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The map label for this gene is pyrC [H]

Identifier: 146284272

GI number: 146284272

Start: 4296748

End: 4298022

Strand: Direct

Name: pyrC [H]

Synonym: PST_3960

Alternate gene names: 146284272

Gene position: 4296748-4298022 (Clockwise)

Preceding gene: 146284271

Following gene: 146284274

Centisome position: 94.07

GC content: 68.31

Gene sequence:

>1275_bases
ATGGTGGCAACAAGAATCCTCGGCGCGCGCGTTATCGACCCCAACAGCGGGCGCGACGAAGTCGCCGATATCTTCCTGCA
GGATGGCAGGATCACGTCCATTGGCCAGGCTCCTGCCGGCTTCGAGGCTCAGCAGACAATCGATGCGCAAGGCCTGATCG
CCGCACCCGGGCTCGTCGATCTCTCGGTCGCGCTGCGCGAGCCGGGCTACAGCCGCAAGGGCACGATCGCCAGTGAAACC
CTGGCTGCGGCGGCCGGCGGCATCACCAGTCTGTGCTGCCCACCGCAGACGCGTCCGGTGCTGGACACCGCCGCGGTGGC
CGAGCTGATCCTCGACCGCGCCCGCGAATCCGGCCATGCCAAGGTCTTCCCGATCGGTGCGATGACCCGCAACCTGGCCG
GGGAACAGCTGTCCGAGCTGGTCGCCTTGCGCGAGGCCGGCTGCGTCGCTTTCGGCAACGGGCTCACCGAGTTCGCCAGC
AACCGCAACCTGCGCCGCGCCCTGGAATACGCCGCCACCTTCGACCTGACGGTGATCTTTCATTCCCAGGACAGCGACCT
GGCCGAAGGCGGCCTCGCCCATGAGGGTGCCGCCGCCAGCTTTCTCGGCCTGTCAGGCATTCCGGATACCGCGGAAACCG
TGGCCCTGGCGCGCAACCTCCTGCTGGTGGAGCGCTCCGGCGTGCGCGCGCACTTCGCTCAGCTGACCAGCGCCCGCGGT
GCGGAGATGATCGCCCAGGCCCAGGCGCGCGGCTTGCCGGTAACCGCCGACGTGGCCATGTATCAGCTGATCCTCACCGA
CGAGGCGCTGCACGGCTTCTCCAGCCTCTATCACGTGCAGCCGCCACTGCGCGGCACGGCCGATCGCGACGGCTTGCGCG
AGGCGGTCAAGGCGGGCGTGATCTCGACGATTTCCAGCCACCATCAACCGCACGAAGCCGACGCCAAGCTGGCGCCGTTC
GGTGAAACCGAGCCGGGGATCAGCAGCGCGGAGATTCTTCTGCCACTGGCGATGACGCTGGTGGACGACGGTTTGCTCGA
CCTGCCGACCCTGCTGGCGCGCCTCACCAGCGGCCCGGCCGCCGCGCTGCAACTGTCCGCCGGCAGACTGCAGGCCGGTC
AGCCCGCCGACCTGGTGCTGTTCGACCCGCACAGCTCGACCCTGGTTGGCGAAAGCTGGTACTCGAAAGGGCGCAACTGT
CCGTTCATGGGCCATTGCCTGCCCGGTTCGGTGCGCTACACGCTCGTCGACGGCCACATCAGCTACCAGGCCTGA

Upstream 100 bases:

>100_bases
ACGGCATCGCCATCCGCATGGCCGTGCTGTCCATGGCGATGAGCGGCCAGACCGCGCAGCGCCAGATCGATTCCGAATCC
GTATCCGAGGAGCAGCAGTG

Downstream 100 bases:

>100_bases
GCGCAGACGGCCGGGGCGGCTGCTCGCCCGCTCCGGCCCAAGGCTTCTCGGCCGAACTCAGACCCGCGCGCGATTGCGCT
CGGATATCTGTGTGTTCAGC

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 44 kDa Non-catalytic chain [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MVATRILGARVIDPNSGRDEVADIFLQDGRITSIGQAPAGFEAQQTIDAQGLIAAPGLVDLSVALREPGYSRKGTIASET
LAAAAGGITSLCCPPQTRPVLDTAAVAELILDRARESGHAKVFPIGAMTRNLAGEQLSELVALREAGCVAFGNGLTEFAS
NRNLRRALEYAATFDLTVIFHSQDSDLAEGGLAHEGAAASFLGLSGIPDTAETVALARNLLLVERSGVRAHFAQLTSARG
AEMIAQAQARGLPVTADVAMYQLILTDEALHGFSSLYHVQPPLRGTADRDGLREAVKAGVISTISSHHQPHEADAKLAPF
GETEPGISSAEILLPLAMTLVDDGLLDLPTLLARLTSGPAAALQLSAGRLQAGQPADLVLFDPHSSTLVGESWYSKGRNC
PFMGHCLPGSVRYTLVDGHISYQA

Sequences:

