQNRALFEAYQALASGPAAAGFEVAQKTILEHSLRDFRLSGIDLPPVEQQRFGAIQMKLAELGSRFSNQLLDATQAWTRH
ITDESLLAGITDSAKAQMAEAAKAKGLDGWLITLEFPSYYAVMTYADDRGLREEVYTAYCTRASDQGPNAGQFDNGPVMA
EILELRHELAGLLGYRNFAELSLATKMAESTEQVLSFLRDLAVRSKPFAERDLAELRAFAAEQGLDDLQSWDLGYYAEKL
RQQRYSLNQEELRAYFPIDKVLSGLFGIVQRLYGIQIHELEQFDGWHPDVRLFEITENGEHVGRFFFDLYARPNKRGGAW
MDGARDKRRTADGTLQTPVANLVCNFTPPVGERPALLTHDEVTTLFHEFGHGLHHLLTQVEHAGASGINGVAWDAVELPS
QFMENWCWDPEGLALISGHYQTGEALPQDKLDMMLAAKNFQSGMMMARQLEFSLFDFELHATHGDGRSVLEVLEHIRDEV
SVMRPPAYNRFPNSFAHIFSGGYAAGYYSYKWAEVLSSDAFSRFEEEGVFNAETGRAFREAILARGGSQEPMVLFVDFRG
REPSIDALLRHLGLVAEAAA
>Mature_739_residues
PLRTRAEQHAARRGQSNNRPTGVENARQRVHLGHLPATSGLAPASGLQPSSSQGVPVSANNPLLQQFDLPPYSEIRPEHV
EPAVDTILGDNRVAIQELLSRPAESLDWQTLVVGLDELNDRLARAWGPVGHLNSVCNSPELRTAYEACLPKLSAYYTELG
QNRALFEAYQALASGPAAAGFEVAQKTILEHSLRDFRLSGIDLPPVEQQRFGAIQMKLAELGSRFSNQLLDATQAWTRHI
TDESLLAGITDSAKAQMAEAAKAKGLDGWLITLEFPSYYAVMTYADDRGLREEVYTAYCTRASDQGPNAGQFDNGPVMAE
ILELRHELAGLLGYRNFAELSLATKMAESTEQVLSFLRDLAVRSKPFAERDLAELRAFAAEQGLDDLQSWDLGYYAEKLR
QQRYSLNQEELRAYFPIDKVLSGLFGIVQRLYGIQIHELEQFDGWHPDVRLFEITENGEHVGRFFFDLYARPNKRGGAWM
DGARDKRRTADGTLQTPVANLVCNFTPPVGERPALLTHDEVTTLFHEFGHGLHHLLTQVEHAGASGINGVAWDAVELPSQ
FMENWCWDPEGLALISGHYQTGEALPQDKLDMMLAAKNFQSGMMMARQLEFSLFDFELHATHGDGRSVLEVLEHIRDEVS
VMRPPAYNRFPNSFAHIFSGGYAAGYYSYKWAEVLSSDAFSRFEEEGVFNAETGRAFREAILARGGSQEPMVLFVDFRGR
EPSIDALLRHLGLVAEAAA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=610, Percent_Identity=33.2786885245902, Blast_Score=312, Evalue=9e-85,
Organism=Homo sapiens, GI14149738, Length=612, Percent_Identity=32.0261437908497, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI156105687, Length=635, Percent_Identity=24.4094488188976, Blast_Score=186, Evalue=5e-47,
Organism=Escherichia coli, GI1789913, Length=678, Percent_Identity=58.5545722713864, Blast_Score=801, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=695, Percent_Identity=32.3741007194245, Blast_Score=309, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI71999758, Length=573, Percent_Identity=25.8289703315881, Blast_Score=152, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI32565901, Length=676, Percent_Identity=23.0769230769231, Blast_Score=130, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319793, Length=685, Percent_Identity=29.0510948905109, Blast_Score=291, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6322715, Length=663, Percent_Identity=24.4343891402715, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI21356111, Length=584, Percent_Identity=28.5958904109589, Blast_Score=245, Evalue=8e-65,
Organism=Drosophila melanogaster, GI20129717, Length=697, Percent_Identity=25.2510760401722, Blast_Score=179, Evalue=8e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 82355; Mature: 82224

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLRTRAEQHAARRGQSNNRPTGVENARQRVHLGHLPATSGLAPASGLQPSSSQGVPVSA
CCCCCHHHHHHHHCCCCCCCCCCHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NNPLLQQFDLPPYSEIRPEHVEPAVDTILGDNRVAIQELLSRPAESLDWQTLVVGLDELN
CCCHHHHCCCCCHHHCCCCCCCHHHHHHHCCCHHHHHHHHHCCHHHCCHHHHHHHHHHHH
DRLARAWGPVGHLNSVCNSPELRTAYEACLPKLSAYYTELGQNRALFEAYQALASGPAAA
HHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
GFEVAQKTILEHSLRDFRLSGIDLPPVEQQRFGAIQMKLAELGSRFSNQLLDATQAWTRH
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITDESLLAGITDSAKAQMAEAAKAKGLDGWLITLEFPSYYAVMTYADDRGLREEVYTAYC
CCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHH
TRASDQGPNAGQFDNGPVMAEILELRHELAGLLGYRNFAELSLATKMAESTEQVLSFLRD
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LAVRSKPFAERDLAELRAFAAEQGLDDLQSWDLGYYAEKLRQQRYSLNQEELRAYFPIDK
HHHCCCCCHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCHHH
VLSGLFGIVQRLYGIQIHELEQFDGWHPDVRLFEITENGEHVGRFFFDLYARPNKRGGAW
HHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCC
MDGARDKRRTADGTLQTPVANLVCNFTPPVGERPALLTHDEVTTLFHEFGHGLHHLLTQV
CCCCCHHHHCCCCCHHCCHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHH
EHAGASGINGVAWDAVELPSQFMENWCWDPEGLALISGHYQTGEALPQDKLDMMLAAKNF
HHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
QSGMMMARQLEFSLFDFELHATHGDGRSVLEVLEHIRDEVSVMRPPAYNRFPNSFAHIFS
HHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHC
GGYAAGYYSYKWAEVLSSDAFSRFEEEGVFNAETGRAFREAILARGGSQEPMVLFVDFRG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCC
REPSIDALLRHLGLVAEAAA
CCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLRTRAEQHAARRGQSNNRPTGVENARQRVHLGHLPATSGLAPASGLQPSSSQGVPVSA
CCCCHHHHHHHHCCCCCCCCCCHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NNPLLQQFDLPPYSEIRPEHVEPAVDTILGDNRVAIQELLSRPAESLDWQTLVVGLDELN
CCCHHHHCCCCCHHHCCCCCCCHHHHHHHCCCHHHHHHHHHCCHHHCCHHHHHHHHHHHH
DRLARAWGPVGHLNSVCNSPELRTAYEACLPKLSAYYTELGQNRALFEAYQALASGPAAA
HHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
GFEVAQKTILEHSLRDFRLSGIDLPPVEQQRFGAIQMKLAELGSRFSNQLLDATQAWTRH
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITDESLLAGITDSAKAQMAEAAKAKGLDGWLITLEFPSYYAVMTYADDRGLREEVYTAYC
CCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHH
TRASDQGPNAGQFDNGPVMAEILELRHELAGLLGYRNFAELSLATKMAESTEQVLSFLRD
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LAVRSKPFAERDLAELRAFAAEQGLDDLQSWDLGYYAEKLRQQRYSLNQEELRAYFPIDK
HHHCCCCCHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCHHH
VLSGLFGIVQRLYGIQIHELEQFDGWHPDVRLFEITENGEHVGRFFFDLYARPNKRGGAW
HHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCC
MDGARDKRRTADGTLQTPVANLVCNFTPPVGERPALLTHDEVTTLFHEFGHGLHHLLTQV
CCCCCHHHHCCCCCHHCCHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHH
EHAGASGINGVAWDAVELPSQFMENWCWDPEGLALISGHYQTGEALPQDKLDMMLAAKNF
HHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
QSGMMMARQLEFSLFDFELHATHGDGRSVLEVLEHIRDEVSVMRPPAYNRFPNSFAHIFS
HHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHC
GGYAAGYYSYKWAEVLSSDAFSRFEEEGVFNAETGRAFREAILARGGSQEPMVLFVDFRG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCC
REPSIDALLRHLGLVAEAAA
CCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]