>Translated_424_residues
MVATRILGARVIDPNSGRDEVADIFLQDGRITSIGQAPAGFEAQQTIDAQGLIAAPGLVDLSVALREPGYSRKGTIASET
LAAAAGGITSLCCPPQTRPVLDTAAVAELILDRARESGHAKVFPIGAMTRNLAGEQLSELVALREAGCVAFGNGLTEFAS
NRNLRRALEYAATFDLTVIFHSQDSDLAEGGLAHEGAAASFLGLSGIPDTAETVALARNLLLVERSGVRAHFAQLTSARG
AEMIAQAQARGLPVTADVAMYQLILTDEALHGFSSLYHVQPPLRGTADRDGLREAVKAGVISTISSHHQPHEADAKLAPF
GETEPGISSAEILLPLAMTLVDDGLLDLPTLLARLTSGPAAALQLSAGRLQAGQPADLVLFDPHSSTLVGESWYSKGRNC
PFMGHCLPGSVRYTLVDGHISYQA
>Mature_424_residues
MVATRILGARVIDPNSGRDEVADIFLQDGRITSIGQAPAGFEAQQTIDAQGLIAAPGLVDLSVALREPGYSRKGTIASET
LAAAAGGITSLCCPPQTRPVLDTAAVAELILDRARESGHAKVFPIGAMTRNLAGEQLSELVALREAGCVAFGNGLTEFAS
NRNLRRALEYAATFDLTVIFHSQDSDLAEGGLAHEGAAASFLGLSGIPDTAETVALARNLLLVERSGVRAHFAQLTSARG
AEMIAQAQARGLPVTADVAMYQLILTDEALHGFSSLYHVQPPLRGTADRDGLREAVKAGVISTISSHHQPHEADAKLAPF
GETEPGISSAEILLPLAMTLVDDGLLDLPTLLARLTSGPAAALQLSAGRLQAGQPADLVLFDPHSSTLVGESWYSKGRNC
PFMGHCLPGSVRYTLVDGHISYQA

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=399, Percent_Identity=29.5739348370927, Blast_Score=112, Evalue=9e-25,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=25.1716247139588, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI193204318, Length=407, Percent_Identity=25.7985257985258, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=384, Percent_Identity=28.125, Blast_Score=110, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.3

Molecular weight: Translated: 44422; Mature: 44422

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVATRILGARVIDPNSGRDEVADIFLQDGRITSIGQAPAGFEAQQTIDAQGLIAAPGLVD
CCCCEECCEEEECCCCCHHHHHHHHHCCCCEEECCCCCCCCCHHHHCCCCCEEECCCCEE
LSVALREPGYSRKGTIASETLAAAAGGITSLCCPPQTRPVLDTAAVAELILDRARESGHA
EEHHHCCCCCCCCCCCHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCE
KVFPIGAMTRNLAGEQLSELVALREAGCVAFGNGLTEFASNRNLRRALEYAATFDLTVIF
EEEECHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHCCCCHHHHHHHHHEEEEEEEE
HSQDSDLAEGGLAHEGAAASFLGLSGIPDTAETVALARNLLLVERSGVRAHFAQLTSARG
ECCCCCHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHHCCC
AEMIAQAQARGLPVTADVAMYQLILTDEALHGFSSLYHVQPPLRGTADRDGLREAVKAGV
HHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHH
ISTISSHHQPHEADAKLAPFGETEPGISSAEILLPLAMTLVDDGLLDLPTLLARLTSGPA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCH
AALQLSAGRLQAGQPADLVLFDPHSSTLVGESWYSKGRNCPFMGHCLPGSVRYTLVDGHI
HEEEEECCCCCCCCCCCEEEECCCCCCEECCHHHHCCCCCCEECCCCCCCEEEEEEECEE
SYQA
ECCC
>Mature Secondary Structure
MVATRILGARVIDPNSGRDEVADIFLQDGRITSIGQAPAGFEAQQTIDAQGLIAAPGLVD
CCCCEECCEEEECCCCCHHHHHHHHHCCCCEEECCCCCCCCCHHHHCCCCCEEECCCCEE
LSVALREPGYSRKGTIASETLAAAAGGITSLCCPPQTRPVLDTAAVAELILDRARESGHA
EEHHHCCCCCCCCCCCHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCE
KVFPIGAMTRNLAGEQLSELVALREAGCVAFGNGLTEFASNRNLRRALEYAATFDLTVIF
EEEECHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHCCCCHHHHHHHHHEEEEEEEE
HSQDSDLAEGGLAHEGAAASFLGLSGIPDTAETVALARNLLLVERSGVRAHFAQLTSARG
ECCCCCHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHHCCC
AEMIAQAQARGLPVTADVAMYQLILTDEALHGFSSLYHVQPPLRGTADRDGLREAVKAGV
HHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHH
ISTISSHHQPHEADAKLAPFGETEPGISSAEILLPLAMTLVDDGLLDLPTLLARLTSGPA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCH
AALQLSAGRLQAGQPADLVLFDPHSSTLVGESWYSKGRNCPFMGHCLPGSVRYTLVDGHI
HEEEEECCCCCCCCCCCEEEECCCCCCEECCHHHHCCCCCCEECCCCCCCEEEEEEECEE
SYQA
ECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]